Fight Aging! Newsletter, April 29th 2019

In this study, we report the age-associated differences between fetal MSC (fMSC) populations and MSCs isolated from elderly donors with respect to their transcriptomes. We successfully reprogrammed fMSCs (55 days post conception) and adult MSC (aMSC; 60-74 years) to iPSCs and, subsequently, generated the corresponding iMSCs. In addition, iMSCs were also derived from ESCs. The iMSCs were similar although not identical to primary MSCs. We unraveled a putative rejuvenation and aging gene expression signature. We show that iMSCs irrespective of donor age and cell type re-acquired a similar secretome to that of their parental MSCs, thus re-enforcing their capabilities of context-dependent paracrine signaling relevant for tissue regeneration. Towards an Artificial Lymph Node https://www.fightaging.org/archives/2019/04/towards-an-artificial-lymph-node/ Artificial structures capable of replicating at least some of the functions of natural organs and tissues may turn out to be quite different in shape, structure, and content when compared to their natural counterparts. This is particularly true for chemical factory tissues, such as the liver, or tissues in which cells migrate and collaborate, such as lymph nodes. In today's research, scientists demonstrate that a comparatively simple structure can perform some of the same useful functions of a lymph node, at least those related to training and replicating T cells to attack a particular pathogen or canc...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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DiscussionMCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies. CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Authors: Roshangar L, Soleimani Rad J, Kheirjou R, Reza Ranjkesh M, Ferdowsi Khosroshahi A Abstract Burn wounds are one of the main causes of skin damage. Based on World Health Organization statistics, almost 300 000 people worldwide die of burns each year. In severe burns, the cells and blood vessels are often injured and the blood supply to the wound is disturbed. Many factors such as oxygenation, infection, aging, hormones, and nutrition potentially can influence burn progression and disrupt repair with unbalanced release of various growth factors and cytokines. Different treatment approaches such as dressings a...
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
CONCLUSIONS: An illustrated guide for dressing application in burn wounds was developed and validated for content by an expert panel. PMID: 31730512 [PubMed - as supplied by publisher]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
CONCLUSIONS: This is the largest cohort reported in the literature of patients with frostbite injuries treated with HBOT. Hyperbaric oxygen therapy may show positive impact on the demarcation level of frostbite and, despite the common side effects, it generally causes no long-term sequelae. PMID: 31730511 [PubMed - as supplied by publisher]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
Authors: Bolton L Abstract Falls are the leading cause of injury, premature institutionalization, and long-term disability in elderly adults worldwide, with a fall-related fatality in the United States every 19 minutes.1 According to the Centers for Disease Control and Prevention,2 3 million people over 65 years of age receive emergency room treatment for fall injuries at an average cost of $30 000. The annual cost of fall injuries was more than $50 billion in 2015.1,2 Community-based interventions effective in preventing falls include exercise, medication, and nutritional management as well as improving safety of ...
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
ConclusionComputed tomography examinations are a more reliable method for differential diagnosis of thyroid nodules than ultrasound examinations followed by fine needle aspiration biopsy.Level of EvidenceIII.ResumoIntroduçãoA ultrassonografia é um método rápido para determinar de qual nódulo deve-se coletar uma amostra para biópsia por aspiração com agulha fina. Por outro lado, o exame de tomografia computadorizada não é restringido pela atenuação do eco e distingue entre nódulos benignos e malignos.ObjetivoComparar exames tom...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Authors: Dams S, Holasek S, Tsiountsioura M, Malliga DE, Meier-Allard N, Poncza B, Lackner S, Jansenberger Y, Lamprecht M Abstract Vitamins and carotenoids are organic compounds that are important for vital functions of the human organism. Since the human body is not able to synthesize most of these micronutrients, they need to be supplied by the intake of food or supplements. The aim of this study was to analyze whether a whole food based, encapsulated fruit, berry, and vegetable juice powder concentrate provides bioavailable carotenoids and vitamins A (all-trans retinol), E and C. Eighteen healthy subjects recei...
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
Conclusions/interpretationThese results demonstrate a fundamental role for AIM2 in energy metabolism, inflammation and insulin resistance. Our studies establish a novel link between the innate immunity proteins, AIM2 and p202, and metabolism.
Source: Diabetologia - Category: Endocrinology Source Type: research
Conclusions/interpretationThis study provides a proof of principle for the use of iPSC-derived immune cells for modelling key cellular interactions in human type 1 diabetes.
Source: Diabetologia - Category: Endocrinology Source Type: research
Conclusions/interpretationOur results show a previously unappreciated role of adipocyteAtp7a in the regulation of ageing-related metabolic disease and identify new metallophysiologies in whole-body fat metabolism.Data availabilityThe datasets generated during the current study are available in the Genome Sequence Archive in BIG Data Center, Beijing Institute of Genomics (BIG), Chinese Academy of Sciences, under accession number CRA001769 (http://bigd.big.ac.cn/gsa).
Source: Diabetologia - Category: Endocrinology Source Type: research
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