Fight Aging! Newsletter, May 15th 2023
In this study, we examined the average telomere length and telomerase activity, as well as the formation of telomere associated foci (TAFs) and the mRNA expression levels of the shelterin components in cultured primary cells of Spalax, a long-lived, hypoxia-tolerant, and cancer-resistant blind mole-rat species.
We showed that with cell passages, Spalax fibroblasts demonstrated significant shortening in telomere length, similar to rat cells, and in line with the processes observed earlier in tissues. We also demonstrated that the average telomere length in Spalax fibroblasts was significantly higher than the average ...
Source: Fight Aging! - May 14, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Knowing Both a Great Deal and Too Little About the Mechanisms of Sarcopenia
Today's open access paper is a tour of the better known mechanisms of post-translational modification of proteins, and their relevance to the universal age-related loss of muscle mass and strength, the onset of sarcopenia. It is a good example of the state of knowledge in much of the life sciences, where it is possible to know both a great deal and very little about an important topic such as maintenance of muscle tissue.
Thus one can find any number of papers in which specific mechanisms of post-translational modification when applied to specific proteins are investigated in connection to the regulation of muscle g...
Source: Fight Aging! - May 12, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Targeting Mitochondrial Oxidative Stress
Cells are each packed with hundreds of the organelles called mitochondria, the distant descendants of ancient symbiotic bacteria, constantly dividing, fusing, and passing around component parts. Mitochondria are the power plants of the cell, conducting energetic reactions to produce the chemical energy store molecule adenosine triphosphate. As a side-effect, these reactions produce a flux of oxidative molecules that can react with other cell components to damage them. This damage is constantly repaired in a healthy cell, and even acts as a hormetic signal under some circumstances. It is involved in the beneficial response ...
Source: Fight Aging! - May 10, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Inflammation and Oxidative Stress in Frailty and Metabolic Disease
Chronic inflammation and oxidative stress go hand in hand, both disruptive of tissue function and health. This is in part because mitochondrial dysfunction, which generates an increased amount of oxidative molecules, can provoke inflammation via the innate immune sensing of damage-associated molecular patterns, such as mislocated mitochondrial DNA fragments. Further, broad mitochondrial dysfunction can push a greater number of cells into a senescent state, in which they produce pro-inflammatory signaling. Other links also exist between these two harmful states.
Both frailty and metabolic syndromes lead to the foll...
Source: Fight Aging! - May 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What is Mitochondrial Cardiomyopathy?
Mitochondria have two genomes – mitochondrial and nuclear. Mitochondrial disease could be due to mutations of nuclear or mitochondrial DNA. Mitochondrial DNA is inherited maternally while nuclear DNA has Mendelian inheritance, which could be dominant or recessive [1]. It may be noted in about one in 5000 live births. Cardiac involvement in mitochondrial disease seldom occurs in isolation and is often part of multiorgan dysfunction [2]. Mitochondria being part of the cellular respiratory chain, tissues with high energy requirements like heart, muscle, kidneys and endocrine system are often involved in mitochondrial d...
Source: Cardiophile MD - May 9, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Mitochondrial Dysfunction as a Feature of Neurodegenerative Conditions
Increasing dysfunction of mitochondria, the power plants of the cell, is a feature of aging. It is also strongly connected to neurodegenerative conditions. The brain is an energy-hungry organ, and anything that interferes with the supply of nutrients and their processing to power cellular operations is going to cause issues. In this review paper, researchers discuss the link between mitochondrial dysfunction and neurodegeneration, and go on to note a few of the efforts underway to produce pharmacological treatments capable of restoring greater mitochondrial function in aged tissues. Sadly all too few of these treatments ca...
Source: Fight Aging! - May 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Inhibition of miR-141-3p Reduces Age-Related Inflammation, Improves Health
Researchers here demonstrate an approach to inhibiting miR-141-3p that leads to improved health in old mice following twelve weeks of treatment. It appears that this microRNA is involved in the at least the inflammatory signaling characteristic of old age, but potentially a range of other mechanisms as well, such as mitochondrial function, and tendency for cells to become senescent. Since every aspect of cellular biochemistry influences every other aspect, one can produce benefits in this way and still be left with an unclear understanding of exactly why the results are positive.
We previously demonstrated elevate...
Source: Fight Aging! - May 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 8th 2023
In conclusion, NAT mitigated age-associated cerebral injury in mice through gut-brain axis. The findings provide novel evidence for the effect of NAT on anti-aging, and highlight the potential application of NAT as an effective intervention against age-related diseases.
Retinal Cell Reprogramming Restores Vision in Non-Human Primate Study
https://www.fightaging.org/archives/2023/05/retinal-cell-reprogramming-restores-vision-in-non-human-primate-study/
Early applications of in vivo cellular reprogramming to medicine are cautiously focused on retinal regeneration. The eye is as close to an isolated system...
Source: Fight Aging! - May 7, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 1st 2023
In conclusion, frailty progression accelerates in males with one LTCs and females with two LTCs or more. Health providers should be aware of planning a suitable intervention once the elderly have two or more health conditions.
Plasma Transfer Lowers Epigenetic Age and Mortality in Rats
https://www.fightaging.org/archives/2023/04/plasma-transfer-lowers-epigenetic-age-and-mortality-in-rats/
Plasma transfer from young to old individuals has produced mixed results in animals and little to no benefit in humans where assessed rigorously. These studies were driven by the hypothesis that young plasma contains m...
Source: Fight Aging! - April 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Exercise and Alternative Mechanisms of Telomerase
Discussion on the canonical and extra-telomeric roles of telomerase are presented, followed by a detailed summary of the evidence on how exercise influences telomerase. Finally, the potential cell signalling underpinning the exercise-induced modulation of telomerase are discussed with directions for future research.
Link: https://doi.org/10.1111/acel.13836 (Source: Fight Aging!)
Source: Fight Aging! - April 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 24th 2023
In this study, researchers show that mice lacking a functional ATF4 gene show little to no loss of grip strength and treadmill performance into late life; it is quite an impressive effect size. Assessments of muscle biochemistry do show age-related declines, but to a lesser degree than the controls. How ATF4 knockout functions to produce this outcome is an interesting question. The researchers point out a range of possible downstream and upstream targets that have been implicated in the regulation of muscle growth, but it will clearly require further work to identify the important mechanisms involved.
Aging slowly...
Source: Fight Aging! - April 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Myocardial Ischemia-Reperfusion Injury
Myocardial Ischemia-Reperfusion Injury is a paradoxical exacerbation of cellular dysfunction and cell death occurring after restoration of blood supply in previously ischemic tissues. Reperfusion of the myocardium after coronary occlusion in acute myocardial infarction can cause reperfusion arrhythmias like accelerated idioventricular rhythm. Myocardial ischemia-reperfusion injury can also occur after cardiac surgery and circulatory arrest [1]. Though reperfusion is essential for salvage of the myocardium it can sometimes cause paradoxical damage. Reperfusion injury can also affect distant organs occasionally leadin...
Source: Cardiophile MD - April 20, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, April 17th 2023
In conclusion, oral NR altered the gut microbiota in rats and mice, but not in humans. In addition, NR attenuated body fat mass gain in rats, and increased fat and energy absorption in the HFD context.
Glycine Supplementation as a Methionine Restriction Mimetic
https://www.fightaging.org/archives/2023/04/glycine-supplementation-as-a-methionine-restriction-mimetic/
Supplementation with the non-essential amino acid glycine has been shown to modestly slow aging in short-lived laboratory species. In today's open access review paper, researchers note glycine supplementation as essentially a calorie restricti...
Source: Fight Aging! - April 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 10th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing What is Known of TDP-43 Aggregation in Neurodegeneration
TDP-43 is one of the more recently discovered protein aggregates involved in neurodegenerative conditions. A few proteins in the body are capable of misfolding or otherwise becoming altered in ways that encourage other molecules of the same protein to do the same. Toxicity results, and it can spread as these altered proteins move from cell to cell. The condition most clearly associated with TDP-43 pathology is amyotrophic lateral sclerosis (ALS), but it appears to be involved in other forms of neurodegenerative disease as well. Researchers have made inroads into understanding how these aggregates form and disrupt normal ce...
Source: Fight Aging! - April 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
