Effect of Omeprazole Administration on the Pharmacokinetics of Oral Extended-release Nifedipine in Healthy Subjects
In this study, two nifedipine tablet products were tested with or without short term omeprazole comedication in healthy subjects. Seven-day administration of omeprazole before nifedipine dosing significantly increased the gastric pH, and subsequently increased the geometric least square (LS) means of AUC0-t and Cmax of nifedipine to 132.6% (90% CI 120.6%-145.7%) and 112.8% (90% CI 100.8%-126.3%) for pH-dependent ER tablets, and 120.6% (90% CI 109.7%-132.5%) and 122.5% (90% CI 113.7%-131.9%) for the pH-independent ER tablets, respectively. Similar extent of increase in AUC0-t and Cmax was confirmed in the subpopulations who...
Source: Clinical Pharmacology and Therapeutics - September 5, 2023 Category: Drugs & Pharmacology Authors: Liang Zhao Dajun Sun Ming-Liang Tan Mingjiang Xu Minori Kinjo Kairui Feng Hezhen Wang Robert Lionberger Source Type: research
Cost ‐effectiveness of alginic acid in combination with proton pump inhibitor for the treatment of gastroesophageal reflux disease in systemic sclerosis patients
ConclusionsAlginic acid plus PPI does not represent good value for money compared with the standard treatment among such SSc patients in Thailand unless its price is reduced significantly. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - September 5, 2023 Category: Rheumatology Authors: Chingching Foocharoen,
Pritaporn Kingkaew,
Yot Teerawattananon,
Ajanee Mahakkanukrauh,
Siraphop Suwannaroj,
Witsarut Manasirisuk,
Jitjira Chaiyarit,
Apichat Sangchan Tags: ORIGINAL ARTICLE Source Type: research
Transcriptional analysis of Helicobacter pylori cytotoxic-associated gene-pathogenicity island in response to different pH levels and proton pump inhibitor exposure
ConclusionOur results showed that omeprazole could increase the expression ofH. pylori cagA andcagL at acidic pH. Heterogeneity among the strains probably has an impact on the extent of their interplay with PPIs. Further studies are needed to establish this correlation.Graphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - September 4, 2023 Category: Gastroenterology Source Type: research
Over 30 Years of Omeprazole
CONCLUSION: Omeprazole is the prototypical drug in the management of APDs and has withstood the test of time. After 3 decades, omeprazole remains the drug of choice in managing APD.PMID:37651247 | DOI:10.59556/japi.71.0322 (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - August 31, 2023 Category: General Medicine Authors: Praveen Sharma Source Type: research
