Fight Aging! Newsletter, July 18th 2022
In conclusion, we show that PVS morphology in mice is variable and that the structure and function of pia suggests a previously unrecognized role in regulating CSF transport and amyloid clearance in aging and disease.
Reversing Ovarian Fibrosis in Mice
https://www.fightaging.org/archives/2022/07/reversing-ovarian-fibrosis-in-mice/
Researchers here provide evidence for ovarian fibrosis to be an important mechanism in limiting the age at which female mammals can remain fertile. Interestingly, existing antifibrotic drugs can produce some reversal of this fibrosis, enough to restore ovulation in mice. Fibro...
Source: Fight Aging! - July 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Discussion of the Grandmother Hypothesis
We humans are longer-lived than our near primate cousins, and this is a comparatively recent development in evolutionary time. It is thought that this longevity arises from our greater intelligence and culture. When grandparents can contribute to the reproductive success of grandchildren, there is a selection pressure favoring mechanisms that allow for individual survival to older ages than would otherwise be the case. Chimpanzees do not have sufficient intelligence and culture for grandparents to greatly influence the success of their grandchildren, natural selection does not operate as strongly on the shape of later life...
Source: Fight Aging! - July 15, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Contextualizing Menopause in the Law
Emily Gold Waldman (Pace University), Naomi Cahn (University of Virginia), Bridget J. Crawford (Pace University), Contextualizing Menopause in the Law, Harv. J. L.& Gender (Forthcoming): “It is horrendous, but then it’s magnificent,” says one character about menopause in an... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - June 10, 2022 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Commentators and Journalists Weigh In On Digital Health And Related Privacy, Safety, Social Media And Security Matters. Lots Of Interesting Perspectives - June 07, 2022.
-----This weekly blog is to explore the news around the larger issues around Digital Health, data security, data privacy, AI / ML. technology, social media and related matters.I will also try to highlightADHA Propagandawhen I come upon it.Just so we keep count, the latest Notes from the ADHA Board were dated 6 December, 2018 and we have seen none since! It ’s pretty sad!Note: Appearance here is not to suggest I see any credibility or value in what follows. I will leave it to the reader to decide what is worthwhile and what is not! The point is to let people know what is being said / published that I have come upon.-----h...
Source: Australian Health Information Technology - June 7, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Fight Aging! Newsletter, June 6th 2022
This study examines evidence suggesting that mitochondrial dysfunction plays a significant early impact on AD pathology.
Although mitochondrial dysfunction is a typical indication of Alzheimer's disease, it is unclear whether the cellular systems that maintain mitochondrial integrity malfunction, aggravating mitochondrial pathology. Different levels of vigilance and preventive methods are used to reduce mitochondrial damage and efficiently destroy faulty mitochondria to maintain the mitochondrial equilibrium. The form and function of mitochondria are regulated by mitochondrial fusion and fission. In contrast, mitoch...
Source: Fight Aging! - June 5, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Slower Protein Turnover in the Aged Brain
Metabolic activity slows down in late life, perhaps in large part because this reduces the risk of cancer. In an environment of pervasive molecular damage, a growing burden of nuclear DNA mutations, inflammation, and a declining immune system, more cellular replication and activity implies an ever greater risk of cancer. Longevity in our species appears to be a trade-off that selects for a slow decline in tissue function coupled to a lower cancer risk, rather than maintained tissue function coupled to a higher cancer risk.
Greater human longevity relative to other primates is a comparatively recent development in ev...
Source: Fight Aging! - June 3, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Virtual Clinical Trials: Interview with Ivan Jarry, CEO at ObvioHealth
Decentralized and virtual clinical trials are gaining prominence, particularly since the COVID-19 pandemic which made it difficult for trial participants to attend in-person appointments. However, conducting clinical trials remotely has a host of potential benefits beyond reducing COVID-19 transmission, including improved patient compliance, real-world data, real-time data, and reduced costs.
ObvioHealth is championing this approach to clinical trials, and through a partnership with Renovia, completed the first fully virtual clinical trial in urogynecology, which investigated the leva Pelvic Health System. The leva devi...
Source: Medgadget - May 16, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Ob/Gyn Urology clinical trials ObvioHealth Source Type: blogs
Prostate cancer, sex drive, male menopause and conversations to have with your doctor
Americans are having less sex than ever before. Should we be worried? Ask your prostate. A 2022 study from the National Survey of Sexual Health and Behavior found that the rate of all types of sexual intercourse have declined from 2009 to 2018. While the authors speculate as to why this may be the caseRead more …Prostate cancer, sex drive, male menopause and conversations to have with your doctor originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 21, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/kevin-charles-king" rel="tag" data-wpel-link="internal" > Kevin Charles King, MD < /a > < /span > Tags: Conditions Oncology/Hematology Source Type: blogs
Results of the written evidence submitted by organisations and experts to inform the Women ’s Health Strategy for England
This report summarises the written responses to the women's health call for evidence from 436 organisations and experts in women's health. Topics raised include the need for greater support for pregnancy loss and menopause training for clinicians. These responses will help shape the first government-led Women ’s Health Strategy in England as part of plans to level up health care.ReportDepartment of Health and Social Care - press release (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - April 13, 2022 Category: UK Health Authors: The King ' s Fund Library Tags: Equality and diversity Public health and health inequalities Source Type: blogs
Like Dementia, Incontinence is Not Just Reserved for Older Adults
Public understanding is often lacking when it comes to challenges faced by many. Adult incontinence is one of them. While it's true that older adults are more likely to face incontinence due to things like menopause in women and prostate challenges in men, millions of far younger adults struggle to live a quality life while coping with incontinence. Yes, there are medications, treatments, and devices that will help if not eliminate incontinence problems for many people, but as many of these younger people will attest, these approaches don't work for everyone...
Continue reading about the challenges faced by mid...
Source: Minding Our Elders - February 17, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Managing and Monitoring the Menopausal Body
Naomi Cahn (University of Virginia), Bridget J. Crawford (Pace University), Emily Gold Waldman (Pace University), Managing and Monitoring the Menopausal Body, Univ. Chicago L. Forum (forthcoming 2022): This Essay explores how menopausal bodies are managed and monitored through both menopausal... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - February 15, 2022 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Working Through Menopause
Bridget J. Crawford (Pace University), Emily Gold Waldman (Pace University), Naomi Cahn (University of Virginia), Working Through Menopause, Wash. U. L. Rev. (forthcoming): There are over thirty million people ages 44 to 55 in the civilian labor force in the... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - January 26, 2022 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols.
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Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Gameto Raises $20M at an Early Stage to Focus on Ovarian Aging
One of the signs of investor enthusiasm for an industry is the existence of projects that raise significant funding at a very early stage of their development. We're seeing that happen for cellular reprogramming, but companies started by well-connected individuals in other parts of the longevity industry are now raising a great deal of funding in early preclinical stages of development. This suggests that we will continue to see a growing influx of capital into the development of ways to treat aging as a medical condition, pulling more research projects out of the constraints of academia and into an environment of greater ...
Source: Fight Aging! - January 18, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Pregnancy and Childbirth Can Substantially Increase Your Risk of Developing Incontinence
Incontinence often begins with a few leaks when we laugh, cough, sneeze, or even exercise. For many women, that is where it stops. For some, whether right after the birth of a child or later on after menopause, these "leaks" happen when we find we can't always make it to the bathroom on time. For some, though, those unfortunate "leaks" turn into experiencing their bladder spontaneously emptying. Embarrassing? Oh, yeah. Messy? Most definitely. Your next thought is, How do I handle this?"
Read more on Egosancares blog to learn about the different types of incontinence that might affect you after childbirth or beyond.&...
Source: Minding Our Elders - January 4, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
