Blastoid Variant of Mantle Cell Lymphoma with Extranodal Presentation and Aberrant CD10 Expression
We report an elderly man diagnosed with blastoid variant MCL. He presented with disseminated soft-tissue and subcutaneous nodules, and showed aberrant CD10 expression. Presentation of the extranodal site and aberrant CD10 expressions carries an overall poor prognosis. CD10-positive MCL can be mistaken for large B-cell lymphoma.PMID:38504844 | PMC:PMC10947762 | DOI:10.4103/ijabmr.ijabmr_406_23 (Source: Cell Research)
Source: Cell Research - March 20, 2024 Category: Cytology Authors: Arthy Raman Sree Rekha Jinkala Roobashri Murugan Prabhu Manivannan Source Type: research
Rituximab-combined anthracycline-free chemotherapy in newly diagnosed paediatric and adolescent patients with non-high-risk aggressive mature B cell lymphoma: protocol for a single-arm, open-label, multicentre, phase II study (the Japan Childrens Cancer Group Multicentre Trial, JPLSG B-NHL-20)
Introduction
Children and adolescents with mature B cell non-Hodgkin lymphoma (B-NHL) are treated with short-intensive chemotherapy. The burden of short-term and long-term toxicity is highly relative to its high cure rate in good-risk patients. Although the addition of rituximab to standard lymphome Malin B (LMB) chemotherapy markedly prolongs event-free survival and overall survival in high-risk patients, the benefit of rituximab in good-risk patients remains to be elucidated. This clinical trial will examine whether the addition of rituximab eliminates anthracyclines in good-risk patients without compromising treatment o...
Source: BMJ Open - March 19, 2024 Category: General Medicine Authors: Sekimizu, M., Fukano, R., Koga, Y., Mitsui, T., Fujita, N., Mori, T., Hori, D., Tanaka, M., Ohki, K., Iwafuchi, H., Nakazawa, A., Mori, T., Kobayashi, R., Hashimoto, H., M. Saito, A., Kamei, M., on behalf of Lymphoma Committee of Japan Childrens Cancer Gr Tags: Open access, Haematology (incl blood transfusion) Source Type: research
CAR T-cell Therapy for Diffuse Large B-cell Lymphoma in Canada: A Cost-Utility Analysis
CONCLUSIONS: At the current drug price, tisagenlecleucel was not found to be a cost-effective option. These results heavily depend on assumptions regarding long-term survival and the price of CAR T. Real-world evidence is needed to reduce uncertainty.HIGHLIGHTS: For patients with diffuse large B-cell lymphoma who failed 2 or more lines of systemic therapy, CAR T was not found to be a cost-effective treatment option at a willingness-to-pay threshold of $100,000.These results heavily depend on the expected long-term survival. The uncertainty in the model may be improved using real-world evidence reported in the future.PMID:3...
Source: Cancer Control - March 15, 2024 Category: Cancer & Oncology Authors: Lisa Masucci Feng Tian Stephen Tully Zeny Feng Tom McFarlane Kelvin K W Chan William W L Wong Source Type: research
Infection risk and antimicrobial prophylaxis in bendamustine-treated patients with indolent non-Hodgkin lymphoma: An Australasian Lymphoma Alliance study
Br J Haematol. 2024 Mar 14. doi: 10.1111/bjh.19407. Online ahead of print.ABSTRACTInfection and lymphopenia are established bendamustine-related complications. The relationship between lymphopenia severity and infection risk, and the role of antimicrobial prophylaxis, is not well described. This multicentre retrospective study analysed infection characteristics and antimicrobial prophylaxis in 302 bendamustine-treated indolent non-Hodgkin lymphoma patients. Lymphopenia (<1 × 109 /L) was near universal and time to lymphocyte recovery correlated with cumulative bendamustine dose. No association between lymphopenia severi...
Source: Herpes - March 14, 2024 Category: Infectious Diseases Authors: Kate Manos Leonid Churilov Andrew Grigg Pietro Di Ciaccio Jonathan Wong Usha Chandra Sekaran Joel Wight Zhong Goh Hayden Jina Llewyn Butler Costas K Yannakou Nada Hamad Gareth P Gregory Shane Gangatharan Tara Cochrane Eliza A Hawkes Masa Lasica Source Type: research
Infection risk and antimicrobial prophylaxis in bendamustine-treated patients with indolent non-Hodgkin lymphoma: An Australasian Lymphoma Alliance study
Br J Haematol. 2024 Mar 14. doi: 10.1111/bjh.19407. Online ahead of print.ABSTRACTInfection and lymphopenia are established bendamustine-related complications. The relationship between lymphopenia severity and infection risk, and the role of antimicrobial prophylaxis, is not well described. This multicentre retrospective study analysed infection characteristics and antimicrobial prophylaxis in 302 bendamustine-treated indolent non-Hodgkin lymphoma patients. Lymphopenia (<1 × 109 /L) was near universal and time to lymphocyte recovery correlated with cumulative bendamustine dose. No association between lymphopenia severi...
Source: Herpes - March 14, 2024 Category: Infectious Diseases Authors: Kate Manos Leonid Churilov Andrew Grigg Pietro Di Ciaccio Jonathan Wong Usha Chandra Sekaran Joel Wight Zhong Goh Hayden Jina Llewyn Butler Costas K Yannakou Nada Hamad Gareth P Gregory Shane Gangatharan Tara Cochrane Eliza A Hawkes Masa Lasica Source Type: research
Vogt-Koyanagi-Harada disease developed during chemotherapy for Hodgkin lymphoma: a case report
We report a case of Vogt-Koyanagi-Harada (VKH) disease presenting as serous retinal detachment and uveitis in both e... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - March 13, 2024 Category: Opthalmology Authors: Mutsumi Koyama, Euido Nishijima, Takaya Honda, Chizuru Gonmori-Ohta, Takeaki Sasamoto, Katsuyuki Tanaka, Akira Watanabe, Tadashi Nakano and Masaharu Akiyama Tags: Case Report Source Type: research
G-CSF + plerixafor versus G-CSF alone mobilized hematopoietic stem cells in patients with multiple myeloma and lymphoma: a systematic review and meta-analysis
CONCLUSIONS: This study suggests that the combination of G-CSF and plerixafor, resulted in more patients with MM, NHL, and HL, achieving the predetermined apheresis yield of CD34+ cells, which is related to the more effective mobilization of CD34+ cells into PB.PMID:38470973 | DOI:10.1080/07853890.2024.2329140 (Source: Annals of Medicine)
Source: Annals of Medicine - March 12, 2024 Category: Internal Medicine Authors: Yuyao Li Xia Qiu Yupeng Lei Ruixi Zhou Source Type: research
Persistent Polyclonal B-Cell Lymphocytosis (PPBL): An Entity That Is Not What it Seems
Acta Med Port. 2024 Mar 12. doi: 10.20344/amp.19991. Online ahead of print.ABSTRACTPersistent polyclonal B-cell lymphocytosis is a rare disease with chronic lymphocytosis of polyclonal origin, which is more frequent in mostly asymptomatic middle-aged female smokers. The hallmark of this entity is the presence of bilobed/binucleated B lymphocytes, which are polyclonal as demonstrated by immunophenotyping; an elevated IgM level is common. This disease shows, in most cases, an indolent course over many years and, although controversial, it may rarely convert to malignant lymphoma. In addition to smoking, a genetic predisposit...
Source: Acta Medica Portuguesa - March 12, 2024 Category: General Medicine Authors: Ant ónio Figueiredo Ana Carolina Freitas Diogo Paulino Carlos Severino M áriam Calú Rui Barreira Source Type: research
G-CSF + plerixafor versus G-CSF alone mobilized hematopoietic stem cells in patients with multiple myeloma and lymphoma: a systematic review and meta-analysis
CONCLUSIONS: This study suggests that the combination of G-CSF and plerixafor, resulted in more patients with MM, NHL, and HL, achieving the predetermined apheresis yield of CD34+ cells, which is related to the more effective mobilization of CD34+ cells into PB.PMID:38470973 | DOI:10.1080/07853890.2024.2329140 (Source: Annals of Medicine)
Source: Annals of Medicine - March 12, 2024 Category: Internal Medicine Authors: Yuyao Li Xia Qiu Yupeng Lei Ruixi Zhou Source Type: research
Genome-wide methylation profiling of Peripheral T-cell lymphomas identifies TRIP13 as a critical driver of tumor proliferation and survival
Res Sq [Preprint]. 2024 Feb 29:rs.3.rs-3971059. doi: 10.21203/rs.3.rs-3971059/v1.ABSTRACTCytosine methylation of genomic DNA contributes to the regulation of gene expression and is involved in normal development including hematopoiesis in mammals. It is catalyzed by the family of DNA methyltransferases (DNMTs) that include DNMT1, DNMT3A, and DNMT3B. Peripheral T-cell lymphomas (PTCLs) represent a diverse group of aggressive mature T-cell malignancies accounting for approximately 10-15% of non-Hodgkin lymphoma cases in the US. PTCLs exhibit a broad spectrum of clinical, histological, and immunophenotypic features with poor ...
Source: Cell Research - March 11, 2024 Category: Cytology Authors: Pawel Nowialis Julian Tobon Katarina Lopusna Jana Opavska Arshee Badar Duo Chen Reem Abdelghany Gene Pozas Jacob Fingeret Emma Noel Alberto Riva Hiroshi Fujiwara Rene Opavsky Source Type: research
Incidence and survival of second primary non-Hodgkin lymphoma: A Surveillance, Epidemiology, and End Results-based cohort study
This study identified a rising incidence of first and second primary NHL from 2000 to 2014. For the second primary NHL, the OS risk was higher when compared to the first primary NHL (HR: 1.13, 95% CI: 1.11 to 1.15,P (Source: PLoS One)
Source: PLoS One - March 11, 2024 Category: Biomedical Science Authors: Nasha Yu Source Type: research
The RNA sequencing results revealed the expression of different genes and signaling pathways during chemotherapy resistance in peripheral T-cell lymphoma
Peripheral T-cell lymphoma (PTCL) is a subtype of non-Hodgkin's lymphoma that occurs primarily at extranodal sites and is commonly treated using chemotherapy and radiotherapy. PTCL is more malignant than other... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - March 11, 2024 Category: Genetics & Stem Cells Authors: Yunyi Lan, Wei Tao, Luyao Ma, Xiaoxiong Wang, Hongsheng Li, Yaxi Du, Ruijiao Yang, Shunxian Wu, Yingxin Ou, Xin Liu, Yunchao Huang and Yongchun Zhou Tags: Research Source Type: research
Acute, long-term or non-vincristine-induced peripheral neuropathy among non-Hodgkin lymphoma survivors: Symptoms, daily activities, functional status, and quality of life
CONCLUSION: Numbness and cramps should be addressed in survivors of acute and long-term VIPN. Preventing falls is recommended for NHL survivors with VIPN, and psychological support is suggested for long-term VIPN survivors.PMID:38461728 | DOI:10.1016/j.ejon.2024.102540 (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - March 10, 2024 Category: Nursing Authors: Yu-Chen Su Yeur-Hur Lai Sung-Tsang Hsieh Chieh-Lin Jerry Teng Yun-Hsiang Lee Source Type: research
Acute, long-term or non-vincristine-induced peripheral neuropathy among non-Hodgkin lymphoma survivors: Symptoms, daily activities, functional status, and quality of life
CONCLUSION: Numbness and cramps should be addressed in survivors of acute and long-term VIPN. Preventing falls is recommended for NHL survivors with VIPN, and psychological support is suggested for long-term VIPN survivors.PMID:38461728 | DOI:10.1016/j.ejon.2024.102540 (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - March 10, 2024 Category: Nursing Authors: Yu-Chen Su Yeur-Hur Lai Sung-Tsang Hsieh Chieh-Lin Jerry Teng Yun-Hsiang Lee Source Type: research
Rituximab ‐induced psoriasis in a patient with pemphigus vulgaris: A case report and literature review
Key Clinical MessageRituximab which is established as a main treatment for pemphigus vulgaris can be a potential causative factor for development of psoriasis in some patients. It is preferred to avoid using rituximab in patients who had a history of psoriasis. Acquainting medical doctors about rituximab-related cutaneous complications will help them in detection and management.AbstractRituximab is a human/murine monoclonal antibody targeting the CD20 antigen on B-lymphocytes surface. Although it is used as promising treatment for pemphigus, nowadays it is also a new therapy for other autoimmune diseases including systemic...
Source: Clinical Case Reports - March 9, 2024 Category: General Medicine Authors: Leila Ghadirzade Arani,
Shima Moslemi Haghighi,
Soheila Nasiri,
Sahar Dadkhahfar Tags: CASE REPORT Source Type: research
