Potential effects of noni (Morinda citrifolia L.) fruits extract against obsessive-compulsive disorder in marble burying and nestlet shredding behavior mice models
Obsessive-compulsive disorder (OCD) is a chronic and complex psychiatric disorder that usually includes both obsessions and compulsions. Morinda citrifolia L. (Noni) is a functional food and it is a well-known plant due to its potential therapeutic effects on human health in many disorders including neurological and neurodegenerative diseases. The purpose of this study was to evaluate the potential effect of M. citrifolia fruits extract (MCFE) against obsessive-compulsive disorder using the marble burying and nestlet shredding behavior mice models. In addition, brain neurotransmitters such as dopamine (DA), serotonin and n...
Source: Frontiers in Pharmacology - September 16, 2022 Category: Drugs & Pharmacology Source Type: research

D-mannose for preventing and treating urinary tract infections
CONCLUSIONS: There is currently little to no evidence to support or refute the use of D-mannose to prevent or treat UTIs in all populations. This review highlights the severe lack of high-quality RCTs testing the efficacy of D-mannose for UTIs in any population. Despite UTIs being one of the most common adult infections (affecting 50% of women at least once in their lifetime) and the growing global antimicrobial resistance, we found very few studies that adequately test this alternative treatment. Future research in this field requires, in the first instance, a single adequately powered RCT comparing D-mannose with placebo...
Source: Cochrane Database of Systematic Reviews - August 30, 2022 Category: General Medicine Authors: Tess E Cooper Claris Teng Martin Howell Armando Teixeira-Pinto Allison Jaure Germaine Wong Source Type: research

NK cell-mediated immunostimulatory effects of ethanol extract of Morinda citrifolia (noni) fruit
Morinda citrifolia (Noni) is a plant that has long been used in various products such as foods and cosmetics. Although noni has been known to have immunostimulatory activity, detailed mechanism at the cellular le... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - August 22, 2022 Category: Complementary Medicine Authors: Haeyeop Kim, Laily Rahmawati, Yo Han Hong, Su-Young Choi and Jae Youl Cho Tags: Research Source Type: research

Bisabolane-type sesquiterpenoids with potential anti-inflammatory and anti-HIV activities from the stems and leaves of < em > Morinda citrifolia < /em >
Nat Prod Res. 2022 Aug 17:1-8. doi: 10.1080/14786419.2022.2112577. Online ahead of print.ABSTRACTThe phytochemical study on the stems and leaves of Morinda citrifolia L. resulted in the isolation of a new naturally occurring bisabolane-type sesquiterpenoid, morincitrinoid A (1), together with five known analogues (2-6). The chemical structure of 1 was elucidated by comprehensive spectral analyses. The known compounds 2-6 were identified by comparing their spectral data with those reported in the literature, which were isolated from M. citrifolia for the first time. In addition, the anti-inflammatory and anti-HIV activities...
Source: Natural Product Research - August 17, 2022 Category: Biochemistry Authors: Ying-Ying Zhao Yu-Jie Li Xiao-Mei Yu Qin-Ting Su Li-Wen Wang Yu-Shu Zhu Yan-Hui Fu Guang-Ying Chen Yan-Ping Liu Source Type: research

Bisabolane-type sesquiterpenoids with potential anti-inflammatory and anti-HIV activities from the stems and leaves of < em > Morinda citrifolia < /em >
Nat Prod Res. 2022 Aug 17:1-8. doi: 10.1080/14786419.2022.2112577. Online ahead of print.ABSTRACTThe phytochemical study on the stems and leaves of Morinda citrifolia L. resulted in the isolation of a new naturally occurring bisabolane-type sesquiterpenoid, morincitrinoid A (1), together with five known analogues (2-6). The chemical structure of 1 was elucidated by comprehensive spectral analyses. The known compounds 2-6 were identified by comparing their spectral data with those reported in the literature, which were isolated from M. citrifolia for the first time. In addition, the anti-inflammatory and anti-HIV activities...
Source: Natural Product Research - August 17, 2022 Category: Biochemistry Authors: Ying-Ying Zhao Yu-Jie Li Xiao-Mei Yu Qin-Ting Su Li-Wen Wang Yu-Shu Zhu Yan-Hui Fu Guang-Ying Chen Yan-Ping Liu Source Type: research

Molecules, Vol. 27, Pages 5173: Potential Action Mechanism and Inhibition Efficacy of Morinda citrifolia Essential Oil and Octanoic Acid against Stagonosporopsis cucurbitacearum Infestations
Andrade Javier G. Mantilla-Afanador Raimundo W. A. Aguiar Eugênio E. Oliveira Gil R. Santos The use of plant-based products has been shown to efficiently inhibit fungi-mediated diseases in agricultural crops. Here, we extracted and evaluated the composition of noni, Morinda citrifolia L., essential oil and assessed its activities against Stagonosporopsis cucurbitacearum in Cucumis melo L. Using in silico molecular approaches, potential interactions between the essential oil major components and S. cucurbitacearum tyrosine&amp;ndash;tRNA ligase were predicted. Finally, we also measured the potential interf...
Source: Molecules - August 13, 2022 Category: Chemistry Authors: Mateus S. Dalcin Bruna L. Dias Luis O. Viteri Jumbo Ana C. S. S. Oliveira Sabrina H. C. Ara újo Wellington S. Moura Dalmarcia S. C. Mour ão Talita P. S. Ferreira Fabricio S. Campos Alex Sander R. Cangussu Marcos V. G. Alves Bruno S. Andrade Javier G. Ma Tags: Article Source Type: research

In vitro antifungal activity of Morinda citrifolia (noni) extract against Candida albicans
Conclusions: These results indicate thatM. citrifolia exerts biological activity againstC. albicans and reduces the viability and proliferation of human cells. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - July 27, 2022 Category: Infectious Diseases Source Type: research

GSE205467 Genomics analysis of  Drosophila sechellia response to Morinda citrifolia fruit diet
Contributors : Zachary A Drum ; Stephen M Lanno ; Sara M Gregory ; Serena J Shimshak ; Will Barr ; Austin Gatesman ; Mark Schadt ; Jack Sanford ; Aaron Arkin ; Brynn Assignon ; Sofia Colorado ; Carol Dalgarno ; Trevor Devanny ; Tara Ghandour ; Rose Griffin ; Mia Hogan ; Erica Horowitz ; Emily McGhie ; Jake Multer ; Hannah O'Halloran ; Kofi Ofori-Darko ; Dmitry Pokushalov ; Nick Richards ; Kathleen A Sagarin ; Nicholas Taylor ; Acadia Thielking ; Phie Towle ; Joseph D CoolonSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila sechelliaDrosophila sechellia is an island e...
Source: GEO: Gene Expression Omnibus - June 8, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Drosophila sechellia Source Type: research

Evaluation of morinda citrifolia ethanolic extract versus morinda citrifolia fresh fruit juice for tissue response and systemic toxicity in animal model
Conclusion: Ethanolic extract of Morinda citrifolia was not biocompatible and more cytotoxic than a Morinda citrifolia fresh fruit juice. So, fresh fruit juice of Morinda citrifolia can be a preferred choice of natural root canal irrigant, with least possible cytotoxic effects as compared to the ethanolic extract. (Source: Indian Journal of Dental Research)
Source: Indian Journal of Dental Research - May 18, 2022 Category: Dentistry Authors: Kavalipurapu Venkata Teja Sindhu Ramesh Karthik Ganesh Kaligotla Apoorva Vasundhara Source Type: research

Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats
. (Source: Drug and Chemical Toxicology)
Source: Drug and Chemical Toxicology - May 3, 2022 Category: Toxicology Authors: Tha ís Leal-Silva Maysa Rocha Souza Larissa Lopes Cruz Rafaianne Queiroz Moraes-Souza Ver ônyca Gonçalves Paula Thaigra Sousa Soares Vanessa Dela Justina Fernanda Regina Giachini D ébora Cristina Damasceno Madileine Francely Am érico Gustavo Tadeu Vo Source Type: research

[ASAP] Glycolipid Metabolism and Metagenomic Analysis of the Therapeutic Effect of a Phenolics-Rich Extract from Noni Fruit on Type 2 Diabetic Mice
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.1c07441 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - February 17, 2022 Category: Food Science Authors: Ruimin Wang, Lin Zhang, Qingyang Zhang, Jiachao Zhang, Sixin Liu, Congfa Li, and Lu Wang Source Type: research

Studies related to the chemical composition, biological activities and toxicity of methanolic extracts of noni ( < em > Morinda citrifolia < /em > ) fruits and leaves
Nat Prod Res. 2022 Jan 23:1-4. doi: 10.1080/14786419.2021.2021199. Online ahead of print.ABSTRACTMorinda citrifolia is a plant that grows in Brazilian northeast and presented a wide range of therapeutic, industrial and technological applications. Based on this, the aim of this work was to study the chemical composition, main biological activities and potential toxicity of its extracts, aiming their industrial application. Important compounds were identified in the methanolic extracts obtained by ultrasonic and Soxhlet extractions from leaves and fruits. GC × GC allowed for the identification of phytosterols, fatty acids a...
Source: Natural Product Research - January 24, 2022 Category: Biochemistry Authors: Daiane Barbosa de Matos Lima Ana í Loreiro Dos Santos Claudia Andr éa Lima Cardoso Laiza Canielas Krause Elina Bastos Caram ão Source Type: research

Morinda citrifolia Linn. fruit extract mitigates heroin seeking behavior in mice
This study demonstrates that MMC attenuated heroin seeking at different phases of drug self‑administration in a mouse modified runway model.PMID:35014982 (Source: Acta Neurobiologiae Experimentalis)
Source: Acta Neurobiologiae Experimentalis - January 11, 2022 Category: Neurology Authors: Vijayapandi Pandy Yasmin Khan Durga Priyanka Yarlagadda Sri Pravallika Tatinada Source Type: research