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Anti-parietal cell antibodies in patients with autoimmune thyroid diseases
ConclusionsThere is a high prevalence of positive APCA in ATD patients. APCA are more common in those with anemia and less common in those with complaints of heartburn. Almost half of positive APCA patients had atrophic gastritis. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - September 19, 2017 Category: Endocrinology Source Type: research

Preoperative diagnosis of hiatal hernia: barium swallow X-ray, high-resolution manometry, or endoscopy?
SummaryBackgroundThe assessment of hiatal hernias (HH) is typically done with barium swallow X ‑ray, upper endoscopy, and by high-resolution esophageal manometry (HRM). The aim of this study was to assess the clinical utility of these methods in terms of HH detection and their correlation to gastroesophageal reflux disease (GERD).MethodsA retrospective comparative analysis of patients with symptoms of GERD was carried out. The performance of endoscopy and HRM in diagnosing HH was assessed, taking barium swallow X ‑ray as a reference. Furthermore, statistically comparative analysis between detected hernias and the prese...
Source: European Surgery - September 19, 2017 Category: Surgery Source Type: research

Continued Alcohol Misuse in Human Cirrhosis is Associated with An Impaired Gut-Liver Axis.
CONCLUSIONS: Despite cirrhosis, continued alcohol misuse predisposes patients to widespread dysbiosis with alterations in microbial functionality such as a toxic bile acid profile, which can lead to intestinal and systemic inflammation. This article is protected by copyright. All rights reserved. PMID: 28925102 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 19, 2017 Category: Addiction Authors: Bajaj JS, Kakiyama G, Zhao D, Takei H, Fagan A, Hylemon P, Zhou H, Pandak WM, Nittono H, Fiehn O, Salzman N, Holtz M, Simpson P, Gavis EA, Heuman DM, Liu R, Kang DJ, Sikaroodi M, Gillevet PM Tags: Alcohol Clin Exp Res Source Type: research

Dor Vs Toupet Fundoplication After Laparoscopic Heller Myotomy: Long-Term Randomized Controlled Trial Evaluated by High-Resolution Manometry
ConclusionThere were no differences in symptom scores or HRM between fundoplications in the long term. A higher percentage of abnormal 24-h pH test were found for the Toupet group, with no difference in the long term. (Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - September 18, 2017 Category: Surgery Source Type: research

Endoscopy audit over 10years in a community hospital in Egypt
Conclusion Continuous audit over 10years can enhance endoscopy performance, improve the quality of endoscopic procedures and lead to better outcomes. (Source: Alexandria Journal of Medicine)
Source: Alexandria Journal of Medicine - September 13, 2017 Category: General Medicine Source Type: research

Helicobacter pylori infection and nonmalignant diseases
Abstract A substantial decrease in Helicobacter pylori‐associated peptic ulcer disease has been observed during the last decades. Drug‐related ulcers as well as idiopathic ulcers are becoming predominant and are more refractory to treatment; however, H. pylori infection still plays an important role in ulcer bleeding and recurrence after therapy. The effect of H. pylori eradication upon functional dyspepsia symptoms has been reviewed in this article and generally confirms the results of previous meta‐analyses. Additional evidence suggests a lack of impact upon the quality of life, in spite of improvement in symptoms....
Source: Helicobacter - September 10, 2017 Category: Gastroenterology Authors: Olga Sjomina, Frederic Heluwaert, Driffa Moussata, Marcis Leja Tags: REVIEW ARTICLE Source Type: research

Hookworm Infection: A Neglected Cause of Overt Obscure Gastrointestinal Bleeding.
Authors: Wei KY, Yan Q, Tang B, Yang SM, Zhang PB, Deng MM, Lü MH Abstract Hookworm infections are widely prevalent in tropical and subtropical areas, especially in low income regions. In the body, hookworms parasitize the proximal small intestine, leading to chronic intestinal hemorrhage and iron deficiency anemia. Occasionally, hookworms can cause overt gastrointestinal bleeding, but this is often ignored in heavily burdened individuals from endemic infectious areas. A total of 424 patients with overt obscure gastrointestinal bleeding were diagnosed by numerous blood tests or stool examinations as well as es...
Source: Korean Journal of Parasitology - September 9, 2017 Category: Parasitology Tags: Korean J Parasitol Source Type: research

Duodenal pathologies in children: a single-center experience.
CONCLUSION: Duodenal pathology was detected in 30.3% of the present patients. A significantly higher level of chronic diarrhea was observed in subjects with duodenal pathologies compared to those with no such pathology. The rate of H. pylori infection was considerably higher than that in previous studies. In addition, there is a weak correlation between endoscopic appearance and histology of duodenitis. PMID: 28888898 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - September 7, 2017 Category: Pediatrics Authors: Akbulut UE, Fidan S, Emeksiz HC, Ors OP Tags: J Pediatr (Rio J) Source Type: research

Optimal procedural sequence for same ‐day bidirectional endoscopy with moderate sedation: A prospective randomized study
Abstract Background and AimSame‐day bidirectional endoscopy (BDE) is a commonly performed procedure, but the optimal sequence for the procedure with moderate conscious sedation is not well‐established. We investigated the optimal sequence for same‐day BDE under moderate conscious sedation and carbon dioxide insufflation in terms of sedation doses, patient discomfort, and colonoscopy performance. MethodsWe performed a prospective randomized controlled study of 120 patients who were scheduled for BDE examination. Colonoscopy followed by esophagogastroduodenoscopy (EGD) examination was performed in 60 patients (colonosc...
Source: Journal of Gastroenterology and Hepatology - September 5, 2017 Category: Gastroenterology Authors: Shuo ‐Wei Chen, Chi‐Liang Cheng, Nai‐Jen Liu, Jui‐Hsiang Tang, Yen‐Lin Kuo, Cheng‐Hui Lin, Yi‐Ning Tsui, Bai‐Ping Lee, Hsiang‐Ling Hung Tags: Gastroenterology Source Type: research

Safety and Efficacy of a New Swallowable Intragastric Balloon Not Needing Endoscopy: Early Italian Experience
AbstractPurposeThe aim of this study was to evaluate the safety and efficacy of a new intragastric balloon (Elipse ™ Balloon, Allurion Technologies, Natick, MA USA) not needing endoscopy.Materials and MethodsThe balloon was swallowed under fluoroscopy in 38 consecutive patients (F/M 28/10, mean age 46.4  ± 10.6 years, mean weight 109.7 ± 21.9 kg, and mean body mass index (BMI) 38.6 ± 6.7 kg/m2). After 4  months, the balloon spontaneously emptied and it was excreted through the digestive tract without upper endoscopy.ResultsThere were no complicati...
Source: Obesity Surgery - September 4, 2017 Category: Surgery Source Type: research

A Rare Case of Early Gastric Cancer Combined with Underlying Heterotopic Pancreas.
Authors: Yoon JB, Lee BE, Kim DH, Park DY, Jeon HK, Baek DH, Kim GH, Song GA Abstract Heterotopic pancreas in the stomach is usually asymptomatic and benign. Here, we presented a rare case of an early gastric cancer overlying a heterotopic pancreas. A 48-year-old woman underwent esophagogastroduodenoscopy, which revealed a subepithelial mass measuring 2.0×1.5 cm on the gastric antrum with a 1-cm erosive erythematous discoloration on the surface. A biopsy specimen showed moderately differentiated tubular adenocarcinoma. Endosonography showed a heterogeneous hypoechoic mass measuring 1.3×0.6 cm, with indi...
Source: Clinical Endoscopy - September 1, 2017 Category: Gastroenterology Tags: Clin Endosc Source Type: research

First progress report on the Japan Endoscopy Database (JED) project
ConclusionsThe results of the first phase suggest that the JED project can provide vast quantities of useful data about endoscopic procedures.This article is protected by copyright. All rights reserved. (Source: Digestive Endoscopy)
Source: Digestive Endoscopy - September 1, 2017 Category: Gastroenterology Authors: S. Kodashima, K. Tanaka, K. Matsuda, M. Fujishiro, Y. Saito, K. Ohtsuka, I. Oda, C. Katada, M. Kato, M. Kida, K. Kobayashi, S. Hoteya, T. Horimatsu, T. Matsuda, M. Muto, H. Yamamoto, S. Ryozawa, R. Iwakiri, H. Kutsumi, H. Miyata, M. Kato, K. Haruma, K. Fu Tags: Special report Source Type: research

Continued Alcohol Misuse in Human Cirrhosis is Associated with An Impaired Gut ‐Liver Axis
ConclusionsDespite cirrhosis, continued alcohol misuse predisposes patients to widespread dysbiosis with alterations in microbial functionality such as a toxic bile acid profile, which can lead to intestinal and systemic inflammation.This article is protected by copyright. All rights reserved. (Source: Alcoholism: Clinical and Experimental Research)
Source: Alcoholism: Clinical and Experimental Research - September 1, 2017 Category: Addiction Authors: Jasmohan S Bajaj, Genta Kakiyama, Derrick Zhao, Hajime Takei, Andrew Fagan, Phillip Hylemon, Huiping Zhou, William M Pandak, Hiroshi Nittono, Oliver Fiehn, Nita Salzman, Mary Holtz, Pippa Simpson, Edith A Gavis, Douglas M Heuman, Runping Liu, Dae Joong Ka Tags: Original Research Article Source Type: research

Usefulness of esophagogastroduodenoscopy and 18 F-fluorodeoxyglucose positron-emission tomography in detecting synchronous multiple primary cancers with oral cancer
ConclusionsPET-CT for oral cancer patients is an effective supporting diagnostic tool. However, the ability of PET-CT has some limitations. Especially for early detection of the upper gastrointestinal cancers, it is necessary to be supplemented by EGD. (Source: Oral and Maxillofacial Surgery)
Source: Oral and Maxillofacial Surgery - August 31, 2017 Category: ENT & OMF Source Type: research

The Combination Use of an Acetic Acid Indigo Carmine Mixture and Linked-Color Imaging to Detect Early Gastric Cancer
Chromoendoscopy (CE) and image-enhanced endoscopy are useful for accurately diagnosing gastric neoplasms. However, unclear lesions, such as those with a flat morphology or normochromic color, sometimes can be missed. We herein present a case in which CE was performed with the combined use of an  acetic acid indigo carmine mixture (AIM) and linked-color imaging (LCI), and this method was effective for detecting early gastric cancer. A Japanese man in his 70s underwent esophagogastroduodenoscopy for screening purposes. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 30, 2017 Category: Gastroenterology Authors: Yoshiyasu Kono, Yoshiro Kawahara, Hiroyuki Okada Tags: Electronic Image of the Month Source Type: research

A new screening strategy for varices by liver and spleen stiffness measurement (LSSM) in cirrhotic patients: a randomized trial
Abstract BackgroundVariceal bleeding is a common and life‐threatening complication in patients with liver cirrhosis. Screening with upper endoscopy is recommended but is uncomfortable to patients. Non‐invasive assessment with transient elastography for liver/spleen stiffness measurement (LSM and SSM) is accurate in detecting varices. AimsTo test the hypothesis that a new screening strategy for varices guided by LSM/SSM results (LSSM‐guided) is non‐inferior to universal endoscopic screening in detecting clinically significant varices in patients with cirrhosis. MethodsThis was a non‐inferiority, open‐label, rand...
Source: Liver International - August 29, 2017 Category: Gastroenterology Authors: Grace Lai ‐Hung Wong, Raymond Kwok, Aric Josun Hui, Yee‐Kit Tse, Kai‐Tin Ho, Angeline Oi‐Shan Lo, Kelvin Long‐Yan Lam, Heyson Chi‐Hey Chan, Rashid Abdul Lui, Kenneth Hon‐Da Au, Henry Lik‐Yuen Chan, Vincent Wai‐Sun Wong Tags: Original Article Source Type: research

Tablet and oral liquid L-thyroxine formulation in the treatment of na ïve hypothyroid patients with Helicobacter pylori infection
AbstractTo compare the clinical efficacy of tablet and oral liquid L-thyroxine (LT4) formulation in na ïve hypothyroid subjects withHelicobacter pylori infection. Forty-seven adult na ïve hypothyroid subjects with dyspeptic symptoms were investigated with upper endoscopy and divided into: 28 patients withHelicobacter pylori infection (Group A); 15 patients without gastric alterations (group B); 4 patients with autoimmune gastritis were excluded from the study. Subjects were randomly treated with a same dose of LT4 tablet (TAB) or oral liquid formulation (SOL), for 9 months on group A and 6 months on group B.Helic...
Source: Endocrine - August 28, 2017 Category: Endocrinology Source Type: research

Is pH Testing Necessary Before Antireflux Surgery in Patients with Endoscopic Erosive Esophagitis?
ConclusionsThe presence of LA C or D esophagitis was always associated with increased esophageal acid exposure on pH testing and is proof of reflux disease. However, pH testing is recommended prior to antireflux surgery in patients with LA A or B esophagitis. (Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - August 25, 2017 Category: Surgery Source Type: research

Low-impedance Baseline Values Predict Severe Esophagitis
Objectives: The aim of the study was to determine whether esophageal baseline impedance (BI) values in children could be predictive of esophagitis. Materials and Methods: Multichannel intraluminal impedance (MII) tracings of children 3 to 17 years of age suspected of having gastroesophageal reflux and esophagitis, who had also undergone upper endoscopy with multiple esophageal biopsies, were reviewed. Patients with eosinophilic esophagitis were excluded. Esophagitis was assessed by macroscopic and microscopic parameters. Esophageal histology was reported by 2 blinded independent pathologists unaware of the MII results. Me...
Source: Journal of Pediatric Gastroenterology and Nutrition - August 23, 2017 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Lack of Mucosal Healing From Modified Specific Carbohydrate Diet in Pediatric Patients With Crohn Disease
ABSTRACT: Exclusive enteral nutrition is effective in pediatric Crohn disease but challenging as maintenance therapy. There is interest in food-based therapies such as the specific carbohydrate diet (SCD) but paucity of data on efficacy and effect on mucosal healing, an evolving target of IBD therapy. We conducted a retrospective review of the mucosal healing effect of the SCD in pediatric Crohn disease (CD). The endoscopic findings for children younger than 18 years with CD treated exclusively with the SCD or modified SCD (mSCD; SCD + addition of “illegal foods”) were reviewed before and after the diet. Il...
Source: Journal of Pediatric Gastroenterology and Nutrition - August 23, 2017 Category: Gastroenterology Tags: Short Communication: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Spontaneous non-traumatic mediastinal hematoma associated with oral anticoagulant therapy: a case report and literature review
Conclusion To facilitate prompt and proper management, clinicians should be aware of this condition as a potential complication of anticoagulant therapy. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - August 23, 2017 Category: Surgery Source Type: research

Factors impacting patient cooperation during elective gastroscopy.
Abstract Background/Aims: Some people have difficulty tolerating upper endoscopy. The cause of and risk factors for this are not well known. The aim of this study was to investigate the factors involved in poor cooperation during screening upper endoscopy. Methods: A total of 4,422 subjects who underwent a health inspection with upper endoscopy carried out by a single experienced endoscopist were included. We retrospectively investigated subjects' self-reporting questionnaires and medical records, including endoscopic and histologic findings. The examinees' cooperation and the completeness of endoscopic exami...
Source: The Korean Journal of Internal Medicine - August 22, 2017 Category: Internal Medicine Authors: Lee SP, Sung IK, Kim JH, Lee SY, Park HS, Shim CS Tags: Korean J Intern Med Source Type: research

In response to “in reference to is esophagoscopy necessary during panendoscopy?”
(Source: The Laryngoscope)
Source: The Laryngoscope - August 22, 2017 Category: ENT & OMF Authors: Daniel Brickman, Daniel Clayburgh Tags: Letter to the Editor Source Type: research

Identifying Emergency Department Patients at Low Risk for a Variceal Source of Upper Gastrointestinal Hemorrhage.
CONCLUSION: Although this derivation study must be externally validated before widespread use, patients presenting to the ED with an acute UGIB with platelets of greater than 200,000/uL and an INR less than 1.3 may be at very low risk for a variceal source of their upper gastrointestinal hemorrhage. This article is protected by copyright. All rights reserved. PMID: 28833912 [PubMed - as supplied by publisher] (Source: Accident and Emergency Nursing)
Source: Accident and Emergency Nursing - August 22, 2017 Category: Emergency Medicine Authors: Klein LR, Money J, Maharaj K, Robinson A, Lai T, Driver BE Tags: Acad Emerg Med Source Type: research

Identification of distinctive clinical significance in hospitalized patients with endoscopic duodenal mucosal lesions.
Conclusions: Secondary duodenal mucosal lesions with different pathophysiology, such as IBD or CMV infection, are rare. Disease extent and age seems the most distinctive feature of secondary duodenal mucosal lesions. PMID: 28823115 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 21, 2017 Category: Internal Medicine Authors: Han Y, Jung HK, Chang JY, Moon CM, Kim SE, Shim KN, Jung SA, Kim JY, Bae JY, Kim SI, Lee JH, Park S Tags: Korean J Intern Med Source Type: research

ELMSTREET (Esophageal Lesions during MitraClip ® uSing TRansEsophagelEchocardiography-Trial).
ELMSTREET (Esophageal Lesions during MitraClip® uSing TRansEsophagelEchocardiography-Trial). EuroIntervention. 2017 Aug 15;: Authors: Ruf TF, Heidrich FM, Sveric KM, Pfluecke C, Stephan AM, Strasser RH, Wiedemann S Abstract AIMS: We evaluated possible detrimental effects of transoesophageal echocardiography (TEE) on the oesophageal tissue during percutaneous mitral valve repair (PMVR). METHODS AND RESULTS: From March 2014 to July 2015, 186 patients were treated for severe mitral regurgitation (MR) with PMVR using the MitraClip® system. In 40 patients, esophagogastroduodenoscopy was performe...
Source: EuroIntervention - August 15, 2017 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Sudden Increase in EtCO2 During Upper Endoscopy Under General Endotracheal Anesthesia Suggests the Presence of Tracheoesophageal Fistula: A Case Report
We report a case of a patient with lung cancer status after palliative chemoradiotherapy and esophageal stenting for malignant stenosis who presented with signs and symptoms suggestive of tracheoesophageal fistula; however, no evidence of fistula was found on barium esophagram. During subsequent esophagogastroduodenoscopy, the presence of a fistula was verified by capnography, given extreme elevations in end-tidal CO2 concentrations during endoscopic CO2 insufflation. (Source: A&A Case Reports)
Source: A&A Case Reports - August 15, 2017 Category: Anesthesiology Tags: Case Reports: Case Report Source Type: research

Are our endoscopy patients at risk for pyogenic liver abscess?
Abstract This is an editorial comment on a recent publication reporting an increased rate of pyogenic liver abscesses (PLAs) after upper gastrointestinal panendoscopy. Its aim is to critically highlight the findings, limitations and potential clinical implications of this study. Issues of the mucosal barrier, the microbial flora, administration of antibiotics and underlying diseases are discussed. The probability of PLAs after endoscopies is not exactly known and the length of the "incubation period" remains unclear, but a possible causality should already suffice to make us think how to avoid them. Espe...
Source: World Journal of Gastroenterology : WJG - August 14, 2017 Category: Gastroenterology Authors: Cerwenka H, Schemmer P Tags: World J Gastroenterol Source Type: research

Gastrointestinal Manifestations of STAT3-Deficient Hyper-IgE Syndrome
ConclusionThe majority of AD-HIES subjects develop GI manifestations as part of their disease. Most notable are the symptoms and radiologic findings of GI dysmotility, as well as significant eosinophilic infiltration, concerning for a secondary eosinophilic esophagitis. These findings suggest that theSTAT3 pathway may be implicated in a new mechanism for the pathogenesis of several GI disorders. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - August 13, 2017 Category: Allergy & Immunology Source Type: research

A Rare Case of Gastric Ulcer Penetrating the Pancreas that was Successfully Managed by Conservative Therapy.
Authors: Shibukawa N, Ouchi S, Wakamatsu S, Wakahara Y, Tatsumi N, Kaneko A Abstract A 62-year-old woman was admitted to our hospital with septic shock due to left submandibular osteomyelitis and cellulitis. Her condition improved following tooth extraction, drainage, and the administration of antibiotics. However, on the 4th day of hospitalization, she went into hemorrhagic shock after defecating a massive tarry stool. Emergency esophagogastroduodenoscopy (EGD) was performed. We found a giant ulcer at the antral greater curvature of the stomach. Computed tomography (CT) revealed that the gastric ulcer had penetrat...
Source: Internal Medicine - August 12, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Upper Versus Lower Endoscopy in the Diagnosis of Graft-Versus-Host Disease
Conclusions: Upper and lower endoscopy had a similar diagnostic yield in patients with known or suspected GVHD involving the gut, even for patients presenting only with diarrhea. Because of its ease and safety upper endoscopy is the preferred initial endoscopic approach in patients with suspected gut GVHD, however flexible sigmoidoscopy is a reasonable other option. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - August 11, 2017 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

The Effect of Psychological Stress on Mucosal IL-6 and Helicobacter pylori Activity in Functional Dyspepsia.
CONCLUSION: psychological stress seems to have no correlation with IL-6 in gastric mucous of patients with functional dyspepsia; however, there is an evidence of increasing activity of Helicobacter pylori. PMID: 28790223 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - August 10, 2017 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Remnant gastropathy due to bile reflux after Roux-en-Y gastric bypass: a unique cause of abdominal pain and successful treatment with ursodiol
ConclusionsRoux-en-Y gastric bypass patients with unexplained chronic pain, and biopsy-confirmed chemical gastropathy, had a significantly higher rate of abdominal pain resolution with ursodiol treatment compared to PPI. Remnant gastropathy due to bile reflux is a treatable cause of chronic abdominal pain in RYGB patients, and ursodiol should be considered for empiric treatment in RYGB patients with unexplained chronic abdominal pain. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - August 10, 2017 Category: Surgery Source Type: research

Widefield Endoscopic Mucosal Resection for Treatment of Proximal Esophageal Leukoplakia
An 81-year-old woman was referred to our facility for the management of new onset dysphagia to solids. She had a history of oropharyngeal leukoplakia, which was being followed by ear, nose, and throat doctor. She had several medical comorbidities including ischemic heart disease with automatic implantable cardioverter-defibrillator. She denied any tobacco or alcohol use. Esophagogastroduodenoscopy showed narrowing of the proximal esophagus with characteristic white plaques suggestive of esophageal leukoplakia (Figure A). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 10, 2017 Category: Gastroenterology Authors: Nayana George, Saikiran Raghavapuram, Benjamin Tharian Tags: Electronic Image of the Month Source Type: research

A Case of Primary Small Bowel Melanoma Diagnosed by Single-Balloon Enteroscopy.
Authors: Shin JY, Park IS, Bang BW, Kim HK, Shin YW, Kwon KS Abstract Although metastasis from cutaneous malignant melanoma to the small intestine is not uncommon, primary small bowel melanoma (SBM) is extremely rare. This case report describes a rare case of primary SBM, diagnosed by single-balloon enteroscopy. A 74-year-old man presented with recurrent melena. Upper endoscopy and colonoscopy were unremarkable. Abdominal computed tomography (CT) revealed an ileal mass with ileo-ileal intussusception. Subsequent single-balloon enteroscopy identified an ileal tumor, which was histologically diagnosed as melanoma. Ex...
Source: Clinical Endoscopy - August 9, 2017 Category: Gastroenterology Tags: Clin Endosc Source Type: research

Training in Endoscopy: Esophagogastroduodenoscopy.
Authors: Kim JS, Kim BW Abstract Gastrointestinal endoscopy is important in diagnosis, treatment, and prevention of many diseases of the digestive tract. The ability to perform esophagogastroduodenoscopy (EGD) safely, effectively, and efficiently has become the mainstay of gastroenterology practice. In Korea, EGD education is usually imparted as a component of gastroenterology training programs during fellowship. In this review, we discuss the general principles of EGD training. Formal curriculum development with devising clear goals and effective training methods should be developed in the future. PMID: 287839...
Source: Clinical Endoscopy - August 9, 2017 Category: Gastroenterology Tags: Clin Endosc Source Type: research

Marked improvement in gastric involvement in Beh çet's disease with adalimumab treatment.
Marked improvement in gastric involvement in Behçet's disease with adalimumab treatment. Turk J Gastroenterol. 2017 Aug 09;: Authors: Sonoda A, Ogawa R, Mizukami K, Fukuda K, Shuto M, Okamoto K, Matsunari O, Okimoto T, Murakami K Abstract Gastric involvement is the least frequent manifestation of Behçet's disease, and effective treatment for it unknown. Here the case of a patient with gastric involvement in Behçet's disease that was markedly improved with adalimumab therapy is presented. A 68-year-old man developed an oral ulcer, erythema, folliculitis, and arthralgia. Behç...
Source: The Turkish Journal of Gastroenterology - August 9, 2017 Category: Gastroenterology Authors: Sonoda A, Ogawa R, Mizukami K, Fukuda K, Shuto M, Okamoto K, Matsunari O, Okimoto T, Murakami K Tags: Turk J Gastroenterol Source Type: research

Clinical Characteristics of Seven Patients with Lanthanum Phosphate Deposition in the Stomach.
Conclusion We identified 7 patients with lanthanum deposition in the stomach. All patients showed whitish lesions macroscopically. Although the pathogenicity of gastric lanthanum deposition is uncertain, lanthanum-related lesions in the stomach progressed during continuous lanthanum phosphate intake in several patients. PMID: 28781325 [PubMed - as supplied by publisher] (Source: Internal Medicine)
Source: Internal Medicine - August 8, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Up ‐regulation of transient receptor potential vanilloid (TRPV) and down‐regulation of brain‐derived neurotrophic factor (BDNF) expression in patients with functional dyspepsia (FD)
Abstract BackgroundThe role of immune activation in Functional Dyspepsia (FD) patients without previous infection is unclear. We compare the gastric and circulating brain‐derived neurotropic factor (BDNF), receptor potential vanilloid type (TRPV) families and various cytokines in FD patients. MethodsConsecutive adult FD patients (Rome III) with no recent history of gastroenteritis and asymptomatic healthy controls were recruited for upper endoscopy. Subjects with GERD and IBS as predominant symptoms, diabetes mellitus, current or previous Helicobacter pylori infection, psychiatric illness and recent use of NSAID or PPI w...
Source: Neurogastroenterology and Motility - August 7, 2017 Category: Gastroenterology Authors: C. K. Y. Cheung, L. L. Lan, M. Kyaw, A. D. P. Mak, A. Chan, Y. Chan, J. C. Y. Wu Tags: ORIGINAL ARTICLE Source Type: research

Gastric superficial neoplasia: high miss rate but slow progression
Conclusions Our findings illustrate that GSNs are often missed at endoscopy but progress slowly in most cases. Even though the rate of progression to cancer is relatively low, rigorous attempts should be made to reduce the miss rate of GSNs at EGD. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - August 7, 2017 Category: Gastroenterology Authors: Shimodate, Yuichi Mizuno, Motowo Doi, Akira Nishimura, Naoyuki Mouri, Hirokazu Matsueda, Kazuhiro Yamamoto, Hiroshi Tags: Original article Source Type: research

Tailored approach to gastroparesis significantly improves symptoms
ConclusionAll procedures significantly improved symptoms, although numbers are small in the PP group. GES demonstrates more improvement than PP, and if PP or GES does not adequately improve symptoms GSP is appropriate. In our practice, gastrectomy was reserved as a last resort. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - August 4, 2017 Category: Surgery Source Type: research

Identifying Emergency Department Patients at Low Risk for a Variceal Source of Upper Gastrointestinal Hemorrhage
ConclusionAlthough this derivation study must be externally validated before widespread use, patients presenting to the ED with an acute UGIB with platelets of greater than 200,000/uL and an INR less than 1.3 may be at very low risk for a variceal source of their upper gastrointestinal hemorrhage.This article is protected by copyright. All rights reserved. (Source: Academic Emergency Medicine)
Source: Academic Emergency Medicine - August 1, 2017 Category: Emergency Medicine Authors: Lauren R. Klein, Joel Money, Kaveesh Maharaj, Aaron Robinson, Tarissa Lai, Brian E. Driver Tags: Brief Report Source Type: research

Well-differentiated, pedunculated liposarcoma of the hypopharynx
Discussion Well-differentiated liposarcoma is the most common form of liposarcoma, but is only exceptionally reported in the hypopharynx. The main symptoms are related to compression of adjacent structures. Imaging findings are nonspecific. Only histological examination can distinguish liposarcoma from other benign oesophageal tumours. Standard treatment consists of wide, complete resection, which is not always possible in the neck. Long-term follow-up of these patients is essential in order to rapidly detect recurrence. (Source: European Annals of Otorhinolaryngology, Head and Neck Diseases)
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - July 29, 2017 Category: ENT & OMF Source Type: research

Predictors of positive esophagogastroduodenoscopy outcomes in children and adolescents: a single center experience
Esophagogastroduodenoscopy (EGD) has become a key element in the diagnosis and therapy of many gastrointestinal diseases affecting children. The aim of this study was to evaluate predictors of positive outcome... (Source: BMC Research Notes)
Source: BMC Research Notes - July 28, 2017 Category: Research Authors: Hernando Lyons, Ying Zhang, Susan Szpunar and Rajmohan Dharmaraj Tags: Research article Source Type: research

Short article: Stool cytomegalovirus polymerase chain reaction for the diagnosis of cytomegalovirus-related gastrointestinal disease
Objectives: The diagnosis of cytomegalovirus-related gastrointestinal disease (CMV-GI disease) still requires histopathology, but biopsy is considered invasive. Stool CMV PCR has been reported in adults as an alternative method to diagnose this condition; hence, the results between studies are discrepant. Moreover, no pediatric studies on stool CMV real-time PCR in CMV-GI disease have been carried out. Here, we evaluate the value of stool CMV real-time PCR in detecting CMV-GI disease among immunocompromised children. Methods: We enrolled immunocompromised patients aged younger than 20 years who presented with gastrointest...
Source: European Journal of Gastroenterology and Hepatology - July 27, 2017 Category: Gastroenterology Tags: Original Articles: Gastro-intestinal infections Source Type: research

A Novel Stool PCR Test for Helicobacter pylori May Predict Clarithromycin Resistance and Eradication of Infection at a High Rate [Bacteriology]
Clarithromycin-based regimens are commonly used as a first-line therapy for Helicobacter pylori-positive patients; however, resistance to clarithromycin has led to treatment failures. The aim of this study was to evaluate the feasibility of using stool samples to detect the presence of H. pylori DNA while concurrently detecting mutations associated with resistance to clarithromycin. For this purpose, total DNA was extracted from 294 raw stool specimens from H. pylori-positive and -negative patients. TaqMan real-time PCR amplification was used to detect the presence of H. pylori as well as to predict the phenotype of the or...
Source: Journal of Clinical Microbiology - July 25, 2017 Category: Microbiology Authors: Beckman, E., Saracino, I., Fiorini, G., Clark, C., Slepnev, V., Patel, D., Gomez, C., Ponaka, R., Elagin, V., Vaira, D. Tags: Bacteriology Source Type: research

Abstract 3 Impact of Trainee Experience on the Decision to Perform Endoscopy on Weekends
Guidelines recommend endoscopy with 24 hours of admission for patients who present with suspected upper gastrointestinal bleeding (GIB). Endoscopy units often operate only during weekdays, however, resulting in logistical barriers to performing endoscopy on weekends. Weekend endoscopy is therefore typically reserved for a subset of higher acuity patients. We sought to determine if trainee experience influences the decision to proceed with upper endoscopy on weekends. (Source: Gastroenterology)
Source: Gastroenterology - July 24, 2017 Category: Gastroenterology Authors: Srihari Mahadev, Daniel Freedberg Tags: AGA Section Source Type: research

Hemosuccus Pancreaticus
A 47-year-old man with alcohol-related cirrhosis and chronic pancreatitis presented with hematemesis. Upper endoscopy and colonoscopy demonstrated blood in the proximal small bowel, without active bleeding. The patient was hospitalized for 29 days for obscure gastrointestinal hemorrhage with intermittent episodes of hematemesis and hematochezia, for which 8 upper endoscopies, 3 colonoscopies, and 5 tagged red blood cell scans were performed. An image from final endoscopy performed in the intensive care unit for massive hematemesis demonstrated active bleeding emanating from the ampulla of Vater (Fig  1). (Source: Jour...
Source: Journal of Vascular and Interventional Radiology : JVIR - July 21, 2017 Category: Radiology Authors: Bo Liu, Francisco J. Contreras, Thomas J. Ward Tags: Images in IR Source Type: research

Gastric Hyperplastic Polyps Associated with Proton Pump Inhibitor Use in a Case without a History of Helicobacter pylori Infection.
Authors: Miyamoto S, Kato M, Matsuda K, Abiko S, Tsuda M, Mizushima T, Yamamoto K, Ono S, Kudo T, Shimizu Y, Hatanaka KC, Tsunematsu I, Sakamoto N Abstract A 56-year-old man with gastroesophageal reflux disease (GERD) was referred to our hospital. Esophagogastroduodenoscopy (EGD) revealed no evidence of any polypoid lesions in the stomach, and the patient had no history of Helicobacter pylori infection. He received omeprazole (20 mg) once daily for the GERD. EGD was performed at 1 year after the start of omeprazole administration, and this time, gastric hyperplastic polyps (GHPs) were detected. The GHPs increased i...
Source: Internal Medicine - July 20, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Clinical Significance of Spontaneous Pneumomediastinum
Conclusions Spontaneous pneumomediastinum is usually associated with a benign clinical course. Risk factors for esophageal perforation in these patients include age, elevated white blood cell count, and a pleural effusion. In the absence of abnormal laboratory values or associated radiologic findings, the majority of patients with SPM may be safely observed without the need for further diagnostic testing. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - July 20, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research