Two gadolinium-based contrast agents are banned in Italy
Wellwellwellwellwell! WELL!
I just read a bit of welcome (or, wellcome!) news in Italian. If you understand Italian, here’s the link: goo.gl/JYN8ec. In a nutshell, beginning today, yes, TODAY!, two contrast agents used in MRIs have been banned in ITALY. And, quelle surprise (not), they are gadolinium-based.
Remember the study that came out some years ago about how much myeloma cells simply LOVED gadolinium, and proliferated at mad rates when placed in it? If not, just do a search of my blog for “gadolinium.” Gadolinium can also have a bunch of not-very-nice side effects…
The reason for this ban isn...
Source: Margaret's Corner - February 28, 2018 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll gadolinium MRI myeloma Source Type: blogs
Artificial Brain Synapses Replicated in a Chip
Micrograph of electrical probing of NIST’s artificial synapse designed for neuromorphic computing. The synapse is a superconducting device, made of niobium electrodes and a manganese-silicon matrix, which mimics the operation of a switch between two brain cells. The chip is 1 square centimeter in size. One artificial synapse is located at the center of each X.
Our brains mainly consist of brain cells and the connections between them, making them quite modular and incredibly adaptable. Brain synapses, the connections between neurons, seem to be responsible for at least some of the computational magic that allows us to thi...
Source: Medgadget - February 1, 2018 Category: Medical Devices Authors: Editors Tags: Genetics Materials Neurology Source Type: blogs
Highly Selective Manganese(I)/Lewis Acid Cocatalyzed Direct C −H Propargylation Using Bromoallenes
AngewchemHighly Selective Manganese(I)/Lewis Acid Cocatalyzed Direct C −H Propargylation Using Bromoallenes: A manganese(I)/Lewis acid cocatalyzed direct C −H propargylation with high selectivity has been developed. BPh3 was discovered to not only promote the reactivity, but also enhance the selectivity. Secondary,... (Source: Organometallic Current)
Source: Organometallic Current - December 11, 2017 Category: Chemistry Tags: Mn catalyzed Propargylation Source Type: blogs
Manganese Based Alternative to Gadolinium: Journal Watch
The use of gadolinium-based contrast agents in MR images has become one of radiology ’s most debated topic. In a study published in Radiology, a manganese-based contrast agent, manganese-N-picolyl-N,N ’,N’-trans-1,2-cyclohexenediaminetriacetate (Mn-PyC3A) is shown enable contrast-enhanced MR angiography with comparable contrast enhancement to gadolinium-based agents and may overcome concerns regarding gadolinium-associated toxicity and retention. Eric M. Gale et al compared contrast material –enhanced MR angiography in baboons by using Mn-PyC3A and Gd-DTPA. Reference and Furth...
Source: Sumer's Radiology Site - November 16, 2017 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Visible ‐Light‐Initiated Manganese Catalysis for C−H Alkylation of Heteroarenes: Applications and Mechanistic Studies
AngewchemVisible ‐Light‐Initiated Manganese Catalysis for C−H Alkylation of Heteroarenes: Applications and Mechanistic Studies: A visible ‐light‐driven Minisci protocol that employs an inexpensive earth‐abundant metal catalyst, decacarbonyldimanganese Mn2(CO)10, to generate alkyl radicals from alkyl iodides has been developed. This... (Source: Organometallic Current)
Source: Organometallic Current - October 27, 2017 Category: Chemistry Tags: C-H alkylation Mn catalyzed Visible light Source Type: blogs
Synergistic Manganese(I) C −H Activation Catalysis in Continuous Flow: Chemoselective Hydroarylation
AngewchemSynergistic Manganese(I) C −H Activation Catalysis in Continuous Flow: Chemoselective Hydroarylation: Chemoselective hydroarylations were accomplished by a novel synergistic Br ønsted acid/manganese(I)‐catalyzed C−H activation manifold. Thus, alkynes bearing O‐leaving groups could, for the first time, be... (Source: Organometallic Current)
Source: Organometallic Current - October 25, 2017 Category: Chemistry Tags: C-H Activation Continuous Flow Synthesis Mn catalyzed Source Type: blogs
Redox ‐Neutral Manganese(I)‐Catalyzed C−H Activation: Traceless Directing Group Enabled Regioselective Annulation
AngewchemRedox ‐Neutral Manganese(I)‐Catalyzed C−H Activation: Traceless Directing Group Enabled Regioselective Annulation: A strategy is reported in which traceless directing groups (TDGs) are used to promote the redox ‐neutral MnI‐catalyzed regioselective synthesis of N‐heterocycles. Alkyne coupling partners bearing a traceless... (Source: Organometallic Current)
Source: Organometallic Current - September 6, 2017 Category: Chemistry Tags: Mn catalyzed Redox Neutral Source Type: blogs
Nickel ‐Catalyzed Asymmetric Reductive Heck Cyclization of Aryl Halides to Afford Indolines
AngewchemNickel ‐Catalyzed Asymmetric Reductive Heck Cyclization of Aryl Halides to Afford Indolines: A nickel ‐catalyzed asymmetric reductive Heck reaction of aryl chlorides has been developed that affords substituted indolines with high enantioselectivity. Manganese powder is used as the terminal reductant... (Source: Organometallic Current)
Source: Organometallic Current - August 31, 2017 Category: Chemistry Tags: Ni Catalyzed Reductive Heck Reaction Source Type: blogs
Get Ready for Multicolored MRI
Researchers at Case Western University are making MRI multicolored as a way to conduct more comprehensive and precise disease diagnosis. Introduced by Paul Lauterbur and Peter Mansfield in the 1980s, and considered “one of the greatest medical breakthroughs of the 20th century,” MRI traditionally uses one single contrast agent to illuminate images in the brain. This new technique enables radiologists to use these two contrast agents — gadolinium and manganese — to differentiate between healthy tissue a nd diseased tissue. Currently, MRI is limited to only measuring one agent at a time. However, this study utilized ...
Source: radRounds - August 25, 2017 Category: Radiology Authors: Julie Morse Source Type: blogs
Synthesis of Cyclic Imides by Acceptorless Dehydrogenative Coupling of Diols and Amines Catalyzed by a Manganese Pincer Complex
jacsSynthesis of Cyclic Imides by Acceptorless Dehydrogenative Coupling of Diols and Amines Catalyzed by a Manganese Pincer Complex: The first example of base-metal-catalyzed dehydrogenative coupling of diols and amines to form cyclic imides is reported. The reaction is catalyzed by a pincer complex of the earth abundant manganese and forms hydrogen gas as the sole byproduct, making the overall process atom economical and environmentally benign. (Source: Organometallic Current)
Source: Organometallic Current - August 22, 2017 Category: Chemistry Tags: Mn catalyzed Pincer complexes Source Type: blogs
Manganese Catalyzed α-Olefination of Nitriles by Primary Alcohols
JacsManganese Catalyzed α-Olefination of Nitriles by Primary Alcohols: Catalytic α-olefination of nitriles using primary alcohols, via dehydrogenative coupling of alcohols with nitriles, is presented. The reaction is catalyzed by a pincer complex of an earth-abundant metal (manganese), in the absence of any additives, base, or hydrogen acceptor, liberating dihydrogen and wa ter as the only byproducts. (Source: Organometallic Current)
Source: Organometallic Current - August 22, 2017 Category: Chemistry Tags: Mn catalyzed Source Type: blogs
Manganese(I) ‐Catalyzed Enantioselective Hydrogenation of Ketones Using a Defined Chiral PNP Pincer Ligand
AngewchemManganese(I) ‐Catalyzed Enantioselective Hydrogenation of Ketones Using a Defined Chiral PNP Pincer Ligand: A new chiral manganese PNP pincer complex is described. The asymmetric hydrogenation of several prochiral ketones with molecular hydrogen in the presence of this complex proceeds under mild conditions... (Source: Organometallic Current)
Source: Organometallic Current - August 22, 2017 Category: Chemistry Tags: Enantioselective Hydrogenation Mn catalyzed Pincer complexes Source Type: blogs
4 Ways to Ease Back-to-School and Autumn Anxiety
Middle schoolers aren’t the only ones who feel the jitters as school reopens every year.
Most people I know have trouble as summer draws to a close and autumn begins. All of the stress and transition required to accommodate new schedules, activities, and schools can throw off the limbic system (your emotional center) of even the most grounded creatures.
In fact, Ginny Scully, a therapist in Wales, said in an interview so many clients with feelings of anticipation and nervousness during the last week of August through the first weeks of September that she coined the term “autumn anxiety,” which I’ve written ab...
Source: World of Psychology - August 11, 2017 Category: Psychiatry & Psychology Authors: Therese J. Borchard Tags: Alternative and Nutritional Supplements Anxiety and Panic Mental Health and Wellness Parenting Self-Help Alternative Medicine Anxious Thoughts autumn anxiety Back To School Depression Diet Healthy Eating School stress Source Type: blogs
Metal-catalyzed electrochemical diazidation of alkenes
ByNiankai Fu,Gregory S. Sauer,Ambarneil Saha,Aaron Loo,Song LinScience11 Aug 2017 : 575-579Electrochemical oxidation underlies a broadly applicable method to place nitrogen substituents on two adjacent carbons.Adjacent carbon-nitrogen bonds often appear in chemical compounds of pharmaceutical interest. Fuet al. developed a versatile method to form these bonds by pairing manganese catalysis with electrochemical azide oxidation in the presence of olefins. A major advantage of the electrochemical approach is the tunable precision of its oxidizing power, which leaves other sensitive substituents such as alcohols and aldehydes ...
Source: Organometallic Current - August 11, 2017 Category: Chemistry Tags: Azidation C-N Bond Forming Electrochemical Mn catalyzed Source Type: blogs
8 Foods that Boost Your Mood
What we eat might not be able to cure us indefinitely from depression. I learned that hard lesson earlier this year. However, researchers are compiling strong evidence that what we eat can influence our risk for developing depression and can keep persons in remission from possibly relapsing.
Eating better foods has certainly helped my mood and allowed me to get by on less medication. A 2014 review published in the American Journal of Clinical Nutrition examined the link between diet and depression risk and found that a diet consisting mainly of fruit, vegetables, fish, and whole grains was significantly associated with a r...
Source: World of Psychology - July 28, 2017 Category: Psychiatry & Psychology Authors: Therese J. Borchard Tags: Alternative and Nutritional Supplements Depression Mental Health and Wellness Personal Self-Help Caffeine Depressive Episode Major Depressive Episode Mood Disorder phytochemicals Psychology Psychopharmacology Source Type: blogs
