Arguing for Mitochondrial DNA Damage to Spread Between Neurons in Parkinson's Disease
The most noticeable symptoms of Parkinson's disease occur because of the loss of a small but vital population of dopamine-generating neurons in the brain. The condition is associated with the spread of misfolded, aggregated α-synuclein throughout brain tissue. α-synuclein is one of the few molecules in the body capable of misfolding in ways that encourage other molecules o α-synuclein to also misfold in the same way. It can thus spread from cell to cell, perhaps carried in extracellular vesicles. It is thought that misfolding of α-synuclein often first occurs in the intestines, and only then spreads to the brain throug...
Source: Fight Aging! - October 9, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Microglial Proliferation in Alzheimer's Model Mice
Microglia are innate immune cells of the central nervous system, analogous to macrophages elsewhere in the body. In addition to mounting a defense against pathogens and cleaning up metabolic waste, these cells are involved in maintenance of neural connections. Ever more attention is given of late to chronic inflammation in the aging of the brain, and microglia are known to become more active and inflammatory with advancing age, amplifying inflammatory signaling in ways that are disruptive to tissue function.
Some of this microglial inflammatory signaling is due to a growing fraction of senescent microglia, one facet...
Source: Fight Aging! - October 6, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What is Known of the Mechanisms of Age-Related Hearing Loss
Hearing loss is prevalent in older individuals, either involving the destruction of sensory hair cells in the inner ear, or the axonal connections between those hair cells and the brain, or both. Hair cells do not normally regenerate to any great degree in adults, which has led to efforts to grow patient matched replacement cells, or reprogram native cells to convince them to produce new hair cells. Despite promising advances, it is not as yet a solved problem.
Age-related hearing loss, or presbycusis, is a common cause of hearing loss in elderly people worldwide. It typically presents as progressive, irreversible...
Source: Fight Aging! - October 4, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Continued Study of Urolithin A to Improve Mitochondrial Function
Urolithin A is one of a number of compounds available as supplements that can improve mitochondrial function in older individuals. Like others, urolithin A may function by improving the mitochondrial quality control process of mitophagy, responsible for removing damaged and worn mitochondria. Mitophagy becomes less efficient with age, and this is one of the contributing factors to age-related loss of mitochondrial function and its harmful impact on tissues. Like other supplement based approaches to improving mitochondrial function, it is likely that regular exercise delivers larger gains than those demonstrated for supplem...
Source: Fight Aging! - October 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 2nd 2023
In conclusion, we identified several candidate genes that may confer cancer resistance in cetaceans, providing a new avenue for further research into the mechanisms of lifespan extension.
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A Relationship Between the Gut Microbiome and Bone Density
https://www.fightaging.org/archives/2023/09/a-relationship-between-the-gut-microbiome-and-bone-density/
Changes in the gut microbiome take place with advancing age, an increase in populations that provoke chronic inflammation, a reduction in the populations producing beneficial metabolites. Even only considering rising levels of in...
Source: Fight Aging! - October 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Microglia Harm the Brain via Lactate Generation
A sizable body of evidence supports a role for inflammatory microglia in the aging of the brain. Microglia are innate immune cells resident in the central nervous system, analogous to macrophages elsewhere in the body, but with an additional portfolio of duties relating to maintenance of the synapses that connect neurons. Most of the inflammatory microglia present in the aged brain are merely overactive, a maladaptive response to signs of damage and dysfunction characteristic of aging. This can include the presence of protein aggregates, unwanted molecules, cells, and bacteria passing through a leaking blood-brain barrier,...
Source: Fight Aging! - September 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
On the Importance of Controlling Inflammation to Treat Aging
Relevant to the goal of slowing or reversing aging, a broad panoply of evidence points to the need to control the chronic inflammation that is characteristic of aged tissues. Constant, unresolved inflammatory signaling actively disrupts tissue structure and function, changing cell behavior for the worse. It is likely the largest part of the way in which lingering senescent cells provide their contribution to the aging process, and many other forms of cellular dysfunction observed in aging can also generate inflammatory reactions. The contribution of senescent cells to the chronic inflammation of aging will likely be the ea...
Source: Fight Aging! - September 25, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 25th 2023
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls.
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Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug
https://www.fightaging.org/archives/2023/09/results-from-human-clinical-trials-do-not-support-metformin-as-a-longevity-drug/
The SENS Research Fou...
Source: Fight Aging! - September 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Selection of Mechanisms Relevant to Atherosclerosis
Atherosclerosis is the growth of fatty lesions in blood vessel walls, leading eventually to a rupture and blockage to cause a heart attack or stroke, and along the way causing narrowing of blood vessels sufficient to lead to heart failure and dysfunction elsewhere in the body as the supply of blood to tissues is reduced. Today's paper on this topic is a little disorganized, something of a random assembly of thoughts on mechanisms relevant to the development of atherosclerosis. Atherosclerosis is the single largest cause of human mortality, and attempts to treat contributing mechanisms have so far not stopped it from being ...
Source: Fight Aging! - September 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Synaptic Dysfunction Precedes the Death of Neurons in Parkinson's Disease
Parkinson's disease is characterized by the loss of dopamine-generating neurons, with the inflammatory pathology leading up to that issue thought to be driven by the spread of misfolded α-synuclein. Dysfunctional mitochondrial quality control can make these dopamine-generating neurons more vulnerable to the underlying pathology, however, and thus a fraction of Parkinson's disease arises in people with mutations that cause this sort of dysfunction. That has directed researchers towards mitochondrial function as an important factor in the progression of the condition, but it will probably turn out to be more useful to focus...
Source: Fight Aging! - September 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Epigenetics in Age-Related Mitochondrial Dysfunction
The hundreds of mitochondria present in every cell in the body undertake the essential duty of producing chemical energy store molecules, adenosine triphosphate (ATP), used to power the cell. With age, mitochondria become less efficient and more damaged, generating oxidative stress and triggering inflammation while producing less ATP than is optimal. This is thought to be a major contribution to degenerative aging, though as for all contributions to aging, it requires a highly targeted way to improve mitochondrial function in order to determine just how important it is. That highly targeted therapy doesn't yet exist in a u...
Source: Fight Aging! - September 15, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reviewing Evidence for Urolithin A Supplementation
Mitochondria are the power plants of the cell, responsible for generating chemical energy store molecules to power cell processes. Urolithin A is one of a number of supplements shown to improve mitochondrial function, though as for the others it isn't all that impressive when compared to the effects of regular exercise. Nonetheless, this and other approaches to modestly attenuate age-related declines in mitochondrial function are under active development. They are not solutions to the problem of mitochondrial aging, however. For that we must look to more radical approaches to therapy, such as mitochondrial transplantation,...
Source: Fight Aging! - September 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Urolithin A Supplementation Improves Mitochondrial Function and Hematopoiesis in Mice
A number of supplement-based approaches have been demonstrated to modestly improve mitochondrial function with age. This includes the various ways to increase NAD levels using vitamin B3 derivatives, mitochondrially targeted antioxidants such as SkQ1, MitoQ, and SS-31, and other compounds such as urolithin A for which the mechanism causing improved mitochondrial function is not as well determined. There is an argument to be made that all of these compounds work because they in some way improve the operation of mitophagy, a mitochondrial quality control mechanism that senses worn and damaged mitochondria, before directing t...
Source: Fight Aging! - September 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
