CYP2D6 ‐guided opioid therapy for adults with cancer pain: a randomized implementation clinical trial
ConclusionOur study revealed high acceptance of pharmacogenetic testing as part of a clinical trial among patients with cancer pain. However, provider response to genotype-guided recommendations was low, impacting assessment of pain-related outcomes. Addressing barriers to utility of pharmacogenetics results and clinical recommendations will be critical for implementation success. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 12, 2023 Category: Drugs & Pharmacology Authors: Scott A. Mosley,
Emily Cicali,
Alex Del Cueto,
Diane G. Portman,
Kristine A. Donovan,
Yan Gong,
Taimour Langaee,
Priya Gopalan,
Jessica Schmit,
Jason S. Starr,
Natalie Silver,
Young D. Chang,
Sahana Rajasekhara,
Joshua E. Smith,
Heloisa P. S Tags: RESEARCH ARTICLE Source Type: research
Oxycodone prescription after inflatable penile prosthesis has risks of persistent use: a TriNetX analysis
International Journal of Impotence Research, Published online: 08 September 2023; doi:10.1038/s41443-023-00760-yOxycodone prescription after inflatable penile prosthesis has risks of persistent use: a TriNetX analysis (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - September 8, 2023 Category: Urology & Nephrology Authors: Zachary J. Prebay Halle Foss David Ebbott Michael Li Paul H. Chung Source Type: research
Comment on: Effects of selective dopamine D3 receptor partial agonist/antagonists on oxycodone self-administration and antinociception in monkeys
Neuropsychopharmacology, Published online: 08 September 2023; doi:10.1038/s41386-023-01726-wComment on: Effects of selective dopamine D3 receptor partial agonist/antagonists on oxycodone self-administration and antinociception in monkeys (Source: Neuropsychopharmacology)
Source: Neuropsychopharmacology - September 8, 2023 Category: Neurology Authors: Samantha Chong Sandra D. Comer Source Type: research
Counterfeit Pills Increasingly Involved in U.S. Overdose Deaths
The percentage of overdose deaths involving counterfeit pills in the United States more than doubled between late 2019 and late 2021, according tofindings published today in the CDC ’sMorbidity and Mortality Weekly Report. The percentage of overdose deaths involving counterfeit pills more than tripled in western states in the country.“Drug overdose deaths are at historically high levels in the United States, with a preliminary estimate of more than 105,000 deaths in 2022,” wrote Julie O’Donnell, Ph.D., of the National Center for Injury Prevention and Control and colleagues. “Counterfeit pills can expose new popul...
Source: Psychiatr News - September 1, 2023 Category: Psychiatry Tags: benzodiazepines CDC counterfeit pills fentanyl MMWR Morbidity and Mortality Weekly Report overdose death western U.S. Source Type: research
'Dopesick'; why a critical view of the literature may save your patient's life
Educ Prim Care. 2023 Aug 30:1-5. doi: 10.1080/14739879.2023.2243880. Online ahead of print.ABSTRACTINTRODUCTION: Teaching critical literature appraisal is challenging. Providing a compelling clinical context using 'cinemeduation' stimulates interest in the topic.METHODS: After watching the first episode of the mini-series 'Dopesick', where the scope, timeline and extent of the problem of opioid abuse are clearly seen, abstracts of the period literature strongly supporting the use of Oxycontin for use in chronic pain are shown. All were published in highly ranked medical journals. A simple paper evaluation structure is sugg...
Source: Education for Primary Care - August 30, 2023 Category: Primary Care Authors: Raymond O'Connor Source Type: research
'Dopesick'; why a critical view of the literature may save your patient's life
Educ Prim Care. 2023 Aug 30:1-5. doi: 10.1080/14739879.2023.2243880. Online ahead of print.ABSTRACTINTRODUCTION: Teaching critical literature appraisal is challenging. Providing a compelling clinical context using 'cinemeduation' stimulates interest in the topic.METHODS: After watching the first episode of the mini-series 'Dopesick', where the scope, timeline and extent of the problem of opioid abuse are clearly seen, abstracts of the period literature strongly supporting the use of Oxycontin for use in chronic pain are shown. All were published in highly ranked medical journals. A simple paper evaluation structure is sugg...
Source: Primary Care - August 30, 2023 Category: Primary Care Authors: Raymond O'Connor Source Type: research
'Dopesick'; why a critical view of the literature may save your patient's life
Educ Prim Care. 2023 Aug 30:1-5. doi: 10.1080/14739879.2023.2243880. Online ahead of print.ABSTRACTINTRODUCTION: Teaching critical literature appraisal is challenging. Providing a compelling clinical context using 'cinemeduation' stimulates interest in the topic.METHODS: After watching the first episode of the mini-series 'Dopesick', where the scope, timeline and extent of the problem of opioid abuse are clearly seen, abstracts of the period literature strongly supporting the use of Oxycontin for use in chronic pain are shown. All were published in highly ranked medical journals. A simple paper evaluation structure is sugg...
Source: Education for Primary Care - August 30, 2023 Category: Primary Care Authors: Raymond O'Connor Source Type: research
Opioid dispensing in relation to arthroscopic knee surgery in Denmark from 2006 to 2018
CONCLUSION: About 7% of patients had an opioid dispensed within the first seven days after discharge following arthroscopic knee surgery. The incidence of opioids dispensed increased for all investigated procedures from 2006 to 2018. In the same period, the average amount of opioids dispensed within the first seven days after discharge decreased.FUNDING: None.TRIAL REGISTRATION: Not relevant.PMID:37622647 (Source: Danish Medical Journal)
Source: Danish Medical Journal - August 25, 2023 Category: General Medicine Authors: Jonas Bloch Thorlund Matilde Lundberg Jindong Ding Petersen Martin Englund Bjarke Viberg Frans Boch Waldorff Jens S øndergaard Source Type: research
< em > Letter to Editor: < /em > Observations of Deception in Urine Drug Testing
CONCLUSION: Deception can be identified using the metabolite/parent drug ratio.PMID:37625839 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Opioid dispensing in relation to arthroscopic knee surgery in Denmark from 2006 to 2018
CONCLUSION: About 7% of patients had an opioid dispensed within the first seven days after discharge following arthroscopic knee surgery. The incidence of opioids dispensed increased for all investigated procedures from 2006 to 2018. In the same period, the average amount of opioids dispensed within the first seven days after discharge decreased.FUNDING: None.TRIAL REGISTRATION: Not relevant.PMID:37622647 (Source: Danish Medical Journal)
Source: Danish Medical Journal - August 25, 2023 Category: General Medicine Authors: Jonas Bloch Thorlund Matilde Lundberg Jindong Ding Petersen Martin Englund Bjarke Viberg Frans Boch Waldorff Jens S øndergaard Source Type: research
< em > Letter to Editor: < /em > Observations of Deception in Urine Drug Testing
CONCLUSION: Deception can be identified using the metabolite/parent drug ratio.PMID:37625839 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research
Opioid dispensing in relation to arthroscopic knee surgery in Denmark from 2006 to 2018
CONCLUSION: About 7% of patients had an opioid dispensed within the first seven days after discharge following arthroscopic knee surgery. The incidence of opioids dispensed increased for all investigated procedures from 2006 to 2018. In the same period, the average amount of opioids dispensed within the first seven days after discharge decreased.FUNDING: None.TRIAL REGISTRATION: Not relevant.PMID:37622647 (Source: Danish Medical Journal)
Source: Danish Medical Journal - August 25, 2023 Category: General Medicine Authors: Jonas Bloch Thorlund Matilde Lundberg Jindong Ding Petersen Martin Englund Bjarke Viberg Frans Boch Waldorff Jens S øndergaard Source Type: research
