A multiple-session mesotherapy protocol for the management of hip osteoarthritis in police working dogs
Am J Vet Res. 2022 Nov 16:1-8. doi: 10.2460/ajvr.22.08.0132. Online ahead of print.ABSTRACTOBJECTIVE: To describe the effect of a mesotherapy protocol in dogs with osteoarthritis.ANIMALS: 30 dogs.PROCEDURES: Dogs were randomly assigned to a control (CG; n = 10) or a mesotherapy group (MG; 20). CG received meloxicam for 70 days. MG was treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in intradermal points. Seven treatment sessions were conducted. Response to treatment was measured with different instruments: the Canine Brief Pain Inventory (divided into Pain Interference Score [PIS] and Pai...
Source: American Journal of Veterinary Research - November 11, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge P Lafuente Source Type: research

A multiple-session mesotherapy protocol for the management of hip osteoarthritis in police working dogs
Am J Vet Res. 2022 Nov 16:1-8. doi: 10.2460/ajvr.22.08.0132. Online ahead of print.ABSTRACTOBJECTIVE: To describe the effect of a mesotherapy protocol in dogs with osteoarthritis.ANIMALS: 30 dogs.PROCEDURES: Dogs were randomly assigned to a control (CG; n = 10) or a mesotherapy group (MG; 20). CG received meloxicam for 70 days. MG was treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in intradermal points. Seven treatment sessions were conducted. Response to treatment was measured with different instruments: the Canine Brief Pain Inventory (divided into Pain Interference Score [PIS] and Pai...
Source: American Journal of Veterinary Research - November 11, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge P Lafuente Source Type: research

A multiple-session mesotherapy protocol for the management of hip osteoarthritis in police working dogs
Am J Vet Res. 2022 Nov 16:1-8. doi: 10.2460/ajvr.22.08.0132. Online ahead of print.ABSTRACTOBJECTIVE: To describe the effect of a mesotherapy protocol in dogs with osteoarthritis.ANIMALS: 30 dogs.PROCEDURES: Dogs were randomly assigned to a control (CG; n = 10) or a mesotherapy group (MG; 20). CG received meloxicam for 70 days. MG was treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in intradermal points. Seven treatment sessions were conducted. Response to treatment was measured with different instruments: the Canine Brief Pain Inventory (divided into Pain Interference Score [PIS] and Pai...
Source: American Journal of Veterinary Research - November 11, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge P Lafuente Source Type: research

A multiple-session mesotherapy protocol for the management of hip osteoarthritis in police working dogs
Am J Vet Res. 2022 Nov 16:1-8. doi: 10.2460/ajvr.22.08.0132. Online ahead of print.ABSTRACTOBJECTIVE: To describe the effect of a mesotherapy protocol in dogs with osteoarthritis.ANIMALS: 30 dogs.PROCEDURES: Dogs were randomly assigned to a control (CG; n = 10) or a mesotherapy group (MG; 20). CG received meloxicam for 70 days. MG was treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in intradermal points. Seven treatment sessions were conducted. Response to treatment was measured with different instruments: the Canine Brief Pain Inventory (divided into Pain Interference Score [PIS] and Pai...
Source: American Journal of Veterinary Research - November 11, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge P Lafuente Source Type: research

A multiple-session mesotherapy protocol for the management of hip osteoarthritis in police working dogs
Am J Vet Res. 2022 Nov 16:1-8. doi: 10.2460/ajvr.22.08.0132. Online ahead of print.ABSTRACTOBJECTIVE: To describe the effect of a mesotherapy protocol in dogs with osteoarthritis.ANIMALS: 30 dogs.PROCEDURES: Dogs were randomly assigned to a control (CG; n = 10) or a mesotherapy group (MG; 20). CG received meloxicam for 70 days. MG was treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in intradermal points. Seven treatment sessions were conducted. Response to treatment was measured with different instruments: the Canine Brief Pain Inventory (divided into Pain Interference Score [PIS] and Pai...
Source: American Journal of Veterinary Research - November 11, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge P Lafuente Source Type: research

A multiple-session mesotherapy protocol for the management of hip osteoarthritis in police working dogs
Am J Vet Res. 2022 Nov 16:1-8. doi: 10.2460/ajvr.22.08.0132. Online ahead of print.ABSTRACTOBJECTIVE: To describe the effect of a mesotherapy protocol in dogs with osteoarthritis.ANIMALS: 30 dogs.PROCEDURES: Dogs were randomly assigned to a control (CG; n = 10) or a mesotherapy group (MG; 20). CG received meloxicam for 70 days. MG was treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in intradermal points. Seven treatment sessions were conducted. Response to treatment was measured with different instruments: the Canine Brief Pain Inventory (divided into Pain Interference Score [PIS] and Pai...
Source: American Journal of Veterinary Research - November 11, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge P Lafuente Source Type: research

A multiple-session mesotherapy protocol for the management of hip osteoarthritis in police working dogs
Am J Vet Res. 2022 Nov 16:1-8. doi: 10.2460/ajvr.22.08.0132. Online ahead of print.ABSTRACTOBJECTIVE: To describe the effect of a mesotherapy protocol in dogs with osteoarthritis.ANIMALS: 30 dogs.PROCEDURES: Dogs were randomly assigned to a control (CG; n = 10) or a mesotherapy group (MG; 20). CG received meloxicam for 70 days. MG was treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in intradermal points. Seven treatment sessions were conducted. Response to treatment was measured with different instruments: the Canine Brief Pain Inventory (divided into Pain Interference Score [PIS] and Pai...
Source: American Journal of Veterinary Research - November 11, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge P Lafuente Source Type: research

A multiple-session mesotherapy protocol for the management of hip osteoarthritis in police working dogs
Am J Vet Res. 2022 Nov 16:1-8. doi: 10.2460/ajvr.22.08.0132. Online ahead of print.ABSTRACTOBJECTIVE: To describe the effect of a mesotherapy protocol in dogs with osteoarthritis.ANIMALS: 30 dogs.PROCEDURES: Dogs were randomly assigned to a control (CG; n = 10) or a mesotherapy group (MG; 20). CG received meloxicam for 70 days. MG was treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in intradermal points. Seven treatment sessions were conducted. Response to treatment was measured with different instruments: the Canine Brief Pain Inventory (divided into Pain Interference Score [PIS] and Pai...
Source: American Journal of Veterinary Research - November 11, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge P Lafuente Source Type: research

A multiple-session mesotherapy protocol for the management of hip osteoarthritis in police working dogs
Am J Vet Res. 2022 Nov 16:1-8. doi: 10.2460/ajvr.22.08.0132. Online ahead of print.ABSTRACTOBJECTIVE: To describe the effect of a mesotherapy protocol in dogs with osteoarthritis.ANIMALS: 30 dogs.PROCEDURES: Dogs were randomly assigned to a control (CG; n = 10) or a mesotherapy group (MG; 20). CG received meloxicam for 70 days. MG was treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in intradermal points. Seven treatment sessions were conducted. Response to treatment was measured with different instruments: the Canine Brief Pain Inventory (divided into Pain Interference Score [PIS] and Pai...
Source: American Journal of Veterinary Research - November 11, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge P Lafuente Source Type: research

A multiple-session mesotherapy protocol for the management of hip osteoarthritis in police working dogs
Am J Vet Res. 2022 Nov 16:1-8. doi: 10.2460/ajvr.22.08.0132. Online ahead of print.ABSTRACTOBJECTIVE: To describe the effect of a mesotherapy protocol in dogs with osteoarthritis.ANIMALS: 30 dogs.PROCEDURES: Dogs were randomly assigned to a control (CG; n = 10) or a mesotherapy group (MG; 20). CG received meloxicam for 70 days. MG was treated with a combination of lidocaine, piroxicam, and thiocolchicoside, injected in intradermal points. Seven treatment sessions were conducted. Response to treatment was measured with different instruments: the Canine Brief Pain Inventory (divided into Pain Interference Score [PIS] and Pai...
Source: American Journal of Veterinary Research - November 11, 2022 Category: Veterinary Research Authors: Jo ão C Alves Ana Santos Patr ícia Jorge P Lafuente Source Type: research

Molecules, Vol. 27, Pages 7312: Chitosan Encapsulated Meloxicam Nanoparticles for Sustained Drug Delivery Applications: Preparation, Characterization and Pharmacokinetics in Wistar Rats
Prasad Ubaradka Meloxicam (MLX) is currently used in the therapeutic management of both acute and chronic inflammatory disorders such as pain, injuries, osteoarthritis, and rheumatoid arthritis in both humans and animals. Gastrointestinal toxicity and occasional renal toxicity were observed in patients taking it for a long-term period. Meloxicam’s late attainment of peak plasma concentration results in a slow onset of action. The goal of the current study was to prepare and characterize chitosan encapsulated meloxicam nanoparticles (CEMNPs) with high bioavailability and less gastro intestinal toxicit...
Source: Molecules - October 27, 2022 Category: Chemistry Authors: Yegireddy Nadoor Rao Hanumanthu Rajashekaraiah Ramachandrappa Halemani Mannem Prasad Ubaradka Tags: Article Source Type: research

[ASAP] Pharmaceutical Salts of Piroxicam and Meloxicam with Organic Counterions
Crystal Growth& DesignDOI: 10.1021/acs.cgd.2c00722 (Source: Crystal Growth and Design)
Source: Crystal Growth and Design - October 21, 2022 Category: Chemistry Authors: Shan Huang, Dean S. Venables, and Simon E. Lawrence Source Type: research

Evaluation of topical oclacitinib and nail trimming as a treatment for murine ulcerative dermatitis in laboratory mice
by Steven E. Davison, Kathryn M. Emmer, Beatrice Ugiliweneza, Leslie C. Sherwood Murine ulcerative dermatitis (UD) is a common, multifactorial skin disease of C57BL/6 and C57BL/6-background strains of mice. Many treatment options have been previously reported but have been variably successful and may interfere with specific research studies. Janus kinase (JAK) inhibitors, such as oclacitinib, have been used to treat allergic dermatitis in humans, dogs, and other species. Additionally, topical oclacitinib was shown to improve an induced model of dermatitis in mice. We hypothesized that topical application of oclacitinib in...
Source: PLoS One - October 18, 2022 Category: Biomedical Science Authors: Steven E. Davison Source Type: research

Early perioperative versus postoperative meloxicam for pain control in patients undergoing orthopedic surgery: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: Short-term pain management after orthopaedic procedures is better accomplished with perioperative meloxicam than postoperative meloxicam. Before recommending perioperative meloxicam for pain control following orthopaedic surgeries, further multicentre trials are still warranted to examine the impact of perioperative meloxicam in different orthopaedic procedures.PMID:36245362 | DOI:10.1080/03007995.2022.2135837 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 17, 2022 Category: Research Authors: Abdelrahman Mahmoud Mohamed Abuelazm Ali Ashraf Salah Ahmed Mahmoud Elshinawy Toka Ashour Mohamed Abugdida Basel Abdelazeem Source Type: research