Inflammatory Proteins in Extracellular Vesicles Correlate with Mortality
Here, researchers demonstrate that inflammatory proteins found in extracellular vesicles, used by cells to communicate, are correlated with mortality risk. This is not a surprising result, as the signaling associated with chronic inflammation causes disruption of normal tissue function and cell behavior in many ways. It is an important contributing factor in the progression of age-related degeneration, and the risk of suffering many of the common age-related conditions is strongly correlated with the burden of chronic inflammation. Aiming to minimize age-related inflammation without disrupting immune function is a notewort...
Source: Fight Aging! - September 6, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Arguing for an Expansion of the Hallmarks of Aging
The hallmarks of aging form a catalog of largely better studied changes in cells and tissues considered relevant, and possibly more important, in the onset and development of age-related degeneration and disease. This is not the same thing as a list of causes of aging. A few of the hallmarks mostly likely are or include deeper causes of aging, or close to causes of aging. The hallmarks do overlap with the SENS description of aging as a set of root causes, forms of molecular damage that result from the normal operation of a youthful metabolism. Since the hallmarks of aging are not, and are not intended to be a list of cause...
Source: Fight Aging! - September 5, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fat Tissue Changes With Age to Become Less Functional and More Harmful
People bearing more visceral fat are less healthy as a rule, due to its contribution to inflammation and burden of senescent cells, among other issues. Additionally, however, that fat tissue becomes more harmful with age, as there are changes in its function, as well as the function of other fat deposits in the body. The paper here looks at some of what is known of the functional decline in fat tissue with age.
Adipose tissue undergoes significant anatomical and functional changes with aging, leading to an increased risk of metabolic diseases. Age-related changes in adipose tissue include overall defective adipoge...
Source: Fight Aging! - September 5, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 5th 2022
Conclusion
Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome.
The most interesting part of the data is perhaps the decline in microbial diversity, when considered against the gains elsewhere. Microbial dive...
Source: Fight Aging! - September 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Short Tour of Scientific Thought on Vascular Aging
The aging of the vasculature, set aside from any other part of the body, arguably kills the largest fraction of humanity at the present time. It isn't just the dysfunctions of macrophages that lead to atherosclerotic plaque, and the narrowing of blood vessels and stroke and heart attack. It isn't just the declining density of capillary networks, reducing blood supply to energy-hungry tissues. It isn't just blood-brain barrier leakage and the consequent inflammation of the brain, or the stiffening of arteries that causes hypertension and remodeling of the heart. The vasculature is so vital that a great many mechanisms compe...
Source: Fight Aging! - August 31, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 29th 2022
This study demonstrates that adoptive astrocytic Mt transfer enhances neuronal Mn-SOD-mediated anti-oxidative defense and neuroplasticity in the brain, which potentiate functional recovery following ICH.
First Generation Stem Cell Therapies Remain Comparatively Poorly Understood
https://www.fightaging.org/archives/2022/08/first-generation-stem-cell-therapies-remain-comparatively-poorly-understood/
We are something like thirty years into the increasingly widespread use of first generation stem cell therapies. Cells are derived from a variety of sources, processed, and transplanted into patients. Near all...
Source: Fight Aging! - August 28, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MItochondrial Epigenetics in Aging and Cancer
Mitochondria, the power plants of the cell, are the descendants of ancient symbiotic bacteria, and still carry a remnant circular genome, separately from the DNA of the cell nucleus. Some forms of mutational damage to mitochondrial DNA, and the downstream consequences of that damage, are thought to be an important contributing cause of degenerative aging, but what about epigenetic changes? Epigenetic aging in nuclear DNA is a hot topic at the moment, so it is inevitable that attention would turn to the epigenetics of the much smaller mitochondrial genome.
Inflammation is a defining factor in disease progression; e...
Source: Fight Aging! - August 24, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 22nd 2022
In conclusion, application of a multi-species bat epigenetic clock provides strong evidence that hibernation is associated with slower epigenetic ageing. The multi-species clock explains 94% of the variation in the chronological ages of both hibernating and non-hibernating big brown bats; however, the clock estimates are equal to or greater than the chronological age, suggesting big brown bats age slightly faster than a 'typical' bat, especially during the active period. (Source: Fight Aging!)
Source: Fight Aging! - August 21, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Path to the Clinic for First Generation Senolytic Therapies
Senolytic therapies selectively destroy lingering senescent cells in old tissues, improving health as a result. Senescent cells, while never very large in absolute numbers, even in late life, actively maintain a degraded state of tissue and organ function via secretions that provoke chronic inflammation, detrimental alterations to the behavior of normal cells, and harmful remodeling of tissue structure, such as the development of fibrosis. A large number of animal studies have demonstrated rapid rejuvenation and reversal of aspects of specific age-related conditions to result from clearance of senescent cells. The best of ...
Source: Fight Aging! - August 18, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reviewing the Evidence for a Viral Contribution to Neurodegenerative Conditions
Are many of the common neurodegenerative conditions driven in their onset and progression by the consequences of persistent viral infection? The evidence is compelling, but not completely convincing at the present time. Given that these conditions are likely the result of a number of quite different, interacting mechanisms, including viral infection, vascular aging, immune system aging, mitochondrial dysfunction, and aggregation of toxic proteins, amongst others, it is a challenge to produce cut and dried data to show, definitively, the degree to which any one cause contributes. In the case of viral infection, there are st...
Source: Fight Aging! - August 18, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Small Trial of NMN Supplementation Shows Improved Muscle Function
Nicotinamide adenine dinucleotide (NAD) is central to mitochondrial function, but declines with age. Mitochondria are the power plants of the cell, producing chemical energy store molecules to power cellular processes. When mitochondria run down, everything suffers. Thus a great deal of attention has been given over the years to approaches that might help to boost mitochondrial function in old individuals: mitochondrially targeted antioxidants; increasing NAD levels; transplantation of mitochondria; copying mitochondrial genes into the nucleus to provide resistance against mitochondrial DNA damage. The small molecule appro...
Source: Fight Aging! - August 15, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 15th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - August 14, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Senesence, a Key Target in the Treatment of Aging
Scores of animal studies provide compelling evidence for cellular senescence to contribute meaningfully to many age-related conditions, and yet more such studies demonstrate rapid and sizable rejuvenation via targeted removal of senescent cells in old animals using varieties of senolytic therapy. Senescent cells are created constantly in the body, the result of cells reaching the Hayflick limit on replication, tissue injury, or encountering cellular damage or toxicity. When an individual is young, these newly senescent cells are near all removed by a combination of programmed cell death and the actions of the immune system...
Source: Fight Aging! - August 10, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Hypoxia, Inflammation, and Cellular Senescence
Researchers here review what is know of links between hypoxia and the onset of inflammation in age-related disease. Hypoxia in tissues can arise for a range of reasons in aging, and the processes of regulation that respond to localized hypoxia, primarily in order to induce regrowth of blood vessels to the affected region, may be meaningfully detrimental when consistently triggered. Inflammation is involved in this response, while chronic inflammation is a well-known feature of aging, driving numerous forms of tissue dysfunction.
When tissues are subjected to acute injury resulting in ischemia/hypoxia, cells adapt ...
Source: Fight Aging! - August 10, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Building a Better Spermadine to Improve Mitophagy
Researchers here report on their efforts to improve on the ability of spermadine to modestly slow aging in short-lived species, producing new derived molecules with larger effects on the cellular maintenance process of mitophagy. Mitophagy clears damaged and worn mitochondria, and is known to decline in effectiveness with age. A range of approaches that somewhat improve mitochondrial function, including mitochondrially targeted antioxidants such as mitoQ and compounds that raise NAD+ levels such as nicotinamide riboside, may produce their effects via boosted mitophagy.
The related publicity materials for this resear...
Source: Fight Aging! - August 8, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
