A rapid and sensitive LC-MS/MS method for quantifying oxycodone, noroxycodone, oxymorphone and noroxymorphone in human plasma to support pharmacokinetic drug interaction studies of oxycodone
Biomed Chromatogr. 2024 Apr 8:e5874. doi: 10.1002/bmc.5874. Online ahead of print.ABSTRACTA sensitive and reliable LC-MS/MS method was developed and validated for the quantification of oxycodone and metabolites in human plasma. The method has a runtime of 6 min and a sensitivity of 0.1 μg/L for all analytes. Sample preparation consisted of protein precipitation. Separation was performed on a Kinetix biphenyl column (2.1 × 100 mm, 1.7 μm), using ammonium formate 5 mm in 0.1% aqueous formic acid and methanol LC-MS grade 100% in gradient elution at a flow rate of 0.4 ml/min. Detection was performed in multiple reaction mon...
Source: Biomedical Chromatography : BMC - April 8, 2024 Category: Biomedical Science Authors: Lotte M G Hulskotte Inge Wilbrink-Pijffers Maurits E L Arbouw Guillemette E Benoist Frank G A Jansman Inge R F van Berlo-van de Laar Source Type: research
Opioid-induced respiratory depression suspected of drug interaction in a prostate cancer patient: a case report
CONCLUSIONS: The cause of respiratory depression in this case was thought to be a combination of factors, including drug interactions between oxycodone and antiemetics, and oxycodone accumulation due to renal dysfunction.PMID:38584476 | DOI:10.21037/apm-23-581 (Source: Pain Physician)
Source: Pain Physician - April 8, 2024 Category: Anesthesiology Authors: Hiroshi Hamada Eisuke Suzuki Mitsufumi Endo Yukiko Mihara Sayaka Iketani Miki Ishida Akime Miyasato Kanako Miyazaki Source Type: research
A rapid and sensitive LC-MS/MS method for quantifying oxycodone, noroxycodone, oxymorphone and noroxymorphone in human plasma to support pharmacokinetic drug interaction studies of oxycodone
Biomed Chromatogr. 2024 Apr 8:e5874. doi: 10.1002/bmc.5874. Online ahead of print.ABSTRACTA sensitive and reliable LC-MS/MS method was developed and validated for the quantification of oxycodone and metabolites in human plasma. The method has a runtime of 6 min and a sensitivity of 0.1 μg/L for all analytes. Sample preparation consisted of protein precipitation. Separation was performed on a Kinetix biphenyl column (2.1 × 100 mm, 1.7 μm), using ammonium formate 5 mm in 0.1% aqueous formic acid and methanol LC-MS grade 100% in gradient elution at a flow rate of 0.4 ml/min. Detection was performed in multiple reaction mon...
Source: Biomedical Chromatography : BMC - April 8, 2024 Category: Biomedical Science Authors: Lotte M G Hulskotte Inge Wilbrink-Pijffers Maurits E L Arbouw Guillemette E Benoist Frank G A Jansman Inge R F van Berlo-van de Laar Source Type: research
