Artificial intelligence-assisted system for the assessment of Forrest classification of peptic ulcer bleeding: a multicenter diagnostic study
Conclusion The DCNN system for the assessment of the Forrest classification of PUB showed satisfactory diagnostic performance, which was slightly superior to that of senior endoscopists. It could therefore effectively assist junior endoscopists in making such diagnoses during gastroscopy. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Endoscopy)
Source: Endoscopy - February 27, 2024 Category: Gastroenterology Authors: He, Xiao-Jian Wang, Xiao-Ling Su, Tian-Kang Yao, Li-Jia Zheng, Jing Wen, Xiao-Dong Xu, Qin-Wei Huang, Qian-Rong Chen, Li-Bin Chen, Chang-Xin Lin, Hai-Fan Chen, Yi-Qun Hu, Yan-Xing Zhang, Kai-Hua Jiang, Chuan-Shen Liu, Gang Li, Da-Zhou Li, Dong-Liang Wen, Tags: Original article Source Type: research

Strategies of Helicobacter pylori in evading host innate and adaptive immunity: insights and prospects for therapeutic targeting
Helicobacter pylori (H. pylori) is the predominant pathogen causing chronic gastric mucosal infections globally. During the period from 2011 to 2022, the global prevalence of H. pylori infection was estimated at 43.1%, while in China, it was slightly higher at approximately 44.2%. Persistent colonization by H. pylori can lead to gastritis, peptic ulcers, and malignancies such as mucosa-associated lymphoid tissue (MALT) lymphomas and gastric adenocarcinomas. Despite eliciting robust immune responses from the host, H. pylori thrives in the gastric mucosa by modulating host immunity, particularly by altering the functions of ...
Source: Frontiers in cellular and infection microbiology - February 26, 2024 Category: Microbiology Source Type: research

Spirulina Platensis Attenuates Rebound Dyspeptic Symptoms After Proton Pump Inhibitors' Discontinuation: Phase 2 Placebo-controlled Trial
CONCLUSIONS: A two-month course of Spirulina platensis was able to attenuate rebound dyspepsia but not reflux symptoms after PPI discontinuation. Considering its good safety profile, spirulina might be useful to relieve dyspeptic symptoms after PPI discontinuation.PMID:38401078 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 24, 2024 Category: Complementary Medicine Authors: Andreia T M Gronevalt Telma E Bertolin Cassiano M Forcelini Pedro H M Polletto Bruna W Pasetti Daniela B Graeff Rubens Rodriguez Fernando Fornari Source Type: research

Spirulina Platensis Attenuates Rebound Dyspeptic Symptoms After Proton Pump Inhibitors' Discontinuation: Phase 2 Placebo-controlled Trial
CONCLUSIONS: A two-month course of Spirulina platensis was able to attenuate rebound dyspepsia but not reflux symptoms after PPI discontinuation. Considering its good safety profile, spirulina might be useful to relieve dyspeptic symptoms after PPI discontinuation.PMID:38401078 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 24, 2024 Category: Complementary Medicine Authors: Andreia T M Gronevalt Telma E Bertolin Cassiano M Forcelini Pedro H M Polletto Bruna W Pasetti Daniela B Graeff Rubens Rodriguez Fernando Fornari Source Type: research

Spirulina Platensis Attenuates Rebound Dyspeptic Symptoms After Proton Pump Inhibitors' Discontinuation: Phase 2 Placebo-controlled Trial
CONCLUSIONS: A two-month course of Spirulina platensis was able to attenuate rebound dyspepsia but not reflux symptoms after PPI discontinuation. Considering its good safety profile, spirulina might be useful to relieve dyspeptic symptoms after PPI discontinuation.PMID:38401078 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 24, 2024 Category: Complementary Medicine Authors: Andreia T M Gronevalt Telma E Bertolin Cassiano M Forcelini Pedro H M Polletto Bruna W Pasetti Daniela B Graeff Rubens Rodriguez Fernando Fornari Source Type: research

Spirulina Platensis Attenuates Rebound Dyspeptic Symptoms After Proton Pump Inhibitors' Discontinuation: Phase 2 Placebo-controlled Trial
CONCLUSIONS: A two-month course of Spirulina platensis was able to attenuate rebound dyspepsia but not reflux symptoms after PPI discontinuation. Considering its good safety profile, spirulina might be useful to relieve dyspeptic symptoms after PPI discontinuation.PMID:38401078 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - February 24, 2024 Category: Complementary Medicine Authors: Andreia T M Gronevalt Telma E Bertolin Cassiano M Forcelini Pedro H M Polletto Bruna W Pasetti Daniela B Graeff Rubens Rodriguez Fernando Fornari Source Type: research

What is Valentino's syndrome?
AbstractThe eponym ‘Valentino's syndrome’ is used to describe patients with perforated peptic ulcer disease who present with right lower quadrant pain and suspected appendicitis. It is named for Rudolph Valentino, the film star who died on 23 August 1926 at the age of 31 from complications of perforated peptic ulc er disease. In the early 1920s, the Italian-born actor had a meteoric rise to fame in the burgeoning film industry. His first starring role in the 1921 silent film,The Four Horseman of the Apocalypse, was a sensation and was followed quickly by a string of commercially successful movies. He was in good health...
Source: Surgical Practice - February 23, 2024 Category: Surgery Authors: Theodore N. Pappas Tags: HISTORY Source Type: research

Vonoprazan: A Review in Helicobacter pylori Infection
AbstractTreatment for the eradication ofHelicobacter pylori infection, a leading cause of peptic ulcer disease and an important risk factor for gastric cancer and mucosa-associated lymphoid tissue lymphoma, is indicated whenever infection is identified. However, treatment success rates with current guideline-recommended proton-pump inhibitor (PPI)-based regimens remain suboptimal, with one potential factor associated with treatment failure being inadequate acid suppression. Vonoprazan (Voquezna®) is a first-in-class potassium-competitive acid blocker with the potential to provide potent and sustained acid suppression. Fol...
Source: Drugs - February 23, 2024 Category: Drugs & Pharmacology Source Type: research

Over-the-scope clips versus standard therapy in upper gastrointestinal bleeding
We read with high interest the randomised controlled trial (RCT) of Chan et al investigating over-the-scope clips (OTSC) versus standard therapy for the prevention of rebleeding in large (≥1.5 cm) peptic ulcers.1 However, this study and some aspects of study design deserve further critical evaluation and interpretation. One hundred patients with peptic ulcer bleeding and lesion size ≥1.5 cm were randomised to OTSC or standard treatment. In the intention-to-treat analysis, the primary endpoint of clinical rebleeding within 30 days was achieved in 10% with OTSC vs 18% with standard therapy. The difference was statistic...
Source: Gut - February 23, 2024 Category: Gastroenterology Authors: Meier, B., Schmidt, A., Caca, K. Tags: Gut PostScript Source Type: research

Design of floating formulations and antiulcer activity of Desmostachya bipinnata
AAPS PharmSciTech. 2024 Feb 21;25(3):44. doi: 10.1208/s12249-024-02745-6.ABSTRACTThe study aims to design and optimize the floating formulations of the aqueous extract of Desmostachya bipinnata (ADB) to treat peptic ulcers. The trial concentrations of HPMC E50, HPMC K4M, and Carbopol 940 were used as factors, and floating lag time, total floating time, and % drug release at 12 h were used as responses. The formulation underwent evaluation for different parameters: aspirin-induced ulcers in rats assessed the antiulcer activity, and X-ray studies in rabbits evaluated the gastroretentive nature. The optimized formulation has ...
Source: AAPS PharmSciTech - February 22, 2024 Category: Drugs & Pharmacology Authors: Sanjay Kumar Putta Koteshwara Kb Usha Y Nayak Sreedhara Ranganath Pai K Raghuveer Pathuri Aswatha Ram Hn Source Type: research

The Effect of Tegoprazan on the Treatment of Endoscopic Resection-Induced Artificial Ulcers: A Multicenter, Randomized, Active-Controlled Study
CONCLUSIONS: : Tegoprazan showed similar effects on post-ESD artificial ulcer healing in comparison with esomeprazole.PMID:38384180 | DOI:10.5009/gnl230242 (Source: Gut and Liver)
Source: Gut and Liver - February 22, 2024 Category: Gastroenterology Authors: Byung-Wook Kim Jong Jae Park Hee Seok Moon Wan Sik Lee Ki-Nam Shim Gwang Ho Baik Yun Jeong Lim Hang Lak Lee Young Hoon Youn Jun Chul Park In-Kyung Sung Hyunsoo Chung Jeong Seop Moon Gwang Ha Kim Su Jin Hong Hyuk Soon Choi Source Type: research

Design of floating formulations and antiulcer activity of Desmostachya bipinnata
AAPS PharmSciTech. 2024 Feb 21;25(3):44. doi: 10.1208/s12249-024-02745-6.ABSTRACTThe study aims to design and optimize the floating formulations of the aqueous extract of Desmostachya bipinnata (ADB) to treat peptic ulcers. The trial concentrations of HPMC E50, HPMC K4M, and Carbopol 940 were used as factors, and floating lag time, total floating time, and % drug release at 12 h were used as responses. The formulation underwent evaluation for different parameters: aspirin-induced ulcers in rats assessed the antiulcer activity, and X-ray studies in rabbits evaluated the gastroretentive nature. The optimized formulation has ...
Source: AAPS PharmSciTech - February 22, 2024 Category: Drugs & Pharmacology Authors: Sanjay Kumar Putta Koteshwara Kb Usha Y Nayak Sreedhara Ranganath Pai K Raghuveer Pathuri Aswatha Ram Hn Source Type: research

The Effect of Tegoprazan on the Treatment of Endoscopic Resection-Induced Artificial Ulcers: A Multicenter, Randomized, Active-Controlled Study
CONCLUSIONS: : Tegoprazan showed similar effects on post-ESD artificial ulcer healing in comparison with esomeprazole.PMID:38384180 | DOI:10.5009/gnl230242 (Source: Gut and Liver)
Source: Gut and Liver - February 22, 2024 Category: Gastroenterology Authors: Byung-Wook Kim Jong Jae Park Hee Seok Moon Wan Sik Lee Ki-Nam Shim Gwang Ho Baik Yun Jeong Lim Hang Lak Lee Young Hoon Youn Jun Chul Park In-Kyung Sung Hyunsoo Chung Jeong Seop Moon Gwang Ha Kim Su Jin Hong Hyuk Soon Choi Source Type: research

Design of floating formulations and antiulcer activity of Desmostachya bipinnata
AAPS PharmSciTech. 2024 Feb 21;25(3):44. doi: 10.1208/s12249-024-02745-6.ABSTRACTThe study aims to design and optimize the floating formulations of the aqueous extract of Desmostachya bipinnata (ADB) to treat peptic ulcers. The trial concentrations of HPMC E50, HPMC K4M, and Carbopol 940 were used as factors, and floating lag time, total floating time, and % drug release at 12 h were used as responses. The formulation underwent evaluation for different parameters: aspirin-induced ulcers in rats assessed the antiulcer activity, and X-ray studies in rabbits evaluated the gastroretentive nature. The optimized formulation has ...
Source: AAPS PharmSciTech - February 22, 2024 Category: Drugs & Pharmacology Authors: Sanjay Kumar Putta Koteshwara Kb Usha Y Nayak Sreedhara Ranganath Pai K Raghuveer Pathuri Aswatha Ram Hn Source Type: research

The Effect of Tegoprazan on the Treatment of Endoscopic Resection-Induced Artificial Ulcers: A Multicenter, Randomized, Active-Controlled Study
CONCLUSIONS: : Tegoprazan showed similar effects on post-ESD artificial ulcer healing in comparison with esomeprazole.PMID:38384180 | DOI:10.5009/gnl230242 (Source: Gut and Liver)
Source: Gut and Liver - February 22, 2024 Category: Gastroenterology Authors: Byung-Wook Kim Jong Jae Park Hee Seok Moon Wan Sik Lee Ki-Nam Shim Gwang Ho Baik Yun Jeong Lim Hang Lak Lee Young Hoon Youn Jun Chul Park In-Kyung Sung Hyunsoo Chung Jeong Seop Moon Gwang Ha Kim Su Jin Hong Hyuk Soon Choi Source Type: research