Smart Textiles to Release Drugs When and Where Needed
At the Swiss Federal Laboratories for Materials Science and Technology (Empa) researchers are working on integrating therapeutic drugs into textiles that can release them into the skin as needed. The researchers envision pain medication to be administered as soon as the body severely during a sports injury, or an antibiotic can be released as soon as a wound forms on the skin.
The researchers are using biodegradable polymers and making them release the drugs that are embedded within them in a controlled manner. Polymers can be made to break up by the sweat of the skin, for example, or liquid blood can be the trigger for ...
Source: Medgadget - October 17, 2018 Category: Medical Devices Authors: Editors Tags: Materials Medicine Source Type: blogs
Fight Aging! Newsletter, October 15th 2018
This study suggests that exocrine glands can be induced from pluripotent stem cells for organ replacement regenerative therapy.
Replacement of Aged Microglia Partially Reverses Cognitive Decline in Mice
https://www.fightaging.org/archives/2018/10/replacement-of-aged-microglia-partially-reverses-cognitive-decline-in-mice/
Researchers here report on a compelling demonstration that shows the degree to which dysfunctional microglia contribute to age-related neurodegeneration. The scientists use a pharmacological approach to greatly deplete the microglial population and then allow it to recover naturally. Th...
Source: Fight Aging! - October 14, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Biodegradable Device for Electrical Stimulation of Nerve Regrowth
Living tissue has an electromagnetic component to its operation, both at the very small scale inside cellular processes, but also at the larger scale of signaling through the nervous system. I would say that beyond a few well established lines of research and development, such as work on pacemakers or direct stimulation of nerves, the manipulation of electromagnetic fields and currents for therapeutic effect is far from being a mature area of the life sciences. If one roves the literature in search of connections between electromagnetism, regeneration, and metabolism, there are many small interesting areas of study, a few ...
Source: Fight Aging! - October 9, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, September 10th 2018
In conclusion, HSC ageing is characterised by reduced self-renewal, myeloid and platelet HSC skewing, and expanded clonal haematopoiesis that is considered a preleukaemic state. The underlying molecular mechanisms seem to be related to increased oxidative stress due to ROS accumulation and DNA damage, which are influenced by both cell- and cell non-autonomous mechanisms such as prolonged exposure to infections, inflammageing, immunosenescence, and age-related changes in the HSC niche. Thus, HSC ageing seems to be multifactorial and we are only beginning to connect all the dots.
The Price of Progress or the Waste...
Source: Fight Aging! - September 9, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Price of Progress or the Waste of Regulation?
The average cost of delivering a new therapy from laboratory to clinic is increasing at a fast pace, more than doubling since the turn of the century according to some studies, to stand at $2.5 billion or more. This is not driven by the work of research and development becoming more expensive: if anything, the price of the tools of biotechnology is in free fall, even as capacity increases by orders of magnitude. Biotechnology has gone through, and is still going through, its own echoed version of the computing revolution of recent decades. A mix of advances in computational power and materials science means that a graduate...
Source: Fight Aging! - September 7, 2018 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
More mothing favourites
A few more mothing favourites from six weeks of trapping. The full collection can be seen with captions in my Lepidoptera gallery on Imaging Storm.
Elephant Hawk-moth (Deilephila elpenor) – Trapped overnight 7 Aug 2018
Scalloped Oak (Crocallis elinguaria) – Morning of 25th July 2018
Poplar Hawk Moth (Laothoe populi) – 24th July 2018, Rob’s trap in Rob’s garden.
It was Mrs Sciencebase spotting this Copper Underwing (Amphipyra pyramidea) in our garden on 23rd July 2018, that motivated me to borrow Rob’s actinic trap and begin my mothing career…
Burnished Brass (Diachrysia chrysitis) ...
Source: David Bradley Sciencebase - Songs, Snaps, Science - September 6, 2018 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs
Biomedical Engineering in Medicine and Aging
Today, the effective treatment of aging can only proceed rapidly as an engineering project. The fine details of the way in which aging progresses at the level of cells and proteins are far from fully understood - but that is not a roadblock to progress. The research community knows enough of the causes of aging to repair them and observe the results. In fact the repair approach, where it has been tried, and as typified by senolytic development to clear senescent cells, is doing far more, with far less expenditure, and in far less time, than other strategies that involve mapping and adjusting the extreme complexity of cellu...
Source: Fight Aging! - July 6, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
C –N Cross-Coupling via Photoexcitation of Nickel–Amine Complexes
JacsC –N Cross-Coupling via Photoexcitation of Nickel–Amine ComplexesChern-Hooi Lim , Max Kudisch, Bin Liu, and Garret M. MiyakeC –N cross-coupling is an important class of reactions with far-reaching impacts across chemistry, materials science, biology, and medicine. Transition metal complexes can elegantly orchestrate diverse aminations but typically require demanding reaction conditions, precious metal catalysts, or oxyge n-sensitive procedures. Here, we introduce a mild nickel-catalyzed C–N cross-coupling methodology that operates at room temperature using an inexpensive nickel source (NiBr2...
Source: Organometallic Current - June 13, 2018 Category: Chemistry Tags: C-N Bond Forming Ni Catalyzed Photoredox Catalysis Source Type: blogs
Prolific U.S. Inventor Prof. Esther Sans Takeuchi Named European Inventor Award Finalist (Interview)
In the category of Non-EPO countries, the European Patent Office (EPO) named U.S. Inventor Prof. Esther Sans Takeuchi a finalist for the 2018 European Inventor Award. Sans Takeuchi is being recognized for her work developing a battery that increases the lifespan of implantable cardiac defibrillators (ICDs) fivefold, effectively reducing the need for multiple replacement surgeries. Her contributions not only advanced the field of chemistry through the compact lithium/silver vanadium oxide (Li/SVO) battery, but also increased the acceptance of ICDs beginning in the 1980s.
Compact, implantable ICD battery
Sans Takeuchi’...
Source: Medgadget - May 22, 2018 Category: Medical Devices Authors: Michael Batista Tags: Exclusive Source Type: blogs
Spraying Technique Creates Muscle Fibers
A network of muscle fibers grows on spun plastic scaffold. Under a confocal laser scanning microscope the muscle fibers appear in red, and the cell nuclei in blue. Image: Lukas Weidenbacher
Researchers at the Swiss Federal Laboratories for Materials Science and Technology (EMPA) have developed an electrospraying technique that can incorporate living cells into a 3D synthetic polymer scaffold. The cells can then grow to form elongated fibers, mimicking natural muscular tissue, and the technique brings the possibility of lab-developed organs for transplant patients, such as artificial hearts, closer to reality.
Tissue engine...
Source: Medgadget - November 14, 2017 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Materials Source Type: blogs
Optical Fiber Pajamas Light Up to Treat Jaundice in Newborns
Kids born with jaundice have to spend a good deal of time in an illuminated incubator before they can metabolize bilirubin hepatically. Nobody likes this, as the child has to be taken away from the parents to spend time inside a glass box.
At the Swiss Federal Laboratories for Materials Science and Technology (Empa), a new illuminated fabric has been developed that can be used to make baby pajamas that literally blanket the child in light. There are technologies that resemble this, such as the Biliblanket, but Empa’s technology integrates optical fibers that are no wider than regular thread, right into traditional...
Source: Medgadget - November 1, 2017 Category: Medical Devices Authors: Editors Tags: Pediatrics Source Type: blogs
Remote, Late-Stage Oxidation of Aliphatic C –H Bonds in Amide-Containing Molecules
JacsRemote, Late-Stage Oxidation of Aliphatic C –H Bonds in Amide-Containing Molecules: Amide-containing molecules are ubiquitous in natural products, pharmaceuticals, and materials science. Due to their intermediate electron-richness, they are not amenable to any of the previously developedN-protection strategies known to enable remote aliphatic C –H oxidations. Using information gleaned from a systematic study of the main features that makes remote oxidations of amides in peptide settings possible, we developed an imidate salt protecting strategy that employs methyl trifluoromethanesulfonate as a reversible alkylatin...
Source: Organometallic Current - October 11, 2017 Category: Chemistry Tags: Fe catalyzed oxidation Source Type: blogs
Erin ’s Things: October 1
You're reading Erin’s Things: October 1, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles.
This week for my favorite things, there's a lot of technology, a great new book and a cool home store for those in California! Check out this week's list and leave your comments (and suggestions for other cool stuff) below!
ALDEA HOME + BABY – The San Francisco home goods store is cooly curated with different rooms impeccably decorated as if in a showroom. Frequently on every best design list, it boasts some quirky and al...
Source: PickTheBrain | Motivation and Self Improvement - October 1, 2017 Category: Consumer Health News Authors: Erin Falconer Tags: Erin's Things featured cool list erin falconer now trending pickthebrain self improvement Source Type: blogs
Rapid Access to Nanographenes and Fused Heteroaromatics by Palladium ‐Catalyzed Annulative π‐Extension Reaction of Unfunctionalized Aromatics with Diiodobiaryls
AngewchemRapid Access to Nanographenes and Fused Heteroaromatics by Palladium ‐Catalyzed Annulative π‐Extension Reaction of Unfunctionalized Aromatics with Diiodobiaryls: Efficient and rapid access to nanographenes and π‐extended fused heteroaromatics is important in materials science. Herein, we report a palladium‐catalyzed efficient one‐step annulative π‐extension (APEX)... (Source: Organometallic Current)
Source: Organometallic Current - August 28, 2017 Category: Chemistry Tags: Advanced materials annulation Pd Catalyzed Source Type: blogs
Review: Annulative π‐Extension (APEX): Rapid Access to Fused Arenes, Heteroarenes, and Nanographenes
AngewchemAnnulative π‐Extension (APEX): Rapid Access to Fused Arenes, Heteroarenes, and Nanographenes: The annulative π‐extension (APEX) reaction has the potential to have a tremendous impact on the fields of materials science and bioimaging, as well as on the pharmaceutical/agrochemical industries, since... (Source: Organometallic Current)
Source: Organometallic Current - August 11, 2017 Category: Chemistry Tags: annulation Heterocycles PAHs Reviews Source Type: blogs
