Ziverel for PPI-refractory reflux symptoms: efficacy and mechanisms of action in humans
CONCLUSION: Ziverel did not show a benefit on acid sensitivity, reflux symptoms or esophageal mucosal integrity compared to placebo in PPI-refractory patients with reflux symptoms.Trial registration: Netherlands Trial Register number: NL7670.PMID:38088584 | DOI:10.1080/00365521.2023.2290457 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - December 13, 2023 Category: Gastroenterology Authors: Thijs Kuipers Renske A B Oude Nijhuis Ren é M van den Wijngaard Jac M Oors Andr é J P M Smout Albert J Bredenoord Source Type: research
Prevalence of Histological Gastritis in a Community Population and Association with Epigastric Pain
ConclusionGastritis is common in the population with a prevalence of 40% and is usually asymptomatic. Chronic body gastritis may be associated with epigastric pain, but independent validation is required to confirm these findings. Clinicians should not generally ascribe symptoms to histological gastritis. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - December 13, 2023 Category: Gastroenterology Source Type: research
Ketosis-prone Diabetes presenting with Acute Esophageal Necrosis or "Black Esophagus": An Intriguing New Clinical Association
CONCLUSIONS: KPD remains an under-recognized and under-diagnosed type of diabetes which can present as DKA. Since DKA could be a possible trigger of AEN, a rare but potentially lifethreatening condition, that clinicians should be aware of, in patients presenting with upper gastrointestinal bleeding and ketoacidosis. The prompt management and classification of DKA, combined with the EGD execution for early AEN diagnosis and follow-up, is essential.PMID:38083890 | DOI:10.2174/0118715303279019231127065331 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - December 12, 2023 Category: Drugs & Pharmacology Authors: Riccardo Maria Pollis Damiano Furlanetto Elena Pagin Carla Scaroni Mattia Barbot Giacomo Voltan Source Type: research
Ketosis-prone Diabetes presenting with Acute Esophageal Necrosis or "Black Esophagus": An Intriguing New Clinical Association
CONCLUSIONS: KPD remains an under-recognized and under-diagnosed type of diabetes which can present as DKA. Since DKA could be a possible trigger of AEN, a rare but potentially lifethreatening condition, that clinicians should be aware of, in patients presenting with upper gastrointestinal bleeding and ketoacidosis. The prompt management and classification of DKA, combined with the EGD execution for early AEN diagnosis and follow-up, is essential.PMID:38083890 | DOI:10.2174/0118715303279019231127065331 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - December 12, 2023 Category: Endocrinology Authors: Riccardo Maria Pollis Damiano Furlanetto Elena Pagin Carla Scaroni Mattia Barbot Giacomo Voltan Source Type: research
Ketosis-prone Diabetes presenting with Acute Esophageal Necrosis or "Black Esophagus": An Intriguing New Clinical Association
CONCLUSIONS: KPD remains an under-recognized and under-diagnosed type of diabetes which can present as DKA. Since DKA could be a possible trigger of AEN, a rare but potentially lifethreatening condition, that clinicians should be aware of, in patients presenting with upper gastrointestinal bleeding and ketoacidosis. The prompt management and classification of DKA, combined with the EGD execution for early AEN diagnosis and follow-up, is essential.PMID:38083890 | DOI:10.2174/0118715303279019231127065331 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - December 12, 2023 Category: Drugs & Pharmacology Authors: Riccardo Maria Pollis Damiano Furlanetto Elena Pagin Carla Scaroni Mattia Barbot Giacomo Voltan Source Type: research
Ketosis-prone Diabetes presenting with Acute Esophageal Necrosis or "Black Esophagus": An Intriguing New Clinical Association
CONCLUSIONS: KPD remains an under-recognized and under-diagnosed type of diabetes which can present as DKA. Since DKA could be a possible trigger of AEN, a rare but potentially lifethreatening condition, that clinicians should be aware of, in patients presenting with upper gastrointestinal bleeding and ketoacidosis. The prompt management and classification of DKA, combined with the EGD execution for early AEN diagnosis and follow-up, is essential.PMID:38083890 | DOI:10.2174/0118715303279019231127065331 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - December 12, 2023 Category: Endocrinology Authors: Riccardo Maria Pollis Damiano Furlanetto Elena Pagin Carla Scaroni Mattia Barbot Giacomo Voltan Source Type: research
Ketosis-prone Diabetes presenting with Acute Esophageal Necrosis or "Black Esophagus": An Intriguing New Clinical Association
CONCLUSIONS: KPD remains an under-recognized and under-diagnosed type of diabetes which can present as DKA. Since DKA could be a possible trigger of AEN, a rare but potentially lifethreatening condition, that clinicians should be aware of, in patients presenting with upper gastrointestinal bleeding and ketoacidosis. The prompt management and classification of DKA, combined with the EGD execution for early AEN diagnosis and follow-up, is essential.PMID:38083890 | DOI:10.2174/0118715303279019231127065331 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - December 12, 2023 Category: Drugs & Pharmacology Authors: Riccardo Maria Pollis Damiano Furlanetto Elena Pagin Carla Scaroni Mattia Barbot Giacomo Voltan Source Type: research
Utility of gastroscopy in the left lateral semi-recumbent position: A blood-free coup!
Conclusions These data show that endotherapy in the left lateral semi-recumbent position is feasible, safe, and effective. It should be done when endoscopy in the left lateral decubitus position reveals a pool of blood in the fundus and there is inadequate visualization of the fundus. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - December 12, 2023 Category: Gastroenterology Authors: Patra, Biswa Ranjan Harindranath, Sidharth Ansari, Abu Aasim Gupta, Shubham Saner, Chetan Pujalwar, Shashank Vaidya, Arun Singh, Ankita Aggarwal, Mohit Shukla, Akash Tags: Original article Source Type: research
How I do it: robotic hiatal hernia repair with stapled conversion from Nissen to Toupet fundoplication
AbstractThe purpose of this paper is to describe a robotic surgical technique for converting a slipped Nissen fundoplication to a Toupet fundoplication. Our technique utilizes four 8 mm robotic ports placed in a horizontal pattern above the umbilicus. The robotic tools we used are a vessel sealer, bipolar forceps, and Cadière forceps. In addition, an esophagogastroduodenoscopy (EGD) is placed through the esophagus into the stomach to be used as a bougie. If a hernia is present, we dissect it from the mediastinum until the posterior confluence is identified. Next sutures from the previous Nissen fundoplication are ident...
Source: Updates in Surgery - December 9, 2023 Category: Surgery Source Type: research
Clinical characteristics, diagnosis, treatment, and prognosis of nivolumab induced gastritis
SummaryGastritis has recently been reported to be associated with nivolumab, and the clinical characteristics of nivolumab induced gastritis remain unclear. To explore the clinical characteristics of nivolumab induced gastritis, and to provide reference for the classification and treatment guidelines of immune checkpoint inhibitors -related gastritis. Case reports, case series, and clinical studies of nivolumab induced gastritis were retrospectively analyzed by searching the database from the establishment of the database until September 30, 2023. Forty-seven were included, with a median age of 57 years (range 16, 93). T...
Source: Investigational New Drugs - December 8, 2023 Category: Drugs & Pharmacology Source Type: research
A generic scope actuation system for flexible endoscopes
ConclusionsThe proposed scope actuation system enhances the maneuverability of flexible endoscopes. It also lays the groundwork for future development of modular and generic scope assistant systems that can be used in both laparoscopic and endoscopic procedures. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - December 8, 2023 Category: Surgery Source Type: research
Characteristics of Esophageal Motility and Associated Symptom Profiles in Patients with Esophageal Diverticulum: A Study Based on High-Resolution Impedance Manometry
ConclusionPatients with ED tended to be older and was associated with a high prevalence of EMD. A multi-disciplinary evaluation, including complete anatomical and motility surveys, may help clarify the underlying pathophysiology and tailor further treatment strategies.Graphical Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - December 7, 2023 Category: Gastroenterology Source Type: research
