Get Ready for Multicolored MRI

Researchers at Case Western University are making MRI multicolored as a way to conduct more comprehensive and precise disease diagnosis. Introduced by Paul Lauterbur and Peter Mansfield in the 1980s, and considered “one of the greatest medical breakthroughs of the 20th century,” MRI traditionally uses one single contrast agent to illuminate images in the brain. This new technique enables radiologists to use these two contrast agents — gadolinium and manganese — to differentiate between healthy tissue a nd diseased tissue. Currently, MRI is limited to only measuring one agent at a time. However, this study utilized Dual Contrast – Magnetic Resonance Fingerprinting (DC-MRF) to assess the “local concentration of multiple MRI contrast agents following simultaneous administration.” According to ScienceDaily, follow-up application of this methodology could potentially be applied to the study of cystic fibrosis, diabetes, a nd cancer. The group of researchers was comprised of nurses, uniting engineers, clinicians, scientific researchers, and members of the Case Comprehensive Cancer Center. In theirstudy published inNature, they explain how gadolinium and manganese can be used to interpret images. “The development of a ‘multi-color’ MRI methodology to independently monitor simultaneously-administered targeted and control MRI contrast agents, and potentially multiple targeted MRI contrast agents, would significantly impr...
Source: radRounds - Category: Radiology Authors: Source Type: blogs

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Dalton Trans., 2019, Accepted Manuscript DOI: 10.1039/C9DT03886H, PaperHEMANTA DEKA, Ankit Kumar, Soumyadip Patra, Mahendra Kumar Awasthi, Sanjay Kumar Singh New mononuclear manganese(II) complexes [Mn( κ2-L1)(OAc)2] ([Mn]-1), [Mn(κ2-L2)(OAc)2] ([Mn]-2) and [Mn(κ2-L3)(OAc)2] ([Mn]-3) with imidazole based ligands {4,4'-(phenylmethylene)bis(2-ethyl-5-methyl-1H-imidazole)} (L1), {(4,4'-((2-methoxy phenyl)methylene)bis(2-ethyl-5-methyl-1H-imidazole)} (L2) and {4,4'-((2-chlorophenyl) methylene)bis(2- ethyl-5-methyl-1H-imidazole)} (L3) are synthesized and fully characterized by... The content of this RSS Feed (...
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
Abstract Type I interferons (IFNs) facilitate cancer immunosurveillance, antitumor immunity and antitumor efficacy of conventional cell death-inducing therapies (chemotherapy/radiotherapy) as well as immunotherapy. Moreover, it is clear that dendritic cells (DCs) play a significant role in aiding type I IFN-driven immunity. Owing to these antitumor properties several immunotherapies involving, or inducing, type I IFNs have received considerable clinical attention, e.g., recombinant IFNα2 or agonists targeting pattern recognition receptor (PRR) pathways like Toll-like receptors (TLRs), cGAS-STING or RIG-I/MDA...
Source: International Review of Cell and Molecular Biology - Category: Cytology Authors: Tags: Int Rev Cell Mol Biol Source Type: research
Conclusions This review describes how leukocyte-heparanase can be a double-edged sword in tumor progression; it can enhance tumor immune surveillance and tumor cell clearance, but also promote tumor survival and growth. We also discuss the potential of using heparanase in leukocyte therapies against tumors, and the effects of heparanase inhibitors on tumor progression and immunity. We are just beginning to understand the influence of heparanase on a pro/anti-tumor immune response, and there are still many questions to answer. How do the pro/anti-tumorigenic effects of heparanase differ across different cancer types? Does...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
This study evaluated the effects of dried ginger and LGWWJX decoction on cold asthma at the metabolomics level. It provides a reference for the research on the compatibility of Chinese Medicine. Introduction Ginger is a Chinese medicine (CM) used as a food and as a medicine, and is often used to treat cold syndrome through the property of warming. Dried ginger (Zingiberis Rhizoma, GanJiang, GJ) is processed from fresh ginger and is also commonly used in CM. It is used to treat cold asthma by “warming the stomach to dispel cold, warming the lung to resolve fluid,” and it has significant anti-inflammatory...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Blood, saliva, urine, sweat or even ear wax can carry valuable information about an individual’s medical state. Until now, even simpler tests on such bodily fluids had to be carried out at medical facilities, but with the recent uptick in the development of digital diagnostic technologies, more and more solutions appear on the market which enable the patient to do such tests at home. Here we take a look around the bodily fluid business. From bloodletting to digital sweat measurement Blood, yellow bile, black bile, phlegm. Although it doesn’t sound appealing, the ancient Greek already thought that bodily f...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Health Sensors & Trackers Portable Diagnostics blood bodily fluid digital digital health digital solutions digital tattoo saliva smart smart healthcare sweat technology urine Source Type: blogs
NEW MEMBERS: Spring ’18 Brief bios/plugs for new members (extracted from the Introduce Yourself Connect Community) Katherine Infantes-Cordova, a bilingual patient liaison passionate about improving the patient experience, is eager to take part in eliminating health inequities and empowering patients to be proactive in their health. Leah Jones has a background in consumer public relations and social media. Her company, Natiiv Facilitation, offers independent focus group moderation, event facilitation, and patient engagement projects. She advocates about fibroids and the challenges people struggling with their weight f...
Source: Society for Participatory Medicine - Category: General Medicine Authors: Tags: Newsletter Source Type: news
Thread Starter List of Oxbridge Past Interview Questions Follow 9 hours ago 9h ago • Why do you want to study Medicine? • General knowledge of medical current affairs and medical ethics vital – e.g. the woman who wanted to use her dead husband’s sperm, and the Siamese twins that the...
Source: The Student Room - Category: Universities & Medical Training Authors: Tags: Medicine Source Type: forums
When we think about protein, images of body builders and athletes come to mind. But protein has important health benefits for everyone, not just for sports enthusiasts eager to build muscle. To understand why this nutrient is so necessary in our diets, it's important to understand more about it. Think back to high school science class. Proteins are molecules that make sure that our bodies' organs and tissues function properly. They are also key components in our skin, eyes, hair, bones and nails. Proteins are made up of smaller molecules called amino acids. When we digest protein, the amino acids are what's left. These un...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Table of contents O1: Assessing the protective effect of dexrazoxane against doxorubicin-induced toxicity in HL-1 cardiomyocytes Yvonne Sweeney, Hugh O’Neill, Garry Duffy O2: Role of KCNQ1 in epithelial barrier repair Daniel Creegan, Viviana Bustos, Brian J. Harvey O3: The suitability of non-small cell lung cancer cytology preparations for the analysis of anaplastic lymphoma kinase gene rearrangements Alexander Dalphy, Anthony O’Grady, Elaine Kay O4: Penetrating keratoplasty and descemet’s stripping automated endothelial keratoplasty ma...
Source: BMC Proceedings - Category: Biomedical Science Source Type: research
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