Fight Aging! Newsletter, September 12th 2022
Discussion of Present Drug Development to Target Senescent Cells
Targeting Senescent Cells to Better Address Cancer and Consequences of Cancer Therapy
Calorie Restriction Suppresses Generation of Immune Cells via Changes to the Gut Microbiome
Arguing for an Expansion of the Hallmarks of Aging
https://www.fightaging.org/archives/2022/09/arguing-for-an-expansion-of-the-hallmarks-of-aging/
The hallmarks of aging form a catalog of largely better studied changes in cells and tissues considered relevant, and possibly more important, in the onset and development of age-related degeneration and disease. Thi...
Source: Fight Aging! - September 11, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Germline Stem Cells in Ovaries and Female Reproductive Aging
In today's open access paper, researchers discuss the evidence for the existence of germline stem cells in the ovaries, responsible for maintaining fertility in the usual manner of stem cells, by generating daughter cells that replace losses and ensure function. Is ovarian aging, leading into age-related infertility, much accelerated over the aging of other organs in our species because this stem cell population loses function more rapidly than those in other tissues? That is a reasonable hypothesis, and some of the possible mechanisms are discussed. That overies are a hypoxic environment to begin with, and that supply of ...
Source: Fight Aging! - September 6, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Mining Ultrasound Data to Improve Liver Diagnostics: Interview with Beth Rogozinski, CEO at Oncoustics
Oncoustics, a medtech company based in Ontario, Canada, developed the OnX Liver Assessment Solution, an AI-powered ultrasound-based diagnostic system for liver disease. At present, detecting liver disease is a challenge, potentially involving high-end imaging systems, specialists, and invasive biopsies. These challenges, and the related expense, can limit patient access to such testing for those with strong indications of liver disease.
Consequently, in many cases, liver disease may not be detected until it is already quite advanced, limiting the potential for early detection and treatment. There is a clear need for a n...
Source: Medgadget - August 23, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Oncology Radiology liver disease oncoustics Source Type: blogs
Closing the Gender Health Gap: How Digital Technology Can Support Better Women ’s Health
The following is a guest article by Juliet Bauer, Chief Growth and Marketing Officer at Livi
I’m often asked where I believe digital technology can make the biggest impact in healthcare. My answer? Women’s health. Today, women spend around a quarter of their lives in poor health or disability, compared with one fifth for men. In a health system that has historically been geared towards men, a gender health gap persists where you are more likely to receive poorer medical advice and diagnosis if you are a woman.
When I look at that gap, I see a key space for digital healthcare in helping us overcome many of the obstacles...
Source: EMR and HIPAA - August 8, 2022 Category: Information Technology Authors: Guest Author Tags: Ambulatory Communication and Patient Experience Healthcare IT Hospital - Health System Digital Technology FemTech Healthcare Discrimination Juliet Bauer Livi UK Health IT Women's Health Source Type: blogs
Science Snippet: Lipids in the Limelight
This study could inform the advancement of new antibiotics.Developing new imaging technologies to track lipid droplet formation and breakdown in cancer cells. Understanding this phenomenon could shed light on why lipid droplets accumulate in these cells, which could aid in creating new therapies.
Learn about other scientific terms with the NIGMS glossary. (Source: Biomedical Beat Blog - National Institute of General Medical Sciences)
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 27, 2022 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Cellular Processes COVID-19 Medicines Science-snippet Source Type: blogs
Fight Aging! Newsletter, July 18th 2022
In conclusion, we show that PVS morphology in mice is variable and that the structure and function of pia suggests a previously unrecognized role in regulating CSF transport and amyloid clearance in aging and disease.
Reversing Ovarian Fibrosis in Mice
https://www.fightaging.org/archives/2022/07/reversing-ovarian-fibrosis-in-mice/
Researchers here provide evidence for ovarian fibrosis to be an important mechanism in limiting the age at which female mammals can remain fertile. Interestingly, existing antifibrotic drugs can produce some reversal of this fibrosis, enough to restore ovulation in mice. Fibro...
Source: Fight Aging! - July 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reversing Ovarian Fibrosis in Mice
Researchers here provide evidence for ovarian fibrosis to be an important mechanism in limiting the age at which female mammals can remain fertile. Interestingly, existing antifibrotic drugs can produce some reversal of this fibrosis, enough to restore ovulation in mice. Fibrosis is a malfunction of tissue maintenance; cells produce too much collagen, creating scar-like deposits that disrupt tissue structure and function. The range of present drug treatments can produce only a little benefit for most fibrotic conditions, and thus the positive results here are quite intriguing.
The female ovary contains a finite nu...
Source: Fight Aging! - July 11, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 20th 2022
This study showed a negative relationship between the gaps and the number of senescence cells. Moreover, we found a similar reduction in 30-month-old naturally and 7-month-old D-gal-induced aging rats. Given these consistent data from different eukaryotic organisms, it suggests that the Youth-DNA-GAP is a marker of phenotype-related aging degree
Towards Scaffold-Based Regeneration of Dental Pulp
https://www.fightaging.org/archives/2022/06/towards-scaffold-based-regeneration-of-dental-pulp/
Researchers are working towards the ability to regenerate the dental pulp inside teeth. Full regeneration of teeth ...
Source: Fight Aging! - June 19, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fecal Microbiota Transplantation Improves Ovarian Function in Old Mice
Fecal microbiota transplantation from a young individual to an old individual has been shown in animal studies to reset the aging gut microbiome to a more youthful configuration for a lasting period of time. The gut microbiome changes in detrimental ways with age, harmful and inflammatory populations displacing beneficial populations that produce needed metabolites. A fecal microbiota transplant removes these changes, improving health, reducing inflammation, and extending life span in short-lived species. It is a procedure already used in humans, and which should be further developed as a means to improve the health of all...
Source: Fight Aging! - June 13, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Infertility treatment ’s hidden costs [PODCAST]
“Looking to the future, since I only froze one embryo and my ovary reserve is diminishing, we are hoping to go through another infertility treatment cycle. Although, once again, the medications are once again being denied. Infertility is just like any other mental or physical health condition and should be fully covered, including pharmaceutical, medical,Read more …Infertility treatment’s hidden costs [PODCAST] originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 19, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/the-podcast-by-kevinmd" rel="tag" data-wpel-link="internal" > The Podcast by KevinMD < /a > < /span > Tags: Podcast Medical school OB/GYN Source Type: blogs
Health Care Through the Back Door: The Dangers of Nurse Visits
By HANS DUVEFELT
In some practices, patients with seemingly simple problems are scheduled to be seen by a nurse or medical assistant. Sometimes they can even just drop off a urine sample in case of a suspected urinary tract infection.
This is a dangerous trap. What if the patient rarely gets urinary infections, has back pain and assumes it is a UTI instead of a kidney stone or shingles on their back just where one kidney is located; what if they have lower abdominal pain from an ovarian cyst or an ectopic pregnancy?
Another dangerous type of “nurse visit” is when patients focus on one symptom or parameter, thi...
Source: The Health Care Blog - May 12, 2022 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Primary Care Hans Duvefelt Source Type: blogs
Underfunding Research Of Female Health Leaves Huge Amounts Of Money On The Table
“Did you know that at least one-third of women have lower back pain before their periods every month, and yet, nobody seems to fully understand why?” – asked a Medical Futurist team member a little while ago. The question led to a discussion about the differences in research, funding and understanding of male-only and female-only health issues, and consequently, to this article.
It is a well-known fact that some diseases or conditions dominantly affect one gender or the other. There are the trivial ones, like prostate cancer or ovarian, cervical, uterine cancers. But there is a long list of diseases and condit...
Source: The Medical Futurist - May 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Future of Medicine Healthcare Policy Medical Education women female health under-reseached gender gap in healthcare Source Type: blogs
Women, partner violence and pain
As the potential for greater repression of women’s autonomy grows (Afghanistan, United States, Mexico), along with racist and misogynist statements from business leaders (DGL CEO Simon Henry) it’s timely to look at pain in women. We already know that more women than men present with persistent pain (Blyth, n.d.), while women who are seen for their pain are more often misdiagnosed, offered psychiatric medication or psychological intervention only and have their experiences dismissed as “hysterical, fabricated, or nonexistent” (Samulowitz, et al., 2018). My daughter, when attending Emergency Departmen...
Source: HealthSkills Weblog - May 8, 2022 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Professional topics Research Science in practice biopsychosocial gender Health pain management partner violence Source Type: blogs
Wireless Implant for Anti-Cancer Photodynamic Therapy
Researchers at Texas A&M University created a wireless device that aims to illuminate and destroy residual tumor cells left after cancer resection. The device can be used by surgeons to illuminate the tumor bed after resection. It works in combination with a photosensitizer drug that is administered before the procedure and accumulates in tumor cells, making them vulnerable to the lethal effects of the delivered light. The small device can also be implanted within the body, potentially to provide longer term photodynamic therapy and guard against cancer recurrence.
For many cancers, surgery is the primary treatment,...
Source: Medgadget - April 28, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Oncology Radiology Surgery TAMU Source Type: blogs
Excitable Nanoparticles Destroy Endometriosis Lesions
Researchers at Oregon State University developed a nanoparticle system that can aid with the removal of endometrial lesions in a minimally invasive fashion. In endometriosis, endometrial tissue grows outside of the uterus, causing pain and affecting fertility. Surgery to remove these lesions is often unsuccessful and repeat surgeries are often required. The research team’s nanoparticle technology can aid in minimally invasively destroying such lesions.
The iron oxide nanoparticles can be delivered intravenously and are targeted to accumulate in endometrial lesions, and also handily act as an MRI contrast agent. By ap...
Source: Medgadget - April 25, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Nanomedicine Ob/Gyn Radiology OregonState Source Type: blogs
