Comparison of promestriene with vaginal fractional CO2 laser and radiofrequency treatments of genitourinary syndrome of menopause
Life expectancy has been increasing worldwide in the last decades and at least one third of women's life will be lived in the postmenopausal period [1]; thus, many suffering of the Genitourinary Syndrome of Menopause (GSM) [2,3]; This is a chronic and progressive female condition involving several lower genital tract signs and symptoms, including dyspareunia, vaginal dryness, itching, burning and also urinary symptoms. Such symptoms may affect women's sexuality and quality of life, hence, there is a need for therapeutic options to ameliorate these symptoms [2]. (Source: Maturitas)
Source: Maturitas - April 24, 2024 Category: Primary Care Authors: Isadora B. Seganfredo, Cristina Bianchi, Maricy Tacla, Peter Chedraui, Jorge M. Haddad, Ricardo Simoes, Edmund C. Baracat, Jos é M. Soares Tags: Original article Source Type: research
Menopause experiences in sexual minority women and non-binary people
By 2060, there will be an estimated 5 million sexual and gender minority adults who are 50+ years old in the United States [1]. Lesbian/gay, bisexual, and queer-identified1 cisgender women, to whom we refer as sexual minority women (SMW), and non-binary people are resilient and diverse. Despite making substantial strides towards achieving visibility and acceptance, the healthcare experiences of these communities remain overwhelmingly characterized by challenges, disparities, and unmet needs. Additionally, SMW and non-binary people continue to be excluded or overlooked in medical research even as population numbers grow. (Source: Maturitas)
Source: Maturitas - April 24, 2024 Category: Primary Care Authors: Talia Sobel, Donya Derakshani, Jennifer A. Vencill Tags: Review article Source Type: research
Insights into the vulvar component of the genitourinary syndrome of menopause (GSM)
Genital, urinary and sexual symptoms are common in elderly women because menopausal hypoestrogenism interacts with both reduced androgen circulating levels and degenerative processes driven by age, leading to anatomical and functional modifications in urogenital tissues [1]. Clinical presentations are highly heterogeneous in terms of type, severity and localization of symptoms, as well as influence on quality of life (QoL), which greatly varies according to a multitude of bio-psycho-social determinants [2]. (Source: Maturitas)
Source: Maturitas - April 24, 2024 Category: Primary Care Authors: Laura Cucinella, Lara Tiranini, Chiara Cassani, Ellis Martini, Andrea Cumetti, Stefano Memoli, Sara Tedeschi, Rossella E. Nappi Tags: Review article Source Type: research
Impact of HER2 status on clinicopathological characteristics and pathological complete response to neoadjuvant chemotherapy in triple-negative breast cancer
ConclusionsIn our cohort, HER2-low TNBC patients exhibits specific clinical characteristics and response features to NAC. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 24, 2024 Category: Cancer & Oncology Source Type: research
Disentangling the relationships of body mass index and circulating sex hormone concentrations in mammographic density using Mendelian randomization
ConclusionOur findings support a positive causal association between BMI and mammographic non-dense area and an inverse association between BMI and dense area. Evidence was weaker and inconsistent for a causal effect of circulating sex hormone concentrations on mammographic density phenotypes. Based on our findings, associations between circulating sex hormone concentrations and mammographic density phenotypes are weak at best. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 24, 2024 Category: Cancer & Oncology Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Rev Endocr Metab Disord. 2024 Apr 23. doi: 10.1007/s11154-024-09882-0. Online ahead of print.ABSTRACTProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; r...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Eleni Memi Polina Pavli Papagianni Maria Nikolaos Vrachnis George Mastorakos Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Rev Endocr Metab Disord. 2024 Apr 23. doi: 10.1007/s11154-024-09882-0. Online ahead of print.ABSTRACTProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; r...
Source: ENDOCR REV - April 23, 2024 Category: Endocrinology Authors: Eleni Memi Polina Pavli Papagianni Maria Nikolaos Vrachnis George Mastorakos Source Type: research
Therapeutic benefits of central LH receptor agonism in the APP/PS1 AD model involve trophic and immune regulation and reproductive status dependent
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167165. doi: 10.1016/j.bbadis.2024.167165. Online ahead of print.ABSTRACTThe mechanisms that underly reproductive hormone effects on cognition, neuronal plasticity, and AD risk, particularly in relation to gonadotropin LH receptor (LHCGR) signaling, remain poorly understood. To address this knowledge gap and clarify the impact of circulating steroid hormones the therapeutic effects of CNS LHCGR activation, we delivered the LHCGR agonist human chorionic gonadotropin (hCG) intracerebroventricularly (ICV) and evaluated functional, structural, plasticity-related signaling cascade...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Megan Mey Sabina Bhatta Sneha Suresh Luis Montero Labrador Helen Piontkivska Gemma Casadesus Source Type: research
Correction to: Psychometric Evaluation of the MENQOL Instrument in Women Experiencing Vasomotor Symptoms Associated with Menopause
(Source: Advances in Therapy)
Source: Advances in Therapy - April 23, 2024 Category: Drugs & Pharmacology Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
AbstractProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system,progesterone contributes to the control ofluteinizing hormone andfollicle-stimulating hormone secretion and their pulsatility,via itsreceptors on thekisspeptin,neurokinin B, anddynorphin neurons in the hypothalamus.Progesterone together withestradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; regulates normal menstrual bleeding; contributes to fertilization and pregnancy maintenance; participate...
Source: Reviews in Endocrine and Metabolic Disorders - April 23, 2024 Category: Endocrinology Source Type: research
EMAS position statement: Thyroid disease and menopause
Women experience menopause at a particular stage of their lifetime. On the other hand, subclinical hypothyroidism, mainly due to autoimmune thyroiditis, is a common endocrine disease in women during their reproductive years (the prevalence rate is 6 –10 %) [1] and is often present or arises during the menopausal transition. (Source: Maturitas)
Source: Maturitas - April 23, 2024 Category: Primary Care Authors: Gesthimani Mintziori, Stavroula Veneti, Kris Poppe, Dimitrios G. Goulis, Eleni Armeni, C. Tamer Erel, Ivan Fistoni ć, Timothy Hillard, Angelica Lindén Hirschberg, Blazej Meczekalski, Nicolás Mendoza, Alfred O. Mueck, Tommaso Simoncini, Petra Stute, Dor Tags: Original article Source Type: research
Menopausal women struggling with symptoms at work - a conundrum unsolved?
Women Health. 2024 Apr;64(4):295-297. doi: 10.1080/03630242.2024.2331263. Epub 2024 Apr 21.NO ABSTRACTPMID:38644573 | DOI:10.1080/03630242.2024.2331263 (Source: Women and Health)
Source: Women and Health - April 22, 2024 Category: Primary Care Authors: Ana L R Valadares M árcio Alexandre Hipólito Rodrigues Source Type: research
Efficacy evaluation of standardized < em > Rheum rhaponticum < /em > root extract (ERr 731 < sup > ® < /sup > ) on symptoms of menopause: A systematic review and meta-analysis study
J Biomed Res. 2024 Apr 18:1-9. doi: 10.7555/JBR.37.20230219. Online ahead of print.ABSTRACTMenopause is characterized by various physical, mental and emotional symptoms. ERr 731 ® is a standardized extract from Rheum rhaponticum root and has been clinically studied for its role in reducing menopausal symptoms. The current systematic review and meta-analysis aimed to evaluate the efficacy of ERr 731 ® supplementation in alleviating the severity of menopausal symptoms. In this review, we searched across three online databases up to March 2023, evaluated the quality of the included studies by the Physiotherapy Evidence Data...
Source: Biomed Res - April 22, 2024 Category: Research Authors: Vishal P Dubey Varun P Sureja Dharmeshkumar B Kheni Source Type: research
The Allostery and Modification of hGHRH Molecules and Specific Dimer Produced Significant Fertility Effect by Proliferating and Activating in-situ Ovarian Mesenchymal Stem Cells
Eur J Pharm Sci. 2024 Apr 19:106768. doi: 10.1016/j.ejps.2024.106768. Online ahead of print.ABSTRACTThe negative coordination of growth hormone secretagogue receptor (GHS-R) and growth hormone-releasing hormone receptor (GHRH-R) involves in the repair processes of cellular injury. The allosteric U- or H-like modified GHRH dimer Grinodin and 2Y were comparatively evaluated in normal Kunming mice and hamster infertility models induced by CPA treatment. 1-3-9 µg of Grinodin or 2Y per hamster stem-cell-exhaustion model was subcutaneously administered once a week, respectively inducing 75-69-46 or 45-13-50% of birth rates. In ...
Source: European Journal of Pharmaceutical Sciences - April 21, 2024 Category: Drugs & Pharmacology Authors: Xu-Dong Zhang Qun Luo Yan Du Li Yang Li-Cheng Yu Lan Feng Dan Rao Jing-Xuan Tang Hong-Mei Tan Xiao-Yuan Guo Song-Shan Tang Tao Liu Feng Yue Hui-Xian Huang Source Type: research
The impact of a specialist-led digital health application on menopause symptoms in the workplace: A single-arm, longitudinal evaluation
Menopause is a natural process in normal female aging, resulting from depletion of ovarian follicles, and occurs at a median age of 51 years in Caucasian women and earlier in others, with the menopause transition usually starting at about 47 years. This period lasts until a year after menstruation has ceased and marks the menopause transition [1]. Although the transition happens to half the population, the experience varies co nsiderably from person to person [2]. While some women report no menopausal symptoms, others experience severe symptoms lasting for, at its worst, over a decade. (Source: Maturitas)
Source: Maturitas - April 20, 2024 Category: Primary Care Authors: Thea S. Schei, Kathy Abernethy Tags: Original Article Source Type: research
