Blockade of aryl hydrocarbon receptor restricts omeprazole-induced chronic kidney disease
We described the process of renal injury after exposure to OME in mice; the early renal injury markers were increased in renal tubular epithelial cells (RTECs). And after long-term OME treatment, the OME-induced CKD mice model was established. Herein, aryl hydrocarbon receptor (AHR) translocation appeared after exposure to OME in HK-2 cells. Then for both in vivo and in vitro, we found that Ahr-knockout (KO) and AHR small interfering RNA (siRNA) substantially alleviated the OME-induced renal function impairment and tubular cell damage. Furthermore, our data demonstrate that antagonists of AHR and CYP1A1 could attenuate OME...
Source: Journal of Molecular Medicine - March 8, 2024 Category: Molecular Biology Source Type: research
Factors influencing outcome in patients with perforated peptic ulcer disease at a South African tertiary hospital
CONCLUSION: The Boey score was a significant predictor of mortality and leak rate in our patients with PPU. Adding age as a variable may improve the ability to predict mortality in our setting, while the impact of gender and ethnicity needs further investigation.PMID:38450692 (Source: South African Journal of Surgery)
Source: South African Journal of Surgery - March 7, 2024 Category: Surgery Authors: J J Nanack L Ferndale Source Type: research
A comparative analysis of univariate versus multivariate eco-friendly spectrophotometric manipulations for resolving severely overlapped spectra of vonoprazan and amoxicillin new combination
Anal Biochem. 2024 Mar 5:115501. doi: 10.1016/j.ab.2024.115501. Online ahead of print.ABSTRACTVonoprazan and amoxicillin are pharmacological combinations that demonstrate synergistic effects in treating Helicobacter pylori (H. pylori), a global public health concern associated with peptic ulcer disease and gastric cancer. Four spectrophotometric methods were developed, including two univariate techniques (Fourier self-deconvolution and ratio difference) and two multivariate chemometric approaches (partial least squares and principal component regression). These methods provide innovative solutions for effectively resolving...
Source: Analytical Biochemistry - March 7, 2024 Category: Biochemistry Authors: Ahmed K Kammoun Hani M Hafez Ebraam B Kamel Michael Gamal Fawzy Source Type: research
Blockade of aryl hydrocarbon receptor restricts omeprazole-induced chronic kidney disease
We described the process of renal injury after exposure to OME in mice; the early renal injury markers were increased in renal tubular epithelial cells (RTECs). And after long-term OME treatment, the OME-induced CKD mice model was established. Herein, aryl hydrocarbon receptor (AHR) translocation appeared after exposure to OME in HK-2 cells. Then for both in vivo and in vitro, we found that Ahr-knockout (KO) and AHR small interfering RNA (siRNA) substantially alleviated the OME-induced renal function impairment and tubular cell damage. Furthermore, our data demonstrate that antagonists of AHR and CYP1A1 could attenuate OME...
Source: Molecular Medicine - March 7, 2024 Category: Molecular Biology Authors: Nan Sun Yimeng Zhang Lin Ding Xin An Fang Bai Yanjiang Yang Kuipeng Yu Jiahui Fan Lei Liu Huimin Yang Xiangdong Yang Source Type: research
Factors influencing outcome in patients with perforated peptic ulcer disease at a South African tertiary hospital
CONCLUSION: The Boey score was a significant predictor of mortality and leak rate in our patients with PPU. Adding age as a variable may improve the ability to predict mortality in our setting, while the impact of gender and ethnicity needs further investigation.PMID:38450692 (Source: South African Journal of Surgery)
Source: South African Journal of Surgery - March 7, 2024 Category: Surgery Authors: J J Nanack L Ferndale Source Type: research
A comparative analysis of univariate versus multivariate eco-friendly spectrophotometric manipulations for resolving severely overlapped spectra of vonoprazan and amoxicillin new combination
Anal Biochem. 2024 Mar 5:115501. doi: 10.1016/j.ab.2024.115501. Online ahead of print.ABSTRACTVonoprazan and amoxicillin are pharmacological combinations that demonstrate synergistic effects in treating Helicobacter pylori (H. pylori), a global public health concern associated with peptic ulcer disease and gastric cancer. Four spectrophotometric methods were developed, including two univariate techniques (Fourier self-deconvolution and ratio difference) and two multivariate chemometric approaches (partial least squares and principal component regression). These methods provide innovative solutions for effectively resolving...
Source: Analytical Biochemistry - March 7, 2024 Category: Biochemistry Authors: Ahmed K Kammoun Hani M Hafez Ebraam B Kamel Michael Gamal Fawzy Source Type: research
Factors influencing outcome in patients with perforated peptic ulcer disease at a South African tertiary hospital
CONCLUSION: The Boey score was a significant predictor of mortality and leak rate in our patients with PPU. Adding age as a variable may improve the ability to predict mortality in our setting, while the impact of gender and ethnicity needs further investigation.PMID:38450692 (Source: South African Journal of Surgery)
Source: South African Journal of Surgery - March 7, 2024 Category: Surgery Authors: J J Nanack L Ferndale Source Type: research
