Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Evidence for a Mechanism that Operates in Oocytes to Reduce Mitochondrial DNA Mutation Rate
Researchers here show that, in primates, oocyte cells are more protected from mutations to mitochondrial DNA in later life. This suggests that one or more mechanisms are operating to produce this outcome. Given that mitochondrial DNA mutations are implicated in age-related loss of mitochondrial function and other aspects of aging, the existence of protective mechanisms is potentially interesting. It is not as interesting as the ability to repair or replace damaged mitochondrial DNA, of course. Mechanisms that can only produce sizable differences by operating over long periods of time are a poor foundation upon which to bui...
Source: Fight Aging! - April 12, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 28th 2022
In conclusion, we summarized here evidence for a novel therapeutic approach to exploit the incredible ability of mitochondria to engage multifaceted neuroprotective stress response triggered by partial complex I inhibition. This approach promises relief for multiple human conditions, and to promote healthy aging to delay the onset of neurogenerative diseases, AD in particular, where age is the greatest risk factor. There is a mounting body of evidence generated in model organisms and humans in support of the safety of chronic application of complex I inhibitors. However, a better understanding of the molecular mechanisms i...
Source: Fight Aging! - March 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Heterochromatin Loss and Transposon Activity in the Aging Female Germline
In today's open access paper, researchers note that the characteristic loss of maintainance of heterochromatin structure that occurs with age appears sufficient to produce signatures of aging in female germline cells, oocytes, accompanied by a rising level of transposon activity. Along with thymic involution, loss of function in female germline cells is one of the more rapid aspects of aging. This is the subject of a range of research programs, investigating the causes, and potential means of addressing the issue, ranging from tissue engineered ovaries to the usual panoply of pharmacological approaches to slow the mechanis...
Source: Fight Aging! - March 22, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Cell-Loaded Beads Release Cytokines to Eradicate Tumors
In this study, we demonstrated that the ‘drug factories’ allow regulatable local administration of interleukin-2 and eradication of tumor in several mouse models, which is very exciting. This provides a strong rationale for clinical testing.”
This new technology aims to provide localized immunotherapy in the form of beads that act as “drug factories,” constantly pumping out a cytokine. The beads consist of ARPE-19 cells that are encapsulated in a polymer shell. The polymer coating protects the cells from the worst ravages of the foreign body response, but keeps them in place and allows the secreted...
Source: Medgadget - March 21, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Oncology Source Type: blogs
The (sort of, partial) Father mRNA Vaccines Who Now Spreads Vaccine Misinformation (Part 2)
By DAVID WARMFLASH, MD
This is part 2 of David Warmlash’s takedown of Robert W. Malone’s appearance (transcript) on the Rogan podcast. Part 1 is here
Menstruation and Fertility
Much more than the line about reproductive damage in the Wisconsin News clip that we used to open the story, Malone used the Rogan interview to dive more deeply into the topic, starting with:
…there’s a huge number of dysmenorrhea and menometrorrhagia…
By that, he meant excessive menstrual cramping and very heavy, often irregular, bleeding, which he followed up with:
…they DENY it…
Judging by other parts ...
Source: The Health Care Blog - March 18, 2022 Category: Consumer Health News Authors: matthew holt Tags: COVID-19 Health Policy antivaxxer COVID-19 vaccine David Warmflash Joe Rogan Robert Malone Source Type: blogs
Fight Aging! Newsletter, March 14th 2022
This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. The metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens.
Muscle Strengthening Activities in Later Life Correlate ...
Source: Fight Aging! - March 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Many Mediocre Cancer Therapies Become Much Better When More Targeted to Cancerous Tissues
One of the important areas of cancer research and development that appears to receive a great deal of attention and funding, but in practice seems slow to make it from the laboratory to the clinic, is the targeting of therapeutics to cancerous cells. Reductio ad absurdum, near any of dozens of existing chemotherapeutics would do the job of completely clearing tumors, with minimal to no side-effects, if one could only find a way to delivery tiny amounts of the therapeutic to every cancer cell while avoiding every healthy cell. The inability to target treatments this effectively is exactly why cancer remains such a problem. ...
Source: Fight Aging! - March 9, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Pithiatism Redux
BY MARTIN SAMUELS
Those of us in medicine have all seen the famous painting of the Tuesday afternoon lessons at the Salpȇtrière in Paris in the 19th century. In Pierre Aristide André Brouillet’s painting, one can clearly see the great professor, Jean-Martin Charcot, holding forth while the patient, Blanche Whitman, is being supported by a tall young man, Joseph Jules Francois Felix Babinski, the Chef de Clinique (the chief resident) and allegedly the favorite to succeed Charcot. He never did as he was failed repeatedly on the exam necessary to become a faculty member at the university by a jealous, xenophobic, anti...
Source: The Health Care Blog - February 25, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Patients Physicians Andre Brouillet Martin Samuels Mental Health Patient Care Pithiatism Source Type: blogs
Dermoid Cyst Ovary- Clinicoradiological Approach
Sharing a teaching video on integrated approach to Dermoid cyst. Famous Radiology Blog by Dr Sumer Sethi www.sumersethi.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - February 10, 2022 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols.
FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Gameto Raises $20M at an Early Stage to Focus on Ovarian Aging
One of the signs of investor enthusiasm for an industry is the existence of projects that raise significant funding at a very early stage of their development. We're seeing that happen for cellular reprogramming, but companies started by well-connected individuals in other parts of the longevity industry are now raising a great deal of funding in early preclinical stages of development. This suggests that we will continue to see a growing influx of capital into the development of ways to treat aging as a medical condition, pulling more research projects out of the constraints of academia and into an environment of greater ...
Source: Fight Aging! - January 18, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Well Studied Mutations that Extend Life in Mammals
Mutations affecting growth hormone metabolism and insulin metabolism, and that lead to extended life, are comparatively well studied in mammals. The longest lived mice are those in which growth hormone receptor is knocked out. Unfortunately this, like many interventions related to growth, nutrient sensing, and the like, produces a much greater effect on life span in short-lived species than in long-lived species. Humans with analogous loss-of-function mutations in growth hormone receptor may be resistant to some common age-related diseases, but do not live meaningfully longer than the rest of us.
In 1996, a report...
Source: Fight Aging! - December 22, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Women Are No More Emotionally Turbulent Than Men
By Emily Reynolds
Women are commonly assumed to be more emotionally turbulent than men: moodier, more volatile, and more likely to experience rapid changes in affect across the course of the menstrual cycle. Aside from being the basis of many a sexist joke, this assumption has had an impact on research, with cisgender women excluded from research due to apparent fluctuations in mood.
Building on research exploring fluctuations in rodents, a team from the University of Michigan has looked more closely at such variability in humans. Their study in Scientific Reports finds no difference in emotional variance between ci...
Source: BPS RESEARCH DIGEST - December 2, 2021 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Emotion Sex Source Type: blogs
