26. Dopamine Abnormalities in the Substantia Nigra of Diverse and Comorbid Substance Users are Linked to Stimulant Use Disorder Severity and Executive Dysfunction
This study aimed to utilize NM-MRI as a proxy measure of dopamine function in the substantia nigra (SN) of individuals with diverse SUDs, and to examine relationships amongst SN signal intensity and cognitive dysfunction. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Diana Valdes Cabrera, Peter Pangarov, Colin Hawco, Isabelle Boileau, Philip Gerretsen, Victor Tang, Matthew Sloan, Rodrigo Pimentel Sabido, Jon Erebara, Jeffrey Wardell, Etienne Sibille, Lena Quilty, Anthony C. Ruocco, Yuliya Nikolova Source Type: research
34. Intermittent Theta Burst Stimulation Normalizes Error Signals in the Anterior Cingulate Cortex for Individuals Receiving Methadone
Dysregulation of error processing, specifically hypoactivation in the anterior cingulate cortex (ACC), is a hallmark of substance use disorders. Normalizing this signal could lead to an effective treatment, especially for individuals receiving methadone to treat opioid use disorder (MOUD). Intermittent theta burst stimulation (iTBS), a form of transcranial magnetic stimulation (TMS), applied to the left dorsolateral prefrontal cortex (l-dlPFC) may modulate the ACC error signal. As a proof of concept, we measured ACC activation related to error processing via functional magnetic resonance imaging (fMRI) before and after we ...
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Dongyu Kang, Kira Gresser, Patrick Fang, Michael Stevens, Vaughn Steele Source Type: research
434. Improving Image Accuracy in Low-Field Magnetic Resonance Imaging to Make Accessible Biomarkers for Psychiatric Disorders
Low-field magnetic resonance imaging (MRI) systems represent promising alternatives to high-field systems, holding potential to improve MR technology accessibility and enable development of brain-based screening and risk prediction models for psychiatric disorders. However, lower image resolution limits their clinical utility. We tested the efficacy of a super-resolution approach to enhance image correspondence between a low-field and high-field MR system in a sample of young people. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Rebecca Cooper, Rebecca Hayes, Mary Corcoran, Kevin N. Sheth, Thomas Campbell Arnold, Joel Stein, David C. Glahn, Maria Jalbrzikowski Source Type: research
379. Multivariate Transdiagnostic Neural Biomarkers of Schizophrenia and Autism Spectrum Disorders During the Empathic Accuracy Task
In this study, we aimed to identify group-specific and shared brain functional network configurations present during a social processing functional magnetic resonance imaging (fMRI) task. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Ju-Chi Yu, Colin Hawco, Lindsay D. Oliver, Maria T. Secara, Iska Moxon-Emre, Fariah A. Sandhu, Zara Z. Khan, Peter Szatmari, Meng-Chuan Lai, Miklos Argyelan, James M. Gold, Sunny X. Tang, George Foussias, Robert W. Buchanan, Anil K. Malhotra, Aristotle N. Source Type: research
234. Low-Intensity Focused Ultrasound (FUS) Amygdala Neuromodulation: An fMRI Target Engagement Study and Open-Label Treatment Trial in Mixed Mood, Anxiety, and Trauma-Related Disorders
Affective disorders (ADs), i.e. mood, anxiety, and trauma-related disorders, show common amygdala (AMYG) hyperactivity to emotional cues. Low-intensity focused ultrasound (FUS) can modulate brain function in subcortical areas. Here, using concurrent FUS/functional magnetic resonance imaging (fMRI), we tested FUS modulation of the left AMYG in AD patients (N=23) and healthy controls (HCs)(N=23). ADs then underwent once-daily open-label (OL) left AMYG FUS for 3 weeks to assess FUS therapeutic potential. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Bryan Barksdale, Lauren Enten, Annamarie DeMarco, Rachel Kline, Charles Nemeroff, Gregory Fonzo Source Type: research
260. Widespread Network Connectivity Alterations in Remitted Late-Life Depression
A major challenges of late-life depression (LLD) is its refractory nature. As a first step toward understanding the neurobiology of relapse in late-life depression, we compared intrinsic network integrity between recently remitted and healthy control groups using functional magnetic resonance imaging (fMRI). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Andrew Gerlach, Helmet Karim, Robert Krafty, Warren Taylor, Olusola Ajilore, Carmen Andreescu Source Type: research
262. Executive Function Self-Report Metrics Correlated With Resting State Brain Activity in Adolescents With Remitted Depression
Current research paradigms combine self-report, cognitive tasks, and functional magnetic resonance imaging (fMRI) to capture executive function (EF). In adolescents, inconsistency emerges between self-/parent-report EF measures and cognitive task performance. Adolescents with depression show disruptions in brain networks associated with EF in resting state fMRI. Whether brain activity at rest and behavioral measures of EF converge in adolescents with remitted depression remains unclear. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Anna Jacobsen, Brian Farstead, Daniel Feldman, Summer Frandsen, Erin Kaufman, Mindy Westlund-Schreiner, Scott Langenecker Source Type: research
294. Developmental Differences in Striatal Recruitment by Reward Prospects as a Function of Attentional Demand
Adolescent risk-taking has been attributed to earlier-developing motivational neurocircuitry that is poorly controlled by immature executive-control neurocircuitry. Functional magnetic resonance imaging findings of increased ventral striatum (VS) recruitment by reward prospects in adolescents compared to adults support this theory. Other studies found blunted VS recruitment by reward-predictive cues in adolescents compared to adults. Task features may explain this discrepancy but have never been systematically explored. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Chelsea Sawyers, Lisa Straub, Joseph Gauntlett, James Bjork Source Type: research
295. Rare Variant Genetic Architecture of the Human Cortical MRI Phenotypes in General Population
The development and organization of the human cortex are influenced by both common and rare variants. While genome-wide association studies (GWAS) have identified common variants that influence global and regional cortical phenotypes derived using magnetic resonance imaging (MRI), the rare variant genetic architecture of the human cortex has not yet been characterized, and the relationship between common and rare variant architectures remains unknown. We hypothesize that common and rare variants exert similar influences on cortical phenotypes. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Kuldeep Kumar, Sayeh Kazem, Zhijie Liao, Jakub Kopal, Guillaume Huguet, Thomas Renne, Martineau Jean-Louis, Zhe Xie, Zohra Saci, Laura Almasy, David Glahn, Tomas Paus, Guillaume Dumas, Carrie Bearden, Paul Thompson, Richard Bethlehem, Varun Warrier, Sebas Source Type: research
191. The Effects of Estradiol on Hippocampal Volumes in Perimenopausal-Onset Depression
We examined whether est rogen (E2) administration changed hippocampal volume in those with PO-MDD vs. euthymic controls. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Kathryn Gibson, Melissa Walsh, Megan Hynd, Paul Cernasov, Erin Bondy, Reese Gray, James Brierley, Joshua Bizzell, Martin Styner, Gabriel Dichter, David Rubinow, Crystal Schiller Source Type: research
178. Neural Effects of Acute Ketamine Administration in Healthy Individuals: A Meta-Analysis of Functional Activation Studies
Ketamine has gained substantial attention due to its rapid antidepressant effects, particularly in treatment-resistant depression and suicidality. Despite the growing literature, questions remain about the neural mechanisms underlying its psychopharmacological effects, particularly executive functioning in both clinical and healthy populations. This meta-analysis investigates the effects of acute subanesthetic ketamine administration on neural activation patterns, as measured by functional magnetic resonance imaging (fMRI) in healthy participants. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jonah H. Shepherd, Angela Hickman, Caitlin Baten, Amanda M. Klassen, Gladys Zamora, Ellie Johnson-Venegas, Sasidhar S. Madugula, Ellen Woo, J. Paul Hamilton, Jennifer A. Miller, Matthew D. Sacchet, Dawson W. Hedges, Chris H. Miller Source Type: research
107. Brain Insulin Sensitivity and Reward Behavior in Mood Disorders
Evidence indicates that brain insulin signaling is involved in the regulation of reward. We aimed to evaluate the brain sensitivity to insulin in individuals with mood disorders, using acutely administered intranasal insulin and functional magnetic resonance imaging (fMRI). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Rodrigo Mansur, Colin Hawco, Joshua Rosenblat, Andrea Mckenzie, Aniqa Tabassum, Joshua Di Vincenzo, Hartej Gill, Sebastian Badulescu, Roger McIntyre Source Type: research
136. Identifying Brain Anatomical Areas Linked to Suicidal Thoughts in Bipolar Disorder Using Deep Learning Algorithms
This study uses AI to detect suicidal thoughts in Bipolar Disorder (BD) patients through structural Magnetic Resonance Imaging (sMRI) scans. Bipolar Disorder is marked by extreme mood swings and an increased risk of suicidal thoughts. Understanding these risks' neurobiological aspects is crucial for prevention and early intervention. Our research employed an open-source dataset from the “UCLA Consortium for Neuropsychiatric Phenomics LA5c Study,” using anatomical data in native space that was preprocessed by fmriprep tool. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Melanie Garcia, Joan Camprodon, Benjamin Wade Source Type: research
Microvascular Perfusion Imaging in Alzheimer's Disease
J Integr Neurosci. 2024 Apr 1;23(4):70. doi: 10.31083/j.jin2304070.ABSTRACTAlzheimer's disease (AD) is the leading cause of dementia worldwide and significantly impacts the essential functions of daily life and social activities. Research on AD has found that its pathogenesis is related to the extracellular accumulation of amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles in the cortical and limbic areas of the human brain, as well as cerebrovascular factors. The detection of Aβ or tau can be performed using various probes and methodologies. However, these modalities are expensive to implement and often...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Yi Song Hang Xing Zhiqi Zhang Source Type: research
Altered Resting-State Amygdalar Functional Connectivity in Primary Angle-Closure Glaucoma Patients
CONCLUSIONS: Patients with PACG exhibit extensive resting state abnormalities with respect to the FC between the amygdala and other regions of the brain, suggesting that dysregulated amygdalar FC may play a role in the pathophysiology of PACG.PMID:38682218 | DOI:10.31083/j.jin2304075 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Ye Chen Yuanyuan Wang Linglong Chen Feng Ouyang Mingxue Yin Lianjiang Lv Zihe Xu Jie Liu Xianjun Zeng Source Type: research
