Comparison with surgically resected mucinous cystic neoplasm of pancreas and branch-duct type intraductal papillary mucinous neoplasm considering clinico-radiological high-risk features: a reassessment of current guidelines
ConclusionWhile current guidelines may be appropriate for managing BD-IPMNs, our results showed a notably larger optimal threshold size for malignant MCNs than that suggested by current guidelines. This warrants reconsidering existing guideline thresholds for initial risk stratification and management of MCNs. (Source: Abdominal Imaging)
Source: Abdominal Imaging - May 15, 2024 Category: Radiology Source Type: research
Outcomes in Nonmetastatic Hormone Receptor-Positive HER2-Negative Pure Mucinous Breast Cancer: A Multicenter Cohort Study
CONCLUSIONS: Compared with IDC, PMBC demonstrated superior RFI, RFS, and OS. Lymph node negativity, adjuvant radiotherapy, and endocrine therapy were associated with superior RFI. Adjuvant chemotherapy was not associated with better outcomes.PMID:38744306 | DOI:10.6004/jnccn.2023.7121 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - May 14, 2024 Category: Cancer & Oncology Authors: Ryan Ying Cong Tan Whee Sze Ong Kyung-Hun Lee Seri Park Jabed Iqbal Yeon Hee Park Jeong Eon Lee Jong Han Yu Ching-Hung Lin Yen-Shen Lu Makiko Ono Takayuki Ueno Yoichi Naito Tatsuya Onishi Geok-Hoon Lim Su-Ming Tan Han-Byoel Lee Jiwon Koh Wonshik Han Seock Source Type: research
Axillary lymph node metastasis in pure mucinous carcinoma of breast: clinicopathologic and ultrasonographic features
The purpose of this research is to study the sonographic and clinicopathologic characteristics that associate with axillary lymph node metastasis (ALNM) for pure mucinous carcinoma of breast (PMBC). (Source: BMC Medical Imaging)
Source: BMC Medical Imaging - May 14, 2024 Category: Radiology Authors: Na Li, Jia-Wei Li, Yu Qian, Ya-Jing Liu, Xiu-Zhu Qi, Ya-Ling Chen, Yi Gao and Cai Chang Tags: Research Source Type: research
Ulcerative colitis-associated neoplasms often harbor poor prognostic histologic components with low detection by biopsy
CONCLUSIONS: This is the first investigation that shows UCANs with a por/sig/muc component tended to be deeply invasive and were often not recognized preoperatively. Endoscopists should be aware that UCAN often has a por/sig/muc component that is not always recognized on biopsy, and the optimal treatment strategy needs to be carefully considered.PMID:38712359 | DOI:10.5217/ir.2024.00006 (Source: Cell Research)
Source: Cell Research - May 7, 2024 Category: Cytology Authors: Ryoya Sakakibara Shinya Sugimoto Kaoru Takabayashi Hiroki Kiyohara Yusuke Wakisaka Yuta Kaieda Miho Kawaida Yusuke Yoshimatsu Tomohisa Sujino Naoki Hosoe Motohiko Kato Masayuki Shimoda Yohei Mikami Yasushi Iwao Takanori Kanai Source Type: research
Perioperative management of a patient with unexpectedly detected early-stage ovarian mucinous carcinoma combined with progressive bulbar paralysis: a case report and literature review
Giant ovarian cysts (GOCs)complicated with progressive bulbar paralysis (PBP) are very rare, and no such literature about these cases have been reported. Through the diagnosis and treatment of this case, the p... (Source: BMC Women's Health)
Source: BMC Women's Health - May 4, 2024 Category: OBGYN Authors: Dingbei Zhang, Ruibo Xu, Tingting Huo, Ying Liu, Zengfang Hao, Yao Sun, Xiaoyu Xi, Xiaoli Du, Lili Wang and Jiexian Du Tags: Case Report Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
