Meloxicam loaded hydroxypropyl methylcellulose (HPMC) microparticulate: Fabrication, characterization and in vivo pharmacokinetic assessment
Pak J Pharm Sci. 2022 Jul;35(4(Special)):1251-1260.ABSTRACTMeloxicam (MEL) is an oxicam derivative with low water solubility that is useful in the treatment of colorectal cancer (CRC) as a COX-2 inhibitor. MEL-loaded HPMC micro particles were fabricated using an oil-in-oil (o/o) emulsion solvent evaporation (ESE) method. FTIR, XRD, particle size analysis, DSC, SEM and in vitro dissolution investigation were utilized to evaluate the produced micro particles physiochemically. Finally, rabbits were used as animal models in an in vivo pharmacokinetic study to assess the MEL concentration in the plasma of rabbits. Pure MEL, F1 ...
Source: Cancer Control - October 11, 2022 Category: Cancer & Oncology Authors: Syed Abdul Wasay Syed Umer Jan Muhammad Akhtar Rabbiya Ahmad Pervaiz Akhtar Shah Ghulam Razaque Shafi Muhammad Nisar Ahmad Shahwani Mohammad Younis Ghulam Mustafa Shahwani Jahangir Khan Achakzai Source Type: research
A novel long-acting local anesthetic - HTX-011 (ZYNRELEF ™) for postoperative pain control
Expert Rev Clin Pharmacol. 2022 Oct 5. doi: 10.1080/17512433.2022.2132227. Online ahead of print.ABSTRACTINTRODUCTION: Pain following most surgical procedures is expected. However, the treatment and management of postoperative surgical pain has remained challenging. The use of opioid therapy has increasingly become controversial given the limited therapeutic window of these drugs, the adverse side effects, and the potential for abuse. A multimodal approach to the treatment of postoperative pain has been shown to improve pain outcomes after surgery and improve patient satisfaction. Here, we examine a new formulation of bupi...
Source: Expert Review of Clinical Pharmacology - October 6, 2022 Category: Drugs & Pharmacology Authors: Ramanjot S Kang Zhaosheng Jin Tong J Gan Source Type: research
A novel long-acting local anesthetic - HTX-011 (ZYNRELEF ™) for postoperative pain control
Expert Rev Clin Pharmacol. 2022 Oct 5. doi: 10.1080/17512433.2022.2132227. Online ahead of print.ABSTRACTINTRODUCTION: Pain following most surgical procedures is expected. However, the treatment and management of postoperative surgical pain has remained challenging. The use of opioid therapy has increasingly become controversial given the limited therapeutic window of these drugs, the adverse side effects, and the potential for abuse. A multimodal approach to the treatment of postoperative pain has been shown to improve pain outcomes after surgery and improve patient satisfaction. Here, we examine a new formulation of bupi...
Source: Pharmacological Reviews - October 6, 2022 Category: Drugs & Pharmacology Authors: Ramanjot S Kang Zhaosheng Jin Tong J Gan Source Type: research
A novel long-acting local anesthetic - HTX-011 (ZYNRELEF ™) for postoperative pain control
Expert Rev Clin Pharmacol. 2022 Oct 5. doi: 10.1080/17512433.2022.2132227. Online ahead of print.ABSTRACTINTRODUCTION: Pain following most surgical procedures is expected. However, the treatment and management of postoperative surgical pain has remained challenging. The use of opioid therapy has increasingly become controversial given the limited therapeutic window of these drugs, the adverse side effects, and the potential for abuse. A multimodal approach to the treatment of postoperative pain has been shown to improve pain outcomes after surgery and improve patient satisfaction. Here, we examine a new formulation of bupi...
Source: Expert Review of Clinical Pharmacology - October 6, 2022 Category: Drugs & Pharmacology Authors: Ramanjot S Kang Zhaosheng Jin Tong J Gan Source Type: research
A novel long-acting local anesthetic - HTX-011 (ZYNRELEF ™) for postoperative pain control
Expert Rev Clin Pharmacol. 2022 Oct 5. doi: 10.1080/17512433.2022.2132227. Online ahead of print.ABSTRACTINTRODUCTION: Pain following most surgical procedures is expected. However, the treatment and management of postoperative surgical pain has remained challenging. The use of opioid therapy has increasingly become controversial given the limited therapeutic window of these drugs, the adverse side effects, and the potential for abuse. A multimodal approach to the treatment of postoperative pain has been shown to improve pain outcomes after surgery and improve patient satisfaction. Here, we examine a new formulation of bupi...
Source: Pharmacological Reviews - October 6, 2022 Category: Drugs & Pharmacology Authors: Ramanjot S Kang Zhaosheng Jin Tong J Gan Source Type: research
A novel long-acting local anesthetic - HTX-011 (ZYNRELEF ™) for postoperative pain control
Expert Rev Clin Pharmacol. 2022 Oct 5. doi: 10.1080/17512433.2022.2132227. Online ahead of print.ABSTRACTINTRODUCTION: Pain following most surgical procedures is expected. However, the treatment and management of postoperative surgical pain has remained challenging. The use of opioid therapy has increasingly become controversial given the limited therapeutic window of these drugs, the adverse side effects, and the potential for abuse. A multimodal approach to the treatment of postoperative pain has been shown to improve pain outcomes after surgery and improve patient satisfaction. Here, we examine a new formulation of bupi...
Source: Expert Review of Clinical Pharmacology - October 6, 2022 Category: Drugs & Pharmacology Authors: Ramanjot S Kang Zhaosheng Jin Tong J Gan Source Type: research
Optimization of Meloxicam Solid Dispersion Formulations for Dissolution Enhancement and Storage Stability Using 3 < sup > 3 < /sup > Full Factorial Design Based on Response Surface Methodology
This study aimed to formulate and optimize solid-dispersion of meloxicam (MX) employing response-surface-methodology (RSM). RSM allowed identification of the main effects and interactions between studied factors on MX dissolution and acceleration of the optimization process. 33 full factorial design with 27 different formulations was proposed. Effects of drug loading percentage (A), carriers' ratio (B), method of preparation (C), and their interactions on percent MX dissolved after 10 and 30 min (Q10min & Q30min) from fresh and stored samples were studied in distilled water. The considered levels were 2.5%, 5.0%, and 7...
Source: AAPS PharmSciTech - September 2, 2022 Category: Drugs & Pharmacology Authors: Maha F Emam Ahmed A El-Ashmawy Nadia M Mursi Laila H Emara Source Type: research
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years
Paediatr Drugs. 2022 Sep 2. doi: 10.1007/s40272-022-00514-1. Online ahead of print.ABSTRACTNon-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in infants, children, and adolescents worldwide; however, despite sufficient evidence of the beneficial effects of NSAIDs in children and adolescents, there is a lack of comprehensive data in infants. The present review summarizes the current knowledge on the safety and efficacy of various NSAIDs used in infants for which data are available, and includes ibuprofen, dexibuprofen, ketoprofen, flurbiprofen, naproxen, diclofenac, ketorolac, indomethacin, niflumic acid, melo...
Source: Paediatric Drugs - September 2, 2022 Category: Pediatrics Authors: Victoria C Ziesenitz Tatjana Welzel Madel é van Dyk Patrick Saur Matthias Gorenflo Johannes N van den Anker Source Type: research
Optimization of Meloxicam Solid Dispersion Formulations for Dissolution Enhancement and Storage Stability Using 3 < sup > 3 < /sup > Full Factorial Design Based on Response Surface Methodology
This study aimed to formulate and optimize solid-dispersion of meloxicam (MX) employing response-surface-methodology (RSM). RSM allowed identification of the main effects and interactions between studied factors on MX dissolution and acceleration of the optimization process. 33 full factorial design with 27 different formulations was proposed. Effects of drug loading percentage (A), carriers' ratio (B), method of preparation (C), and their interactions on percent MX dissolved after 10 and 30 min (Q10min & Q30min) from fresh and stored samples were studied in distilled water. The considered levels were 2.5%, 5.0%, and 7...
Source: AAPS PharmSciTech - September 2, 2022 Category: Drugs & Pharmacology Authors: Maha F Emam Ahmed A El-Ashmawy Nadia M Mursi Laila H Emara Source Type: research
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years
Paediatr Drugs. 2022 Sep 2. doi: 10.1007/s40272-022-00514-1. Online ahead of print.ABSTRACTNon-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in infants, children, and adolescents worldwide; however, despite sufficient evidence of the beneficial effects of NSAIDs in children and adolescents, there is a lack of comprehensive data in infants. The present review summarizes the current knowledge on the safety and efficacy of various NSAIDs used in infants for which data are available, and includes ibuprofen, dexibuprofen, ketoprofen, flurbiprofen, naproxen, diclofenac, ketorolac, indomethacin, niflumic acid, melo...
Source: Paediatric Drugs - September 2, 2022 Category: Pediatrics Authors: Victoria C Ziesenitz Tatjana Welzel Madel é van Dyk Patrick Saur Matthias Gorenflo Johannes N van den Anker Source Type: research
Optimization of Meloxicam Solid Dispersion Formulations for Dissolution Enhancement and Storage Stability Using 3 < sup > 3 < /sup > Full Factorial Design Based on Response Surface Methodology
This study aimed to formulate and optimize solid-dispersion of meloxicam (MX) employing response-surface-methodology (RSM). RSM allowed identification of the main effects and interactions between studied factors on MX dissolution and acceleration of the optimization process. 33 full factorial design with 27 different formulations was proposed. Effects of drug loading percentage (A), carriers' ratio (B), method of preparation (C), and their interactions on percent MX dissolved after 10 and 30 min (Q10min & Q30min) from fresh and stored samples were studied in distilled water. The considered levels were 2.5%, 5.0%, and 7...
Source: AAPS PharmSciTech - September 2, 2022 Category: Drugs & Pharmacology Authors: Maha F Emam Ahmed A El-Ashmawy Nadia M Mursi Laila H Emara Source Type: research
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years
Paediatr Drugs. 2022 Sep 2. doi: 10.1007/s40272-022-00514-1. Online ahead of print.ABSTRACTNon-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in infants, children, and adolescents worldwide; however, despite sufficient evidence of the beneficial effects of NSAIDs in children and adolescents, there is a lack of comprehensive data in infants. The present review summarizes the current knowledge on the safety and efficacy of various NSAIDs used in infants for which data are available, and includes ibuprofen, dexibuprofen, ketoprofen, flurbiprofen, naproxen, diclofenac, ketorolac, indomethacin, niflumic acid, melo...
Source: Paediatric Drugs - September 2, 2022 Category: Pediatrics Authors: Victoria C Ziesenitz Tatjana Welzel Madel é van Dyk Patrick Saur Matthias Gorenflo Johannes N van den Anker Source Type: research
Optimization of Meloxicam Solid Dispersion Formulations for Dissolution Enhancement and Storage Stability Using 3 < sup > 3 < /sup > Full Factorial Design Based on Response Surface Methodology
This study aimed to formulate and optimize solid-dispersion of meloxicam (MX) employing response-surface-methodology (RSM). RSM allowed identification of the main effects and interactions between studied factors on MX dissolution and acceleration of the optimization process. 33 full factorial design with 27 different formulations was proposed. Effects of drug loading percentage (A), carriers' ratio (B), method of preparation (C), and their interactions on percent MX dissolved after 10 and 30 min (Q10min & Q30min) from fresh and stored samples were studied in distilled water. The considered levels were 2.5%, 5.0%, and 7...
Source: AAPS PharmSciTech - September 2, 2022 Category: Drugs & Pharmacology Authors: Maha F Emam Ahmed A El-Ashmawy Nadia M Mursi Laila H Emara Source Type: research
