The Landscape of New Drugs in Extranodal NK/T-Cell Lymphoma
Extranodal natural killer/T-cell lymphoma (ENKTCL) is an aggressive hematological malignancy and accounts for 5.2% and 3% of all non-Hodgkin lymphoma in the Far East and Central/South America, respectively.(1,2) Chinese statistics disclosed that ENKTCL constituted 6.4% of non-Hodgkin lymphoma, and more than 20% of mature T- and NK-cell lymphoma.(3) ENKTCL shows a predilection for population with EBV infection and shares strong associations with Asian genetic background.(1,4,5) However, both the pathogenesis of ENKTCL and the significant role of EBV during the lymphomagenesis remain largely unknown. (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - July 1, 2020 Category: Cancer & Oncology Authors: Liang Wang, Lin-Rong Li, Luo Zhang, Jing-wen Wang Tags: Anti-tumour Treatment Source Type: research
Chimeric Antigen Receptors for the Tumour Microenvironment.
Authors: Habib R, Nagrial A, Micklethwaite K, Gowrishankar K Abstract Chimeric antigen receptor T (CAR-T) cell therapy has dramatically revolutionised cancer treatment. The FDA approval of two CAR-T cell products for otherwise incurable refractory B-cell acute lymphoblastic leukaemia (B-ALL) and aggressive B-cell non-Hodgkin lymphoma has established this treatment as an effective immunotherapy option. The race for extending CAR-T therapy for various tumours is well and truly underway. However, response rates in solid organ cancers have been inadequate thus far, partly due to challenges posed by the tumour microenvi...
Source: Advances in Experimental Medicine and Biology - June 28, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research
Light alcohol drinking and the risk of cancer development: a controversial relationship.
Abstract BACKGROUND: In accordance with the scientific literature heavy alcohol consumption (>50g per day) represents a risk factor for several diseases development, including cancer. However, the oncogenic role of light alcohol drinking (
Source: Reviews on Recent Clinical Trials - June 28, 2020 Category: Cancer & Oncology Authors: Caprio GG, Picascia D, Dallio M, Vitiello PP, Giunta EF, De Falco V, Abenavoli L, Procopio AC, Famiglietti V, Martinelli E, Gravina AG, Federico A, Ciardiello F, Loguercio C, Ciardiello D Tags: Rev Recent Clin Trials Source Type: research
Novel Agents Beyond Immunomodulatory Agents and Phosphoinositide-3-Kinase for Follicular Lymphoma.
Abstract Follicular lymphoma is the most common indolent non-Hodgkin lymphoma. Although median overall survival rates exceed 12 years with rituximab, follicular lymphoma remains largely incurable. The growing understanding of the molecular drivers of lymphomagenesis and the tumor microenvironment have led to novel therapies. Prognostic markers have identified a subset of patients with chemoresistant and/or refractory disease-associated poor outcomes. We identify the patients with follicular lymphoma in need of novel therapies, describe the drivers of lymphomagenesis and importance of the tumor microenvironmen...
Source: Clinical Lymphoma and Myeloma - June 27, 2020 Category: Cancer & Oncology Authors: Chin CK, Nastoupil LJ Tags: Hematol Oncol Clin North Am Source Type: research
Cutaneous T cell lymphoma PDX drug screening platform identifies cooperation between inhibitions of PI3K α/δ and HDAC
Cutaneous T-cell lymphoma (CTCL) is a form of non-Hodgkin lymphoma that manifests initially in the skin and disseminates systemically as disease progresses. Mycosis fungoides and S ézary syndrome (MF/SS) are the most common subtypes of CTCL. Advanced MF/SS are life-threatening with few treatment options. We searched for new agents by high-throughput screening of selected targeted compounds and identified high value targets including phosphatidylinositol 3-kinase (PI3K) and cy clin-dependent kinases. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - June 27, 2020 Category: Dermatology Authors: Chi-Heng Wu, Chen-Yen Yang, Linlin Wang, Hua-Xin Gao, Taha Rakhshandehroo, Shervin Afghani, Laura Pincus, Ronald Balassanian, James Rubenstein, Ryan Gill, Sourav Bandyopadhyay, Frank McCormick, Mark Moasser, Weiyun Z. Ai Tags: Original Article Source Type: research
Shear wave elastography as a new method to identify parotid lymphoma in primary Sj ögren Syndrome patients: an observational study
AbstractParotid non-Hodgkin lymphoma (NHL) in primary Sj ögren syndrome (pSS) has no specific biomarker for diagnosis. Salivary glands ultrasound (US) is largely used, but its contribution in detecting parotid NHL has not been established. The aim of our study was to determine the added value of bidimensional shear wave elastography (2D-SWE) in pSS diagn osis and to determine its accuracy in identifying parotid NHL. Grey-scale US (GSUS) and 2D-SWE of salivary glands were performed in 35 patients with pSS and 35 healthy controls. The GSUS scores were calculated and the mean of three SWE consecutive measurements was use...
Source: Rheumatology International - June 26, 2020 Category: Rheumatology Source Type: research
Primary pulmonary extranodal natural killer/T-cell lymphoma (ENKTL), nasal type: Two case reports and literature review
Conclusion: The diagnosis of ENKTL should be considered when patients present with fever and expansile consolidation of the lung not responding to antibiotics. The diagnosis depends on histopathology and immunophenotyping. Percutaneous transthoracic needle biopsy is a safe and effective biopsy method. Chemotherapy may improve the prognosis, but this should be confirmed by prospective multicenter studies. (Source: Medicine)
Source: Medicine - June 26, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Primary testicular T-lymphoblastic lymphoma in a child: A case report
Rationale: Primary non-Hodgkin lymphoma (NHL) of the testes is rare, representing about 9% of testicular neoplasms and 1% to 2% of non-Hodgkin lymphomas. Patient concerns: A previously healthy 47-month-old boy came to our institution for 3 months unilateral testicular swelling without tenderness. After preliminary examination, inguinal orchiectomy was performed to resect the right scrotal mass. The histopathological diagnosis of high-grade lymphoma was rendered and paraffin blocks were sent for immunophenotyping. Diagnosis: The final diagnosis by histopathological combined with immunohistochemical staining revealed...
Source: Medicine - June 26, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Histone Deacetylase 6 as a Therapeutic Target in B cell-associated Hematological Malignancies
This article reviews recent progress in the mechanisms of action of HDAC6 inhibitors for the treatment of B cell-associated hematological malignancies, such as multiple myeloma and B cell non-Hodgkin lymphoma, which are often resistant to targeted therapies. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 26, 2020 Category: Drugs & Pharmacology Source Type: research
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children With Non-Hodgkin Lymphoma
The aim of this study is to evaluate the clinical and laboratory findings of pediatric patients with non-Hodgkin lymphoma (NHL) who developed Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Between 2006 and 2018, the medical records of child patients with NHL who developed SJS and TEN were reviewed retrospectively. SJS/TEN developed in 7 of 70 patients with NHL (10%). The pathologic subgroups of the patients with SJS/TEN were ALK-negative anaplastic large cell lymphoma (n: 3), Burkitt lymphoma (n: 2), lymphoblastic lymphoma (n: 1), and primary mediastinal B-cell lymphoma (n: 1). Five patients had TEN, ...
Source: Journal of Pediatric Hematology Oncology - June 25, 2020 Category: Hematology Tags: Online Articles: Original Articles Source Type: research
Correction to: Phase I dose escalation study of BI 836826 (CD37 antibody) in patients with relapsed or refractory B cell non-Hodgkin lymphoma
The original version of this article unfortunately contained an error. In the Conflict of interest statement, Anne-Marie Quinson is described as declaring no conflict of interest. (Source: Investigational New Drugs)
Source: Investigational New Drugs - June 23, 2020 Category: Drugs & Pharmacology Source Type: research
Coexistence of Hodgkin and Non-Hodgkin Lymphoma; Composite Lymphoma [CL] in a Patient Presenting with Waxing and Waning Lymphadenopathy
(Source: Cardiovascular and Haematological Disorders - Drug Targets)
Source: Cardiovascular and Haematological Disorders - Drug Targets - June 20, 2020 Category: Cardiology Authors: Geladari, Eleni Dimopoulou, Georgia Margellou, Evangelia Paraskevas, Andreas Kafetzis, Georgios Rontogianni, Dimitra Vadiaka, Maria Tags: Case report Source Type: research
Genomics of Peripheral T-Cell Lymphoma and Its Implications for Personalized Medicine
Peripheral T-cell lymphoma (PTCL) is a rare, heterogenous group of mature T-cell neoplasms that comprise 10–15% of non-Hodgkin lymphoma cases in the United States. All subtypes of PTCL, except for ALK+ anaplastic T-cell lymphoma, are associated with poor prognosis, with median overall survival (OS) rates of 1–3 years. The diagnosis of PTCL is mainly based on clinical presentation, morphologic features, and immunophenotypes. Recent advances in genome sequencing and gene expression profiling have given new insights into the pathogenesis and molecular biology of PTCL. An enhanced understanding of its genomic lands...
Source: Frontiers in Oncology - June 19, 2020 Category: Cancer & Oncology Source Type: research
The Association of Pre-diagnostic Inflammatory Markers and Adipokines and the Risk of Non-Hodgkin Lymphoma Development in Egypt
AbstractNon-Hodgkin lymphoma (NHL) is an etiologically, clinically, and histologically heterogeneous group of lymphoproliferative disorders. Immune dysfunction is a well-known risk factor and dysregulation of cytokines may mediate disease progression. Obesity is one of the important relations connecting immune system abnormalities and lymphomagenesis. We conducted a study to find out the association between obesity as measured by body mass index (BMI), and risk of non-Hodgkin lymphoma (NHL) development by assessment the of inflammatory cytokines levels, (IL-6, IL-10, IFN-gamma and CRP) and adipokines levels (leptin and adi...
Source: Indian Journal of Hematology and Blood Transfusion - June 19, 2020 Category: Hematology Source Type: research
Different roles of surveillance positron emission tomography according to the histologic subtype of non-Hodgkin's lymphoma.
Conclusions: The role of FDG-PET/CT surveillance is limited, and differs according to the lymphoma subtype. FDG-PET/CT may be useful in detecting early relapse in patients with aggressive T-cell NHL, including those with low/low-intermediate risk secondary IPI; as already known, FDG-PET/CT has no role in aggressive B-cell NHL. Repeat biopsy should be performed to discriminate relapse or transformation from false positive findings in patients with positive surveillance FDG-PET/CT results. PMID: 32550718 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 19, 2020 Category: Internal Medicine Authors: Kim YR, Kim SJ, Cheong JW, Kim Y, Jang JE, Cho H, Chung H, Min YH, Yang WI, Cho A, Kim JS Tags: Korean J Intern Med Source Type: research
Indolent varicella encephalitis with vasculopathy in an immunocompromised patient.
Authors: Maramattom BV Abstract A 68-year-old female with B-cell non-Hodgkin's lymphoma presented to us with sequential blindness followed by hemiparesis. Four months earlier, the patient had developed chicken pox that was treated with intravenous acyclovir. An MRI brain showed multiple cerebral infarcts and beaded appearance of her intracranial vasculature. PET-CT showed hypermetabolism in the right frontal lobe and pons suggestive of encephalitis. Cerebral spinal fluid examination showed 15 cells and varicella zoster vasculopathy (VZVV) polymerase chain reaction was positive. A final diagnosis of indolent VZVV va...
Source: Journal of the Royal College of Physicians of Edinburgh - June 18, 2020 Category: General Medicine Tags: J R Coll Physicians Edinb Source Type: research
Ibrutinib is not an effective drug in primografts of TCF3-PBX1.
CONCLUSIONS: We conclude that ibrutinib is not the precision medicine of choice for TCF3-PBX1 positive BCP-ALL. PMID: 32563910 [PubMed - as supplied by publisher] (Source: Translational Oncology)
Source: Translational Oncology - June 18, 2020 Category: Cancer & Oncology Authors: van de Ven C, Boeree A, Stalpers F, Zwaan CM, Den Boer ML Tags: Transl Oncol Source Type: research
B7-H6 Promotes Cell Proliferation, Migration and Invasion of Non-Hodgkin Lymphoma via Ras/MEK/ERK Pathway Based on Quantitative Phosphoproteomics Data
(Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - June 17, 2020 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Primary extra nodal Non-Hodgkin's lymphoma of urinary bladder presenting as a bladder tumor: A case report
Publication date: Available online 17 June 2020Source: Annals of Medicine and SurgeryAuthor(s): Namita Bhutani, Vartika Goel, Pradeep Kajal, Devendra Pawar, Pooja Sharma, Rajeev Sen (Source: Annals of Medicine and Surgery)
Source: Annals of Medicine and Surgery - June 17, 2020 Category: General Medicine Source Type: research
Risk of second primary cancers in individuals diagnosed with index smoking- and non-smoking- related cancers.
CONCLUSION: We found that 1-in-11 cancer survivors developed a SPC. Given the increasing number of cancer survivors and the importance of SPC as a cause of cancer death, there is a need for increased screening for and prevention of SPC. PMID: 32356175 [PubMed - indexed for MEDLINE] (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - June 17, 2020 Category: Cancer & Oncology Authors: Adjei Boakye E, Wang M, Sharma A, Jenkins WD, Osazuwa-Peters N, Chen B, Lee M, Schootman M Tags: J Cancer Res Clin Oncol Source Type: research
110 RNA expression analysis in stage IVA-B cutaneous T-cell lymphoma to identify novel biomarkers of prognosis and diagnosis
Cutaneous T-cell lymphoma (CTCL) is a primary non-Hodgkin lymphoma and the most common primary cutaneous lymphoma. Due to its varied clinical and histological presentation, the accurate diagnosis of CTCL is difficult and therefore delayed; in advanced stages, CTCL is incurable and often fatal, though treatment-resistant phenotypes and survival time can be difficult to predict. There remains an unmet need for new and more effective diagnostic and prognostic indicators and novel therapies. To this end, malignant cells were isolated from the peripheral blood of 15 CTCL patients using antibody-magnetic bead or FACS sorting for...
Source: Journal of Investigative Dermatology - June 17, 2020 Category: Dermatology Authors: F.N. Mirza, S. Yumeen, J.M. Lewis, A.O. King, S. Kim, K.R. Carlson, F.M. Foss, M. Girardi Tags: Carcinogenesis and Cancer Genetics Source Type: research
Leptomeningeal metastasis in a marginal zone lymphoma, presenting as a delirium: case report
Hematologic malignancies can spread to the central nervous system (CNS), either as focal lesions or as leptomeningeal disease. Marginal zone lymphoma (MZL) is a low-grade non-Hodgkin lymphoma and generally pre... (Source: BMC Geriatrics)
Source: BMC Geriatrics - June 17, 2020 Category: Geriatrics Authors: Lisa Dreessen, Nicolas Mar échal, Michel Verheyden, Ann De Becker, Kristin Jochmans, Tim Vanderhasselt, Bert Bravenboer and Ingo Beyer Tags: Case report Source Type: research
Unilateral multiple serous retinal detachments secondary to non-Hodgkin's lymphoma responsive to systemic steroids.
CONCLUSION: Neurosensory retina detachments may be an initial manifestation of large B-cell lymphoma as a consequence of a pro-inflammatory state involving the chorioretinal structures, thus adding steroid treatment could be useful for its resolution. PMID: 32551955 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - June 17, 2020 Category: Opthalmology Authors: Vujosevic S, Toma C, Muraca A, Alkabes M, Villani E, Nucci P, De Cilla S Tags: Eur J Ophthalmol Source Type: research
Clinical characteristics and treatment outcome of type I cryoglobulinemia in Chinese patients: a single-center study of 45 patients
In conclusion, for patients with multisystemic involvement, such as skin damage, kidney damage, or peripheral neuropathy, the diagnosis of type I CG should be considered, and the underlying disease needs to be explored. Symptoms and primary diseases should be taken into consideration before choosing initial management. (Source: Annals of Hematology)
Source: Annals of Hematology - June 13, 2020 Category: Hematology Source Type: research
Validation of a modified pre-lysis sample preparation technique for flow cytometric minimal residual disease assessment in multiple myeloma, chronic lymphocytic leukemia, and B-non Hodgkin lymphoma.
CONCLUSION: This modified pre-lysis procedure provides a sensitive, robust, time efficient, and relatively cost-effective alternative for MRD testing by MFC at 10-5 , facilitating clinically meaningful deeper response assessment for MM, CLL, and B-NHL. This method adaptation may facilitate more widespread adoption of highly sensitive flow cytometry-based MRD assessment. PMID: 32530574 [PubMed - as supplied by publisher] (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - June 12, 2020 Category: Cancer & Oncology Authors: Bayly E, Nguyen V, Binek A, Piggin A, Baldwin K, Westerman D, Came N Tags: Cytometry B Clin Cytom Source Type: research
MiR-645 regulates the proliferation and apoptosis of diffuse large B-cell lymphoma by targeting DACH1
In this study, we found that miR-645 was up-regulated in DLBCL tissues and cell lines. Down-regulation of miR-645 significantly inhibited the proliferation, cell cycle progression and promoted the apoptosis of DLBCL cells. Experimental study identified Dachshund family transcription factor 1 (DACH1) as a target of miR-645. MiR-645 bound the 3 ′-untranslated region of DACH1 and reduced the expression of DACH1 in DLBCL cells. Decreased expression of DACH1 was inversely correlated with that of miR-645 in DLBCL tissues. The promoting effect of miR-645 on the proliferation of DLBCL cells was attenuated with the overexpres...
Source: Human Cell - June 11, 2020 Category: Cytology Source Type: research
Impact of prednisolone dosage in the CHOP regimen for follicular lymphoma: a retrospective study.
In conclusion, the PSL dose adjusted based on body surface area appeared to be appropriate in terms of efficacy and safety. PMID: 32529585 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 11, 2020 Category: Hematology Authors: Ikeda T, Fujiwara SI, Nakajima H, Kawaguchi SI, Toda Y, Ito S, Ochi S, Nagayama T, Mashima K, Umino K, Minakata D, Nakano H, Morita K, Yamasaki R, Kawasaki Y, Ashizawa M, Yamamoto C, Hatano K, Sato K, Oh I, Ohmine K, Muroi K, Kanda Y Tags: Int J Hematol Source Type: research
Cancer and Systemic Lupus Erythematosus
Systemic lupus erythematosus is associated with a small overall increased cancer risk compared with the general population. This risk includes a 4-fold increased risk of non-Hodgkin lymphoma, but a decreased risk of other cancers (such as breast cancer). The pathophysiology underlying the increased risk of hematologic cancer is not fully understood, but many potential mechanisms have been proposed, including dysfunction of the tumor necrosis factor and other pathways. A decreased risk of breast, ovarian, and endometrial cancer might be driven by hormonal factors or lupus-related antibodies, but these links have not been pr...
Source: Rheumatic Disease Clinics of North America - June 10, 2020 Category: Rheumatology Authors: Alexandra Ladouceur, Basile Tessier-Cloutier, Ann E. Clarke, Rosalind Ramsey-Goldman, Caroline Gordon, James E. Hansen, Sasha Bernatsky Source Type: research
Correlative analysis of overall survival with clinical characteristics in 127 patients with mantle cell lymphoma: a multi-institutional cohort in Taiwan.
Abstract Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma often with extranodal involvement at diagnosis, and yet how this feature correlates with survival awaits elucidation. To address this issue, a correlative analysis between clinical features of 127 MCL patients and their overall survival (OS) was conducted. In this cohort, the median age at MCL diagnosis was 62 years and 81% were males. Eighty-four percent of patients were Ann Arbor stage 4, and 15% were blastoid variants. In patients with gastrointestinal MCL, approximately 40% had gastric involvement. In treatment, CHOP-based induction chem...
Source: International Journal of Hematology - June 9, 2020 Category: Hematology Authors: Wang YH, Yu SC, Ko BS, Yang YT, Yao M, Tang JL, Huang TC Tags: Int J Hematol Source Type: research
Profile of Polatuzumab Vedotin in the Treatment of Patients with Relapsed/Refractory Non-Hodgkin Lymphoma: A Brief Report on the Emerging Clinical Data
(Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - June 8, 2020 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Ultrasonographic assessment of right heart intracardiac mass in patients with hepatitis B virus infection
Objective: The characteristics of right heart intracardiac mass in hepatitis B virus infection patients are not well known. Our aim is to describe their ultrasonographic features and nature of such masses. Methods: We retrospectively reviewed imaging reports of hepatitis B virus infection patients from January 2014 to December 2018. Patients with a confirmed finding of right heart intracardiac mass were included, whose pathology reports and contrast-enhanced images were analyzed. Various masses were compared to a general control group from a published study. Results: Thirty-eight cases were finally included. Differ...
Source: European Journal of Gastroenterology and Hepatology - June 3, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
Residential Proximity to Intensive Animal Agriculture and Risk of Lymphohematopoietic Cancers in the Agricultural Health Study
Conclusion: Residential proximity to intensive animal agriculture was positively associated with risk of NHL and leukemia, even after consideration of occupational animal and pesticide exposures. (Source: Epidemiology)
Source: Epidemiology - June 3, 2020 Category: Epidemiology Tags: Environmental Epidemiology Source Type: research
[PERSPECTIVES] Epidemiology and Etiology of Leukemia and Lymphoma
Available evidence suggests that the incidence of leukemia and lymphoma tends to be higher in highly developed regions of the world and among Whites in the United States. Temporal trends in incidence are dynamic and multifactorial; for instance, the incidence of non-Hodgkin's lymphoma increased around the turn of the century, in part because of the acquired immune deficiency syndrome (AIDS) epidemic. Most leukemias and lymphomas are sporadic and the specific etiology remains elusive. Still, research shows that these malignancies often develop in the context of genetic abnormalities, immunosuppression, and exposure to risk ...
Source: Cold Spring Harbor perspectives in medicine - June 1, 2020 Category: Research Authors: Bispo, J. A. B., Pinheiro, P. S., Kobetz, E. K. Tags: Leukemia and Lymphoma: Molecular and Therapeutic Insights PERSPECTIVES Source Type: research
69. Evidence-based review of genomic aberrations in DLBCL, NOS
The most common type of Non-Hodgkin lymphoma is Diffuse Large B-Cell Lymphoma, Not Otherwise Specified (DLBCL, NOS) accounting for 30% of all NHL cases. It is more common in the elderly with an average age of 60 years, but it is also seen in all age groups. Due to clinicopathologic, biological and genetic diversity, DLBCL is sub divided into morphological variants and molecular subtypes. Initial workup and evaluation of DLBCL has become increasingly complex partly due to the genetic abnormalities that are targets for specific therapy and play an important role in monitoring residual disease. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - June 1, 2020 Category: Genetics & Stem Cells Authors: Ashwini Yenamandra, Greg Corboy, Susan Crocker, James Fink, Mary Haddadin, Anna Hodge, Rashmi Kanagal Shamana, Kilannin Krysiak, Susan Mathew, Sarah Rapisardo, Debra Saxe, Rebecca Smith, Pascale Willem, Min Fang Source Type: research
Immunotherapy in Hodgkin and Non-Hodgkin Lymphoma: Innate, Adaptive and Targeted Immunological Strategies
The concept of harnessing the immune system to defend against cancer has been recognized since around the turn of the last century when Dr. William Coley advocated cancer immunotherapy with bacterial toxins [1,2]. The advancement of molecular medicine and increased understanding of tumor-immune cell interactions has led to the development of novel immunotherapeutic strategies that have been implemented for the treatment of a wide variety of malignancies. Lymphoma, however, is somewhat unique in that it is a malignancy of the immune system; hence, the malignant cell interacts with the immune system, regulates the host immun...
Source: Cancer Treatment Reviews - May 29, 2020 Category: Cancer & Oncology Authors: Aung M. Tun, Stephen M. Ansell Tags: Anti-tumour Treatment Source Type: research
Risk of second primary cancers in individuals diagnosed with index smoking- and non-smoking- related cancers
ConclusionWe found that 1-in-11 cancer survivors developed a SPC. Given the increasing number of cancer survivors and the importance of SPC as a cause of cancer death, there is a need for increased screening for and prevention of SPC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 28, 2020 Category: Cancer & Oncology Source Type: research
Dental treatment needs in hospitalized cancer patients: a retrospective cohort study
ConclusionThis study can be considered original in the oncologic context, providing new information about the most frequent dental treatment needs among a large population of hospitalized cancer patients. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - May 28, 2020 Category: Cancer & Oncology Source Type: research
Burden of Hodgkin and non-Hodgkin lymphoma in Spain over a 10-year period: productivity losses due to premature mortality.
CONCLUSIONS: Lymphoma represents a significant burden that can be reduced with the implementation of improved diagnosis and treatment methods, which must be taken into account in resource allocation and management policies. PMID: 32450710 [PubMed - as supplied by publisher] (Source: Expert Review of Pharmacoeconomics and Outcomes Research)
Source: Expert Review of Pharmacoeconomics and Outcomes Research - May 28, 2020 Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
CAR T-Cell Therapy for B-Cell non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia: Clinical Trials and Real-World Experiences
Chimeric antigen receptor-modified (CAR) T cells targeting CD19 have revolutionized the treatment of relapsed or refractory aggressive B-cell lymphomas, and their use has increased the cure rate for these cancers from 10 to 40%. Two second-generation anti-CD19 CAR T-cell products, axicabtagene ciloleucel and tisagenlecleucel, have been approved for use in patients, and the approval of a third product, lisocabtagene maraleucel, is expected in 2020. The commercial availability of the first two products has facilitated the development of real-world experience in treating relapsed or refractory aggressive B-cell lymphomas, she...
Source: Frontiers in Oncology - May 27, 2020 Category: Cancer & Oncology Source Type: research
Cancer mortality risk, fine particulate air pollution, and smoking in a large, representative cohort of US adults
ConclusionsExposure to PM2.5 air pollution contributes to lung cancer mortality and may be a risk factor for other cancer types. Cigarette smoking has a larger impact on cancer mortality than PM2.5 , but is associated with similar cancer types. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - May 27, 2020 Category: Cancer & Oncology Source Type: research
B-cell non-Hodgkin lymphoma: importance of angiogenesis and antiangiogenic therapy
AbstractAngiogenesis is critical for the initiation and progression of solid tumors, as well as hematological malignancies. While angiogenesis in solid tumors has been well characterized, a large body of investigation is devoted to clarify the impact of angiogenesis on lymphoma development. B-cell non-Hodgkin lymphoma (B-NHL) is the most common lymphoid malignancy with a highly heterogeneity. The malignancy remains incurable despite that the addition of rituximab to conventional chemotherapies provides substantial improvements. Several angiogenesis-related parameters, such as proangiogenic factors, circulating endothelial ...
Source: Angiogenesis - May 25, 2020 Category: Molecular Biology Source Type: research
Non-Hodgkin`s Lymphoma presenting as deep venous thrombosis; a case report with literature review
Publication date: Available online 22 May 2020Source: International Journal of Surgery Case ReportsAuthor(s): Okba F. Ahmad, Fahmi H. Kakamad, Abdulwahid M. Salih, Mohammed Q. Mustafa, Shvan H. Mohammed (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - May 22, 2020 Category: Surgery Source Type: research
Sepsis and Septic Shock in Patients With Malignancies: A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique Study*
Objectives: Cancer affects up to 20% of critically ill patients, and sepsis is one of the leading reasons for ICU admission in this setting. Early signals suggested that survival might be increasing in this population. However, confirmation studies have been lacking. The goal of this study was to assess trends in survival rates over time in cancer patients admitted to the ICU for sepsis or septic shock over the last 2 decades. Data Source: Seven European ICUs. Study Selection: A hierarchical model taking into account the year of admission and the source dataset as random variables was used to identify risk factors ...
Source: Critical Care Medicine - May 22, 2020 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
Therapeutic effects of chimeric antigen receptor T cells (CAR-T) on relapse/refractory diffuse large B-cell lymphoma (R/R DLBCL): a meta-analysis.
CONCLUSIONS: CAR-T treatment for R/R DLBCL demonstrated evident curative effect and high complete remission rate. CAR-T cell immunotherapy would be expected to become mainstream therapy for hematolymph system tumors. PMID: 32432755 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - May 22, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Combining gene expression profiling and machine learning to diagnose B-cell non-Hodgkin lymphoma
Blood Cancer Journal, Published online: 22 May 2020; doi:10.1038/s41408-020-0322-5Combining gene expression profiling and machine learning to diagnose B-cell non-Hodgkin lymphoma (Source: Blood Cancer Journal)
Source: Blood Cancer Journal - May 22, 2020 Category: Hematology Authors: Victor Bob ée Fanny Drieux Vinciane Marchand Vincent Sater Liana Veresezan Jean-Michel Picquenot Pierre-Julien Viailly Marie-Delphine Lanic Mathieu Viennot Elodie Bohers Lucie Oberic Christiane Copie-Bergman Thierry Jo Molina Philippe Gaulard Corinne Hai Source Type: research
Primary central nervous system lymphoma: status and advances in diagnosis, molecular pathogenesis, and treatment.
This article aims to present a brief profile of PCNSL diagnosis and treatment in immunocompetent patients. The authors retrieved information from the PubMed database up to September 2019. The annual incidence of PCNSL increased over the last four decades. The prognosis of PCNSL has improved mainly due to the introduction and wide-spread use of high-dose methotrexate, which is now the backbone of all first-line treatment polychemotherapy regimens. Gene expression profiling and next-generation sequencing analyses have revealed mutations that induce activation of nuclear factor-κB, B cell antigen receptor, and Janus kin...
Source: Chinese Medical Journal - May 21, 2020 Category: General Medicine Authors: Zhang Y, Zhou DB Tags: Chin Med J (Engl) Source Type: research
Bone marrow involvement in pediatric malignancies: a comparison study of Positron emission tomographycomputed tomography and bone marrow biopsy.
CONCLUSION: PET-CT may not have high sensitivity and specificity to identify bone marrow involvement for each type of cancer. The approach of using bone marrow biopsy and PET-CT as complementary modalities seems reliable. PMID: 32419409 [PubMed - in process] (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - May 20, 2020 Category: Pediatrics Authors: Tezol Ö, Sağcan F, Özcan PP, Çıtak EÇ Tags: Turk J Pediatr Source Type: research
Non-Hodgkin Lymphoma of the jejunum presenting as perforation peritonitis: A case report
Publication date: Available online 18 May 2020Source: Annals of Medicine and SurgeryAuthor(s): Warsinggih, Suluh Darmadi, Prihantono, Muhammad Faruk (Source: Annals of Medicine and Surgery)
Source: Annals of Medicine and Surgery - May 19, 2020 Category: General Medicine Source Type: research
Sequential anti-CD19, 22, and 20 autologous chimeric antigen receptor T-cell (CAR-T) treatments of a child with relapsed refractory Burkitt lymphoma: a case report and literature review
ConclusionAutologous anti-CD19, anti-CD22, and anti-CD20 CAR-T cell therapies targeting multiple tumor antigens could be an innovative and sound treatment for children with r/r BL, provided that they are closely monitored during treatment. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 17, 2020 Category: Cancer & Oncology Source Type: research
Targeting the PI3K/AKT/mTOR Signaling Pathway in Primary Central Nervous System Lymphoma: Current Status and Future Prospects.
Abstract Primary central nervous system lymphoma (PCNSL) is a rare invasive extranodal non-Hodgkin lymphoma, the vast majority of which is diffuse large B-cell lymphoma (DLBCL). Although high-dose methotrexate-based immunochemotherapy achieves a high remission rate, the risk of relapse and related death remains a crucial obstruction to long-term survival. Novel agents for the treatment of lymphatic malignancies have greatly broadened the horizons of therapeutic options for PCNSL. The PI3K/AKT/mTOR signaling pathway is one of the most important pathways for B-cell malignancy growth and survival. Novel therapies tha...
Source: CNS and Neurological Disorders Drug Targets - May 17, 2020 Category: Drugs & Pharmacology Authors: Xiaowei Z, Yuanbo L Tags: CNS Neurol Disord Drug Targets Source Type: research