IMiDs New and Old
AbstractPurpose of ReviewIMiDs are a class of biologic agents with immunomodulatory, anti-angiogenic, and direct anti-cancer activities. This review summarizes current data on clinical development and application of IMiDs in non-Hodgkin lymphoma (NHL) subtypes, focusing primarily on lenalidomide, with additional discussion on managing common side effects.Recent FindingsImproved upon the prototype thalidomide, the second-generation compound lenalidomide has enhanced immunological and anti-cancer properties with fewer side effects, while next-generation small molecule cereblon/E3 ubiquitin ligase modulator CC-122 is in early...
Source: Current Hematologic Malignancy Reports - July 13, 2019 Category: Hematology Source Type: research

Metabolic tumor burden on baseline 18 F-FDG PET/CT improves risk stratification in pediatric patients with mature B-cell lymphoma
ConclusionsBaseline TMTV and TLG are both strong independent prognostic factors for pediatric B-NHL and provide a potential approach to aid in risk sub-stratification, especially in patients with high-risk disease. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 12, 2019 Category: Nuclear Medicine Source Type: research

Common conditions associated with mandibular canal widening: A literature review.
Conclusion: When clinicians encounter a lesion associated with mandibular canal widening, they should immediately consider these entities in the differential diagnosis. Doing so will help dentists make more accurate diagnoses and develop better treatment plans based on patients' radiographs. PMID: 31281785 [PubMed] (Source: Imaging Science in Dentistry)
Source: Imaging Science in Dentistry - July 12, 2019 Category: Dentistry Tags: Imaging Sci Dent Source Type: research

Expression and clinical significance of neuropilin-1 in EBV-associated lymphomas.
CONCLUSIONS: NRP-1 exhibited higher expression in lymphomas, and it was positively expressed in EBV-positive lymphomas. Moreover, highly expressed NRP-1 can be used as an undesirable independent prognostic factor in NHL. PMID: 31282408 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - July 11, 2019 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Daratumumab displays in vitro and in vivo anti-tumor activity in models of B cell non-Hodgkin lymphoma and improves responses to standard chemo-immunotherapy regimens.
u C, Doshi P, Pérez-Galán P Abstract CD38 is expressed in several types of non-Hodgkin lymphoma and constitutes a promising target for antibody-based therapy. Daratumumab (Darzalex) is a first-in-class anti-CD38 antibody approved for the treatment of relapsed/refractory multiple myeloma. It has also demonstrated clinical activity in Waldenstrom macroglobulinaemia and amyloidosis. Here, we have evaluated the activity and mechanism of action of daratumumab in preclinical in vitro and in vivo models of mantle cell lymphoma, follicular lymphoma and diffuse large B cell lymphoma, as monotherapy or in comb...
Source: Haematologica - July 11, 2019 Category: Hematology Authors: Vidal-Crespo A, Matas-Céspedes A, Rodriguez V, Rossi C, Valero JG, Serrat N, Sanjuan Pla A, Menéndez P, Roué G, López-Guillermo A, Giné E, Campo E, Colomer D, Bezombes C, Lammerts van Bueren J, Chiu C, Doshi P, Pérez-Galán P Tags: Haematologica Source Type: research

Prophylactic Antiemetics for Haematological Malignancies: Prospective Nationwide Survey Subset Analysis in Japan
Conclusion: Guideline compliance was very low. Although not statistically significant, there was a trend for reduced CINV and improved disease control for triple versus double antiemetics, suggesting that triple antiemetics should be considered for HEC, especially in young female patients with non-Hodgkin lymphoma receiving CHOP-like regimens. (Source: In Vivo)
Source: In Vivo - July 6, 2019 Category: Research Authors: YOSHIDA, I., TAMURA, K., MIYAMOTO, T., SHIMOKAWA, M., TAKAMATSU, Y., NANYA, Y., MATSUMURA, I., GOTOH, M., IGARASHI, T., TAKAHASHI, T., AIBA, K., KUMAGAI, K., ISHIZAWA, K., KURITA, N., USUI, N., HATAKE, K. Tags: Clinical Studies Source Type: research

Emergence of a lymphoma imitating an infectious infiltration surrounding the infrarenal aorta after EVAR.
We present a case of an appearance of periaortic infiltration after successful endovascular treatment which turned out to be of malignant origin. PMID: 31271346 [PubMed - as supplied by publisher] (Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases)
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - July 4, 2019 Category: Surgery Authors: Vajda M, Raupach J, Krajina A, Hoffmann P, Hůlek M, Živný O, Malý R, Vršanská V, Belada D Tags: Vasa Source Type: research

Heterogeneity among diffuse large B-cell lymphoma: new entities in WHO classification, a first step in personalized therapy.
Authors: Rotaru I, Tănase AD, Nacea JG, Pătraşcu Ş, Olteanu OA, Pătraşcu AM Abstract Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive lymphoma, being part of mature B-cell neoplasm according to the 2016 World Health Organization (WHO) Classification of lymphoid tumors. This type of non-Hodgkin's lymphoma (NHL) can develop in the lymph nodes in most cases, or in extranodal sites (the most frequent involvement being the digestive tract, but also the thyroid, central nervous system, testes, etc.). Despite being an aggressive lymphoma, DLBCL benefits of potentially curable therapy. The ...
Source: Romanian Journal of Morphology and Embryology - July 3, 2019 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Association of diabetes mellitus with non-Hodgkin lymphoma risk: a meta-analysis of cohort studies.
Authors: Xu J, Wang T Abstract Background: Diabetes mellitus (DM) is considered to be a risk factor in the prognosis of many types of cancer, but the effect of DM on the risk of non-Hodgkin lymphoma (NHL) is still under dispute. We performed this study to examine the association between DM and subsequent NHL risk. Methods: A systematically search had been performed in PubMed, EmBase, and the Cochrane Library to identify eligible studies from inception to September 2018. Results: Thirteen cohort studies were included, with a total of 9024761 participants. The results showed that DM was associated with an increased r...
Source: Hematology - July 3, 2019 Category: Hematology Tags: Hematology Source Type: research

Fatigue level changes with time in long-term Hodgkin and non-Hodgkin lymphoma survivors: a joint EORTC-LYSA cross-sectional study
Long-term lymphoma survivors often complain of persistent fatigue that remains unexplained. While largely reported in Hodgkin lymphoma (HL), long-term fatigue is poorly documented in non-Hodgkin lymphomas (NHL... (Source: Health and Quality of Life Outcomes)
Source: Health and Quality of Life Outcomes - July 2, 2019 Category: International Medicine & Public Health Authors: Rapha ël Busson, Marleen van der Kaaij, Nicolas Mounier, Berthe M. P. Aleman, Catherine Thiéblemont, Aspasia Stamatoullas, Vincent Ribrag, Hervé Tilly, Corinne Haioun, René-Olivier Casasnovas, Hanneke C. Kluin-Nelemans and Michel Henry-Amar Tags: Research Source Type: research

Cancers, Vol. 11, Pages 928: The Use of Optimal Treatment for DLBCL Is Improving in All Age Groups and Is a Key Factor in Overall Survival, but Non-Clinical Factors Influence Treatment
Conclusion: Delivery of optimal treatment for DLBCL is associated with hospital location and category, highlighting possible demographic variation in treatment patterns. Together with an increase in the proportion of patients receiving optimal treatment in the more recent time period, this suggests that treatment decisions in DLBCL may be subject to non-clinical influences, which may have implications when evaluating equity of treatment access. The positive association with survival emphasizes the importance of delivering optimal treatment in DLBCL. (Source: Cancers)
Source: Cancers - July 2, 2019 Category: Cancer & Oncology Authors: Wong Doo White Martin Bassett Prince Harrison Jefford Winship Millar Milne Seymour Giles Tags: Article Source Type: research

Upper gastrointestinal bleeding caused by direct invasion of diffuse large B-cell lymphoma into the stomach in a patient with HIV infection: A case report
We present a rare case of direct invasion of DLBCL to the stomach wall that presented as upper GI bleeding in a patient with HIV. Diagnosis: Upper endoscopy showed a large ulcerofungating mass in the lesser curvature of upper stomach body. The computed tomography scan showed an about 22 × 12 cm sized huge mass that invades into the stomach wall in the abdominal cavity. A diagnosis of DLBCL was established after histological examination. Intervention: The patient was treated with 6 courses of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Outcomes: The patient achieved a...
Source: Medicine - July 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Clinical characteristics of primary cutaneous lymphoma: two centers analysis in China.
This article is protected by copyright. All rights reserved. PMID: 31260087 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 1, 2019 Category: Dermatology Authors: Hao-Ze S, Liu YX, Jiang YQ, Chen SL, Xu XL, Lu XM, Zhang W, Zeng XS, Zhou GZ, Sun JF, Chen H Tags: Br J Dermatol Source Type: research

Chimeric Antigen Receptor T-Cell Therapy: Reach to Solid Tumor Experience.
Abstract Chimeric antigen receptor (CAR) modified T-cell therapy, a unique platform technology highlighting precision medicine through utilization of molecular biology and cell-based therapeutics has shown unprecedented rates in patients with hematological malignancies such as acute lymphocyte leukemia, non-Hodgkin's lymphoma and multiple myeloma (MM). With the approval of CD19-targeted CAR T-cells by the Food and Drug Administration in acute lymphoblastic leukemia (ALL) and NHL, this technology is positioned for aggressive expansion to combination therapeutic opportunities and proof of principle towards utility i...
Source: Oncology - July 1, 2019 Category: Cancer & Oncology Authors: Metzinger MN, Verghese C, Hamouda DM, Lenhard A, Choucair K, Senzer N, Brunicardi FC, Dworkin L, Nemunaitis J Tags: Oncology Source Type: research

Front-Line Treatment of High Grade B Cell Non-Hodgkin Lymphoma
AbstractPurpose of ReviewRituximab-based chemoimmunotherapy has resulted in a marked improvement in the survival of diffuse large B cell lymphoma (DLBCL). We reflect upon the history front-line (1L) therapy and highlight advances in management.Recent FindingsSince the introduction of R-CHOP, the majority of randomized studies in the front-line treatment of DLBCL have failed to show a benefit. Such studies have involved treatment intensification, adding novel agents to the R-CHOP backbone and targeting such novel agents to biologically defined subgroups. R-CHOP therefore remains standard-of-care for most but new insights in...
Source: Current Hematologic Malignancy Reports - June 29, 2019 Category: Hematology Source Type: research

Glyphosate use and associations with non-Hodgkin lymphoma major histological sub-types: findings from the North American Pooled Project
Conclusions There was some limited evidence of an association between glyphosate use and NHL in this pooled analysis. Suggestive associations, especially for SLL, deserve additional attention.byPahwa M, Beane Freeman LE, Spinelli JJ, Blair A, McLaughlin JR, Zahm SH, Cantor KP, Weisenburger DD, Punam Pahwa, Dosman JA, Demers PA, Harris SA. doi:10.5271/sjweh.3838 (Source: Scandinavian Journal of Work, Environment and Health)
Source: Scandinavian Journal of Work, Environment and Health - June 27, 2019 Category: Occupational Health Tags: Original article Source Type: research

Glyphosate use and associations with non-Hodgkin lymphoma major histological sub-types: findings from the North American Pooled Project.
Conclusions There was some limited evidence of an association between glyphosate use and NHL in this pooled analysis. Suggestive associations, especially for SLL, deserve additional attention. PMID: 31246262 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Work, Environment and Health)
Source: Scandinavian Journal of Work, Environment and Health - June 27, 2019 Category: Occupational Health Authors: Pahwa M, Beane Freeman LE, Spinelli JJ, Blair A, McLaughlin JR, Zahm SH, Cantor KP, Weisenburger DD, Punam Pahwa PP, Dosman JA, Demers PA, Harris SA Tags: Scand J Work Environ Health Source Type: research

Characterizing lymphoma incidence and disparities for a cancer center catchment region
Publication date: Available online 26 June 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Amy A. Ayers, Lin Lyu, Kaylin Dance, Kevin C. Ward, Christopher R. Flowers, Jean L. Koff, Lauren E. McCulloughAbstractBackgroundRacial disparities in non-Hodgkin lymphoma (NHL) are not well elucidated for specific catchment areas, which can influence outcomes. Leveraging regional data from a population-based cancer registry may provide unique opportunities to quantify NHL disparities.MethodsUsing Surveillance, Epidemiology and End Results (SEER) data for NHL cases diagnosed in Georgia from 2001 to 2015, we examined NHL i...
Source: Clinical Lymphoma Myeloma and Leukemia - June 26, 2019 Category: Cancer & Oncology Source Type: research

Why is This Patient Dizzy, Weak, and Tachycardic?
​BY ANGEL BERMUDEZ, MD, & WESLEY EILBERT, MDAn 81-year-old woman with a history of metastatic lung cancer, hypertension, and COPD presented with dizziness that she described as lightheadedness, generalized weakness, and mild shortness of breath for three days. She also reported recent anorexia and a sensation of impending loss of consciousness.She was thin and appeared ill, and she was unable to stand unsupported. She was afebrile with a heart rate of 101 bpm and a blood pressure of 92/55 mm Hg.Her initial ECG is shown. What else could this be if not ST-elevation myocardial infarction?Our patient was found to have a ...
Source: The Case Files - June 25, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Malnutrition, sepsis and tumor lysis syndrome are associated with increased rate of acute mortality in mature b cell non-hodgkin lymphoma in pediatric population- study from tertiary care hospital in pakistan
Conclusion:Rate of acute mortality in B cell NHL is high in our set up and significant riskfactors are tumor lysis syndrome, sepsis and malnourishment at time of presentation. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - June 24, 2019 Category: Hematology Source Type: research

Ontogeny, Genetics, Molecular Biology, and Classification of B- and T-Cell Non-Hodgkin Lymphoma.
Abstract Mature B- and T-cell lymphomas are diverse in their biology, etiology, genetics, clinical behavior, and response to specific therapies. Here, we review the principles of diagnostic classification for non-Hodgkin lymphomas, summarize the characteristic features of major entities, and place recent biological and molecular findings in the context of principles that are applicable across the spectrum of mature lymphoid cancers. PMID: 31229154 [PubMed - in process] (Source: The Medical Clinics of North America)
Source: The Medical Clinics of North America - June 24, 2019 Category: General Medicine Authors: Ryan RJH, Wilcox RA Tags: Hematol Oncol Clin North Am Source Type: research

Efficacy and Safety of Bcl-2 Inhibitor Venetoclax in Hematological Malignancy: A Systematic Review and Meta-Analysis of Clinical Trials
Conclusion : Venetoclax is a mild and efficient drug in treating advanced hematological malignancy which is specially fit for the CLL patients with del[17p], and AEs are well-tolerable. Few tumor lysis syndrome (TLS) occurred after taking the drugs. The AEs aroused by venetovlax and combination are well-tolerable. Therefore, the use of venetoclax monotherapy or its combination with other therapies is desirable in hematological malignancy. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 21, 2019 Category: Drugs & Pharmacology Source Type: research

High Concentrations of Serum Soluble E-Cadherin in Patients With Q Fever
Cadherins switching is a hallmark of neoplasic processes. The E-cadherin (E-cad) subtype is one of the surface molecules regulating cell-to-cell adhesion. After its cleavage by sheddases, a soluble fragment (sE-cad) is released that has been identified as a pro-carcinogenic inflammatory signal in several bacteria-induced cancers. Recently we reported that Q fever, a disease due to Coxiella burnetii infection, can be complicated by occurrence of non-Hodgkin lymphoma (NHL). Therefore, we studied E-cad switching in Q fever. The sE-cad levels were found increased in the sera of acute and persistent Q fever patients, whereas th...
Source: Frontiers in cellular and infection microbiology - June 21, 2019 Category: Microbiology Source Type: research

Non-Hodgkin Lymphoma
Publication date: August 2019Source: Hematology/Oncology Clinics of North America, Volume 33, Issue 4Author(s): Caron A. Jacobson (Source: Hematology Oncology Clinics of North America)
Source: Hematology Oncology Clinics of North America - June 20, 2019 Category: Hematology Source Type: research

Improvement in Waldenstr öm's Macroglobulinemia after Successful Treatment of HCV with Direct-acting Antivirals.
Improvement in Waldenström's Macroglobulinemia after Successful Treatment of HCV with Direct-acting Antivirals. Ann Hepatol. 2018 Nov - Dec;17(6):1072-1077 Authors: Crespi M, Demarzo MG, Brunacci M, Pellegatta G, Ferrando F, Ballestrero A, Grillo F, Savarino V, Giannini EG Abstract Chronic hepatitis C (HCV) virus infection may be associated with several non-hepatic manifestations, mainly driven by chronic immune stimulation, such as mixed cryoglobulinemia and Non-Hodgkin's Lymphoma. This association has been proved by several meta-analyses and some interventional studies demonstrating that antivir...
Source: Annals of Hepatology - June 20, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Non-Hodgkin Lymphoma
HEMATOLOGY/ONCOLOGY CLINICS OF NORTH AMERICA (Source: Hematology/Oncology Clinics of North America)
Source: Hematology/Oncology Clinics of North America - June 20, 2019 Category: Cancer & Oncology Authors: Caron A. Jacobson Source Type: research

GSE132929 Pathognomonic and epistatic genetic alterations in B-cell non-Hodgkin lymphoma
Contributor : Michael R GreenSeries Type : Expression profiling by arrayOrganism : Homo sapiensB-cell non-Hodgkin lymphoma (B-NHL) encompasses multiple clinically and phenotypically distinct subtypes of malignancy with unique molecular etiologies. Common subtypes of B-NHL such as diffuse large B-cell lymphoma (DLBCL) have been comprehensively interrogated at the genomic level, but other less common subtypes such as mantle cell lymphoma (MCL) remain sparsely characterized. Furthermore, multiple B-NHL subtypes have thus far not been comprehensively compared to identify conserved or subtype-specific patterns of genomic altera...
Source: GEO: Gene Expression Omnibus - June 19, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Mantle Cell Lymphoma: Which Patients Should We Transplant?
AbstractPurpose of ReviewMantle cell lymphoma is a CD5+ non-Hodgkin lymphoma associated with suboptimal outcome. Young, fit patients are generally offered intensive induction followed by autologous hematopoietic cell transplantation (AHCT) in first remission. Some patients may not benefit from this strategy.Recent FindingsRecent studies have investigated the role of AHCT in the modern era. First, an analysis of the National Cancer Database demonstrated improved progression-free survival (PFS) for consolidative AHCT. Second, a multi-center study associated consolidative AHCT with improved PFS even after propensity-weighted ...
Source: Current Hematologic Malignancy Reports - June 19, 2019 Category: Hematology Source Type: research

Bruton tyrosine kinase inhibitors for the treatment of mantle cell lymphoma: review of current evidence and future directions.
Authors: Bond DA, Alinari L, Maddocks K Abstract Mantle cell lymphoma (MCL) is a heterogeneous and uncommon non-Hodgkin lymphoma that affects predominantly older patients and often is associated with an aggressive clinical course. MCL relies upon B-cell receptor signaling through Bruton tyrosine kinase (BTK); therefore, the development of the BTK inhibitors ibrutinib and acalabrutinib represents a therapeutic breakthrough. In this review, we provide a summary of the efficacy and safety data from the landmark trials of single-agent ibrutinib and acalabrutinib that led to US Food and Drug Administration approval of t...
Source: Clinical Advances in Hematology and Oncology - June 14, 2019 Category: Cancer & Oncology Tags: Clin Adv Hematol Oncol Source Type: research

Lymphomas with oral manifestations – 18 cases in our institution and review of literature
Lymphomas are the heterogeneous group of malignant diseases characterized by proliferation of malignant lymphoid cells or their precursors. Lymphomas are the ninth most common cancer worldwide and constitute 3.2% of malignant tumor. Lymphomas are generally classified to two main categories: Hodgkin's lymphomas (HL) and the non-Hodgkin lymphomas (NHL), and about 90% are NHL. Non-Hodgkin lymphoma represents 4.3% of all new cancer cases in the U.S. and the ninth most common cancer in male patient of Taiwan. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - June 13, 2019 Category: ENT & OMF Authors: Dr. Chih-Huang Tseng, Dr. Yuk-Kwan Chen, Dr. Wen-chen Wang, Dr. Ching-yi Chen, Dr. Edward Chengchuan KO Tags: #25 Source Type: research

Increasing Levels of Serum Heat Shock Protein 70 Precede the Development of AIDS-Defining Non-Hodgkin Lymphoma Among Carriers of HLA-B8-DR3
Conclusion: Our combined genetic and functional approach suggests that the altered level of Hsp70 is a correlate of 8.1AH-mediated AIDS-NHL. Further investigation of the Hsp70 gene cluster and nearby loci that are tagged by A-G-A-C could better elucidate the genetic determinants of the malignancy. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - June 13, 2019 Category: Infectious Diseases Tags: Epidemiology Source Type: research

Non-coding RNAs in Natural Killer/T-Cell Lymphoma
Natural killer/T-cell lymphoma (NKTCL) is a rare and aggressive subtype of non-Hodgkin's lymphoma that is associated with a poor outcome. Noncoding RNAs (ncRNAs), which account for 98% of human RNAs, lack the function of encoding proteins but instead have the important function of regulating gene expression, including transcription, translation, RNA splicing, editing, and turnover. However, the roles and mechanisms of aberrantly expressed noncoding RNAs in NKTCL are not fully clear. Aberrant expressions of miRNAs affect the PI3K/AKT signaling pathways (miR-21, miR-155, miR-150, miR-142, miR-494), NF-ĸB (miR-146a, miR-155)...
Source: Frontiers in Oncology - June 13, 2019 Category: Cancer & Oncology Source Type: research

Acalabrutinib for mantle cell lymphoma
Mantle cell lymphoma (MCL) is a unique type of non-Hodgkin lymphoma characterized by the overexpression of cyclin D1. MCL patients typically live for years but experience multiple relapses. Acalabrutinib is a novel second-generation oral Bruton tyrosine kinase inhibitor approved by the US Food and Drug Administration for relapsed MCL based on a clinical trial demonstrating an overall response rate of 81%. It provides a valuable new treatment option for MCL patients and is now being tested upfront. (Source: Blood)
Source: Blood - June 13, 2019 Category: Hematology Authors: Witzig, T. E., Inwards, D. Tags: Lymphoid Neoplasia, Blood Spotlight Source Type: research

Predictive value of pre-treatment FDG PET in patients with non-Hodgkin lymphoma treated with radioimmunotherapy: a systematic review
ConclusionsAlthough it is still not possible to specifically define the best PET-based predictor (i.e. SUVmax, TLG, MTV), FDG-PET is a promising tool for a more accurate and individualized selection of NHL patients candidates to RIT. The availability of FDG  PET examinations in homogenous group of patients included in already completed clinical trials might be used in the next future also to specifically assess the prognostic value of baseline FDG PET in patients treated with RIT based on the study design. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - June 11, 2019 Category: Radiology Source Type: research

A novel biomarker score for the screening and management of patients with plasma cell proliferative disorders.
CONCLUSIONS: We showed that BS mean values follow the ingravescence disease status towards the two main lines of progression to cancerous conditions; it could represent an additional useful tool in the management of screening and/or follow-up. PMID: 31173301 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - June 9, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Infradiaphragmal radiotherapy in patients with lymphoma: volume definition and side effects.
INFRADIAPHRAGMAL RADIOTHERAPY IN PATIENTS WITH LYMPHOMA: VOLUME DEFINITION AND SIDE EFFECTS. Acta Clin Croat. 2018 Sep;57(3):554-560 Authors: Galunić-Bilić L, Šantek F Abstract - Lymphomas are very radiosensitive and radiotherapy (RT) was the first treatment modality that enabled cure. It is the most effective single modality for local control of lymphomas. However, as a local form of treatment, curative intention is only possible if all lymphoma tissue can be incorporated in the volume to be irradiated with the prescribed total irradiation dose. That is why RT is a single modality only in ear...
Source: Acta Clinica Croatica - June 8, 2019 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Bendamustine: an old drug in the new era for patients with non-hodgkin lymphomas and chronic lymphocytic leukemia.
In conclusion, bendamustine as a single agent or in combinations has shown activity with acceptable toxic profile in the treatment of patients with indolent NHLs or CLL without del(17p) mutation. PMID: 31168188 [PubMed - in process] (Source: Acta Clinica Croatica)
Source: Acta Clinica Croatica - June 8, 2019 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Targeting IL-6 receptor reduces IgM levels and tumor growth in Waldenstr öm macroglobulinemia.
Targeting IL-6 receptor reduces IgM levels and tumor growth in Waldenström macroglobulinemia. Oncotarget. 2019 May 21;10(36):3400-3407 Authors: Han W, Matissek SJ, Jackson DA, Sklavanitis B, Elsawa SF Abstract The tumor microenvironment (TME) plays an important role in cancer cell biology and is implicated in resistance to therapy. In Waldenström macroglobulinemia (WM), a subtype of Non-Hodgkin lymphoma, the TME modulates WM biology by secreting cytokines that promote the malignant phenotype. In previous work, we have shown that TME-IL-6 promotes WM cell growth and IgM secretion in WM. Tocili...
Source: Oncotarget - June 7, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

68Ga CXCR-4 PET/CT Imaging in an Atypical Case of Extramedullary Plasmacytoma Mimicking as Renal Cell Carcinoma
We report a case of plasmacytoma with suspicious renal cell carcinoma, in whom 68Ga CXCR-4 PET/CT revealed tracer-avid lesion in the left perinephric region. PET/CT-guided biopsy from the tracer-avid lesion revealed plasmacytoma. PET/CT-imaging and guided biopsy using 68Ga CXCR4 receptor ligand, proved its usefulness for accurate localization of the culprit lesion and helped in definitive management of the patient. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 6, 2019 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Concomitant Orbital Tumours: Small Lymphocytic Lymphoma Involving the Lacrimal Gland of a Patient with Clinical Diagnoses of Muir-Torre Syndrome and Extensive Sebaceous Gland Carcinoma of the Ipsilateral Eyelid
Conclusion: We report for the first time a case of a patient with Muir-Torre syndrome who developed an orbital recurrent SC with an incidental finding of a lacrimal gland B non-Hodgkin lymphoma consistent with SLL. Clinicians should be aware of the possibility of this coexistence of multiple cancer types in patients with sebaceous carcinoma and Muir-Torre syndrome.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - June 5, 2019 Category: Opthalmology Source Type: research

GSE112086 A transcriptional signature associated with non-Hodgkin lymphoma in the blood of patients with Q fever
Contributors : Cl éa Melenotte ; Soraya Mezouar ; Amira Ben Amara ; Simon Benatti ; Jacques Chiaroni ; Christian Devaux ; Guido Kroemer ; Jean-Louis Mege ; Didier RaoultSeries Type : Expression profiling by arrayOrganism : Homo sapiensCoxiella burnetii, the agent causing Q fever, has been associated with B-cell non-Hodgkin lymphoma (NHL). To better clarify this link, we analysed the genetic transcriptomic profile of peripheral blood leukocytes from patients with C. burnetii infection to identify possible links to lymphoma. Microarray analyses revealed that 1189 genes were expressed differently (p (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 5, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Mediastinal Lymphoma Presenting in Cardiogenic Shock with Superior Vena Cava Syndrome in a Primigravida at Full Term: Salvage Resection after Prolonged Extracorporeal Life Support
Primary mediastinal large B-cell lymphoma (PMBCL) is a rare type of non-Hodgkin lymphoma that typically has a good response rate to first line chemotherapy regimens. There have been reports of successful chemotherapy, but with a residual mass from fibrosis. Here, we report the case of a 19-year-old primigravida presenting with cardiogenic shock and superior vena cava (SVC) syndrome at full term who was found to have a PMBCL. Following delivery via urgent cesarean section, she was put on veno-arterial extra corporeal membrane oxygenation (VA-ECMO) and once hemodynamically stable was started on chemotherapy. In view of limit...
Source: Case Reports in Oncology - June 4, 2019 Category: Cancer & Oncology Source Type: research

Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis
ConclusionsIn the setting of a literature reporting mainly null and some positive associations, and the lack of a clear methodologic explanation for our inverse association restricted to NHW men, the current body of evidence suggests that there is no association of blood transfusion with risk of NHL. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - June 4, 2019 Category: Cancer & Oncology Source Type: research

Results of the First Clinical Study in Humans That Combines Hyperbaric Oxygen Pretreatment with Autologous Peripheral Blood Stem Cell Transplantation
Autologous hematopoietic cell transplantation (auto-HCT) following high-dose chemotherapy has an important role in treating many patients with lymphoma and multiple myeloma. For patients with a variety of lymphomas, including Hodgkin disease (HD) and non-Hodgkin lymphoma (NHL), auto-HCT might potentially be a curative procedure, in addition to improving overall survival and progression-free survival [1 –5]. For multiple myeloma, auto-HCT is not curative, but its role is well established as a consolidation treatment to achieve deep durable remissions in most patients [6–9]. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - June 3, 2019 Category: Hematology Authors: Haitham Abdelhakim, Leyla Shune, Sajjad Bhatti, Amy Rose Cantilena, Andrea Baran, Tara L. Lin, Siddhartha Ganguly, Anurag K. Singh, Sunil Abhyankar, Clint Divine, Brea Lipe, Joseph McGuirk, Dennis Allin, Omar S. Aljitawi Source Type: research

Association between occupational exposure to trichloroethylene and serum levels of microRNAs: a cross-sectional molecular epidemiology study in China
The objective of our study was to evaluate the association between occupational exposure to trichloroethylene (TCE), a suspected lymphomagen, and serum levels of miRNAs in a cross-sectional molecular epidemiology study of TCE-exposed workers and comparable unexposed controls in China.MethodsSerum levels of 40 miRNAs were compared in 74 workers exposed to TCE (median: 12  ppm) and 90 unexposed control workers. Linear regression models were used to test for differences in serum miRNA levels between exposed and unexposed workers and to evaluate exposure–response relationships across TCE exposure categories using a ...
Source: International Archives of Occupational and Environmental Health - June 3, 2019 Category: Occupational Health Source Type: research

Results of the first clinical study in humans that combines hyperbaric oxygen pre-treatment with autologous peripheral blood stem cell transplantation
Autologous hematopoietic cell transplantation (Auto-HCT) following high dose chemotherapy has an important role in treating many patients with lymphoma and multiple myeloma. For patients with a variety of lymphomas including Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL), Auto-HCT might potentially be a curative procedure, in addition to improving overall survival (OS) and progression free survival (PFS) [1-5]. For multiple myeloma, Auto-HCT is not curative, but its role is well-established as a consolidation treatment to achieve deep durable remissions in the majority of patients [6-9]. (Source: Biology of Blood ...
Source: Biology of Blood and Marrow Transplantation - June 3, 2019 Category: Hematology Authors: Haitham Abdelhakim, Leyla Shune, Sajjad Bhatti, Amy Rose Cantilena, Andrea Baran, Tara L. Lin, Siddhartha Ganguly, Anurag K. Singh, Sunil Abhyankar, Clint Divine, Brea Lipe, Joseph McGuirk, Dennis Allin, Omar S. Aljitawi Source Type: research

Meta-analytical methods for estimating outcomes from overall response rate in patients with relapsed/refractory diffuse large B-cell lymphoma.
Authors: Wang L, Lam H, Shou Y, Galaznik A Abstract Relapsed/refractory diffuse large B-cell lymphoma (DLBCL) is highly heterogeneous and current trials are investigating new approaches to improve outcomes. Limited data on response endpoints can confound estimation of a treatment effect when designing studies of novel agents in this setting, which can hinder study sample size calculations, especially if a net estimate is required for a 'physician's choice' comparator arm. Here we estimate complete response rate (CRR), overall response rate (ORR), and extrapolate durable response rates (DRR; CR/partial response last...
Source: Oncotarget - June 1, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Systemic and prophylactic intrathecal chemotherapy for primary adrenal lymphoma: A retrospective study of 20 case reports
Primary adrenal lymphoma (PAL) is a rare entity of lymphoma with dismal prognosis using systemic chemotherapy. More clinical reports are needed to guide the treatment for PAL. We performed a retrospective analysis of 20 patients diagnosed with PAL who presented to our center between January 2005 and January 2014. Median age at presentation was 48 years (range: 27–73) with a male-to-female ratio of 7:3. Bilateral and right-sided adrenal involvement were seen in 11 of 20 and 7 of 20 patients, respectively. Adrenal insufficiency (AI) was seen in 6 of 10 evaluated patients. Diffuse large B cell lymphoma (DLBCL) was the...
Source: Medicine - June 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

High Glucose Promotes Epithelial-Mesenchymal Transition, Migration and Invasion in A20 Murine Di ffuse Large B-Cell Lymphoma Cells Through Increased Expression of High Mobility Group AT-Hook 2 (HMGA2).
CONCLUSIONS In the A20 murine DLBCL cell line, high glucose upregulated the expression of HMGA2 to induce EMT and promote cell migration and invasion through the Wnt/ß-catenin signaling pathway. PMID: 31124542 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 30, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Updates in Prognostication and Treatment of Waldenström’s Macroglobulinemia
Publication date: Available online 29 May 2019Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Pooja Advani, Aneel Paulus, Sikander AilawadhiAbstractWaldenström’s macroglobulinemia (WM) is a rare, incurable hematologic disorder with a relatively indolent course in a majority of the patients. Despite this, a significant proportion of patients require treatment because of hypersecretion of immunoglobulin M and the invasion of bone marrow and peripheral organs by neoplastic lymphoplasmacytic lymphoma cells. Historically, there has been a dearth of research and therapeutic advancements in the field of WM,...
Source: Hematology Oncology and Stem Cell Therapy - May 29, 2019 Category: Cancer & Oncology Source Type: research