Effects of Preoperative Quadruple Therapy for Helicobacter pylori on Bariatric Surgery Metabolic Outcomes
ConclusionsPreoperative treatment with OCAM has been associated to poorer glycemic and weight loss outcomes after BS. More research is needed on the influence of OCAM on gut microbiota, and in turn, the effect of the latter on metabolic and weight loss outcomes after BS.Graphical Abstract (Source: Obesity Surgery)
Source: Obesity Surgery - February 24, 2024 Category: Surgery Source Type: research

Assessment of drug utilization and potentially inappropriate medications in hemodialysis patients with end-stage renal dysfunction: A study in a tertiary care hospital in Bahrain
CONCLUSION: A huge burden of drug therapy was observed in the hemodialysis patients in terms of higher proportions of PIM, complex medical regimen, and prescription of drugs with risk of TdP. Implementation of clinical decision support tools enhancing rational prescription and identification of drugs with TdP risk, introducing antimicrobial stewardship, and stepwise deprescription of the drugs with the least benefit-risk ratio are warranted.PMID:38393922 | DOI:10.3233/JRS-230004 (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - February 23, 2024 Category: Drugs & Pharmacology Authors: Kannan Sridharan Source Type: research

Time Course of the Interaction Between Oral Short-Term Ritonavir Therapy with Three Factor Xa Inhibitors and the Activity of CYP2D6, CYP2C19, and CYP3A4 in Healthy Volunteers
ConclusionThis trial with three microdosed FXaI suggests that at most the rivaroxaban dose should be reduced during short-term ritonavir, and only in patients receiving high maintenance doses. Thorough time series analyses demonstrated differential effects on three different drug-metabolising enzymes over time with immediate profound inhibition of CYP3A4 and only slow recovery after discontinuation.Clinical Trial RegistrationEudraCT number: 2021-006643-39. (Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - February 23, 2024 Category: Drugs & Pharmacology Source Type: research

Interaction Between Tacrolimus and Proton Pump Inhibitor in a Kidney Transplant Recipient
Exp Clin Transplant. 2024 Jan;22(Suppl 1):354-355. doi: 10.6002/ect.MESOT2023.P89.ABSTRACTWe aimed to present a drug monitoring profile of tacrolimus and proton pump inhibitor coadministration in a 23-year-old male patient with a history of high blood pressure who underwent kidney transplant. The patient's serum trough levels of tacrolimus were in the therapeutic range until omeprazole 20 mg daily was prescribed. Tacrolimus trough serum level increased to 29.5 ng/mL under the same daily dose and to 13.9 ng/mL after tacrolimus daily dose was decreased to 6 mg/day. This increase in tacrolimus serum level was behind a renal f...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research

Interaction Between Tacrolimus and Proton Pump Inhibitor in a Kidney Transplant Recipient
Exp Clin Transplant. 2024 Jan;22(Suppl 1):354-355. doi: 10.6002/ect.MESOT2023.P89.ABSTRACTWe aimed to present a drug monitoring profile of tacrolimus and proton pump inhibitor coadministration in a 23-year-old male patient with a history of high blood pressure who underwent kidney transplant. The patient's serum trough levels of tacrolimus were in the therapeutic range until omeprazole 20 mg daily was prescribed. Tacrolimus trough serum level increased to 29.5 ng/mL under the same daily dose and to 13.9 ng/mL after tacrolimus daily dose was decreased to 6 mg/day. This increase in tacrolimus serum level was behind a renal f...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research

Interaction Between Tacrolimus and Proton Pump Inhibitor in a Kidney Transplant Recipient
Exp Clin Transplant. 2024 Jan;22(Suppl 1):354-355. doi: 10.6002/ect.MESOT2023.P89.ABSTRACTWe aimed to present a drug monitoring profile of tacrolimus and proton pump inhibitor coadministration in a 23-year-old male patient with a history of high blood pressure who underwent kidney transplant. The patient's serum trough levels of tacrolimus were in the therapeutic range until omeprazole 20 mg daily was prescribed. Tacrolimus trough serum level increased to 29.5 ng/mL under the same daily dose and to 13.9 ng/mL after tacrolimus daily dose was decreased to 6 mg/day. This increase in tacrolimus serum level was behind a renal f...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research

Interaction Between Tacrolimus and Proton Pump Inhibitor in a Kidney Transplant Recipient
Exp Clin Transplant. 2024 Jan;22(Suppl 1):354-355. doi: 10.6002/ect.MESOT2023.P89.ABSTRACTWe aimed to present a drug monitoring profile of tacrolimus and proton pump inhibitor coadministration in a 23-year-old male patient with a history of high blood pressure who underwent kidney transplant. The patient's serum trough levels of tacrolimus were in the therapeutic range until omeprazole 20 mg daily was prescribed. Tacrolimus trough serum level increased to 29.5 ng/mL under the same daily dose and to 13.9 ng/mL after tacrolimus daily dose was decreased to 6 mg/day. This increase in tacrolimus serum level was behind a renal f...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research

Interaction Between Tacrolimus and Proton Pump Inhibitor in a Kidney Transplant Recipient
Exp Clin Transplant. 2024 Jan;22(Suppl 1):354-355. doi: 10.6002/ect.MESOT2023.P89.ABSTRACTWe aimed to present a drug monitoring profile of tacrolimus and proton pump inhibitor coadministration in a 23-year-old male patient with a history of high blood pressure who underwent kidney transplant. The patient's serum trough levels of tacrolimus were in the therapeutic range until omeprazole 20 mg daily was prescribed. Tacrolimus trough serum level increased to 29.5 ng/mL under the same daily dose and to 13.9 ng/mL after tacrolimus daily dose was decreased to 6 mg/day. This increase in tacrolimus serum level was behind a renal f...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research

Interaction Between Tacrolimus and Proton Pump Inhibitor in a Kidney Transplant Recipient
Exp Clin Transplant. 2024 Jan;22(Suppl 1):354-355. doi: 10.6002/ect.MESOT2023.P89.ABSTRACTWe aimed to present a drug monitoring profile of tacrolimus and proton pump inhibitor coadministration in a 23-year-old male patient with a history of high blood pressure who underwent kidney transplant. The patient's serum trough levels of tacrolimus were in the therapeutic range until omeprazole 20 mg daily was prescribed. Tacrolimus trough serum level increased to 29.5 ng/mL under the same daily dose and to 13.9 ng/mL after tacrolimus daily dose was decreased to 6 mg/day. This increase in tacrolimus serum level was behind a renal f...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research

The safety and efficacy of Houtou Jianweiling tablet in patients with chronic non-atrophic gastritis: a double-blind, non-inferiority, randomized controlled trial
Conclusion: The lower limit of confidence interval (CI, 95%) for the differences in the effective rate between the treatment and the control groups was found to be −0.0781 which is greater than −0.15, hence the treatment group is non-inferior to the control group. The therapeutic dosage used in the trial and treatment period did not cause any significant adverse event, and there were no obvious changes in the ECG profile, vital signs and biochemistry of the patients. Based on the clinical efficacy evaluation and reported adverse events, it can be concluded that the HTJWT is a safe and effective traditional chinese medi...
Source: Frontiers in Pharmacology - February 19, 2024 Category: Drugs & Pharmacology Source Type: research