Importance of Considering Fed-State Gastrointestinal Physiology in Predicting the Reabsorption of Enterohepatic Circulation of Drugs
ConclusionFor drugs which undergo EHC and can be solubilized by bile micelles, compensating for the permeation rate constant in the reabsorption process based on the free fraction ratio appears an important factor in increasing the accuracy of PK profile prediction. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 12, 2024 Category: Drugs & Pharmacology Source Type: research
Drug-induced liver injury (DILI) ascribed to non-steroidal anti-inflammatory drugs (NSAIDs) in the USA-Update with genetic correlations
CONCLUSIONS: Despite prevalent use, NSAID-DILI is infrequent in the United States. Diclofenac is the most commonly implicated, and adherence to warnings of risk and close observation are recommended. The increased frequency of HLA-B*35:03 and DRB1*04:03, driven by diclofenac, suggests the importance of immune-mediated responses.PMID:38451034 | DOI:10.1111/liv.15892 (Source: Cancer Control)
Source: Cancer Control - March 7, 2024 Category: Cancer & Oncology Authors: Herbert L Bonkovsky Marwan Ghabril Paola Nicoletti Andrew Dellinger Robert J Fontana Huiman Barnhart Jiezhun Gu Ann K Daly Guruprasad P Aithal Elizabeth J Phillips David E Kleiner US DILIN Investigators Source Type: research
Nanoformulated meloxicam and rifampin: inhibiting quorum sensing and biofilm formation in Pseudomonas aeruginosa
Nanomedicine, Ahead of Print. (Source: Future Medicine: Nanomedicine)
Source: Future Medicine: Nanomedicine - February 13, 2024 Category: Nanotechnology Authors: Malihe Khorramdel Fatemeh Peyravii Ghadikolaii Seyed Isaac Hashemy Hossein Javid Masoud Homayouni Tabrizi Source Type: research
Nanoformulated meloxicam and rifampin: inhibiting quorum sensing and biofilm formation in Pseudomonas aeruginosa
Nanomedicine, Ahead of Print. (Source: Nanomedicine)
Source: Nanomedicine - February 13, 2024 Category: Nanotechnology Authors: Malihe Khorramdel Fatemeh Peyravii Ghadikolaii Seyed Isaac Hashemy Hossein Javid Masoud Homayouni Tabrizi Source Type: research
Tumor Homing Chimeric Peptide Rhomboids to Improve Photodynamic Performance by Inhibiting Therapy ‐Upregulated Cyclooxygenase‐2
Tumor homing chimeric peptide rhomboids (designated as NP-Mel) are developed to promote the targeting delivery of drugs to breast cancer overexpressing neuropilin receptors (NRPs). NP-Mel decrease the secretion of prostaglandin E2 (PGE2) after photodynamic therapy (PDT), inducing the downregulation of pro-inflammatory cytokines to reverse PDT induced inflammation for enhanced breast cancer treatment. AbstractNegative therapeutic feedback of inflammation would extensively attenuate the antitumor effect of photodynamic therapy (PDT). In this work, tumor homing chimeric peptide rhomboids (designated as NP-Mel) are fabricated ...
Source: Small - February 12, 2024 Category: Nanotechnology Authors: Wei Zhang,
Bai ‐Xue Yu,
Xia‐Yun Chen,
Meng‐Yi Yan,
Qian‐Qian Liu,
Yi‐Bin Liu,
Ni Yang,
Hua Cai,
Ni Yan,
Ren‐Jiang Kong,
Hong Cheng,
Shi‐Ying Li,
A‐Li Chen Tags: Research Article Source Type: research
Repurposing of non-steroidal anti-inflammatory drugs for combination therapies to combat multidrug-resistant S. aureus of bovine reproductive tract origin
In conclusion, MDRS. aureus resistance was mitigatedin-vitro through the combination of antibiotics (oxytetracycline, gentamicin) with NSAIDs (meloxicam, ketoprofen) that could be used to create therapeutic strategies for bovine reproductive issues. (Source: Veterinary Research Communications)
Source: Veterinary Research Communications - February 12, 2024 Category: Veterinary Research Source Type: research
Preemptive use of anti-inflammatories and analgesics in oral surgery: a review of systematic reviews
Conclusion: Further randomized clinical trials should be conducted to confirm these findings, given the wide variety of drugs, doses, and routes of administration used. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 24, 2024 Category: Drugs & Pharmacology Source Type: research
Refinement of the motorised laminectomy-assisted rat spinal cord injury model by analgesic treatment
This study aimed to probe into the effects of some commonly used regimens with NSAIDs and opioids on well-being of the rats as well as on the functional outcome of the model. This eight-week study used forty-two female Wistar rats (Crl: WI), randomly and equally divided into 6 treatment groups, viz. I) tramadol (5mg/kg) and buprenorphine (0.05mg/kg); II) carprofen (5mg/kg) and buprenorphine (0.05m g/kg); III) carprofen (5mg/kg); IV) meloxicam (1mg/kg) and buprenorphine (0.05mg/kg); V) meloxicam (1mg/kg); and VI) no analgesia (0.5 ml sterile saline). Buprenorphine was administered twice daily whereas other treatments were g...
Source: PLoS One - January 16, 2024 Category: Biomedical Science Authors: Harikrishnan Vijayakumar Sreelatha Source Type: research
What Is the Role of a Periarticular Injection for Knee Arthroplasty Patients Receiving a Multimodal Analgesia Regimen Incorporating Adductor Canal and Infiltration Between the Popliteal Artery and Capsule of the Knee Blocks? A Randomized Blinded Placebo-Controlled Noninferiority Trial
CONCLUSIONS: For TKA patients given a comprehensive analgesic protocol, use of saline PAI did not demonstrate noninferiority compared to active PAI. Neither the primary nor any secondary outcomes demonstrated superiority for active PAI, however. As we cannot claim either technique to be better or worse, there remains flexibility for use of either technique.PMID:38190339 | DOI:10.1213/ANE.0000000000006805 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - January 8, 2024 Category: Anesthesiology Authors: Jacques T YaDeau Fred D Cushner Geoffrey Westrich Justas Lauzadis Richard L Kahn Yi Lin Enrique A Goytizolo David J Mayman Kethy M Jules-Elysee Ejiro Gbaje Douglas E Padgett Source Type: research
Phototoxic action of meloxicam contributes to dysregulation of redox homeostasis in normal human skin cells - Molecular and biochemical analysis of antioxidant enzymes in melanocytes and fibroblasts
In conclusion, MLX in combination with UVAR induces oxidative stress in melanocytes and fibroblasts, however, the analyses showed that the drug's effect the activity and expression of SOD, CAT and GPx differently, depending on the cell line. The observed dissimilarity between tested cell lines may result from the presence of melanin pigments.PMID:38036073 | DOI:10.1016/j.tiv.2023.105745 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - November 30, 2023 Category: Toxicology Authors: Marta Karkoszka Jakub Rok Justyna Kowalska Zuzanna Rzepka Klaudia Banach Dorota Wrze śniok Source Type: research
Phototoxic action of meloxicam contributes to dysregulation of redox homeostasis in normal human skin cells - Molecular and biochemical analysis of antioxidant enzymes in melanocytes and fibroblasts
In conclusion, MLX in combination with UVAR induces oxidative stress in melanocytes and fibroblasts, however, the analyses showed that the drug's effect the activity and expression of SOD, CAT and GPx differently, depending on the cell line. The observed dissimilarity between tested cell lines may result from the presence of melanin pigments.PMID:38036073 | DOI:10.1016/j.tiv.2023.105745 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - November 30, 2023 Category: Toxicology Authors: Marta Karkoszka Jakub Rok Justyna Kowalska Zuzanna Rzepka Klaudia Banach Dorota Wrze śniok Source Type: research
Computational quality-by-design strategy to validate high-performance liquid chromatography method for the estimation of meloxicam in bulk dosage forms and milk samples
In conclusion, the optimized and validated RP-HPLC method of meloxicam may further be used for the analysis of drug content in pharmaceutical dosage forms in addition to biological fluids.PMID:37882956 | DOI:10.1007/s44211-023-00448-9 (Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry)
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - October 26, 2023 Category: Chemistry Authors: Vaskuri G S Sainaga Jyothi Harithasree Veerabomma Chantibabu Katta Jitender Madan Source Type: research
Computational quality-by-design strategy to validate high-performance liquid chromatography method for the estimation of meloxicam in bulk dosage forms and milk samples
In conclusion, the optimized and validated RP-HPLC method of meloxicam may further be used for the analysis of drug content in pharmaceutical dosage forms in addition to biological fluids.PMID:37882956 | DOI:10.1007/s44211-023-00448-9 (Source: Anal Sci)
Source: Anal Sci - October 26, 2023 Category: Chemistry Authors: Vaskuri G S Sainaga Jyothi Harithasree Veerabomma Chantibabu Katta Jitender Madan Source Type: research
Computational quality-by-design strategy to validate high-performance liquid chromatography method for the estimation of meloxicam in bulk dosage forms and milk samples
In conclusion, the optimized and validated RP-HPLC method of meloxicam may further be used for the analysis of drug content in pharmaceutical dosage forms in addition to biological fluids.PMID:37882956 | DOI:10.1007/s44211-023-00448-9 (Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry)
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - October 26, 2023 Category: Chemistry Authors: Vaskuri G S Sainaga Jyothi Harithasree Veerabomma Chantibabu Katta Jitender Madan Source Type: research
Computational quality-by-design strategy to validate high-performance liquid chromatography method for the estimation of meloxicam in bulk dosage forms and milk samples
In conclusion, the optimized and validated RP-HPLC method of meloxicam may further be used for the analysis of drug content in pharmaceutical dosage forms in addition to biological fluids.PMID:37882956 | DOI:10.1007/s44211-023-00448-9 (Source: Anal Sci)
Source: Anal Sci - October 26, 2023 Category: Chemistry Authors: Vaskuri G S Sainaga Jyothi Harithasree Veerabomma Chantibabu Katta Jitender Madan Source Type: research
