An unusual case of longstanding mammary Paget's disease presenting with reticulated skin changes.
Abstract A Caucasian female presented initially at the age of 84 with a 20-year history of an erythematous, reticular plaque over her left areola with a large cutaneous horn. Over the preceding years, the rash slowly spread and became mildly pruritic. Previous topical treatments included emollients and hydrocortisone cream which had little beneficial effect. There was no personal or family history of breast cancer. PMID: 33400312 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 5, 2021 Category: Cancer & Oncology Authors: Dhariwal S, Rytina E, Sterling J Tags: Clin Exp Dermatol Source Type: research

Clinical outcomes of patients with ductal carcinoma in situ in Hong Kong: 10-year territory-wide cancer registry study.
CONCLUSION: Despite excellent long-term survival among patients with DCIS, these patients were more likely to die of breast cancer, compared with the general population of women in Hong Kong. PMID: 33277445 [PubMed - as supplied by publisher] (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - December 6, 2020 Category: General Medicine Tags: Hong Kong Med J Source Type: research

Case for diagnosis. Phagedenic ulcer on the thorax,
Abstract Paget's disease is a rare disorder of the nipple and/or the areola that is characterized by an erythematosquamous lesion and is often associated with in situ or invasive breast carcinoma. The authors present an atypical, exuberant case that had evolved over eight years, emphasizing the importance of early diagnosis. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - December 1, 2020 Category: Dermatology Source Type: research

Cancer-associated fibroblasts support bone tropic metastasis by acting as coordinators between the tumor microenvironment and bone matrix in breast cancer.
Abstract Bone is a common site of metastasis for various types of cancer cells, including breast cancer, and the consequent skeleton-related events observed in patients are severe and often fatal. Currently, it is widely accepted that cancer-associated fibroblasts (CAFs) confer a metastasis-promoting property to breast cancer cells. Furthermore, clinical observations suggest that CAFs mediate the bone tropism of metastatic breast cancer cells. Therefore, a deeper understanding of the mechanism by which CAFs are involved in the bone-tropic metastasis of breast cancer can facilitate the study of the novel an...
Source: Neoplasma - November 25, 2020 Category: Cancer & Oncology Authors: Li H, Lin X, Yang D, Chen Z, Wang X, Re F, Wei J, Chen J Tags: Neoplasma Source Type: research

Male Mammary Paget Disease: A Tale of 2 Contrasting Cases
Abstract: Mammary Paget disease (MPD) comprises 1.45% all male breast cancers, compared with only 0.68% of all female breast cancers. Patients usually present in the fifth and sixth decades of life with ulceration, eczematous changes, discharge, bleeding, itching, and induration of the nipple and areola. Typically, there is a delay in definitive diagnosis and treatment from the onset of symptoms because most patients are initially treated for a rash. At the time of diagnosis, about half of the patients may have palpable breast mass, positive lymph nodes, or both. In this article, we present 2 cases of male MPD represen...
Source: The American Journal of Dermatopathology - November 20, 2020 Category: Pathology Tags: Extraordinary Case Report Source Type: research