Multidisciplinary management of mammary Paget's disease: recommendations to optimize oncological and aesthetic outcomes
In conclusion, a dedicated multidisciplinary pathway with meticulous repetitive performance of some specific tasks could help to perform a successful work while optimizing oncological and aesthetic outcomes in patients with MPD.PMID:36196555 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - October 5, 2022 Category: Surgery Authors: Gianluca Franceschini Elena Jane Mason Alba Di Leone Lorenzo Scardina Riccardo Masetti Source Type: research

Large Mammary Paget Disease without Underlying Breast Carcinoma
This article emphasizes the need to pay close attention to diagnosis, progression, and treatment of the disease. (Source: Plastic and Reconstructive Surgery – Global Open)
Source: Plastic and Reconstructive Surgery – Global Open - October 1, 2022 Category: Cosmetic Surgery Tags: Breast: Case Report Source Type: research

Acute pulmonary embolism originating from upper limb venous thrombosis following breast cancer surgery: Two case reports
CONCLUSION: ULVT as a source of PE after breast cancer surgery cannot be ignored.PMID:36157985 | PMC:PMC9353904 | DOI:10.12998/wjcc.v10.i21.7445 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 26, 2022 Category: Cancer & Oncology Authors: Yan Duan Guo-Li Wang Xin Guo Li-Li Yang Fu-Guo Tian Source Type: research

Acute pulmonary embolism originating from upper limb venous thrombosis following breast cancer surgery: Two case reports
CONCLUSION: ULVT as a source of PE after breast cancer surgery cannot be ignored.PMID:36157985 | PMC:PMC9353904 | DOI:10.12998/wjcc.v10.i21.7445 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - September 26, 2022 Category: Cancer & Oncology Authors: Yan Duan Guo-Li Wang Xin Guo Li-Li Yang Fu-Guo Tian Source Type: research

Cancers, Vol. 14, Pages 4371: Mitochondrial Protein Cox7b Is a Metabolic Sensor Driving Brain-Specific Metastasis of Human Breast Cancer Cells
oye Pierre Sonveaux Distant metastases are detrimental for cancer patients, but the increasingly early detection of tumors offers a chance for metastasis prevention. Importantly, cancers do not metastasize randomly: depending on the type of cancer, metastatic progenitor cells have a predilection for well-defined organs. This has been theorized by Stephen Paget, who proposed the “seed-and-soil hypothesis”, according to which metastatic colonization occurs only when the needs of a given metastatic progenitor cell (the seed) match with the resources provided by a given organ (the soil). Here,...
Source: Cancers - September 8, 2022 Category: Cancer & Oncology Authors: Marine C. N. M. Blackman Tania Capeloa Justin D. Rondeau Luca X. Zampieri Zohra Benyahia Justine A. Van de Velde Maude Fransolet Evangelos P. Daskalopoulos Carine Michiels Christophe Beauloye Pierre Sonveaux Tags: Article Source Type: research

Local recurrence of mammary Paget ’s disease after nipple-sparing mastectomy and implant breast reconstruction: a case report and literature review
To provide a rare case of local recurrent Paget ’s disease after nipple-sparing mastectomy (NSM) with immediate breast reconstruction with 10 years of disease-free survival and to analyze the clinical and patho... (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - September 6, 2022 Category: Cancer & Oncology Authors: Qian Pu, Qianqian Zhao and Dezong Gao Tags: Case Report Source Type: research

Local recurrence of mammary Paget's disease after nipple-sparing mastectomy and implant breast reconstruction: a case report and literature review
CONCLUSIONS: The local recurrence of Paget's disease after NSM is uncommon; it may develop at a very early age and have a very long time to recurrence, as in our patient, who presented with recurrence 10 years after primary surgery. Surgeons should be wary of local recurrence of the nipple-areola complex after NSM in patients with ER-negative and HER-2-positive primary tumors. However, patients with ER/PR-positive and HER-2-negative tumors should not be neglected; we reported a case of an ER/PR-positive and HER-2-negative primary tumor, and ER-positive recurrent cases have the longest latency period. The local recurrence r...
Source: Ann Oncol - September 5, 2022 Category: Cancer & Oncology Authors: Qian Pu Qianqian Zhao Dezong Gao Source Type: research

Nipple Adenoma: A Benign Disease With a Suspicious Presentation
We report two cases of this uncommon entity, highlighting the variable clinical presentation and keys to the diagnostic evaluation and management.PMID:36007058 | DOI:10.1177/00031348221117026 (Source: The American Surgeon)
Source: The American Surgeon - August 25, 2022 Category: Surgery Authors: Paula Porras Rodriguez Matthew Crabtree Rose Venegas Junko Ozao-Choy Christine Dauphine Source Type: research

Nipple Adenoma: A Benign Disease With a Suspicious Presentation
We report two cases of this uncommon entity, highlighting the variable clinical presentation and keys to the diagnostic evaluation and management.PMID:36007058 | DOI:10.1177/00031348221117026 (Source: The American Surgeon)
Source: The American Surgeon - August 25, 2022 Category: Surgery Authors: Paula Porras Rodriguez Matthew Crabtree Rose Venegas Junko Ozao-Choy Christine Dauphine Source Type: research

Unusual Manifestations of Vulval Paget Disease
We report 2 cases of metaplastic MGLA of the vulva with associated Paget disease and postulate that some cases of vulval MGLA may arise from Paget disease rather than originating in mammary-like glands. We also report a unique case of secondary vEMPD resulting from spread of urothelial carcinoma in situ that subsequently progressed to invasive urothelial carcinoma within the vulva. (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - August 18, 2022 Category: Pathology Tags: Pathology of the Lower Tract: Case Reports Source Type: research

Cancers, Vol. 14, Pages 3519: HER2-Targeted Antibody & ndash;Drug Conjugates Display Potent Antitumor Activities in Preclinical Extramammary Paget & rsquo;s Disease Models: In Vivo and Immunohistochemical Analyses
Cancers, Vol. 14, Pages 3519: HER2-Targeted Antibody–Drug Conjugates Display Potent Antitumor Activities in Preclinical Extramammary Paget’s Disease Models: In Vivo and Immunohistochemical Analyses Cancers doi: 10.3390/cancers14143519 Authors: Keiko Tokuchi Takuya Maeda Shinya Kitamura Teruki Yanagi Hideyuki Ujiie Extramammary Paget’s disease (EMPD) is an adenocarcinoma that develops mainly in the genital region of older adults. The prognosis for advanced EMPD is almost always poor; thus, novel therapeutic strategies need to be developed. HER2-targeted antibody&ndas...
Source: Cancers - July 20, 2022 Category: Cancer & Oncology Authors: Keiko Tokuchi Takuya Maeda Shinya Kitamura Teruki Yanagi Hideyuki Ujiie Tags: Article Source Type: research

Autophagic factors in Paget disease
CONCLUSION: The immunohistochemical autophagic profile of Paget disease suggests a down-regulated autophagic process which, thus, may be implicated in the invasive potential of these cells.PMID:35797853 | DOI:10.1016/j.prp.2022.154001 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - July 7, 2022 Category: Pathology Authors: Georgia Karpathiou Mousa Mobarki Alexandra Papoudou-Bai Vincent Grosjean Celine Chauleur Michel P Ă©oc'h Source Type: research

Autophagic factors in Paget disease
CONCLUSION: The immunohistochemical autophagic profile of Paget disease suggests a down-regulated autophagic process which, thus, may be implicated in the invasive potential of these cells.PMID:35797853 | DOI:10.1016/j.prp.2022.154001 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - July 7, 2022 Category: Pathology Authors: Georgia Karpathiou Mousa Mobarki Alexandra Papoudou-Bai Vincent Grosjean Celine Chauleur Michel P Ă©oc'h Source Type: research

Comment on “Rebound hypercalcemia post-denosumab cessation in metastatic breast cancer”: Waxing-Waning Serum Calcium following Denosumab use in a patient with Polyostotic Paget’s Disease of Bone
(Source: Osteoporosis International)
Source: Osteoporosis International - July 1, 2022 Category: Orthopaedics Source Type: research