Weekly Overseas Health IT Links –3rd September, 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment-----https://healthitanalytics.com/news/machine-learning-tools-predict-post-op-complications-surgery-durationMachine-Learning Tools Predict Post-Op Complications, Surgery DurationResearchers from Washington University in St. Louis have developed machine-learning tools that can predict post-operative complications and surgery duration using perioperative data.ByShania K...
Source: Australian Health Information Technology - September 3, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Weekly Overseas Health IT Links –20th August 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment-----https://www.digitalhealth.net/2022/08/ai-predictive-trial-staffordshire-hn-reduce-ae-admissions/AI predictive trial in Staffordshire reduces A&E admissions by 35%A trial which looked at how existing patient data could be used to predict those most likely to need hospital care has led to a 35% reduction on average in A&E attendances across Staffordshire.Jor...
Source: Australian Health Information Technology - August 20, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
You Need Some Smarter Clothing
BY KIM BELLARD
Much as I’d love to write about Instagram’s feud with the Kardashians over changes to the Instagram feed, and how that and proposed changes to Facebook’s feed reflect Meta’s efforts to combat TikTok’s growing influence, I’ve already given healthcare plenty of warnings about TikTok. Instead, I’ll write about something else that the Kardashians care about: fashion.
Well, not fashion per se, but clothing. If the old, sexist statement was “clothes make the man,” then soon we may be saying “clothes make your health.”
The Washington Post got my attention when it report...
Source: The Health Care Blog - August 3, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, June 13th 2022
In conclusion, long-term cumulative BP was associated with subsequent cognitive decline, dementia risk, and all-cause mortality in cognitively healthy adults aged ≥50 years. Efforts are required to control long-term systolic BP and pulse pressure and to maintain adequate diastolic BP.
Longer-Lived Mammals Tend to Have Lower Expression of Inflammation-Related Genes
https://www.fightaging.org/archives/2022/06/longer-lived-mammals-tend-to-have-lower-expression-of-inflammation-related-genes/
Researchers here make a few interesting observations on gene expression data from a range of mammalian species with...
Source: Fight Aging! - June 12, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Decreasing Clonal Diversity with Age in Human Hematopoiesis
In today's research materials, scientists present data on clonal hematopoiesis with age in humans. Hematopoiesis is the creation of blood and immune cells, taking place in the bone marrow. Clonal hematopoiesis of indeterminate potential (CHIP) is the name given to one of the age-related changes taking place in the populations of stem cells and progenitor cells that carry out hematopoiesis. Stochastic mutations occur constantly in the body. In the dynamic hematopoietic cell populations of the bone marrow, some of these mutations allow the mutated cells to outcompete their undamaged peers to make up a much larger fraction of...
Source: Fight Aging! - June 8, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
New Antimicrobial Surface for Implantable Devices
Researchers at the University of California Los Angeles have created a zwitterion polymer coating for in-dwelling medical devices, such as urinary catheters, that prevents microbes from adhering and creating troublesome biofilms. Recurrent infection and biofouling are a serious problem for such devices, leading to the overuse of antibiotics and the consequent rise of drug-resistant microbes. The new coating is antibiotic free and works by binding water tightly, creating a thin hydration barrier that deters microbes from binding and proliferating.
In-dwelling catheters are a constant worry for patients and healthcare sta...
Source: Medgadget - May 26, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Materials Public Health Surgery Urology ucla Source Type: blogs
Fight Aging! Newsletter, May 23rd 2022
In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan.
Naked Mole-Rat Skin Shows Fewer Signs of Aging
https://www.fightaging.org/archives/2022/05/naked-mole-rat-skin-shows-fewer-signs-of-aging/
Naked mole-rats exhibit a maximum life span that is many times longer than is the case for similarly sized mammals. Further, they are negligibly senescent, showing few age-related declines in function across much of that lengthy life span. That includes maintenance of stem ...
Source: Fight Aging! - May 22, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cerebrospinal Fluid Transfer from Young Mice Improves Memory in Old Mice
Researchers have for some time investigated the effects of transfusing materials from young animals to old animals, largely blood fractions such as blood plasma, but also other line items such as samples of the gut microbiome, thymic tissue, and so forth. The work on blood and plasma transfusions from young to old has proven disappointing in comparison to parabiosis, in the sense that results have been mixed, both in mice and in human trials. Transferring gut microbes to rejuvenate the aged intestinal microbiome looks much more promising.
In today's research materials, scientists report on a more challenging procedu...
Source: Fight Aging! - May 19, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 7th 2022
This study estimates that prescreening with a 500 blood test could reduce by half both the cost and the time it takes to enroll patients in clinical trials that use PET scans. Screening with blood tests alone could be completed in less than six months and cut costs by tenfold or more, the study finds. Known as Precivity AD, the commercial version of the test is marketed by C2N Diagnostics. The current study shows that the blood test remains highly accurate, even when performed in different labs following different protocols, and in different cohorts across three continents.
xCT Knockout Modestly Extends Life in M...
Source: Fight Aging! - March 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Disrupted Autophagy in Parkinson's Disease
Parkinson's disease is associated with the spread of α-synuclein aggregates, misfolded proteins that can pass from cell to cell and encourage other α-synuclein molecules to misfold in the same way. These aggregates are surrounded by a halo of toxic biochemistry, altering cell behavior for the worse, and killing cells. The primary victims are dopaminergenic neurons necessary to motor control, leading to the characteristic symptoms of Parkinson's disease. In later stages neurons throughout the brain die, causing neurological pathologies of other sorts and eventual death.
Maintenance processes in the cell, responsibl...
Source: Fight Aging! - March 1, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols.
FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Blocking Olfactory Receptors in Macrophages Reduces Inflammation in Blood Vessel Walls
Chronic inflammatory signaling is an important issue in aging, both generally throughout the body, and in localized hot spots such as atherosclerotic lesions in blood vessel walls. Macrophage cells responsible for clearing out molecular waste and repairing damage in blood vessels are made less effective by inflammatory signaling. The feedback loop of ineffective macrophages becoming incapacitated by the toxic lesion environment, while inflammation draws in more macrophages, is at the center of the progression of atherosclerosis. Ultimately these fatty lesions grow to the point of rupture, and the result is a heart attack o...
Source: Fight Aging! - January 21, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 17th 2022
In conclusion, fibroblasts in monolayers cultured with soluble pentosidine and tridimensional in vitro skin constructs exposed to the combination of AGEs and UVA promote an inflammatory state and an alteration of the dermal compartment in relation to an elastosis-like environment. (Source: Fight Aging!)
Source: Fight Aging! - January 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Neutrophils Provoke Damaging Inflammation and Scarring Following Heart Damage
The heart is not a very regenerative organ. Following damage, scarring rather than reconstruction results, leading to reduced function. This contributes to the high mortality resulting from a heart attack. While preventing heart attacks is a much better goal than clearing up the damage afterwards, the research community is nonetheless very interested in understanding how to sabotage this scarring process. Interfering in the activities of immune cells has seemed a promising path forwards. Heart attacks provoke lasting inflammation, and such unresolved inflammation is disruptive of regenerative processes.
In today's r...
Source: Fight Aging! - January 12, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 3rd 2022
In this study, we showed that the iPaD (inducing Plagl2 and anti-Dyrk1a) lentivirus substantially rejuvenated the proliferative and neurogenic potential of NSCs in the aged brain. Clonal analysis by a sparse labeling approach as well as transcriptome analysis indicated that iPaD can rejuvenate aged NSCs (19-21 mo of age) to a level comparable with those at 1 or 2 months of age and successfully improved cognition of aged mice.
Once rejuvenated and activated by iPaD, aged dormant NSCs can generate, on average, 4.9 neurons but very few astrocytes in 3-week tracing. Furthermore, these activated NSCs were maintained for ...
Source: Fight Aging! - January 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
