A novel sacral neuromodulation protocol is associated with reduction in removal for device infection
ConclusionsUtilization of a novel SNM infection protocol tailored to a patient ’s preoperative MRSA colonization is associated with a reduction in the overall incidence of explant for device infection while avoiding prolonged postoperative antibiotic regimens.Clinical trial registrationThe study was initiated prior to January 18, 2017 and does not meet the definition of an applicable clinical trial (ACT) as defined in section 402 (J) of the US PHS Act. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - May 8, 2023 Category: OBGYN Source Type: research
A novel sacral neuromodulation protocol is associated with reduction in removal for device infection
ConclusionsUtilization of a novel SNM infection protocol tailored to a patient ’s preoperative MRSA colonization is associated with a reduction in the overall incidence of explant for device infection while avoiding prolonged postoperative antibiotic regimens.Clinical trial registrationThe study was initiated prior to January 18, 2017 and does not meet the definition of an applicable clinical trial (ACT) as defined in section 402 (J) of the US PHS Act. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - May 8, 2023 Category: OBGYN Source Type: research
Topical delivery of mupirocin calcium nanostructured lipid carriers using a full-thickness excision wound healing model
Journal of Wound Care,Volume 32, Issue Sup5a, Page lxiii-lxxiv, May 2023. (Source: Journal of Wound Care)
Source: Journal of Wound Care - April 25, 2023 Category: Nursing Authors: Priyanka V Patil Mala D Menon Aparna D Palshetkar Namita D Desai Source Type: research
921 Inhibition of IARS alleviates skin inflammation in psoriasis through JAK2/STAT3 pathway
The aminoacyl-tRNA synthetases (ARSs) are a family of essential enzymes that participate the protein synthesis through ligate amino acids to their corresponding tRNAs. Although we have previously revealed that mupirocin blocks Imiquimod (IMQ) -induced psoriasis-like skin lesion by inhibiting epidermal isoleucyl-tRNA synthetase (IARS), the mechanisms of IARS in psoriatic local inflammation have remained unelucidated. Here, we investigated that IARS was specifically highly expressed in keratinocytes compared with immune cells. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: X. Chen, Y. Zheng, F. Xu, X. Man Source Type: research
A bilayer mupirocin/bupivacaine-loaded wound dressing based on chitosan/poly (vinyl alcohol) nanofibrous mat: Preparation, characterization, and controlled drug release
In this study, the double-layer CS/PVA/mupirocin (CPM) + CS/PVA/bupivacaine (CPB) mats were prepared by electrospinning method (20 % polymer weight) and then crosslinked with glutaraldehyde (GA) to optimize the water-resistant and biodegradation properties for wound dressing applications. The morphology of mats was characterized as defect-free and interconnected nanofibers by Scanning Electron Microscope (SEM) and Atomic Force Microscopy (AFM). Fourier Transform Infrared Spectrometry (FTIR) analysis also assessed the chemical structural properties. The porosity, surface wettability, and swelling degree of the dual-drug loa...
Source: International Journal of Biological Macromolecules - April 14, 2023 Category: Biochemistry Authors: Soha Habibi Toraj Mohammadi Romina HMTShirazi Fatemeh Atyabi Melika Kiani Amir Atabak Asadi Source Type: research
A bilayer mupirocin/bupivacaine-loaded wound dressing based on chitosan/poly (vinyl alcohol) nanofibrous mat: Preparation, characterization, and controlled drug release
In this study, the double-layer CS/PVA/mupirocin (CPM) + CS/PVA/bupivacaine (CPB) mats were prepared by electrospinning method (20 % polymer weight) and then crosslinked with glutaraldehyde (GA) to optimize the water-resistant and biodegradation properties for wound dressing applications. The morphology of mats was characterized as defect-free and interconnected nanofibers by Scanning Electron Microscope (SEM) and Atomic Force Microscopy (AFM). Fourier Transform Infrared Spectrometry (FTIR) analysis also assessed the chemical structural properties. The porosity, surface wettability, and swelling degree of the dual-drug loa...
Source: International Journal of Biological Macromolecules - April 14, 2023 Category: Biochemistry Authors: Soha Habibi Toraj Mohammadi Romina HMTShirazi Fatemeh Atyabi Melika Kiani Amir Atabak Asadi Source Type: research
Metaviromic analyses of DNA virus community from sediments of the N-Choe stream, North India
This study utilized the long-read nanopore sequencing data analyzed by assembly-free and assembly-based approaches to study the viral community structure and its genetic potential. In the classified fraction of the virome, we observed the dominance of the ssDNA viruses. The prominent ssDNA virus families were Microviridae, Circoviridae, and Genomoviridae. The majority of dsDNA viruses were bacteriophages belonging to class Caudoviricetes. We also recovered metagenome-assembled viruses of Microviridae, CRESS DNA viruses, and viral-like circular molecules. We identified the structural and functional gene repertoire of the vi...
Source: Virus Research - April 9, 2023 Category: Virology Authors: Adhip Mukhopadhyay Shubham Choudhury Manoj Kumar Source Type: research
Metaviromic analyses of DNA virus community from sediments of the N-Choe stream, North India
This study utilized the long-read nanopore sequencing data analyzed by assembly-free and assembly-based approaches to study the viral community structure and its genetic potential. In the classified fraction of the virome, we observed the dominance of the ssDNA viruses. The prominent ssDNA virus families were Microviridae, Circoviridae, and Genomoviridae. The majority of dsDNA viruses were bacteriophages belonging to class Caudoviricetes. We also recovered metagenome-assembled viruses of Microviridae, CRESS DNA viruses, and viral-like circular molecules. We identified the structural and functional gene repertoire of the vi...
Source: Virus Research - April 9, 2023 Category: Virology Authors: Adhip Mukhopadhyay Shubham Choudhury Manoj Kumar Source Type: research
Metaviromic analyses of DNA virus community from sediments of the N-Choe stream, North India
This study utilized the long-read nanopore sequencing data analyzed by assembly-free and assembly-based approaches to study the viral community structure and its genetic potential. In the classified fraction of the virome, we observed the dominance of the ssDNA viruses. The prominent ssDNA virus families were Microviridae, Circoviridae, and Genomoviridae. The majority of dsDNA viruses were bacteriophages belonging to class Caudoviricetes. We also recovered metagenome-assembled viruses of Microviridae, CRESS DNA viruses, and viral-like circular molecules. We identified the structural and functional gene repertoire of the vi...
Source: Virus Research - April 9, 2023 Category: Virology Authors: Adhip Mukhopadhyay Shubham Choudhury Manoj Kumar Source Type: research
Feasibility Study for Randomised Control Trial for Topical Treatment of Impetigo in Australian General Practice
Conclusions Valuable insight was gained into the practicality of conducting a RCT of impetigo treatments in general practice. Future trials should consider recruiting outside of general practice clinics to capture patients at earlier, more mild stages of infection. Further investigation into the prevalence and impact of use of at-home expired antibiotics may be beneficial.PMID:37023250 | DOI:10.1370/afm.21.s1.4047 (Source: Annals of Family Medicine)
Source: Annals of Family Medicine - April 6, 2023 Category: Primary Care Authors: Clare Heal Source Type: research
Feasibility Study for Randomised Control Trial for Topical Treatment of Impetigo in Australian General Practice
Conclusions Valuable insight was gained into the practicality of conducting a RCT of impetigo treatments in general practice. Future trials should consider recruiting outside of general practice clinics to capture patients at earlier, more mild stages of infection. Further investigation into the prevalence and impact of use of at-home expired antibiotics may be beneficial.PMID:37023250 | DOI:10.1370/afm.21.s1.4047 (Source: Annals of Family Medicine)
Source: Annals of Family Medicine - April 6, 2023 Category: Primary Care Authors: Clare Heal Source Type: research
Feasibility Study for Randomised Control Trial for Topical Treatment of Impetigo in Australian General Practice
Conclusions Valuable insight was gained into the practicality of conducting a RCT of impetigo treatments in general practice. Future trials should consider recruiting outside of general practice clinics to capture patients at earlier, more mild stages of infection. Further investigation into the prevalence and impact of use of at-home expired antibiotics may be beneficial.PMID:37023250 | DOI:10.1370/afm.21.s1.4047 (Source: Annals of Family Medicine)
Source: Annals of Family Medicine - April 6, 2023 Category: Primary Care Authors: Clare Heal Source Type: research
Treatment of a large area perioral viral herpes infection following noninvasive ventilation: A case report
CONCLUSION: Through multidisciplinary consultation, the patient's oral and perioral herpes infection was successfully treated with the following combined approach: (1) Application of topical antviral and antibiotic treatments; (2) keeping the wound moist with a wet wound healing strategy; (3) systemic use of oral antiviral drugs; and (4) symptomatic and nutritional supportive care. The patient was discharged from the hospital after successful wound healing.PMID:36969999 | PMC:PMC10037274 | DOI:10.12998/wjcc.v11.i8.1857 (Source: Herpes)
Source: Herpes - March 27, 2023 Category: Infectious Diseases Authors: A-Mao Tang Jia-Ying Xu Rong Wang Yi-Min Li Source Type: research
Low pH nasal rinse solution enhances mupirocin antimicrobial efficacy
CONCLUSION: The choice of irrigant solution for topical mupirocin delivery appears to be important for antimicrobial activity. The delivery of mupirocin via low pH FloCRS could be useful in eliminating S. aureus biofilms present on the sinus mucosa of patients with CRS.PMID:36972583 | DOI:10.4193/Rhin21.495 (Source: Rhinology)
Source: Rhinology - March 27, 2023 Category: ENT & OMF Authors: K Hon S Liu C Cooksley S Vreugde A J Psaltis Source Type: research
Treatment of a large area perioral viral herpes infection following noninvasive ventilation: A case report
CONCLUSION: Through multidisciplinary consultation, the patient's oral and perioral herpes infection was successfully treated with the following combined approach: (1) Application of topical antviral and antibiotic treatments; (2) keeping the wound moist with a wet wound healing strategy; (3) systemic use of oral antiviral drugs; and (4) symptomatic and nutritional supportive care. The patient was discharged from the hospital after successful wound healing.PMID:36969999 | PMC:PMC10037274 | DOI:10.12998/wjcc.v11.i8.1857 (Source: Herpes)
Source: Herpes - March 27, 2023 Category: Infectious Diseases Authors: A-Mao Tang Jia-Ying Xu Rong Wang Yi-Min Li Source Type: research
