A non-invasive miRNA-based approach in early diagnosis and therapeutics of oral cancer
Crit Rev Oncol Hematol. 2022 Oct 16:103850. doi: 10.1016/j.critrevonc.2022.103850. Online ahead of print.ABSTRACTOral or mouth cancer is the 16th most common form of cancer among the world's topmost malignancies. Healthy lifestyle and control of known risk factors can reduce its incidences further. Patients succumb to oral cancer when diagnosed late and lack timely access to tertiary care. Molecular biomarkers might help in early detection of oral cancer. Recently, researchers have identified numerous microRNAs which play a crucial role in promoting and suppressing oral cancers. miRNAs are short non-coding RNA molecules (1...
Source: Cancer Control - October 19, 2022 Category: Cancer & Oncology Authors: Ghulam Mehdi Dar Shreya Agarwal Arun Kumar None Nimisha None Apurva Abhay Kumar Sharma Renu Verma Real Sumayya Abdul Sattar Ejaj Ahmad Asgar Ali Bhawna Mahajan Sundeep Singh Saluja Ravi Meher Source Type: research
GSE196674 Genome-wide profiling of small RNAs in human Oral squamous cell carcinoma (OSCC) cell lines
Contributors : Trisha Chattopadhyay ; Pooja Gupta ; Bibekanand MallickSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensTo elucidate the potential role of small ncRNAs, such as piRNAs and miRNAs in oncogenesis of Oral squamous cell carcinoma (OSCC), we performed genome wide profiling in three human OSCC cell lines, H357 (tongue squamous cell carcinoma), KB (mouth cancer), Hep-2 (laryngeal cancer), and HOK (Normal human oral keratinocyte) using high-throughput RNA sequencing (RNA-Seq) of small RNAs. We discovered 4854 piRNAs in H357, 5184 in KB, 8340 in Hep-2, and 4735 in HOK, whi...
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Industry manipulation of pictorial health warning labels in Pakistan
Approximately 10.5% of adults in Pakistan (about 13 million) smoke cigarettes,1 causing 134 000 deaths annually.2 To reduce the burden of disease, the Pakistan government implemented a requirement in 2010 for 40% pictorial health warning labels (HWLs) that depicted mouth cancer. A 2017 ruling to increase HWL size was implemented in August 2018 (50% throat cancer image) and August 2019 (60% gangrenous foot image).3 4 Pictorial HWLs increase smokers’ quit attempts, deter initiation of use among non-smokers, and prevent relapse in former smokers.5 In 2013, only 58% of unique packs with the current, in-rotation HWL were ...
Source: Tobacco Control - August 24, 2022 Category: Respiratory Medicine Authors: Crespi, E., Iacobelli, M., Welding, K., Saraf, S., Clegg Smith, K., Cohen, J. E. Tags: Open access Industry watch Source Type: research
Comparative Analysis of the Quality of Life in the Pretreatment of Head and Neck Cancer Patients According to Tumor Site
Conclusion Based on the results of this study, it can be concluded that the QoL of patients with head and neck cancer was not influenced by tumor location. The most affected domains in the three groups were pain, appearance, chewing, swallowing, and speech (p < 0.05). [...] Thieme Revinter Publicações Ltda. Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, BrazilArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: International Archives of Otorhinolaryngology)
Source: International Archives of Otorhinolaryngology - August 1, 2022 Category: ENT & OMF Authors: Cruz, Marla S. P. Reis, Tercio G. Nunes, Jackeline Sena Oliveira, Antoniel C. Teixeira, Ágda Braga Costa, Karine Silva Oliveira, M árcio C. Tags: Original Research Source Type: research
Brachytherapy with 198Au grains for cancer of the floor of the mouth: relationships between radiation dose and complications
ConclusionOur study showed that the combination of EBRT and198Au grains brachytherapy for the floor of the mouth cancer patients might be associated with risks of developing complications of soft tissue ulcer and mandibular bone necrosis. (Source: Oral Radiology)
Source: Oral Radiology - January 1, 2022 Category: Radiology Source Type: research
Reirradiation Using (198)Au Grain Brachytherapy for Recurrent Oral Cancer Cases Previously Treated by Definitive Radiotherapy
CONCLUSION: During recurrence of the buccal mucosa and the floor of mouth cancers, reirradiation should be avoided considering mandibular complications. To avoid reirradiation-related complications, tooth extraction near the radiation field should be avoided.PMID:34969737 | DOI:10.21873/anticanres.15485 (Source: Cancer Control)
Source: Cancer Control - December 31, 2021 Category: Cancer & Oncology Authors: Masaru Konishi Yuki Takeuchi Katsumaro Kubo Nobuki Imano Ikuno Nishibuchi Yuji Murakami Kiichi Shimabukuro Pongsapak Wongratwanich Naoya Kakimoto Yasushi Nagata Source Type: research
What is the optimum operative approach for the N0 neck in patients with early Mouth Cancer – A review of current status
Interestingly the same question is still with us - “How best to manage the N0 neck”. But the focus has moved on from END vs “wait and see” policy. Now we ask what is the optimal operative approach to the N0 neck. This is the topic being aired in this present review and has been prompted by a recent editorial “Management of the cN0 neck in early oral cancer: time to revise the guidance?” by Panayiotis Kyzas,1 which follows a theme espoused by Vassiliou, in a EACMFS position paper “Management of the Clinically N0 neck in early-stage oral cancer”. (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - October 30, 2021 Category: ENT & OMF Authors: Mark McGurk, Soudeh Chegini, Clare Schilling, Stephen Y. Lai Tags: Review Source Type: research
What is the optimum operative approach for the N0 neck in patients with early Mouth Cancer: A Review of Current Status
Interestingly the same question is still with us - “How best to manage the N0 neck”. But the focus has moved on from END vs “wait and see” policy. Now we ask what is the optimal operative approach to the N0 neck. This is the topic being aired in this present review and has been prompted by a recent editorial “Management of the cN0 neck in early oral cancer: time to revise the guidance?” by Panayiotis Kyzas [1], which follows a theme espoused by Vassiliou, in a EACMFS position paper “Management of the Clinically N0 neck in early-stage oral cancer” [2]. (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - October 30, 2021 Category: ENT & OMF Authors: Mark McGurk, Soudeh Chegini, Clare Schilling, Stephen Y. Lai Tags: Review Source Type: research
Outcome Evaluation of Mandibular Pull-Through Approach for Glossectomies
AbstractPatients with advanced carcinoma tongue in the Indian subcontinent have an additional component of submucosal fibrosis (SMF) due to chewing of betel. We intend to evaluate mandibular pull-through approach for total or near-total glossectomy and assessed its functional and survival outcome. Prospective study of 77 patients with carcinoma tongue, who underwent total or near-total glossectomy at our institute, were assessed retrospectively. All the patients who under went glossecomy through mandibular pull through approach with pedicled or free flap reconstruction were assessed for functional and survival outcomes...
Source: Indian Journal of Surgical Oncology - August 19, 2021 Category: Cancer & Oncology Source Type: research
Predictive Factors for Submandibular Gland Involvement in Oral Cavity Squamous Cell Carcinoma —a Prospective Study from a Tertiary Cancer Center
This study was aimed to determine the rate of SMG involvement and assess the feasibility of submandibular gland (SMG) preservation. We present a prospective study conducted at a tertiary cancer center from June 2017 to May 2019. All patients of oral squamous cell carcinoma who underwent primary surgery with neck dissection were included and analyzed for incidence and predictive factors for incidence of level IB nodal and SMG involvement as per CAP guidelines. A total of 60 patients were inducted in the study, wherein 63 neck dissections were performed including bilateral dissection in three cases. There was involvement of ...
Source: Indian Journal of Surgical Oncology - August 18, 2021 Category: Cancer & Oncology Source Type: research
PO-1018 Dose Escalation in Advanced Floor of the Mouth Cancer Using a Combination of IMRT and SRT Boost
(Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - August 1, 2021 Category: Radiology Authors: T. Blazek Tags: Digital Poster: Head and neck Source Type: research
Decreased Global Interest in Oral Cancer During the COVID-19 Pandemic
CONCLUSION: Higher-income countries tend to be more interested in seeking information about oral cancer. Noteworthy decline in the interest in seeking information online for oral cancer may have crucial implications during the COVID-19 pandemic. Google Trends offer an invaluable and inexpensive means for oral cancer surveillance and health-seeking behavior. <br />.PMID:34319034 | DOI:10.31557/APJCP.2021.22.7.2117 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - July 28, 2021 Category: Cancer & Oncology Authors: Junhel Dalanon Yoshizo Matsuka Source Type: research
