Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Peak Resembling N-acetylaspartate (NAA) on Magnetic Resonance Spectroscopy of Brain Metastases
Conclusions: The identification of a prominent peak at 2.0 ppm could be a valuable diagnostic marker for distinguishing single ring-enhancing lesions, potentially associated with mucin-expressing metastases, offering a new avenue for diagnostic specificity in challenging cases.PMID:38674308 | PMC:PMC11052432 | DOI:10.3390/medicina60040662 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Jelena Ostojic Dusko Kozic Milana Panjkovic Biljana Georgievski-Brkic Dusan Dragicevic Aleksandra Lovrenski Jasmina Boban Source Type: research
Peak Resembling N-acetylaspartate (NAA) on Magnetic Resonance Spectroscopy of Brain Metastases
Conclusions: The identification of a prominent peak at 2.0 ppm could be a valuable diagnostic marker for distinguishing single ring-enhancing lesions, potentially associated with mucin-expressing metastases, offering a new avenue for diagnostic specificity in challenging cases.PMID:38674308 | PMC:PMC11052432 | DOI:10.3390/medicina60040662 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Jelena Ostojic Dusko Kozic Milana Panjkovic Biljana Georgievski-Brkic Dusan Dragicevic Aleksandra Lovrenski Jasmina Boban Source Type: research
Peak Resembling N-acetylaspartate (NAA) on Magnetic Resonance Spectroscopy of Brain Metastases
Conclusions: The identification of a prominent peak at 2.0 ppm could be a valuable diagnostic marker for distinguishing single ring-enhancing lesions, potentially associated with mucin-expressing metastases, offering a new avenue for diagnostic specificity in challenging cases.PMID:38674308 | PMC:PMC11052432 | DOI:10.3390/medicina60040662 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Jelena Ostojic Dusko Kozic Milana Panjkovic Biljana Georgievski-Brkic Dusan Dragicevic Aleksandra Lovrenski Jasmina Boban Source Type: research
Peak Resembling N-acetylaspartate (NAA) on Magnetic Resonance Spectroscopy of Brain Metastases
Conclusions: The identification of a prominent peak at 2.0 ppm could be a valuable diagnostic marker for distinguishing single ring-enhancing lesions, potentially associated with mucin-expressing metastases, offering a new avenue for diagnostic specificity in challenging cases.PMID:38674308 | PMC:PMC11052432 | DOI:10.3390/medicina60040662 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Jelena Ostojic Dusko Kozic Milana Panjkovic Biljana Georgievski-Brkic Dusan Dragicevic Aleksandra Lovrenski Jasmina Boban Source Type: research
Peak Resembling N-acetylaspartate (NAA) on Magnetic Resonance Spectroscopy of Brain Metastases
Conclusions: The identification of a prominent peak at 2.0 ppm could be a valuable diagnostic marker for distinguishing single ring-enhancing lesions, potentially associated with mucin-expressing metastases, offering a new avenue for diagnostic specificity in challenging cases.PMID:38674308 | PMC:PMC11052432 | DOI:10.3390/medicina60040662 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Jelena Ostojic Dusko Kozic Milana Panjkovic Biljana Georgievski-Brkic Dusan Dragicevic Aleksandra Lovrenski Jasmina Boban Source Type: research
MAML2-Rearrranged Sclerosing Mucoepidermoid Carcinoma of Submandibular Gland: An Incidental Finding in a Patient with History of Recurrent Sialadenitis and Sj ögren's syndrome
We present a new case of sclerosing mucoepidermoid carcinoma (SMEC) with MAML2 rearrangements. A 49-year-old woman with Sj ögren's syndrome experienced recurrent submandibular sialadenitis and sialolithiasis, leading to the removal of her right gland. Postoperative imaging revealed a calcified mass in her left gland which was subsequently resected. The pathological examination revealed a well-defined tumor with extensi ve fibrous stroma, predominantly epidermoid cells, and occasional mucinous components. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 13, 2024 Category: ENT & OMF Authors: Hasanain Hasan, Dinh Quoc Duong, Orly Coblens, Suimin Qiu, Cecilia G. Clement Source Type: research
Cancers, Vol. 16, Pages 1446: Ovarian Causes of Pseudomyxoma Peritonei (PMP) & mdash;A Literature Review
Conclusions. In our study, we aimed to provide a comprehensive overview of the ovarian causes of pseudomyxoma peritonei, including its epidemiology, imagery characteristics, symptoms, current treatment, and promising future therapies, in the hopes of finding feasible solutions, as a lack of understanding of this mucus-secreting malignant disease increases the risk of delayed diagnosis or uncontrolled deterioration. (Source: Cancers)
Source: Cancers - April 9, 2024 Category: Cancer & Oncology Authors: Sinziana Ionescu Marian Marincas Octavia Luciana Madge Irinel Gabriel Dicu-Andreescu Elena Chitoran Vlad Rotaru Ciprian Cirimbei Mirela Gherghe Adina Ene Robert Rosca Madalina Radu Laurentiu Simion Tags: Review Source Type: research
Establishment of a human ovarian clear cell carcinoma cell line mutant in PIK3CB but not PIK3CA
AbstractA human ovarian clear cell carcinoma cell line was established from a 46-year-old Japanese woman. That line, designated MTC-22, has proliferated continuously for over 6 months in conventional RPMI 1640 medium supplemented with 10% foetal bovine serum and has been passaged over 50 times. MTC-22 doubling-time is ~ 18 h, which is much shorter than most ovarian clear cell carcinoma lines reported to date. Morphologically, MTC-22 cells exhibit polygonal shapes an d proliferate to form a monolayer in a jigsaw puzzle-like arrangement without contact inhibition. Ultrastructurally, cells exhibit numerous intracytopla...
Source: Human Cell - April 4, 2024 Category: Cytology Source Type: research
Colorectal cancer disease profile and treatment patterns at an urban tertiary hospital in Rwanda
CONCLUSION: CRC patients presented at an advanced stage and required complex treatment regimens at KFH. Further epidemiologic and molecular research is needed to characterise CRC incidence and presentation at a national level in Rwanda as increasing westernisation continues to change the face of CRC in urban areas of SSA.PMID:38566760 | PMC:PMC10984839 | DOI:10.3332/ecancer.2024.1687 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - April 3, 2024 Category: Cancer & Oncology Authors: Margaret Baldwin Brandon A Niyibizi Daniella Rangira Benita Rangira Madeleine K Kazindu Daniel Seifu Cristina Daniela Stefan Eulade Rugengamanzi Achille V C Manirakiza Source Type: research
