Mantle Cell Lymphoma under the scope of personalized medicine: perspective and directions
Mantle Cell Lymphoma (MCL) is a rare, incurable non-Hodgkin's lymphoma characterized by naive B cells infiltrating the lymphoid follicle's mantle zone. A key feature of MCL is the cytogenetic abnormality t(11;14) (q13:q14), found in 95% of cases, leading to Cyclin D1 overexpression resulting in uncontrolled cell cycle progression and genetic instability. Occasionally, Cyclin D2 or D3 overexpression can substitute for Cyclin D1, causing similar effects. The transcription factor SOX11 is a hallmark of classical Cyclin D1-positive MCL and also in cases without the typical t(11;14) abnormality, making it an important diagnosti...
Source: Clinical Lymphoma, Myeloma and Leukemia - March 27, 2024 Category: Hematology Authors: Lara Gallucci Figorelle, Peterson Tiago Galv ão, Felipe Matheus Ribeiro de Lima, Patricia Marimon, Nathalia Pentagna, Cristiane Milito, Rony Schaffel, Katia Carneiro Tags: Review Article Source Type: research
Acute kidney injury in children with lymphoma
CONCLUSION: TLS, lung infection, and lymphoma clinical stage were identified as independent risk factors for AKI in children with lymphoma during the first 30 days of hospitalization. Clinicians should increase their awareness of AKI in hospitalized patients with lymphoma.PMID:38529931 | DOI:10.5414/CN111157 (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 26, 2024 Category: Urology & Nephrology Authors: Hejia Zhang Yanlong Duan Xiaoxue Li Zhi Chen Xiaorong Liu Source Type: research
Impact of Race and Social Determinants of Health on Outcomes in Patients with Aggressive B-cell nHL Treated with CAR-T
We examined the impact of interactions between race and insurance type on health care utilization and outcomes in patients treated with CAR-T for aggressive B-NHL. Adult patients with r/r B-NHL treated with CD19 CAR-T were identified between 2015 and 2021 across 13 US academic centers. Insurance type, demographic and clinical data were collected and analyzed via Chi-squared and Kaplan-Meier analysis. Cox multivariable regression (MVA) was used to determine the impact of race/ethnicity and other variables on survival. 466 adult patients were included in our analysis. Median follow-up after CAR-T was 12.7 months. Median prog...
Source: Adv Data - March 26, 2024 Category: Epidemiology Authors: Reem Karmali Rushad Machhi Narendranath Epperla Geoffrey Shouse Jason T Romancik Tamara K Moyo Vaishalee P Kenkre Thomas A Ollila Lindsey A Fitzgerald Brian T Hess Kevin A David Ishan Roy Joanna C Zurko Sayan Mullick Chowdhury Kaitlin Annunzio Robert Ferd Source Type: research
Acute kidney injury in children with lymphoma
CONCLUSION: TLS, lung infection, and lymphoma clinical stage were identified as independent risk factors for AKI in children with lymphoma during the first 30 days of hospitalization. Clinicians should increase their awareness of AKI in hospitalized patients with lymphoma.PMID:38529931 | DOI:10.5414/CN111157 (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 26, 2024 Category: Urology & Nephrology Authors: Hejia Zhang Yanlong Duan Xiaoxue Li Zhi Chen Xiaorong Liu Source Type: research
Impact of Race and Social Determinants of Health on Outcomes in Patients with Aggressive B-cell nHL Treated with CAR-T
We examined the impact of interactions between race and insurance type on health care utilization and outcomes in patients treated with CAR-T for aggressive B-NHL. Adult patients with r/r B-NHL treated with CD19 CAR-T were identified between 2015 and 2021 across 13 US academic centers. Insurance type, demographic and clinical data were collected and analyzed via Chi-squared and Kaplan-Meier analysis. Cox multivariable regression (MVA) was used to determine the impact of race/ethnicity and other variables on survival. 466 adult patients were included in our analysis. Median follow-up after CAR-T was 12.7 months. Median prog...
Source: Adv Data - March 26, 2024 Category: Epidemiology Authors: Reem Karmali Rushad Machhi Narendranath Epperla Geoffrey Shouse Jason T Romancik Tamara K Moyo Vaishalee P Kenkre Thomas A Ollila Lindsey A Fitzgerald Brian T Hess Kevin A David Ishan Roy Joanna C Zurko Sayan Mullick Chowdhury Kaitlin Annunzio Robert Ferd Source Type: research
Acute kidney injury in children with lymphoma
CONCLUSION: TLS, lung infection, and lymphoma clinical stage were identified as independent risk factors for AKI in children with lymphoma during the first 30 days of hospitalization. Clinicians should increase their awareness of AKI in hospitalized patients with lymphoma.PMID:38529931 | DOI:10.5414/CN111157 (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 26, 2024 Category: Urology & Nephrology Authors: Hejia Zhang Yanlong Duan Xiaoxue Li Zhi Chen Xiaorong Liu Source Type: research
Acute kidney injury in children with lymphoma
CONCLUSION: TLS, lung infection, and lymphoma clinical stage were identified as independent risk factors for AKI in children with lymphoma during the first 30 days of hospitalization. Clinicians should increase their awareness of AKI in hospitalized patients with lymphoma.PMID:38529931 | DOI:10.5414/CN111157 (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 26, 2024 Category: Urology & Nephrology Authors: Hejia Zhang Yanlong Duan Xiaoxue Li Zhi Chen Xiaorong Liu Source Type: research
Acute kidney injury in children with lymphoma
CONCLUSION: TLS, lung infection, and lymphoma clinical stage were identified as independent risk factors for AKI in children with lymphoma during the first 30 days of hospitalization. Clinicians should increase their awareness of AKI in hospitalized patients with lymphoma.PMID:38529931 | DOI:10.5414/CN111157 (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 26, 2024 Category: Urology & Nephrology Authors: Hejia Zhang Yanlong Duan Xiaoxue Li Zhi Chen Xiaorong Liu Source Type: research
Acute kidney injury in children with lymphoma
CONCLUSION: TLS, lung infection, and lymphoma clinical stage were identified as independent risk factors for AKI in children with lymphoma during the first 30 days of hospitalization. Clinicians should increase their awareness of AKI in hospitalized patients with lymphoma.PMID:38529931 | DOI:10.5414/CN111157 (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 26, 2024 Category: Urology & Nephrology Authors: Hejia Zhang Yanlong Duan Xiaoxue Li Zhi Chen Xiaorong Liu Source Type: research
Acute kidney injury in children with lymphoma
CONCLUSION: TLS, lung infection, and lymphoma clinical stage were identified as independent risk factors for AKI in children with lymphoma during the first 30 days of hospitalization. Clinicians should increase their awareness of AKI in hospitalized patients with lymphoma.PMID:38529931 | DOI:10.5414/CN111157 (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 26, 2024 Category: Urology & Nephrology Authors: Hejia Zhang Yanlong Duan Xiaoxue Li Zhi Chen Xiaorong Liu Source Type: research
Acute kidney injury in children with lymphoma
CONCLUSION: TLS, lung infection, and lymphoma clinical stage were identified as independent risk factors for AKI in children with lymphoma during the first 30 days of hospitalization. Clinicians should increase their awareness of AKI in hospitalized patients with lymphoma.PMID:38529931 | DOI:10.5414/CN111157 (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 26, 2024 Category: Urology & Nephrology Authors: Hejia Zhang Yanlong Duan Xiaoxue Li Zhi Chen Xiaorong Liu Source Type: research
A Study on Geographic Correlation between Indoor Radon Exposure and Leukemia Incidence in Canada
In this study, geographical correlation between residential radon exposure and leukemia incidence was investigated at a provincial level with more accurate long-term radon measurement data in 21,330 homes and 10-y (2000-2009) age standardized incidence rates per 100,000 population for various subtypes of leukemia. The analyses showed that the incidence rate of non-Hodgkin lymphoma is statistically significantly correlated with average indoor radon (222Rn) concentration for Canadian females (p = 0.01210) but not for males. At a provincial level, the association between average indoor radon level and chronic lymphocytic leuk...
Source: Health Physics - March 25, 2024 Category: Physics Authors: Jing Chen Source Type: research
A Study on Geographic Correlation between Indoor Radon Exposure and Leukemia Incidence in Canada
In this study, geographical correlation between residential radon exposure and leukemia incidence was investigated at a provincial level with more accurate long-term radon measurement data in 21,330 homes and 10-y (2000-2009) age standardized incidence rates per 100,000 population for various subtypes of leukemia. The analyses showed that the incidence rate of non-Hodgkin lymphoma is statistically significantly correlated with average indoor radon (222Rn) concentration for Canadian females (p = 0.01210) but not for males. At a provincial level, the association between average indoor radon level and chronic lymphocytic leuk...
Source: Health Physics - March 25, 2024 Category: Physics Authors: Jing Chen Source Type: research
Pediatric non ‐Hodgkin lymphoma as a rare cause of spinal cord injury: When lymphoma hides in the canal
We report on two pediatric patients with NHL who exhibited myelopathy signs as initial presentation. Considering NHL as a differential diagnosis in pediatric patients presenting with spinal cord compression is crucial for optimizing the outcome of these patients. (Source: Clinical Case Reports)
Source: Clinical Case Reports - March 23, 2024 Category: General Medicine Authors: Daniele Zama,
Egidio Candela,
Gennaro Pagano,
Francesco Venturelli,
Fraia Melchionda,
Francesco Toni,
Mino Zucchelli,
Andrea Pession Tags: CASE REPORT Source Type: research
Myelotoxicity and kidney dysfunction related to the use of trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia: a case report of severe adverse events with a common drug
We present the case of a male patient with hypertension and a recent diagnosis of non-Hodgkin lymphoma, undergoing rituximab treatment for two months. He was admitted to the intensive care unit due to dyspnea, tachypnea, and pleuritic pain, requiring mechanical ventilation. Chest computed tomography showed bilateral and multilobed ground-glass opacities, compromising more than 80% of the lung parenchyma. Pulmonary tuberculosis and COVID-19 were ruled out. An angiotomography and Doppler ultrasound revealed an extensive pulmonary thrombus and deep venous thrombosis. Empiric treatment with TMP-SMX for PCP was initiated, but w...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 21, 2024 Category: Tropical Medicine Authors: Isabel Cristina Melo Mendes Roxana Flores Mamani David Richer Araujo Coelho Clarisse Pimentel Source Type: research
