Calcium alginate/PNIPAAm hydrogel with body temperature response and great biocompatibility: Application as burn wound dressing
In this study, we used N-isopropyl acrylamide, sodium alginate and calcium chloride as the main materials, a series of calcium alginate/ poly (N-isopropyl acrylamide)(NIPAAm) hydrogel (CAPH) with different component ratios were synthesized. Its swelling properties, temperature response properties, rheological properties, biocompatibility properties, and in vitro drug release properties were investigated. Based on the above conditions, the CAPH(sodium alginate:NIPAAm = 2:15) with the best comprehensive performance was selected, which has a good biocompatibility. In addition, 0.02 % (w/v) mupirocin was loaded in CAPH. The te...
Source: International Journal of Biological Macromolecules - July 11, 2022 Category: Biochemistry Authors: Guoguang Chen Yaxin Zhou Jie Dai Shiyu Yan Wenjun Miao Lili Ren Source Type: research
Calcium alginate/PNIPAAm hydrogel with body temperature response and great biocompatibility: Application as burn wound dressing
In this study, we used N-isopropyl acrylamide, sodium alginate and calcium chloride as the main materials, a series of calcium alginate/ poly (N-isopropyl acrylamide)(NIPAAm) hydrogel (CAPH) with different component ratios were synthesized. Its swelling properties, temperature response properties, rheological properties, biocompatibility properties, and in vitro drug release properties were investigated. Based on the above conditions, the CAPH(sodium alginate:NIPAAm = 2:15) with the best comprehensive performance was selected, which has a good biocompatibility. In addition, 0.02 % (w/v) mupirocin was loaded in CAPH. The te...
Source: International Journal of Biological Macromolecules - July 11, 2022 Category: Biochemistry Authors: Guoguang Chen Yaxin Zhou Jie Dai Shiyu Yan Wenjun Miao Lili Ren Source Type: research
Optimization, Characterization and In Vivo Evaluation of Mupirocin Nanocrystals for Topical Administration
In this study, the physico-chemical characteristics of MP were modified through nanocrystallization to improve its therapeutic efficacy for the treatment of skin infections. Mupirocin-nanocrystals (MP-NC) were prepared using a nanoprecipitation technique and optimized using a D-optimal response surface design. The optimization of MP-NC produced ultra-small monodisperse spherical particles with a mean diameter of 70 nm and a polydispersity index of 0.2. The design resulted in two optimal MP-NC formulations that were evaluated by performing series of in vitro, ex vivo, microbiological, and in vivo studies. In-vitro results s...
Source: European Journal of Pharmaceutical Sciences - July 5, 2022 Category: Drugs & Pharmacology Authors: Muna B Najm Mutasem Rawas-Qalaji Nouran H Assar Rania Yahia Rania El- Hosary Iman S Ahmed Source Type: research
Optimization, Characterization and In Vivo Evaluation of Mupirocin Nanocrystals for Topical Administration
In this study, the physico-chemical characteristics of MP were modified through nanocrystallization to improve its therapeutic efficacy for the treatment of skin infections. Mupirocin-nanocrystals (MP-NC) were prepared using a nanoprecipitation technique and optimized using a D-optimal response surface design. The optimization of MP-NC produced ultra-small monodisperse spherical particles with a mean diameter of 70 nm and a polydispersity index of 0.2. The design resulted in two optimal MP-NC formulations that were evaluated by performing series of in vitro, ex vivo, microbiological, and in vivo studies. In-vitro results s...
Source: European Journal of Pharmaceutical Sciences - July 5, 2022 Category: Drugs & Pharmacology Authors: Muna B Najm Mutasem Rawas-Qalaji Nouran H Assar Rania Yahia Rania El- Hosary Iman S Ahmed Source Type: research
Phenotypic and molecular characterization of Staphylococcus aureus isolates conducted in nares of psoriatic patients attending a public hospital in Argentina
Rev Argent Microbiol. 2022 Jun 24:S0325-7541(22)00051-7. doi: 10.1016/j.ram.2022.02.008. Online ahead of print.ABSTRACTAlthough Staphylococcus aureus increases its relative abundance in psoriasis when compared with the microbiome of healthy subjects, it is not the most important microorganism underlying this disease. However, there is scant data on the role and molecular features of S. aureus strains in psoriasis; therefore, the aim of this study was to evaluate nasal carriage of this microorganism, its phenotypic and molecular characteristics as well as the impact of host factors on its carriage in psoriatic patients. The...
Source: Revista Argentina de Microbiologia - June 27, 2022 Category: Microbiology Authors: Carina A Boncompain Cristian A Su árez Mario Squeff Valeria Belluzo Gustavo Piccirilli Ana Molteni Ram ón A Fernández Bussy H éctor R Morbidoni Source Type: research
