Spa gene-based molecular typing of nasal methicillin-susceptible staphylococcus aureus from patients and health-care workers in a dialysis center in southeast Iran.
This study was conducted to determine the frequency of S. aureus nasal carriage in hemodialysis patients (HD) and health-care workers (HCW) at the main dialysis center of Bam city, located in southeast of Iran. In this cross-sectional study, a total of 52 nasal swabs were obtained from health-care workers and hemodialysis patients to detect methicillin-sensitive S. aureus (MSSA) isolates. The resistance to different antibacterial agents was determined by disk diffusion method. Also, Panton-Valentine Leukocidin (PVL) - encoding gene as well as Staphylococcal protein A (spa) type were determined. The nasal carriage rate of S...
Source: Pathogens and Global Health - March 29, 2020 Category: International Medicine & Public Health Tags: Pathog Glob Health Source Type: research

Antibiotics Affect ROS Production and Fibroblast Migration in an In-vitro Model of Sinonasal Wound Healing
This study analyzed a broad array of antibiotics used after sinus surgery to assess their effect on wound healing and ROS production in vitro. It was hypothesized that ROS production would be affected by these antibiotics and there would be a negative relationship between ROS activity and cell migration speed.Methods: Monolayers of primary human nasal epithelial cells (HNEC) and primary fibroblasts were disrupted with a linear wound, treated with 10 different antibiotics or a ROS inhibitor and observed over 36 h in a controlled environment using confocal microscopy. ROS activity and migration speed of the wound edge were m...
Source: Frontiers in cellular and infection microbiology - March 19, 2020 Category: Microbiology Source Type: research

Oxymetazoline, Mupirocin, Clotrimazole-Safe, Effective, Off-Label Agents for Tympanostomy Tube Care.
CONCLUSIONS: Oxymetazoline nasal spray, mupirocin ointment, and clotrimazole cream are safe and effective as off-label medications for tympanostomy tube care in children. PMID: 32182136 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - March 17, 2020 Category: ENT & OMF Authors: Isaacson G Tags: Ear Nose Throat J Source Type: research

The prevalence and molecular mechanisms of mupirocin resistance in Staphylococcus aureus isolates from a Hospital in Cape Town, South Africa
This study aimed to describe the rates and molecular mechanisms of mupirocin resistance in clinicalStaphylococcus aureus isolates from Tygerberg Hospital, and to describe its association with strain types.MethodsWe retrospectively selected 212  S. aureus isolates which were identified from blood samples and pus swabs during the years 2009 –2011 and 2015–2017. The isolates were identified using conventional microbiological methods and genotyping was done usingspa typing. Cefoxitin (30  μg) disc diffusion and the two disc strategy (5 μg and 200 μg) were used to determine susce...
Source: Antimicrobial Resistance and Infection Control - March 14, 2020 Category: Infectious Diseases Source Type: research

Repositioning of Hypoglycemic Drug Linagliptin for Cancer Treatment
ConclusionThe combination of key targets based on the protein-protein interaction network that were built by the different gene expression of TCGA data to reposition the marketed drugs turned out to be a new approach to discover new antitumor drugs. Hypoglycemic drug linagliptin could potentially lead to novel therapeutics for the treatment of tumors, especially for colorectal cancer. Gene regulatory network is a valuable method for predicting and explaining the mechanism of drugs action. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 3, 2020 Category: Drugs & Pharmacology Source Type: research

The relationship between hand hygiene practices and nasal Staphylococcus aureus carriage in healthcare workers.
CONCLUSION: The knowledge of hand hygiene practices, high frequency of handwashing, and wearing different gloves during the procedure of each patient decrease S.aureus nasal carriage in HCWs. In addition mupirocin is still effective in nasal S.aureus carriers. PMID: 32096773 [PubMed - in process] (Source: Medicina del Lavoro)
Source: Medicina del Lavoro - February 27, 2020 Category: Occupational Health Tags: Med Lav Source Type: research

[ASAP] A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis
ACS Chemical BiologyDOI: 10.1021/acschembio.9b00969 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - February 6, 2020 Category: Chemistry Authors: Paul D. Walker †‡, Matthew T. Rowe†, Ashley J. Winter†, Angus N.M. Weir†, Nahida Akter†, Luoyi Wang†, Paul R. Race§, Christopher Williams†, Zhongshu Song†, Thomas J. Simpson†, Christine L. Willis*†, and Matthew P. Crump*† Source Type: research

Nanosecond electric pulses rapidly enhance the inactivation of Gram-negative bacteria using Gram-positive antibiotics.
Abstract Physically disrupting microorganism membranes to enable antibiotics to overcome resistance mechanisms that inhibit or excrete antibiotics has great potential for reducing antibiotic doses and rendering resistance mechanisms inert. We demonstrate the synergistic inactivation of a Gram-positive (Staphylococcus aureus) and two Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria by combining 222 30 kV/cm electric pulses (EPs) or 500 20 kV/cm EPs with 300-ns EP duration with various antibiotics with different mechanisms of action is demonstrated. Doses of antibiotics that produced no...
Source: Applied Microbiology and Biotechnology - January 22, 2020 Category: Microbiology Authors: Vadlamani RA, Dhanabal A, Detwiler DA, Pal R, McCarthy J, Seleem MN, Garner AL Tags: Appl Microbiol Biotechnol Source Type: research

Cutaneous paraneoplastic pemphigus syndrome associated with undifferentiated uterine sarcoma
Publication date: Available online 18 January 2020Source: Gynecologic Oncology ReportsAuthor(s): Bijan Morshedi, Kari RingAbstractPemphigus is a group of autoimmune intraepidermal blistering diseases caused by immunoglobulins directed against keratinocyte cell surface components. In this case report, we identify a non-classical paraneoplastic pemphigus (PNP) foliaceous related to an undifferentiated uterine sarcoma.The patient is a 54-year-old female with a past medical history of arthritis who presented with worsening fatigue in November 2017 and an itchy, blistering, erythematous annular plaque that first appeared on her...
Source: Gynecologic Oncology Reports - January 19, 2020 Category: OBGYN Source Type: research

Sub-Inhibitory Concentrations of Mupirocin Stimulate Staphylococcus aureus Biofilm Formation by Up-regulating cidA.
Abstract Previous studies have shown that the administration of antibiotics at sub-inhibitory concentrations stimulates biofilm formation by the majority of MRSA strains. Here, we investigated the effect of sub-inhibitory mupirocin concentrations on biofilm formation by the community-associated (CA) mupirocin-sensitive MRSA strain USA300 and highly mupirocin-resistant clinical S. aureus SA01-SA05 isolates. We found that mupirocin increased the ability of MRSA cells to attach to surfaces and form biofilms. Confocal laser scanning microscopy (CLSM) demonstrated that mupirocin treatment promoted thicker biofilm forma...
Source: Antimicrobial Agents and Chemotherapy - January 13, 2020 Category: Microbiology Authors: Jin Y, Guo Y, Zhan Q, Shang Y, Qu D, Yu F Tags: Antimicrob Agents Chemother Source Type: research

Peritoneal Dialysis–Related Infection Rates and Outcomes: Results From the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS)
We describe peritonitis rates and the associations of selected facility practices with peritonitis risk among countries participating in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS).Study DesignObservational prospective cohort study.Setting & Participants7,051 adult PD patients in 209 facilities across 7 countries (Australia, New Zealand, Canada, Japan, Thailand, United Kingdom, United States).ExposuresFacility characteristics (census count, facility age, nurse to patient ratio) and selected facility practices (use of automated PD, use of icodextrin or biocompatible PD solutions, antibiotic pro...
Source: American Journal of Kidney Diseases - January 11, 2020 Category: Urology & Nephrology Source Type: research

Experimental and Computational Studies on Regiodivergent Chiral Phosphoric Acid Catalyzed Cycloisomerization of Mupirocin Methyl Ester.
This article presents a new strategy for achieving regiocontrol over the endo- vs. exo- modes of cycloisomerizations of epoxide-containing alcohols that lead to the formation of 5- or 6-membered cyclic ethers. Unlike traditional methods relying on achiral reagents or enzymes, our approach utilizes chiral phosphoric acids to catalyze the regiodivergent selective formations of either tetrahydrofuran- or tetrahydropyran-containing products. Using methyl ester of epoxide-containing antibiotic mupirocin as the substrate, we demonstrate that catalytic chiral phosphoric acids ( R )-TCYP and ( S )-TIPSY could be used to achieve th...
Source: Chemistry - January 6, 2020 Category: Chemistry Authors: Wang S, Arguelles AJ, Tay JH, Hotta M, Zimmerman PM, Nagorny P Tags: Chemistry Source Type: research

Iron sequestrant DIBI, potential alternative for nares decolonization of MRSA Staphylococcus aureus, is anti-infective and inhibitory for mupirocin resistant isolates.
Abstract MRSA opportunistic infections are a major health burden. Decolonization of hospitalized patients with mupirocin (MUP) has reduced infection incidence but has led to MUP resistance. DIBI is a developmental-stage anti-infective that sequesters bacterial iron and bolsters innate host iron withdrawal defences. Clinical isolates possessing low, high or no MUP-resistance all had similarly high susceptibilities to DIBI. Intranasal DIBI reduced nares bacterial burdens in mice to the same extent as MUP. No resistance was found following exposure to DIBI. PMID: 31907189 [PubMed - as supplied by publisher] (Sou...
Source: Antimicrobial Agents and Chemotherapy - January 6, 2020 Category: Microbiology Authors: Allan DS, Del Carmen Parquet M, Savage KA, Holbein BE Tags: Antimicrob Agents Chemother Source Type: research

Effect of S aureus Prophylaxis in Parents on S aureus Colonization in ICU Neonates
This randomized clinical trial evaluates whether use of intranasal mupirocin and topical chlorhexidine to treat or prevent Staphylococcus aureus colonization in parents was effective compared with petrolatum ointment and soap cloths at reducing new colonization of concordant-strain S aureus in infants in the neonatal intensive care unit (NICU). (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - December 30, 2019 Category: General Medicine Source Type: research

The small quinolone derived compound HT61 enhances the effect of tobramycin against Pseudomonas aeruginosa in vitro and in vivo
In this study, we investigated the individual antimicrobial activity of HT61 alongside its capability to increase the efficacy of tobramycin against both a tobramycin sensitive laboratory reference strain (PAO1) and tobramycin resistant clinical isolates (RP73, NN2) of the gram-negative bacteria Pseudomonas aeruginosa (P. aeruginosa). Using broth microdilution methods, the MICs of HT61 against all strains were assessed, as well as the effect of HT61 in combination with tobramycin using both the chequerboard method and bacterial time-kill assays. A murine model of pulmonary infection was also used to evaluate the combinatio...
Source: Pulmonary Pharmacology and Therapeutics - December 28, 2019 Category: Respiratory Medicine Source Type: research

Poly(hydroxybutyrate-co-hydroxyvalerate) microparticles embedded in κ-carrageenan/locust bean gum hydrogel as a dual drug delivery carrier.
Poly(hydroxybutyrate-co-hydroxyvalerate) microparticles embedded in κ-carrageenan/locust bean gum hydrogel as a dual drug delivery carrier. Int J Biol Macromol. 2019 Dec 24;: Authors: Pettinelli N, Rodríguez-Llamazares S, Farrag Y, Bouza R, Barral L, Feijoo-Bandín S, Lago F Abstract A novel composite hydrogel was prepared as a dual drug delivery carrier. Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) microparticles were prepared to encapsulate simultaneously ketoprofen and mupirocin, as hydrophobic drug models. These microparticles were embedded in a physically crosslinked hydroge...
Source: International Journal of Biological Macromolecules - December 24, 2019 Category: Biochemistry Authors: Pettinelli N, Rodríguez-Llamazares S, Farrag Y, Bouza R, Barral L, Feijoo-Bandín S, Lago F Tags: Int J Biol Macromol Source Type: research

Nasal decolonization of Staphylococcus aureus in orthopedic surgeons using mupirocin and chlorhexidine
This study examined the effectiveness of a decolonization strategy on orthopedic surgeons in a teaching hospital. S aureus colonization was detected in 43.2% of the surgeons, 25% of which were methicillin-resistant S aureus strains. Eradication was documented in 61.53% of the subjects who completed the decolonization strategy. Among orthopedic surgeons, mupirocin with or without chlorhexidine decolonization strategies was effective in eradicating S aureus colonization. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - December 8, 2019 Category: Infectious Diseases Source Type: research

Effects of nasal lavage with and without mupirocin after endoscopic endonasal skull base surgery: a randomised, controlled study.
CONCLUSION: Nasal lavage with mupirocin seems to yield better outcomes regarding patients' symptoms and endoscopic findings. PMID: 31774052 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)
Source: Journal of Laryngology and Otology - November 28, 2019 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Screening of FDA approved drugs for finding potential inhibitors against Granzyme B as a potent drug-repurposing target
Publication date: Available online 11 October 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): Saima Ikram, Jamshaid Ahmad, Serdar DurdagiAbstractGranzyme B is one of the best-characterized and extensively studied member of cytotoxic lymphocytes (CL) proteases. Initially, it is thought to be involved in eliminating virally infected or cancerous cells by using a specialized mechanism through which they are internalized into target cells. In the last decade, however this dimension has changed as there are several reports show that not only CL but also other immune cells can also synthesize Granzyme B. This l...
Source: Journal of Molecular Graphics and Modelling - November 28, 2019 Category: Molecular Biology Source Type: research

Physiology and Transcriptional Analysis of (p)ppGpp-Related Regulatory Effects in Corynebacterium glutamicum
In this study, (p)ppGpp physiology in the actinobacterial model organism Corynebacterium glutamicum was analyzed by phenotypic characterization and RNAseq-based transcriptome analysis. Total nutrient starvation was identified as the most effective method to induce alarmone production, whereas traditional induction methods such as the addition of serine hydroxamate (SHX) or mupirocin did not show a strong accumulation of (p)ppGpp. The predominant alarmone in C. glutamicum represents guanosine tetraphosphate, whose stress-associated production depends on the presence of the bifunctional RSH enzyme Rel. Interestingly, in addi...
Source: Frontiers in Microbiology - November 28, 2019 Category: Microbiology Source Type: research

Randomized controlled trial of topical mupirocin versus mupirocin with sucralfate combination in chronic skin ulcers
CONCLUSIONS: The wound healing effect of topical sucralfate adds to the antimicrobial effect of mupirocin toward the overall improvement of chronic skin ulcers. The effect of combined topical treatment needs comparison with other topical medications and wound healing strategies. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Subhrangsu Chatterjee Sumit Sen Avijit Hazra Amal Kanti Das Source Type: research

Elimination of Staphylococcus aureus nasal carriage in intensive care patients lowers infection rates
This study surveys the clinical relevance of the nasalStaphylococcus aureus colonization status on intensive care unit (ICU) –acquiredS.aureus infections and compares molecular characteristics of isolates from the nose and infectious sites. The 390 patients included comprised 278 non-carriers and 112 carriers. Among the carriers, 56 were decolonized with mupirocin. Decolonization was verified through a second (negative) culture. Spa typing and virulence gene profiling were performed for all isolates. Twenty sixS.aureus infections were detected in the carriage group and 20 in the non-carriage group. Eighteen of these ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - November 12, 2019 Category: Microbiology Source Type: research

Drug Repurposing Approach for Developing Novel Therapy Against Mupirocin-Resistant Staphylococcus aureus
ASSAY and Drug Development Technologies,Volume 17, Issue 7, Page 298-309, October 2019. (Source: ASSAY and Drug Development Technologies)
Source: ASSAY and Drug Development Technologies - October 18, 2019 Category: Drugs & Pharmacology Authors: Somdutt Mujwar Rohitas Deshmukh Ranjit K. Harwansh Jeetendra Kumar Gupta Alekh Gour Source Type: research

Screening of FDA approved drugs for finding potential inhibitor against Granzyme B as a potent drug-repurposing target
Publication date: Available online 11 October 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): Saima Ikram, Jamshaid Ahmad, Serdar DurdagiAbstractGranzyme B is one of the best-characterized and extensively studied members of cytotoxic lymphocytes (CL) proteases. Initially is thought to be involved in eliminating virally infected or cancerous cells by using a specialized mechanism through which they are internalized into target cells. In the last decade, however this dimension has changed as there are several reports show that not only CL but also other immune cells can also synthesize Granzyme B. This lead...
Source: Journal of Molecular Graphics and Modelling - October 12, 2019 Category: Molecular Biology Source Type: research

A two-part phase I study to establish and compare the safety and local tolerability of two nasal formulations of XF-73 for decolonization of Staphylococcus aureus: A previously investigated 0.5 mg/g viscosified gel formulation versus a modified formulation
ConclusionXF-73 was found to be safe and was tolerated with minimal side effects at doses of 0.5 mg/g 2% gel and 2 mg/g 2% gel in healthy volunteers. These findings support moving on to Phase 2 trials to further evaluate the efficacy of XF-73. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - October 9, 2019 Category: Infectious Diseases Source Type: research

Chlorhexidine-based decolonization to reduce healthcare-associated infections and multidrug-resistant organisms (MDROs): Who, What, Where, When, and Why?
Publication date: Available online 5 September 2019Source: Journal of Hospital InfectionAuthor(s): S.S. HuangSummaryBody surface decolonization with chlorhexidine bathing and nasal mupirocin has become a simple solution for prevention of healthcare-associated infections. The clinical trial evidence for this practice will be reviewed to understand who benefits from this practice, for what reasons, and at what times. The method of bathing and nasal decolonization will also be discussed as proper application is needed for maximal effectiveness. Finally, the conflict between current effectiveness and future potential for fueli...
Source: Journal of Hospital Infection - September 20, 2019 Category: Infectious Diseases Source Type: research

Development, characterization and pharmacokinetics of mupirocin-loaded nanostructured lipid carriers (NLCs) for intravascular administration
The objective of this research is to develop and characterize Mupirocin-Loaded Nanostructured Lipid Carriers (M-NLC) for intravascular administration. The MNLC was produced by a combination of high- shear homogenization and high-pressure homogenization of solid (cetyl palmitate) and liquid (caprylic/caprylic acid) biocompatible lipids in 5 different ratios. The mean particle size, polydispersity index (PDI) and the zeta potential (ZP) of the MNLC formulations were between 99.8 and 235 nm, PDI lower than 0.164, ZP from −25.96 to −19.53 and pH ranging from 6.28–6.49. The MNLC formulation also enhances the...
Source: International Journal of Pharmaceutics - September 20, 2019 Category: Drugs & Pharmacology Source Type: research

Reduction of periprosthetic Staphylococcus aureus infection by preoperative screening and decolonization of nasal carriers undergoing total knee arthroplasty.
DISCUSSION: In patients undergoing TKA a preoperative screening and decolonization protocol for S. aureus nasal carriers, using mupirocin nasal ointment and chlorhexidine soap, is an effective measure to reduce the rate of SSI caused by this microorganism. LEVEL OF EVIDENCE: Level III; Therapeutic Study. PMID: 31537434 [PubMed - as supplied by publisher] (Source: Acta Orthopaedica et Traumatologica Turcica)
Source: Acta Orthopaedica et Traumatologica Turcica - September 16, 2019 Category: Orthopaedics Authors: Pelfort X, Romero A, Brugués M, García A, Gil S, Marrón A Tags: Acta Orthop Traumatol Turc Source Type: research

Evolution of a 72-kb cointegrant, conjugative multiresistance plasmid from early community-associated methicillin-resistant Staphylococcus aureus isolates.
Abstract Horizontal transfer of plasmids encoding antimicrobial-resistance and virulence determinants has been instrumental in Staphylococcus aureus evolution, including the emergence of community-associated methicillin-resistant S. aureus (CA-MRSA). In the early 1990s the first CA-MRSA isolated in Western Australia (WA), WA-5, encoded cadmium, tetracycline and penicillin-resistance genes on plasmid pWBG753 (∼30 kb). WA-5 and pWBG753 appeared only briefly in WA, however, fusidic-acid-resistance plasmids related to pWBG753 were also present in the first European CA-MRSA at the time. Here we characterized a 72-k...
Source: Antimicrobial Agents and Chemotherapy - September 9, 2019 Category: Microbiology Authors: Yui Eto K, Firth N, Davis AM, Kwong SM, Krysiak M, Lee YT, O'Brien FG, Grubb WB, Coombs GW, Bond CS, Ramsay JP Tags: Antimicrob Agents Chemother Source Type: research

Lowbury Lecture 2018. Chlorhexidine-Based Decolonization to Reduce Healthcare-Associated Infections and Multidrug-Resistant Organisms (MDROs): Who, What, Where, When, and Why?
Publication date: Available online 5 September 2019Source: Journal of Hospital InfectionAuthor(s): Susan S. HuangSummaryBody surface decolonization with chlorhexidine bathing and nasal mupirocin has become a simple solution for prevention of healthcare-associated infections. The clinical trial evidence for this practice will be reviewed to understand who benefits from this practice, for what reasons, and at what times. The method of bathing and nasal decolonization will also be discussed as proper application is needed for maximal effectiveness. Finally, the conflict between current effectiveness and future potential for f...
Source: Journal of Hospital Infection - September 5, 2019 Category: Infectious Diseases Source Type: research

Hey, Can You See This Patient From Fast Track?
A 22-year-old man with intellectual disability presented to the emergency department (ED) with scalp and groin lesions. He had been seen previously for the groin problem, diagnosed with syphilis, and treated with doxycycline; mupirocin; azithromycin; and valacyclovir, as penicillin G was unavailable. The patient did not take his prescribed medications and was seen in the ED for various minor complaints without mentioning the worsening severity of the lesions. On examination, several round ulcerated scalp lesions were noted, as well as near-circumferential malodorous, ulcerated lesions on the shaft of the penis with associa...
Source: The Journal of Emergency Medicine - September 3, 2019 Category: Emergency Medicine Authors: Sean Hickey, Jennifer E. Sanders, James W. Tsung Tags: Visual Diagnosis in Emergency Medicine Source Type: research

Pre-operative Decolonization as a Strategy to Reduce Surgical Site Infection
AbstractPurpose of ReviewTo identify the most common strategies currently used forS. aureus decolonization and surgical site infection (SSI) prevention.Recent FindingsPre-operative colonization withStaphylococcus aureus increases SSI risk. Screening and decolonization with intra-nasal mupirocin and pre-operative chlorhexidine bathing remains the most common and effective strategy, especially for orthopedic and cardiovascular surgery. Intra-nasal povidone-iodine immediately before surgery appears effective in preliminary studies, is less expensive, and may be easier to implement in the clinical setting. Future well-designed...
Source: Current Infectious Disease Reports - August 31, 2019 Category: Infectious Diseases Source Type: research

Molecules, Vol. 24, Pages 3105: The Influence of Essential Oil Compounds on Antibacterial Activity of Mupirocin-Susceptible and Induced Low-Level Mupirocin-Resistant MRSA Strains
The objective of the study was to verify the influence of essential oil compounds (EOCs) on the antibacterial activity of MUP against mupirocin-susceptible (MupS) and induced low-level mupirocin-resistant (MupRL) methicillin-resistant Staphylococcus aureus (MRSA) strains. The following parameters were examined: MRSAMupS and MRSAMupRL susceptibility to EOCs (1,8-cineole, eugenol, carvacrol, linalool, (-)-menthone, linalyl acetate, and trans-anethole), the bacterial cell size distribution, and chemical composition by the use of Fourier Transform Infrared Spectroscopy (FTIR) and Raman spectroscopies. The MRSAMupS and MRSAMupR...
Source: Molecules - August 27, 2019 Category: Chemistry Authors: Pawe ł Kwiatkowski Agata Pruss Bartosz Wojciuk Barbara Do łęgowska Anna Wajs-Bonikowska Monika Sienkiewicz Monika M ężyńska Łukasz Łopusiewicz Tags: Article Source Type: research

Mupirocin Resistance in Staphylococcus aureus: A Systematic Review and Meta-Analysis
ConclusionOverall our results show a global increase in the prevalence of HLMuRSA and HLMuRMRSA among clinical S. aureus isolates over time. However, there was only a significant increase in the prevalence of MuRMRSA compared to the other categories of strains especially MuRSA. Since for decolonization of MSSA and MRSA in both patients and healthcare personnel, mupirocin is currently still the most effective antibiotic, a reduction of its effectiveness can provide a risk for invasive infection. Monitoring of mupirocin resistance development remains critical. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - August 21, 2019 Category: Infectious Diseases Source Type: research

A case of furuncular myiasis analyzed with enhanced light microscopy techniques
We present a case of furuncular myiasis in a 6-year-old girl returning from visiting relatives in Ethiopia. She presented with a 10-day history of an enlarging, tender, red nodule on her left anterolateral thigh that appeared during her trip abroad. The lesion was initially diagnosed as a bacterial abscess but failed to improve with oral cephalexin and topical mupirocin. On our examination, we noted a solitary, firm, dark reddish-brown nodule, 3cm in diameter, with an 8mm diameter hemorrhagic central crust. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Impact of skin and nasal decontamination before cardiac surgery on postoperative Staphylococcus infection rate in children
Publication date: Available online 29 July 2019Source: Archives of Cardiovascular Diseases SupplementsAuthor(s): L. Savary, A. De Luca, N. Soulé, P. Neville, J.M. El Arid, J. Chantreuil, Z. Maakaroun, B. LefortAbstractBackgroundPostoperative infections occur in about 10% of pediatric cardiac surgeries, involving Staphylococcus aureus in most of the cases. Nasal decontamination of Staphylococcus aureus with mupirocin has been reported to reduce postoperative Staphylococcus aureus infections after cardiac surgery in adults, but the effect of preoperative decontamination in children undergoing cardiac surgery has not b...
Source: Archives of Cardiovascular Diseases Supplements - July 30, 2019 Category: Cardiology Source Type: research

The effect of fennel essential oil and trans-anethole on antibacterial activity of mupirocin against Staphylococcus aureus isolated from asymptomatic carriers.
Authors: Kwiatkowski P, Pruss A, Masiuk H, Mnichowska-Polanowska M, Kaczmarek M, Giedrys-Kalemba S, Dołęgowska B, Zielińska-Bliźniewska H, Olszewski J, Sienkiewicz M Abstract Introduction: Staphylococcus aureus constitutes the most pathogenic species within the staphylococcal genus. Humans remain the major reservoirs of this pathogen which colonizes mostly anterior nares of healthy individuals. Aim: To investigate the effect of fennel essential oil (FEO) and trans-anethole (tA) on antibacterial activity of mupirocin (MUP) against S. aureus strains isolated from asymptomatic carriers. Material and method...
Source: Advances in Dermatology and Allergology - July 25, 2019 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Topical Ozenoxacin Cream 1% for Impetigo: A Review
Conclusions: Resistance patterns in a wide range of pathogens against oral or topical antibiotics and antiseptics used for the treatment of dermatological conditions, such as impetigo have been observed. When making treatment decisions for impetigo MRSA and other antimicrobial resistance has to be taken into account. Ozenoxacin 1% cream offers a potent bactericidal activity and has demonstrated clinical efficacy and safety. Combined with its favorable features, such as a low dosing frequency and a 5 days treatment regimen, ozenoxacin 1% cream is an important option for the treatment of impetigo for pediatric and adult popu...
Source: Journal of Drugs in Dermatology - July 24, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The Effect of Subinhibitory Concentrations of trans-Anethole on Antibacterial and Antibiofilm Activity of Mupirocin Against Mupirocin-Resistant Staphylococcus aureus Strains
Microbial Drug Resistance, Ahead of Print. (Source: Microbial Drug Resistance)
Source: Microbial Drug Resistance - July 17, 2019 Category: Microbiology Authors: Pawe ł Kwiatkowski Bart łomiej Grygorcewicz Agata Pruss Bartosz Wojciuk Barbara Do łęgowska Stefania Giedrys-Kalemba Monika Sienkiewicz Iwona Wojciechowska-Koszko Source Type: research

Methicillin-Resistant staphylococcus aureus carriage in hemodialysis vicinity: Prevalence and decolonization approach
Khaled M. A. Elzorkany, Asmaa M Elbrolosy, Eman H SalemIndian Journal of Nephrology 2019 29(4):282-287 Hemodialysis (HD) patients are at risk for developing serious infections. Methicillin- resistant Staphylococcus aureus (MRSA) is one of the most prevalent pathogens in healthcare facilities with a major threat to the medical community. We aimed to determine the prevalence of MRSA colonization among patients and medical staff members in a HD Unit and determine efficacy of mupirocin as a decolonizing agent. This cross-sectional study enrolled 250 patients and 35 health care providers of a HD unit. Nasal and hand swabs were...
Source: Indian Journal of Nephrology - July 16, 2019 Category: Urology & Nephrology Authors: Khaled M. A. Elzorkany Asmaa M Elbrolosy Eman H Salem Source Type: research

A cost-effectiveness analysis of mupirocin and chlorhexidine gluconate for Staphylococcus aureus decolonization prior to hip and knee arthroplasty in Alberta, Canada compared to standard of care
ConclusionsDecolonization forStaphylococcus aureus prior to hip and knee replacements resulted in cost savings and fewer SSIs, and should be considered prior to these procedures. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - July 11, 2019 Category: Infectious Diseases Source Type: research

High-level mupirocin resistance in methicillin-resistant staphylococci isolated from dogs and cats
Mupirocin is one of the few antimicrobials active against methicillin-resistant Staphylococcus aureus (MRSA), and is frequently used for the eradication of MRSA nasal colonisation in humans. Initially, mupirocin ... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - July 10, 2019 Category: Veterinary Research Authors: Magdalena Kizerwetter- Świda, Dorota Chrobak-Chmiel and Magdalena Rzewuska Tags: Research article Source Type: research

Safety and Efficacy of Universal Postoperative Decolonization for Kidney Transplant Recipients.
CONCLUSIONS: A universal decolonization protocol was successfully implemented and was well tolerated by all patients. Despite successful implementation, we did not observe any significant differences in infection rates between treated patients and historical controls. PMID: 31266440 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - July 2, 2019 Category: Transplant Surgery Authors: Lee DH, Malat G, Boyle SM, Talluri S, Bias TE, Harhay MN, Ranganna K, Doyle A Tags: Exp Clin Transplant Source Type: research

Preventing Peritoneal Dialysis Infections.
Authors: Bolton L Abstract Many patients with end-stage kidney disease prefer peritoneal dialysis (PD) to hemodialysis to replace kidney function1 but avoid PD due to fears of serious complications, such as peritonitis or catheter exit site and tunnel infections, which often have higher incidences than those recommended by the International Society for Peritoneal Dialysis (ISPD). Factors that increase the risk of PD-related peritonitis include patient nasal Staphylococcus aureus carriage, diabetes, advanced age, obesity, depression, cardiovascular disease, and catheter connection methods or exit site infection (ESI...
Source: Wounds - June 20, 2019 Category: General Medicine Tags: Wounds Source Type: research

Prevalence of mupirocin and chlorhexidine resistance among methicillin-resistant coagulase-negative staphylococci isolated during methicillin-resistant Staphylococcus aureus decolonization strategies
ConclusionsOur findings indicate that both MRSA decolonization strategies have an additional benefit in reducing the prevalence of MR-CoNS. Although the universal MRSA decolonization has superior efficacy in decolonization of CoNS, it may increase the risk of selecting CHX-R and Mu-R. In addition, other potential resistance genes should be studied. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - June 14, 2019 Category: Infectious Diseases Source Type: research

Can a nasal and skin decolonization protocol safely replace contact precautions for colonized MRSA patients?
CONCLUSIONSReplacing CP for MRSA-colonized patients with an alcohol?-based nasal antiseptic and CHG bathing protocol significantly reduced isolation costs with no concurrent increase in MRSA transmission. In addition, the alcohol-based nasal antiseptic was preferred by staff when compared to nasal mupirocin. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - May 28, 2019 Category: Infectious Diseases Source Type: research

Staphylococcus Scalded Skin Syndrome Outbreak in the Neonatal Intensive Care Unit
CONCLUSIONSAlthough no common source was linked to the outbreaks, competency-based Personal Protective Equipment (PPE) and Hand Hygiene (HH) training, increasing infection control practices, changing to hospital laundered scrubs and improving environmental cleaning practices prevented further transmission of SSSS in the NICU. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - May 28, 2019 Category: Infectious Diseases Source Type: research

Decolonization Reduces Risk of Postdischarge MRSA
According to this study: Decolonization with chlorhexidine and mupirocin led to lower risks of postdischarge methicillin-resistant Staphylococcus aureus and readmission compared with hygiene education alone. (Source: AJN)
Source: AJN - May 25, 2019 Category: Nursing Tags: Journal Watch Source Type: research

Topical antibiotic therapy in chronic rhinosinusitis: an update
ConclusionThere is additional evidence to support continuing investigation of topical antibiotic therapies. Further, larger RCTs are required to establish the efficacy of topical antibiotic therapies. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 14, 2019 Category: Allergy & Immunology Authors: Daniel A. Carlton, D. David Beahm, Alexander G. Chiu Tags: REVIEW ARTICLE Source Type: research

Anti-biofilm activity of garlic extract loaded nanoparticles
This study describes a sol–gel based nanoparticle system loaded with garlic extract (GE-np) that exhibits: i) slow and sustained release of garlic components; ii) stabilization of the active components; and iii) significant enhancement of antimicrobial and antibiofilm activity relative to the free garlic extract. Also, GE-np were efficient in penetrating and disrupting the well-established methicillin-resistant Staphylococcus aureus (MRSA) biofilms. Overall, the study suggests that GE-np might be a promising candidate for the treatment of chronic infections due to biofilm forming drug-resistant bacteria.Graphical Abs...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - May 12, 2019 Category: Nanotechnology Source Type: research