Antibody Binding Changes with Age and Can be Used to Build an Immune Aging Clock
In conclusion, the circulating antibody repertoire has increased binding to thousands of peptides in older donors, which can be represented as an immune age. Increased immune age is associated with autoimmune disease, acute inflammatory disease severity, and may be a broadly relevant biomarker of immune function in health, disease, and therapeutic intervention. The immune age has the potential for wide-spread use in clinical and consumer settings. (Source: Fight Aging!)
Source: Fight Aging! - October 30, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 6th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - July 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Loss of Proteasomal Function Leads to Protein Aggregation in Aging Killifish
In today's research materials, scientists investigating the aging of the brain report on their use short-lived killifish. The researchers show that a decline in proteasomal function precedes the destabilization of protein complexes and the formation of harmful protein aggregates, a feature of neurodegenerative conditions. The proteasome is a complex piece of protein machinery, an assembly of numerous distinct proteins into a functional whole. It is responsible for breaking down unwanted and damaged proteins, recycling their component parts to be reused in the synthesis of other proteins.
Increases in proteasomal act...
Source: Fight Aging! - June 29, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 22nd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 21, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Molecular Changes in the Lens of the Eye as a Potential Biomarker of Biological Age
The search for viable biomarkers of aging is an active field of research. The ability to rapidly and cheaply assess biological age, the burden of cell and tissue damage and dysfunction that causes disease and mortality, would greatly speed the development of rejuvenation therapies. At present it is costly and slow to demonstrate that any given approach to rejuvenation actually works: one needs to run a life span study, which is prohibitively expensive in mice and simply impractical in humans. What is needed is a test that can be carried out immediately before and immediately after an intervention, and which accurately asse...
Source: Fight Aging! - June 16, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, April 6th 2020
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted.
Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - April 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Genetic Variants Associated with Risk of Hypertension and Obesity also Correlate with Reduced Life Expectancy
Identification of genetic variants associated with specific conditions has been a going concern for some time, but the creation of large national databases of genetic and biometric data in a number of countries has greatly expanded this area of study. In today's research materials, scientists demonstrate one way in which this can be used, as a confirmation of the importance of hypertension and obesity in present variations in human life expectancy. People with genetic variants that increase the odds of suffering either of these conditions tend to live shorter lives, something that also shows up in standard epidemiological ...
Source: Fight Aging! - March 30, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 2nd 2020
In conclusion, the recently demonstrated protective effects of NMN treatment on neurovascular function can be attributed to multifaceted sirtuin-mediated anti-aging changes in the neurovascular transcriptome. Our present findings taken together with the results of recent studies using mitochondria-targeted interventions suggest that mitochondrial rejuvenation is a critical mechanism to restore neurovascular health and improve cerebral blood flow in aging.
Wnt/β-Catenin Signaling as a Point of Intervention to Spur Greater Neural Regeneration
https://www.fightaging.org/archives/2020/02/wnt-%ce%b2-catenin-signal...
Source: Fight Aging! - March 1, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Preventing Oligomerization of β-arrestin-2 Improves Clearance of Tau via Autophagy
In today's research materials, scientists report on the discovery of a maladaptive response to the presence of tau aggregates in brain cells, one that makes the situation worse than it would otherwise be. Tau is one of a small number of proteins that can become altered in a way that ensures other molecules of the same protein also alter. They join together and precipitate into solid structures, known as neurofibrillary tangles in the case of tau, accompanied by a halo of disrupted biochemistry that is harmful to cell and tissue function. This spreads, seeding dysfunction as it moves from cell to cell, or throughout a tissu...
Source: Fight Aging! - February 26, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Process Used by Cells to Ingest Misfolded Proteins Might be Enhanced to Treat Neurodegenerative Conditions
The aggregation of misfolded proteins is a feature of most neurodegenerative conditions: amyloid-β and tau in Alzheimer's disease, α-synuclein in Parkinson's disease, and so forth. These and a few more of the countless proteins present in the body can become altered, such as via misfolding, in ways that encourage other molecules of the same protein to also alter, forming structures of linked, harmful proteins that can spread through tissue or from cell to cell. Cells, particularly immune cells, are equipped with a range of mechanisms to identify and break down these problem proteins, but, for reasons that are not fully u...
Source: Fight Aging! - February 25, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Body Worn Gas Sensor Sticks to Skin
Potential exposure to dangerous chemicals is a reality for many people working in mining and manufacturing, as well as medicine. While spills of liquids are easily detected, many gases are not. Sensitive wearable gas sensors stuck to the skin would be useful for gas exposure detection, but these devices have to be flexible, need a heating mechanism, and require an integrated electric power source to function.
A team of collaborators from Penn State and Northeastern University brought their expertise together to create an inexpensive way to produce flexible and self-heating devices that can detect a variety of danger...
Source: Medgadget - January 22, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Materials Medicine Military Medicine News Public Health Source Type: blogs
An Engineering Eye for the Tie Buying Guy
At the Mayo Clinic, patients always come first. In my few days of volunteering, I picked up on some subtle ways that the culture supports patient-centric values. Office areas are very utilitarian while patient care areas are well furnished and decorated. Everyone is professionally dressed, regardless of their role. For me, that means wearing a tie every day (and retiring my Dr. Martens). Over the past 20 years, I ' ve worn engineered black clothing in my travels around the world. I ' ve not worn a tie and long ago donated all the ties from my youth. Ad...
Source: Life as a Healthcare CIO - December 27, 2019 Category: Information Technology Source Type: blogs
Nanomesh Loaded with Antibiotics for Targeted Wound and Infection Treatment
Antibiotics are usually only needed at particular sites, where infection is likely to start. Yet, they’re delivered throughout the entire body via pills and injections. This results in poor localized effectiveness, unnecessary effects on the rest of the body, and sometimes leads to the development of resistance.
Researchers at Flinders University in Australia and National Institute for Materials Science in Japan have joined forces to develop a special nanomesh material that can release antibiotics in a programmed way precisely where they’re needed.
The nanomeshes were produced using electrospinning, a...
Source: Medgadget - October 18, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Emergency Medicine Materials Orthopedic Surgery Plastic Surgery Public Health Vascular Surgery Source Type: blogs
The Burnished Brass neck cheek of it
One of the more eye-catching of the moths I’ve seen during more than a year of mothing goes by the name of Burnished Brass (Diachrysia chrysitis). This is also an owlet moth, one of the noctuidae. It rests with its wings folded into a tent shape as many of them do, but what makes it stand out is that, as its name would suggest, it looks metallic. It shimmers in the sunlight and as it begins to warm it set its wings aquiver to speed up the process, revving its engines, as it were, before it can fly away into the garden shrubbery to vanish from sight. But, not before a quick photoshoot, of course.
Burnished Brass mot...
Source: David Bradley Sciencebase - Songs, Snaps, Science - September 12, 2019 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs
Fight Aging! Newsletter, August 19th 2019
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - August 18, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
