Biological Age is No Barrier for Adult Patients Undergoing CAR T for Non-Hodgkin's Lymphoma or Multiple Myeloma
The recent introduction of chimeric antigen receptor T cell therapy (CAR T) into clinical practice has radically shifted the treatment paradigm of relapse/refractory B-cell non-Hodgkin lymphoma (NHL) and multiple myeloma (MM) .1 The current commercially available products including axicabtagene ciloleucel (axi-cel) ,2 tisagenlecleucel (tisa-cel) ,3 and lisocabtagene maraleucel (liso-cel) 4,5 for NHL and idcabtagene vicleucel (ide-cel) 6,7 and ciltacabtagene autoleucel f d(cilta-cel) 8 for MM have shown impressive response rates and survival outcomes in heavily pretreated patients who would otherwise have very limited treat...
Source: Biology of Blood and Marrow Transplantation - April 26, 2024 Category: Hematology Authors: Danai Dima, Craig S. Sauter Tags: The Bottom Line Source Type: research
A Deeper Depth of Response After Salvage Therapy Improves Outcomes of Autologous Stem Cell Transplantation in Relapsed Lymphoma and the Feasibility of Non-controlled Rate Freezing of Peripheral Blood Stem Cells
Conclusion High-dose therapy and autologous stem cell transplantation in low- to middle-income countries are limited to relatively younger patients, potentially curative conditions such as lymphoma, and predominantly after achieving a complete response to salvage therapy due to limited resources. Due to these factors, our study shows excellent response rates and survival outcomes compared to internationally published data. Engraftment was also excellent and comparable to published data despite the non-controlled rate freezing of peripheral blood stem cells.PMID:38659569 | PMC:PMC11039573 | DOI:10.7759/cureus.56851 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Saif Ur Rab Mussadique Ali Uzma Rasool Mahar Bushra Ahsan Usman Ahmad Muhammad Tariq Mahmood Neelam Siddiqui Syed W Bokhari Source Type: research
Long-term follow-up of patients with follicular lymphoma using next generation sequencing to detect minimal residual disease
Follicular lymphoma (FL) is a highly treatable, indolent non-Hodgkin lymphoma. Although FL is considered incurable, a patient without progression of disease by 24 months after treatment is predicted to have a survival consistent with persons without lymphoma. Using a sensitive assessment of minimal residual disease (MRD), we tested the hypothesis that MRD monitoring can predict long term remissions. (Source: Clinical Lymphoma, Myeloma and Leukemia)
Source: Clinical Lymphoma, Myeloma and Leukemia - April 23, 2024 Category: Hematology Authors: Ayushi Chauhan, Lai Catherine, Frank Kuhr, Heidi Simmons, Bruce D. Cheson Source Type: research
Cancers, Vol. 16, Pages 1580: T-Cell Engagers & mdash;The Structure and Functional Principle and Application in Hematological Malignancies
Cancers, Vol. 16, Pages 1580: T-Cell Engagers—The Structure and Functional Principle and Application in Hematological Malignancies
Cancers doi: 10.3390/cancers16081580
Authors:
Paweł Cech
Katarzyna Skórka
Laura Dziki
Krzysztof Giannopoulos
Recent advancements in cancer immunotherapy have made directing the cellular immune response onto cancer cells a promising strategy for the treatment of hematological malignancies. The introduction of monoclonal antibody-based (mAbs) targeted therapy has significantly improved the prognosis for hematological patients. Facing the issues of mAb-based therapies, a ...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Pawe ł Cech Katarzyna Sk órka Laura Dziki Krzysztof Giannopoulos Tags: Review Source Type: research
Mantle Cell Lymphoma Under the Scope of Personalized Medicine: Perspective and Directions
Clin Lymphoma Myeloma Leuk. 2024 Mar 27:S2152-2650(24)00135-6. doi: 10.1016/j.clml.2024.03.010. Online ahead of print.ABSTRACTMantle cell lymphoma (MCL) is a rare, incurable non-Hodgkin's lymphoma characterized by naive B cells infiltrating the lymphoid follicle's mantle zone. A key feature of MCL is the cytogenetic abnormality t(11;14) (q13:q14), found in 95% of cases, leading to Cyclin D1 overexpression resulting in uncontrolled cell cycle progression and genetic instability. Occasionally, Cyclin D2 or D3 overexpression can substitute for Cyclin D1, causing similar effects. The transcription factor SOX11 is a hallmark of...
Source: Clinical Lymphoma and Myeloma - April 19, 2024 Category: Cancer & Oncology Authors: Lara Gallucci Figorelle Peterson Tiago Galv ão Felipe Matheus Ribeiro de Lima Patricia Marimon Nathalia Pentagna Cristiane Milito Rony Schaffel Katia Carneiro Source Type: research
Editors ’ Picks
Cutaneous T-cell lymphomas (CTCLs) comprise an incurable form of non-Hodgkin lymphoma, and advanced-stage forms of this disease, mycosis fungoides and Sezary syndrome, have poor prognosis. Previous case series documented long-lasting remission due to a graft-versus-lymphoma effect in patients treated with allogeneic hematopoietic stem cell transplantation (HSCT). In these studies, lymphoma relapse was common, and treatment-related morbidity and mortality were noted, leading to weaker recommendations for HSCT in this patient population. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Tags: Editors' Picks Source Type: research
Noncoding RNAs in B cell non-Hodgkins lymphoma
Gene. 2024 Apr 16:148480. doi: 10.1016/j.gene.2024.148480. Online ahead of print.ABSTRACTB-cell non-Hodgkins lymphomas (BCNHLs) are a category of B-cell cancers that show heterogeneity. These blood disorders are derived from different levels of B-cell maturity. Among NHL cases, ∼80-90 % are derived from B-cells. Recent studies have demonstrated that noncoding RNAs (ncRNAs) contribute to almost all parts of mechanisms and are essential in tumorigenesis, including B-cell non-Hodgkins lymphomas. The study of ncRNA dysregulations in B-cell lymphoma unravels important mysteries in lymphoma's molecular etiology. It seems also ...
Source: Gene - April 18, 2024 Category: Genetics & Stem Cells Authors: Zahra Abedi Kichi Niloofar Dini Mahbubeh Rojhannezhad Zeinab Shirvani Farsani Source Type: research
Expression and prognostic significance of the PD ‐1/PD‐L1 pathway in AIDS‐related non‐Hodgkin lymphoma
ConclusionsThese data emphasize the importance of PD-1-mediated immune evasion in the complex landscape of immune oncology in AR-NHL co-infected with EBV, and contribute to the diagnostic classification and possible definition of immunotherapeutic strategies for this unique subgroup. (Source: Cancer Medicine)
Source: Cancer Medicine - April 13, 2024 Category: Cancer & Oncology Authors: Han Zhao,
Shaohang Cai,
Yanhua Xiao,
Muye Xia,
Hongjie Chen,
Zhiman Xie,
Xiaoping Tang,
Haolan He,
Jie Peng,
Juanjuan Chen Tags: RESEARCH ARTICLE Source Type: research
Safety and efficacy of a new academic CD19-directed CAR-T cell for refractory/relapsed non-Hodgkin lymphoma and acute lymphoblastic leukemia in Brazil
Bone Marrow Transplantation, Published online: 13 April 2024; doi:10.1038/s41409-024-02283-6Safety and efficacy of a new academic CD19-directed CAR-T cell for refractory/relapsed non-Hodgkin lymphoma and acute lymphoblastic leukemia in Brazil (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 13, 2024 Category: Hematology Authors: Camila D. Donadel Gil C. De Santis Thiago E. Gon çalves Bruno G. Pires Leonardo C. Palma Flavia Gava Renato Luiz Guerino-Cunha Joana T. B. Faria Gabriela V. A. Silva Luiz Guilherme Darrigo-Junior Giancarlo Fatobene Vanderson Rocha Dimas T. Covas Rodrigo Source Type: research
Clinical characteristics and prognostic analysis of primary extranodal non-Hodgkin lymphoma of the head and neck
CONCLUSIONS: The most common site of PE-NHL in these Chinese patients was the Waldeyer's ring, but the incidence in the nasal cavity was higher than that reported in Western countries. Radiotherapy combined with chemotherapy had better efficacy than chemotherapy alone, and the prognosis depended on the ECOG score and clinical stage. IPI had a better prognostic value in patients in the high-risk group of head and neck PE-NHL.PMID:38604163 | DOI:10.18632/aging.205726 (Source: Aging)
Source: Aging - April 11, 2024 Category: Biomedical Science Authors: Jiamu Lv Yining Jiang Tingting Yu Shengrui Gao Wanzhong Yin Source Type: research
Clinical characteristics and prognostic analysis of primary extranodal non-Hodgkin lymphoma of the head and neck
CONCLUSIONS: The most common site of PE-NHL in these Chinese patients was the Waldeyer's ring, but the incidence in the nasal cavity was higher than that reported in Western countries. Radiotherapy combined with chemotherapy had better efficacy than chemotherapy alone, and the prognosis depended on the ECOG score and clinical stage. IPI had a better prognostic value in patients in the high-risk group of head and neck PE-NHL.PMID:38604163 | DOI:10.18632/aging.205726 (Source: Aging)
Source: Aging - April 11, 2024 Category: Biomedical Science Authors: Jiamu Lv Yining Jiang Tingting Yu Shengrui Gao Wanzhong Yin Source Type: research
Clinical characteristics and prognostic analysis of primary extranodal non-Hodgkin lymphoma of the head and neck
CONCLUSIONS: The most common site of PE-NHL in these Chinese patients was the Waldeyer's ring, but the incidence in the nasal cavity was higher than that reported in Western countries. Radiotherapy combined with chemotherapy had better efficacy than chemotherapy alone, and the prognosis depended on the ECOG score and clinical stage. IPI had a better prognostic value in patients in the high-risk group of head and neck PE-NHL.PMID:38604163 | DOI:10.18632/aging.205726 (Source: Aging)
Source: Aging - April 11, 2024 Category: Biomedical Science Authors: Jiamu Lv Yining Jiang Tingting Yu Shengrui Gao Wanzhong Yin Source Type: research
Association between obesity and cancer risk in HIV-infected Asians
CONCLUSIONS: Obesity, which is one of the important health concerns in HIV management, was associated with an increased risk of non-AIDS-defining cancer but not AIDS-defining cancer.PMID:38597513 | DOI:10.1097/QAD.0000000000003904 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Yoonyoung Jang Taehwa Kim Yunsu Choi Kyoung Hwan Ahn Jung Ho Kim Hye Seong Youn Jeong Kim Shin-Woo Kim Jun Yong Choi Hyo Youl Kim Joon Young Song Hee Jung Choi Sang Il Kim Jang Wook Sohn BumSik Chin Bo-Youl Choi Boyoung Park Source Type: research
Anti-CD20 therapy for older patients with B-cell non-Hodgkin lymphoma in the context of epidemic normalization
Asian J Surg. 2024 Apr 10:S1015-9584(24)00581-5. doi: 10.1016/j.asjsur.2024.03.154. Online ahead of print.NO ABSTRACTPMID:38599972 | DOI:10.1016/j.asjsur.2024.03.154 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 10, 2024 Category: Surgery Authors: Dongdong Zhang Shuangnian Xu Source Type: research
Anti-CD20 therapy for older patients with B-cell non-Hodgkin lymphoma in the context of epidemic normalization
Asian J Surg. 2024 Apr 10:S1015-9584(24)00581-5. doi: 10.1016/j.asjsur.2024.03.154. Online ahead of print.NO ABSTRACTPMID:38599972 | DOI:10.1016/j.asjsur.2024.03.154 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 10, 2024 Category: Surgery Authors: Dongdong Zhang Shuangnian Xu Source Type: research
