Evaluation of Appropriate Use of Proton Pump Inhibitors in Non-critically Ill Patients in Tertiary Medical Center: A Retrospective Study
CONCLUSION: The findings show a high trend of inappropriate PPI prescriptions. Hence, educational programs are recommended to encourage healthcare professionals to stick to the approved guidelines when prescribing PPIs.PMID:38347790 | DOI:10.2174/0115748863284762240129092556 (Source: Current Drug Safety)
Source: Current Drug Safety - February 13, 2024 Category: Drugs & Pharmacology Authors: Abdulhamid Althagafi Nesren Magbool Hatoon Altayib Tala Bukhari Nawal Melibari Foud Bahamdain Khalid Eljaaly Source Type: research
Evaluation of Appropriate Use of Proton Pump Inhibitors in Non-critically Ill Patients in Tertiary Medical Center: A Retrospective Study
CONCLUSION: The findings show a high trend of inappropriate PPI prescriptions. Hence, educational programs are recommended to encourage healthcare professionals to stick to the approved guidelines when prescribing PPIs.PMID:38347790 | DOI:10.2174/0115748863284762240129092556 (Source: Current Drug Safety)
Source: Current Drug Safety - February 13, 2024 Category: Drugs & Pharmacology Authors: Abdulhamid Althagafi Nesren Magbool Hatoon Altayib Tala Bukhari Nawal Melibari Foud Bahamdain Khalid Eljaaly Source Type: research
Evaluation of Appropriate Use of Proton Pump Inhibitors in Non-critically Ill Patients in Tertiary Medical Center: A Retrospective Study
CONCLUSION: The findings show a high trend of inappropriate PPI prescriptions. Hence, educational programs are recommended to encourage healthcare professionals to stick to the approved guidelines when prescribing PPIs.PMID:38347790 | DOI:10.2174/0115748863284762240129092556 (Source: Current Drug Safety)
Source: Current Drug Safety - February 13, 2024 Category: Drugs & Pharmacology Authors: Abdulhamid Althagafi Nesren Magbool Hatoon Altayib Tala Bukhari Nawal Melibari Foud Bahamdain Khalid Eljaaly Source Type: research
Evaluation of Appropriate Use of Proton Pump Inhibitors in Non-critically Ill Patients in Tertiary Medical Center: A Retrospective Study
CONCLUSION: The findings show a high trend of inappropriate PPI prescriptions. Hence, educational programs are recommended to encourage healthcare professionals to stick to the approved guidelines when prescribing PPIs.PMID:38347790 | DOI:10.2174/0115748863284762240129092556 (Source: Current Drug Safety)
Source: Current Drug Safety - February 13, 2024 Category: Drugs & Pharmacology Authors: Abdulhamid Althagafi Nesren Magbool Hatoon Altayib Tala Bukhari Nawal Melibari Foud Bahamdain Khalid Eljaaly Source Type: research
Evaluation of the Effects of Meal Type and Acid ‐Reducing Agents on the Pharmacokinetics of Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist
This study suggests that caution should be exercised when cilofexor is administered with ARAs under fed conditions; coadministration of cilofexor (100 or 30 mg) with ARAs under fasting conditions is not recommended with the current clinical trial formulations. (Source: Clinical Pharmacology in Drug Development)
Source: Clinical Pharmacology in Drug Development - February 13, 2024 Category: Drugs & Pharmacology Authors: Elijah J. Weber,
Islam R. Younis,
Lulu Wang,
Deqing Xiao,
William T. Barchuk,
Ahmed A. Othman Tags: Original Article Source Type: research
79-Year-Old Man With Massive Hemoptysis
A 79-year-old man with medical comorbidities notable for a 20-pack-year smoking history, squamous cell carcinoma (SCC), chronic kidney disease stage III, and hypothyroidism presented with hemoptysis. Home medications included aspirin, 81 mg daily, omeprazole, 10 mg twice daily, simvastatin, 20 mg daily, and albuterol nebulizers as needed for dyspnea. He estimated the volume of blood to be about a cup (approximately 200 mL) and described it as bright red with clots and associated with chest tightness. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - February 6, 2024 Category: Internal Medicine Authors: Danielle M. Shilling, Amy N. Montgomery, Regina M. Mackey Tags: Residents ’ Clinic Source Type: research
Inhibitors of gastric acid secretion increase oxidative stress and matrix metalloproteinase-2 activity leading to vascular remodeling
This study aimed at examining whether treatment with the H2RB ranitidine promotes oxidative stress resulting in vascular MMP activation and corresponding functional and structural alterations in the vasculature, as compared with those found with the PPI omeprazole. Male Wistar rats were treated (4 weeks) with vehicle (2% tween 20), omeprazole (10 mg/Kg/day; i.p.) or ranitidine (100 mg/Kg/day; gavage). Then the aorta was collected to perform functional, biochemical, and morphometric analysis. Both ranitidine and omeprazole increased gastric pH and oxidative stress assessed in situ with the fluorescent dye dihydroethidium (D...
Source: Molecular and Cellular Biochemistry - February 1, 2024 Category: Biochemistry Authors: Renato C Nogueira J éssica M Sanches-Lopes Gustavo H Oliveira-Paula Jose E Tanus-Santos Source Type: research
Therapy of Upper Gastrointestinal Symptoms: Experience with a Medical Device Made of Natural Substances
AbstractPurpose of reviewMedical devices made of substances are widely used in clinical practice, but they are considered to have less therapeutic efficacy than pharmacological agents. In this narrative review, we report a recent RCT experience of a medical device made of natural substances (Poliprotect) that proved as effective as the standard reference treatment.The RCT addressed three questions: (1) Is Poliprotect useful in the initial treatment of heartburn and epigastric pain/burning as an alternative to the reference standard therapy with PPI, (2) is Poliprotect useful in the medium-term treatment of heartburn and ep...
Source: Current Treatment Options in Gastroenterology - January 24, 2024 Category: Gastroenterology Source Type: research
In vitro interactions of proton pump inhibitors and azoles against pathogenic fungi
DiscussionThe results suggested that PPIs combined with azoles has the potential to enhance the susceptibilities of azoles against multiple pathogenic fungi and could be a promising strategy to overcome azole resistance issues. However, further investigations are warranted to study the combinational efficacy in more isolates and more species, to investigate the underlying mechanism of interaction and to evaluate the potential for concomitant use of these agents in human. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 17, 2024 Category: Microbiology Source Type: research
Trend analysis of proton pump inhibitor consumption and expenditure: The real-world evidence
ConclusionWithin this analysis, we provide an illustrative representation of the prescribing trends for PPIs within a European context. Omeprazole, rabeprazole and lansoprazole appear to be the cheapest drugs compared to pantoprazole and esomeprazole. However, the results show that the most widely used PPIs, despite their therapeutic equivalence, are precisely the high-cost ones, thus generating higher expenditure for central governments.Graphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 17, 2024 Category: Gastroenterology Source Type: research
Neuropeptide W facilitates chronic gastric ulcer healing by the regulation of cyclooxygenase and NF- κB signaling pathways
In conclusion, NPW facilitated the healing of gastric injury in rats via the inhibition of pro-inflammatory cytokine production, oxidative stress and neutrophil infiltration as well as the downregulation of COX-2 protein and NF- κB gene expressions. (Source: Inflammopharmacology)
Source: Inflammopharmacology - January 16, 2024 Category: Drugs & Pharmacology Source Type: research
The benefit of omeprazole exposure on all-cause mortality and length of ICU/hospital stay might vary with age in critically ill pediatric patients: A cohort study
ConclusionsThis study provided a sign that PPIs used only in the ICU, rather than throughout hospital stay, might provide more benefit for critically ill pediatric patients. Additionally, younger pediatric patients might gain relatively more benefit than older children when receiving PPIs. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 1, 2024 Category: Drugs & Pharmacology Source Type: research
New tools for medication review: DRP in patients treatment with proton pump inhibitors
CONCLUSIONS: The application of the Revisem® digital platform allows the detection of a high prevalence of DRP at the provincial level. The application of new technological tools to detect the prevalence of DRP is essential to optimize patient treatments.PMID:38150850 | DOI:10.1016/j.aprim.2023.102836 (Source: Atencion Primaria)
Source: Atencion Primaria - December 27, 2023 Category: Primary Care Authors: Salvador Guti érrez-Igual Rut Lucas-Dom ínguez Alberto Mart í Rodrigo Isabel Romero Crespo M Carmen Montesinos Mezquita Source Type: research
Prescribing Patterns of Proton Pump Inhibitors in Germany: A Retrospective Study Including 472 146 Patients
This study highlights that discrepancies exist between clinical guidelines and real-life prescribing practices of PPIs in Germany. Particular attention should be given to the incidence of patients being prescribed high-dose or long-duration PPI with mild indications. These findings are particularly apt considering the publication (March 2023) of new guidelines on the "management of gastroesophageal reflux disease and eosinophilic esophagitis," by the DGVS.PMID:38142444 | DOI:10.1177/21501319231221002 (Source: Primary Care)
Source: Primary Care - December 24, 2023 Category: Primary Care Authors: Kate Plehhova Monika Haering Joshua Wray Cathal Coyle Eduardo Ib áñez Karel Kostev Source Type: research
