A dose-ranging study of the physiological and self-reported effects of repeated, rapid infusion of remifentanil in people with opioid use disorder and physical dependence on fentanyl
ConclusionsThis experiment established doses and procedures for the safe delivery of rapid, repeated remifentanil infusions to individuals with OUD and physical fentanyl dependence, which can be applied to the mechanistic study of opioid use decisions. (Source: Psychopharmacology)
Source: Psychopharmacology - February 22, 2024 Category: Psychiatry Source Type: research
Development and validation of a liquid chromatography –tandem mass spectrometry (LC–MS/MS) method including 25 novel synthetic opioids in hair and subsequent analysis of a Swiss opioid consumer cohort
This study investigated the prevalence and abuse patterns of novel synthetic opioids (NSOs) among Swiss opioid users by means of a validated LC –MS/MS-based hair analysis method. Among a cohort of 439 Swiss opioid users, a positivity rate for NSOs of 2.5% was found, including NSOs such as butyrylfentanyl or acrylfentanyl. These findings contribute to the development of appropriate public health and policy measures to mitigate the risks as sociated with NSO abuse. AbstractMajor public health concern is raised by the evidence that common drugs like heroin are now frequently laced or replaced with highly potent novel synthe...
Source: Drug Testing and Analysis - February 21, 2024 Category: Drugs & Pharmacology Authors: Max Polke,
Marta Concheiro,
Gail Cooper,
Christian Bogdal,
Markus R. Baumgartner,
Thomas Kr ämer,
Tina M. Binz Tags: RESEARCH ARTICLE Source Type: research
