Paget Disease of the Nipple Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Case report: Metastatic ovarian mucinous carcinoma to the breast: diagnostic challenges and pitfalls
We report a case of breast metastases from advanced stage ovarian mucinous carcinoma in a 48-year-old female— a case hitherto unreported in the literature. The case is noteworthy for its atypical presentation marked by an areolar rash, clinically suggestive of Paget disease of the nipple. This unique clinical scenario, coupled with histopathological examination revealing in-situ-like carcinoma component, posed a diagnostic challenge in discerning the tumour origin. We emphasize the need for heightened awareness among pathologists to avoid misdiagnosing metastatic carcinomas as primary breast tumours, a potential pitfall ...
Source: Frontiers in Oncology - March 18, 2024 Category: Cancer & Oncology Source Type: research

Paget ’s disease of the breast: Insights from imaging to guide surgical management
Paget ’s disease (PD) of the breast is a rare condition accounting for only 1–3% of breast cancers, as evident by the paucity of published data and small cohort analyses.1 Due to its multifocal variation and the unreliability of mammography and ultrasound to detect underlying breast cancer in PD, mast ectomy had long been the standard of care for adequate disease control.1,2 However, further studies comparing mastectomy to breast-conserving surgery (BCS) followed by adjuvant radiation have shown no statistical difference in overall survival. (Source: American Journal of Surgery)
Source: American Journal of Surgery - March 18, 2024 Category: Surgery Authors: Juliet C. Dalton, Jennifer K. Plichta Tags: Invited Commentary Source Type: research

Paget's disease of the breast: Presentation, treatment, and outcomes in a modern cohort
This study aims to assess outcomes of PD patients based on procedure type and determine the reliability of imaging in estimating disease extent. (Source: American Journal of Surgery)
Source: American Journal of Surgery - January 24, 2024 Category: Surgery Authors: Dorsa Mousa-Doust, Rebecca Warburton, Jin-Si Pao, Carol Dingee, Amy Bazzarelli, Jieun Newman-Bremang, Elaine McKevitt Tags: Featured Article Source Type: research

Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases
AbstractGlycosylation changes of cancer cells are known to be associated with malignant progression and metastases and potentially determine the organ-selective nature of metastasis as theorized by Paget (Lancet 1:571 –573, 1889). Cellular glycans play a variety of roles in the processes of metastasis and may be unique to the cells that metastasize to different organs. We analyzed the glycosylation profiles of the primary tumor and tumors metastasized to lymph node, liver, lung, brain, bone, thyroid, kidney, ad renal, small intestine and pancreas in an autopsy case of breast cancer employing a lectin microarray with 45 l...
Source: Clinical and Experimental Metastasis - January 9, 2024 Category: Cancer & Oncology Source Type: research

Primary melanoma of the nipple: Report of 10 cases including coexistence with Paget's disease
Pathol Res Pract. 2023 Dec 22;253:155058. doi: 10.1016/j.prp.2023.155058. Online ahead of print.ABSTRACTPrimary melanoma of the nipple (PMN) is exceedingly rare, with only single cases reported to date. We identified 10 patients with PMN: 5 females, 5 males, median age 55.5 years (range 29-66) at diagnosis of melanoma in situ (4 cases) or invasive melanoma (6 cases, Breslow depth 0.2 mm to 3.5 mm). Follow-up was available for all 10 patients (median 19 months, range 1-183). Nine patients had no evidence of disease; one patient died of disease (13.5 months) after presenting with a nodal metastasis. One case was exceptional,...
Source: Pathology, Research and Practice - January 5, 2024 Category: Pathology Authors: Carina A Dehner Emma F Johnson Margot S Peters Ruifeng Ray Guo Source Type: research

Mode of Detection of Second Breast Cancers in Patients Undergoing Surveillance After Treatment of Ductal Carcinoma in Situ
CONCLUSIONS: In our cohort of patients undergoing surveillance following diagnosis and treatment of DCIS, 2% of second breast cancers were detected by a clinical breast examination. This suggests that survivorship care should prioritize mammography and patient education regarding breast self-examination and symptoms that warrant evaluation to detect second breast cancers.PMID:38154251 | DOI:10.6004/jnccn.2023.7082 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - December 28, 2023 Category: Cancer & Oncology Authors: Bethany T Waites Liisa Lyon Gillian Kuehner Patience Odele Laurel A Habel Raymond Liu Source Type: research

Clinicopathological profile of breast cancer from Chhattisgarh India: A single-center hospital-based study
CONCLUSION: The clinico-epidemio and histological profile of breast cancer in Chhattisgarh is similar to other parts of India. Scarff Bloom Richardson Grade was predominantly grade 2 in 46.25% (37/80) contrary to Grade III (70%) in other series from India.PMID:38024932 | PMC:PMC10657078 | DOI:10.4103/jfmpc.jfmpc_2315_22 (Source: Primary Care)
Source: Primary Care - November 29, 2023 Category: Primary Care Authors: Niraj Kumar Srivastava Sunita Singh Debajyoti Mohanty Nughat Hussain Source Type: research

Are there clinical and subclinical/pathological forms of Paget ’s disease of the breast?
ConclusionPDB is a rare condition associated with multifocality/multicentricity and HER2 overexpression. Cases of clinical disease and those of subclinical/pathological disease differ significantly. Further studies are required to evaluate the clinical/areolar disease and the impact of advances in breast disease management on PDB. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - November 28, 2023 Category: Cancer & Oncology Source Type: research