1,3-thiazole Derivatives: A Scaffold with Considerable Potential in the Treatment of Neurodegenerative Diseases
Curr Top Med Chem. 2023 Jul 19. doi: 10.2174/1568026623666230719124850. Online ahead of print.ABSTRACT1,3-thiazoles, which contain nitrogen and a sulfur atom is an unsaturated five-membered heterocyclic ring, have achieved a unique significant place in drug design and development because of their versatile structure and a variety of pharmacological activities, viz. anticancer, antiviral, antimicrobial, anticonvulsant, antioxidant, antidiabetic, etc. They have inspired researchers to design novel thiazole with different biological activities. The presence of the thiazole moiety has resulted in a large number of clinically u...
Source: Current Topics in Medicinal Chemistry - July 20, 2023 Category: Chemistry Authors: Jasmine Chaudhary Akash Jain Ashwani Dhingra Bhawna Chopra Vishal Sharma Jatin Gupta Aditi Kaushik Source Type: research
1,3-thiazole Derivatives: A Scaffold with Considerable Potential in the Treatment of Neurodegenerative Diseases
Curr Top Med Chem. 2023 Jul 19. doi: 10.2174/1568026623666230719124850. Online ahead of print.ABSTRACT1,3-thiazoles, which contain nitrogen and a sulfur atom is an unsaturated five-membered heterocyclic ring, have achieved a unique significant place in drug design and development because of their versatile structure and a variety of pharmacological activities, viz. anticancer, antiviral, antimicrobial, anticonvulsant, antioxidant, antidiabetic, etc. They have inspired researchers to design novel thiazole with different biological activities. The presence of the thiazole moiety has resulted in a large number of clinically u...
Source: Current Topics in Medicinal Chemistry - July 20, 2023 Category: Chemistry Authors: Jasmine Chaudhary Akash Jain Ashwani Dhingra Bhawna Chopra Vishal Sharma Jatin Gupta Aditi Kaushik Source Type: research
1,3-thiazole Derivatives: A Scaffold with Considerable Potential in the Treatment of Neurodegenerative Diseases
Curr Top Med Chem. 2023 Jul 19. doi: 10.2174/1568026623666230719124850. Online ahead of print.ABSTRACT1,3-thiazoles, which contain nitrogen and a sulfur atom is an unsaturated five-membered heterocyclic ring, have achieved a unique significant place in drug design and development because of their versatile structure and a variety of pharmacological activities, viz. anticancer, antiviral, antimicrobial, anticonvulsant, antioxidant, antidiabetic, etc. They have inspired researchers to design novel thiazole with different biological activities. The presence of the thiazole moiety has resulted in a large number of clinically u...
Source: Current Topics in Medicinal Chemistry - July 20, 2023 Category: Chemistry Authors: Jasmine Chaudhary Akash Jain Ashwani Dhingra Bhawna Chopra Vishal Sharma Jatin Gupta Aditi Kaushik Source Type: research
1,3-thiazole Derivatives: A Scaffold with Considerable Potential in the Treatment of Neurodegenerative Diseases
Curr Top Med Chem. 2023 Jul 19. doi: 10.2174/1568026623666230719124850. Online ahead of print.ABSTRACT1,3-thiazoles, which contain nitrogen and a sulfur atom is an unsaturated five-membered heterocyclic ring, have achieved a unique significant place in drug design and development because of their versatile structure and a variety of pharmacological activities, viz. anticancer, antiviral, antimicrobial, anticonvulsant, antioxidant, antidiabetic, etc. They have inspired researchers to design novel thiazole with different biological activities. The presence of the thiazole moiety has resulted in a large number of clinically u...
Source: Current Topics in Medicinal Chemistry - July 20, 2023 Category: Chemistry Authors: Jasmine Chaudhary Akash Jain Ashwani Dhingra Bhawna Chopra Vishal Sharma Jatin Gupta Aditi Kaushik Source Type: research
1,3-thiazole Derivatives: A Scaffold with Considerable Potential in the Treatment of Neurodegenerative Diseases
Curr Top Med Chem. 2023 Jul 19. doi: 10.2174/1568026623666230719124850. Online ahead of print.ABSTRACT1,3-thiazoles, which contain nitrogen and a sulfur atom is an unsaturated five-membered heterocyclic ring, have achieved a unique significant place in drug design and development because of their versatile structure and a variety of pharmacological activities, viz. anticancer, antiviral, antimicrobial, anticonvulsant, antioxidant, antidiabetic, etc. They have inspired researchers to design novel thiazole with different biological activities. The presence of the thiazole moiety has resulted in a large number of clinically u...
Source: Current Topics in Medicinal Chemistry - July 20, 2023 Category: Chemistry Authors: Jasmine Chaudhary Akash Jain Ashwani Dhingra Bhawna Chopra Vishal Sharma Jatin Gupta Aditi Kaushik Source Type: research
1,3-thiazole Derivatives: A Scaffold with Considerable Potential in the Treatment of Neurodegenerative Diseases
Curr Top Med Chem. 2023 Jul 19. doi: 10.2174/1568026623666230719124850. Online ahead of print.ABSTRACT1,3-thiazoles, which contain nitrogen and a sulfur atom is an unsaturated five-membered heterocyclic ring, have achieved a unique significant place in drug design and development because of their versatile structure and a variety of pharmacological activities, viz. anticancer, antiviral, antimicrobial, anticonvulsant, antioxidant, antidiabetic, etc. They have inspired researchers to design novel thiazole with different biological activities. The presence of the thiazole moiety has resulted in a large number of clinically u...
Source: Current Topics in Medicinal Chemistry - July 20, 2023 Category: Chemistry Authors: Jasmine Chaudhary Akash Jain Ashwani Dhingra Bhawna Chopra Vishal Sharma Jatin Gupta Aditi Kaushik Source Type: research
Molecules, Vol. 28, Pages 5479: Synthesis, Biological, Spectroscopic and Computational Investigations of Novel N-Acylhydrazone Derivatives of Pyrrolo[3,4-d]pyridazinone as Dual COX/LOX Inhibitors
ukasz Szczukowski
Secure and efficient treatment of diverse pain and inflammatory disorders is continually challenging. Although NSAIDs and other painkillers are well-known and commonly available, they are sometimes insufficient and can cause dangerous adverse effects. As yet reported, derivatives of pyrrolo[3,4-d]pyridazinone are potent COX-2 inhibitors with a COX-2/COX-1 selectivity index better than meloxicam. Considering that N-acylhydrazone (NAH) moiety is a privileged structure occurring in many promising drug candidates, we decided to introduce this pharmacophore into new series of pyrrolo[3,4-d]pyridazinone der...
Source: Molecules - July 18, 2023 Category: Chemistry Authors: Jakub Mikus Piotr Świątek Patrycja Przyby ła Edward Krzy żak Aleksandra Marciniak Aleksadra Kotynia Aleksandra Redzicka Benita Wiatrak Paulina Jawie ń Tomasz G ębarowski Łukasz Szczukowski Tags: Article Source Type: research
Meloxicam emulgel potently suppressed cartilage degradation in knee osteoarthritis: Optimization, formulation, industrial scalability and pharmacodynamic analysis
CONCLUSION: MLX-emulgel may be a potential candidate for translating in to a clinically viable dosage form in the management of knee OA.PMID:37348266 | DOI:10.1016/j.colsurfb.2023.113399 (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - June 22, 2023 Category: Biotechnology Authors: Vaskuri Gs Sainaga Jyothi Harithasree Veerabomma Rahul Kumar Dharmendra Kumar Khatri Shashi Bala Singh Jitender Madan Source Type: research
Meloxicam emulgel potently suppressed cartilage degradation in knee osteoarthritis: Optimization, formulation, industrial scalability and pharmacodynamic analysis
CONCLUSION: MLX-emulgel may be a potential candidate for translating in to a clinically viable dosage form in the management of knee OA.PMID:37348266 | DOI:10.1016/j.colsurfb.2023.113399 (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - June 22, 2023 Category: Biotechnology Authors: Vaskuri Gs Sainaga Jyothi Harithasree Veerabomma Rahul Kumar Dharmendra Kumar Khatri Shashi Bala Singh Jitender Madan Source Type: research
Meloxicam emulgel potently suppressed cartilage degradation in knee osteoarthritis: Optimization, formulation, industrial scalability and pharmacodynamic analysis
CONCLUSION: MLX-emulgel may be a potential candidate for translating in to a clinically viable dosage form in the management of knee OA.PMID:37348266 | DOI:10.1016/j.colsurfb.2023.113399 (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - June 22, 2023 Category: Biotechnology Authors: Vaskuri Gs Sainaga Jyothi Harithasree Veerabomma Rahul Kumar Dharmendra Kumar Khatri Shashi Bala Singh Jitender Madan Source Type: research
Production and certification of BOTS-1: bovine muscle-certified reference material for incurred veterinary drug residues
Anal Bioanal Chem. 2023 Jun 16. doi: 10.1007/s00216-023-04794-5. Online ahead of print.ABSTRACTA freeze-dried bovine muscle-certified reference material (CRM), known as BOTS-1 (DOI: https://doi.org/10.4224/crm.2018.bots-1 ), containing incurred residues of commonly used veterinary drugs was produced and certified for the mass fraction of eight veterinary drug residues. Value assignment was carried out using liquid chromatography tandem mass spectrometry (LC-MS/MS) methods in conjunction with isotope dilution and standard addition approaches involving stable isotope internal standards. Data from the National Research Counci...
Source: Analytical and Bioanalytical Chemistry - June 16, 2023 Category: Chemistry Authors: Garnet McRae Donald M Leek Juris Meija Bryn Shurmer Steven J Lehotay Joachim Polzer Jeremy E Melanson Zoltan Mester Source Type: research
Production and certification of BOTS-1: bovine muscle-certified reference material for incurred veterinary drug residues
Anal Bioanal Chem. 2023 Jun 16. doi: 10.1007/s00216-023-04794-5. Online ahead of print.ABSTRACTA freeze-dried bovine muscle-certified reference material (CRM), known as BOTS-1 (DOI: https://doi.org/10.4224/crm.2018.bots-1 ), containing incurred residues of commonly used veterinary drugs was produced and certified for the mass fraction of eight veterinary drug residues. Value assignment was carried out using liquid chromatography tandem mass spectrometry (LC-MS/MS) methods in conjunction with isotope dilution and standard addition approaches involving stable isotope internal standards. Data from the National Research Counci...
Source: Analytical and Bioanalytical Chemistry - June 16, 2023 Category: Chemistry Authors: Garnet McRae Donald M Leek Juris Meija Bryn Shurmer Steven J Lehotay Joachim Polzer Jeremy E Melanson Zoltan Mester Source Type: research
A142 Bupivacaine/Meloxicam Extended-Release Solution versus Bupivacaine HCl solution on Postoperative Opioid Usage in Laparoscopic Sleeve Gastrectomy: A Prospective Comparative Study
Yannis Raftopoulos Holyoke MA1, Shruthi Rajkumar Holyoke MA1, Elana Davidson Holyoke MA1, Michael Bell Holyoke MA1 (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - June 1, 2023 Category: Surgery Source Type: research
Molecules, Vol. 28, Pages 4099: Preparation and In Vitro and In Vivo Evaluation of Rectal In Situ Gel of Meloxicam Hydroxypropyl- & beta;-cyclodextrin Inclusion Complex
This study suggests that the MLX/HP-β-CD-ISG can have a wide application prospect with superior therapeutic benefits. (Source: Molecules)
Source: Molecules - May 15, 2023 Category: Chemistry Authors: Xiaomeng Lei Guansheng Zhang Tao Yang Yuhuan Wu Ying Peng Tiantian Wang Dongxun Li Qian Liu Canjian Wang Guosong Zhang Tags: Article Source Type: research
