Declines in Limb Muscle Mass Correlate with Higher Mortality in Late Life
Given that resistance training is shown to reduce mortality in older individuals, it makes sense that we would see the opposite effect when looking at low muscle mass in limbs. Skeletal muscle isn't an inert tissue, being quite involved in insulin metabolism, for example, and exercise has all sorts of interesting effects on the operation of metabolism, such as upregulation of beneficial cellular stress response mechanisms. Aging is associated with a progressive loss of muscle mass and strength, with the loss of stem cell activity being a leading cause. This ultimately results in frailty and the condition of weakness known ...
Source: Fight Aging! - September 2, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Why Don ’t Digital Health Investors Finance Tough Medical Issues?
Why did activity trackers flood the digital health market, while there’s barely a company dealing with menopause, arthritis, or rare diseases? How do digital health investors decide when it comes to funding a new project, and what are the specific factors to take into account in relation to the healthcare market? We looked around what could scare off financiers from funding tough medical issues, and have a suggestion on how to bring forward solutions for marginalized health problems. Read on.
Investment in digital health for everyone?
Investment in healthcare, especially in the digital
health market, is growing ste...
Source: The Medical Futurist - August 3, 2019 Category: Information Technology Authors: nora Tags: Business Future of Medicine companies company digital digital health digital health startups finance funding Healthcare investment technology Source Type: blogs
Why Don ’t Digital Health Investors Finance Solutions To Tough Medical Issues?
Why did activity trackers flood the digital health market, while there’s barely a company dealing with menopause, arthritis, or rare diseases? How do digital health investors decide when it comes to funding a new project, and what are the specific factors to take into account in relation to the healthcare market? We looked around what could scare off financiers from funding tough medical issues, and have a suggestion on how to bring forward solutions for marginalized health problems. Read on.
Investment in digital health for everyone?
Investment in healthcare, especially in the digital
health market, is growing ste...
Source: The Medical Futurist - August 3, 2019 Category: Information Technology Authors: nora Tags: Business Future of Medicine companies company digital digital health digital health startups finance funding Healthcare investment technology Source Type: blogs
Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications.
Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression
https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/
Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vesse...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Diminished Estradiol Explains Faster Muscle Loss Following Menopause
In this study, we use rigorous and unbiased approaches to demonstrate the in vivo necessity of estradiol to maintain the satellite cell number in females. Further, we use mouse genetics to show that the molecular mechanism of estradiol action is cell-autonomous signaling through estrogen receptor α (ERα). Specifically, we show the functional consequence of estradiol-ERα ablated signaling in satellite cells including impaired self-renewal, engraftment, and muscle regeneration, and the activation of satellite cell mitochondrial caspase-dependent apoptosis. Together, these results demonstrate an important role for estrogen...
Source: Fight Aging! - July 19, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A new therapy for osteoporosis: Romosozumab
Osteoporosis is a condition in which bones become porous (less dense) and weaker. It affects 10 million people in the United States: approximately eight million women and two million men. As bone weakens, people are more likely to experience fractures, especially in the spine, hip, and forearm. This causes pain, diminishes a person’s ability to function, and reduces quality of life. Anything that can lower the risk of osteoporosis and fractures has major positive public health implications. That’s why a new drug called romosozumab is getting a lot of attention.
Which medications can help treat osteoporosis?
There are c...
Source: Harvard Health Blog - July 17, 2019 Category: Consumer Health News Authors: David M. Slovik, MD Tags: Bones and joints Menopause Osteoporosis Women's Health Source Type: blogs
New Definition for DTC Lab Testing Prompted by EverlyWell Business Model
A recent article in Dark Daily convinced me that we need a new definition for direct-to-consumer (DTC) lab testing which has also been called direct-access-testing (DAT) (see:Direct-to-Consumer Lab Test Start-Up EverlyWell Puts Clinical Laboratory Tests on Shelves at CVS and Target). Below is an excerpt from the article:....Julia Taylor Cheek, Founder and CEO ofEverlyWell, a well-financed digital health company based in Austin —hopes to build a... disruptive business in the clinical laboratory industry....Cheek is talking about the same primary business strategy of letting consumers purchase their own lab tests....The co...
Source: Lab Soft News - July 17, 2019 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Clinical Lab Industry News Clinical Lab Testing Diagnostics Direct Access Testing (DAT) Healthcare Innovations Lab Industry Trends Lab Processes and Procedures Medical Consumerism Medical Research Reference Laboratories Test Kits and H Source Type: blogs
Will IVF affect my future reproductive cycles?
One of the biggest concerns patientshave with IVF is that when IVF doctors make them grow so many eggs during the IVF cycle, that this will affect the remaining eggs in their ovary .Theyare worried that if they're left with fewer eggs, because the doctor has taken somany out, they will reach menopause more quickly , becausetheir ovarian reserve has been reduced.This is not true.Remember that youstart to produce about 40 follicles in every menstrual cycle. Of these , 39 will die naturally in the bedroom every month,whether or not you do anything. This is a natural process , called follicle atresia, ...
Source: Dr.Malpani's Blog - June 6, 2019 Category: Reproduction Medicine Source Type: blogs
Surviving Menopause with Diabetes
DiabetesMine offers key information and tips on thriving with menopause when you live with diabetes. (Source: Diabetes Mine)
Source: Diabetes Mine - May 23, 2019 Category: Endocrinology Authors: DiabetesMine Team Source Type: blogs
Fight Aging! Newsletter, April 29th 2019
In this study, we report the age-associated differences between fetal MSC (fMSC) populations and MSCs isolated from elderly donors with respect to their transcriptomes. We successfully reprogrammed fMSCs (55 days post conception) and adult MSC (aMSC; 60-74 years) to iPSCs and, subsequently, generated the corresponding iMSCs. In addition, iMSCs were also derived from ESCs. The iMSCs were similar although not identical to primary MSCs. We unraveled a putative rejuvenation and aging gene expression signature. We show that iMSCs irrespective of donor age and cell type re-acquired a similar secretome to that of their parent...
Source: Fight Aging! - April 28, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Amyloid- β is not Merely Molecular Waste
Alzheimer's disease begins with the accumulation of amyloid-β in the brain, but this doesn't mean that amyloid-β is purely molecular waste. Yes, it is harmful given the presence of too much of it in the central nervous system, but that is true of most of our biochemistry. There is good evidence for amyloid-β to act as an antimicrobial system, for example, which is the basis for considering persistent infection as a potential contributing cause of Alzheimer's disease, in which infectious agents drive the generation of ever increasing amounts of amyloid-β. Even setting aside that and other evidence, however, it is quite ...
Source: Fight Aging! - April 25, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
10 Outstanding Companies for Women ’s Health
The women’s health technology or so-called femtech
market has been on the rise for the last couple of years, but it has mainly
revolved around fertility and pregnancy. We believe that female health topics reach
far beyond such traditional issues and players should concentrate more on
menopause, endometriosis, or mental health, just to name a few areas. Thus, we
tried to collect companies which are on top of their game in the conventional
fertility and/or pregnancy area, but also start-ups and ventures who are
looking way beyond that. Here’s our guide to 10 outstanding companies in
women’s health.
The women’s hea...
Source: The Medical Futurist - April 18, 2019 Category: Information Technology Authors: nora Tags: Business Future of Medicine Health Sensors & Trackers Telemedicine & Smartphones companies company digital digital health digital health technologies femtech health technology Innovation market women women's health Source Type: blogs
Five Facts About Atypical Depression You Need to Know
Despite its name, atypical depression is one of the most common types of depression, affecting between 25 to 40 percent of depressed people. Because the symptoms differ from those of typical depression, this subtype of depression is often misdiagnosed.
Atypical depression was named in the 1950s to classify a group of patients who did not respond to electroconvulsive therapy or to the tricyclic antidepressant Tofranil (imipramine). They did, however, respond to monoamine oxidase inhibitor (MAOI) antidepressants.
Some of the same treatments that work for classic depression work for atypical depression, such as selective sero...
Source: World of Psychology - April 16, 2019 Category: Psychiatry & Psychology Authors: Therese J. Borchard Tags: Depression Mental Health and Wellness Atypical Depression Major Depressive Episode Mood Disorder Source Type: blogs
Why the wheelchair? Could it be gout?
When Paul Manafort appeared in court for sentencing recently, he was in a wheelchair and pleaded for leniency, in part because “his confinement had taken a toll on his physical and mental health.” He reportedly had symptoms of depression and anxiety — but what was the health problem that put him in a wheelchair? According to multiple news reports, the answer is gout. Yes, that ancient disease you may have thought didn’t exist anymore has stricken Mr. Manafort. He joins the rising number of people in the country diagnosed with this common disease.
What is gout?
Gout is a cause of severe joint pain and inflammation....
Source: Harvard Health Blog - March 29, 2019 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Arthritis Bones and joints Health Inflammation Source Type: blogs
Mental Health and Hyperhidrosis
Hyperhidrosis is defined as abnormally excessive sweating unrelated to heat or exercise. If you have this condition you might find yourself sweating so much that it soaks through your clothes or drips off your hands. Hands, feet, underarms and the face are areas that are typically affected, and the sweating usually occurs on both sides of the body.
The most common form of hyperhidrosis is known as primary focal (essential) hyperhidrosis. The nerves responsible for signaling sweat glands become overactive, even though they haven’t been triggered by physical activity or a rise in temperature. It’s interesting to note...
Source: World of Psychology - March 9, 2019 Category: Psychiatry & Psychology Authors: Janet Singer Tags: Mental Health and Wellness Dehydration Hyperhidrosis Sweat sweating Source Type: blogs
