The 4-Hour Cairns Sepsis Model: A novel approach to predicting sepsis mortality at intensive care unit admission
Sepsis commonly causes intensive care unit (ICU) mortality, yet early identification of adults with sepsis at risk of dying in the ICU remains a challenge. The aim of the study was to derive a mortality prediction model (MPM) to assist ICU clinicians and researchers as a clinical decision support tool for adults with sepsis within 4 h of ICU admission. A cohort study was performed using 500 consecutive admissions between 2014 and 2018 to an Australian tertiary ICU, who were aged ≥18 years and had sepsis. A total of 106 independent variables were assessed against ICU episode-of-care mortality. Multivariable backward stepw...
Source: Current Awareness Service for Health (CASH) - November 10, 2021 Category: Consumer Health News Source Type: news
What is Refeeding Syndrome?
Discussion
Anorexia nervosa is an eating disorder with an intense fear of being overweight (i.e. distorted body image), and self-starvation and excessive weight loss. It is more common in women (1.2%) than men (0.2%) but can be seen in both genders. Risk factors include high-intelligence, perfectionism/inflexibility, anxiety, activities where thinner body types are expected (e.g. dancer, diver, gymnast, long-distance runner, volleyball player, etc.)
Other eating disorders include bulimia nervosa (i.e. cycles of binge eating and then purging), binge eating disorder (i.e. purging), orthorexia (i.e. obsessions with healthful ...
Source: PediatricEducation.org - October 25, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Does the association of therapeutic exercise and supplementation with sucrosomial magnesium improve posture and balance and prevent the risk of new falls? - Scaturro D, Vitagliani F, Terrana P, Tomasello S, Camarda L, Letizia Mauro G.
BACKGROUND: Fracture of the proximal femur is the most feared complication of osteoporosis. Given the numerous physiological functions that magnesium performs in our body, in the literature there is a correlation between osteoporosis and low serum levels o... (Source: SafetyLit)
Source: SafetyLit - September 18, 2021 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Janssen Presents Results from Phase 1b/2 NORSE Study in Patients with Metastatic or Locally Advanced Urothelial Carcinoma Treated with BALVERSA ® (erdafitinib) in Combination with Cetrelimab, a PD-1 Inhibitor
September 17, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced results from the Phase 1b/2 NORSE (NCT03473743) study evaluating BALVERSA® (erdafitinib) in combination with cetrelimab, an anti-programmed cell death protein 1 (PD-1) monoclonal antibody, compared to BALVERSA® monotherapy in patients with locally advanced or metastatic urothelial carcinoma (mUC) with fibroblast growth factor receptor (FGFR)3 or FGFR2 genetic alterations who are ineligible for cisplatin, a current standard of care treatment for mUC. The results were highlighted in an oral presentation at t...
Source: Johnson and Johnson - September 17, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
Head impact modeling to support a rotational combat helmet drop test - Terpsma R, Carlsen RW, Szalkowski R, Malave S, Fawzi AL, Franck C, Hovey C.
INTRODUCTION: The Advanced Combat Helmet (ACH) military specification (mil-spec) provides blunt impact acceleration criteria that must be met before use by the U.S. warfighter. The specification, which requires a helmeted magnesium Department of Transporta... (Source: SafetyLit)
Source: SafetyLit - September 13, 2021 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news
Janssen Announces U.S. FDA Approval of INVEGA HAFYERA ™(6-month paliperidone palmitate), First and Only Twice-Yearly Treatment for Adults with Schizophrenia
TITUSVILLE, N.J., Sept. 1, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the U.S. Food and Drug Administration (FDA) has approved long-acting atypical antipsychotic INVEGA HAFYERA™ (6-month paliperidone palmitate), the first-and-only twice-yearly injectable for the treatment of schizophrenia in adults. Before transitioning to INVEGA HAFYERA™, patients must be adequately treated with INVEGA SUSTENNA® (1-month paliperidone palmitate) for at least four months, or INVEGA TRINZA® (3-month paliperidone palmitate) for at least one 3-month injection cycle.1 The FDA approval of INVEGA ...
Source: Johnson and Johnson - September 1, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
Can Magnesium Supplements Really Help You Sleep?
The evidence for their sleep-inducing benefits is thin, but experts say that in some cases there ’s no harm in giving them a try. (Source: NYT Health)
Source: NYT Health - August 31, 2021 Category: Consumer Health News Authors: Anahad O ’Connor Tags: Sleep Insomnia Apnea (Sleep Disorder) Restless Leg Syndrome Diet and Nutrition Dietary Supplements and Herbal Remedies Source Type: news
Should Magnesium Be Used for COPD Exacerbations? Should Magnesium Be Used for COPD Exacerbations?
Dr Holley reviews whether magnesium is beneficial or harmful when treating acute exacerbations of COPD in an emergency setting.Medscape Critical Care (Source: Medscape Emergency Medicine Headlines)
Source: Medscape Emergency Medicine Headlines - August 30, 2021 Category: Emergency Medicine Tags: Pulmonary Medicine Viewpoint Source Type: news
What are Some of the Complications of Short Bowel Syndrome?
Discussion
Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal emergencies in neonates. Mortality rates are from 0-45% depending on infant weight and gestation with more premature and smaller infants having greater mortality. NEC usually occurs in premature infants but it also occurs in term infants. The etiology is unknown but is probably multifactorial with ischemia and/or reperfusion playing some role. There are ‘outbreaks’ of NEC but no causative organism has been identified. Regardless of the originating cause, inflammation of the intestine and release of inflammatory mediators causes variou...
Source: PediatricEducation.org - August 30, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Xywav (calcium, magnesium, potassium, sodium oxybates)
Title: Xywav (calcium, magnesium, potassium, sodium oxybates)Category: MedicationsCreated: 8/18/2021 12:00:00 AMLast Editorial Review: 8/18/2021 12:00:00 AM (Source: MedicineNet Sleep General)
Source: MedicineNet Sleep General - August 18, 2021 Category: Sleep Medicine Source Type: news
FDA Approves First Drug for Idiopathic Hypersomnia FDA Approves First Drug for Idiopathic Hypersomnia
Xywav, an oral solution of calcium, magnesium, potassium, and sodium oxybates, was approved last year for treating cataplexy or excessive daytime sleepiness in patients with narcolepsy.FDA Approvals (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - August 13, 2021 Category: Neurology Tags: Neurology & Neurosurgery News Alert Source Type: news
Jazz Pharmaceuticals Announces U.S. FDA Approval of Xywav (calcium, magnesium, potassium, and sodium oxybates) Oral Solution for Idiopathic Hypersomnia in Adults
DUBLIN, Aug. 12, 2021 /PRNewswire/ -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that the U.S. Food and Drug Administration (FDA) approved Xywav (calcium, magnesium, potassium, and sodium oxybates) oral solution for the treatment of... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - August 12, 2021 Category: Drugs & Pharmacology Source Type: news
Magnesium ocular injury - a case report - Little A, Dietze-Fiedler M, Fernstrum C, Mancera N, Wilcox R, Do V.
Common agents described in ocular chemical and thermal injuries include cleaning agents, fertilizers, refrigerants, cement, preservatives, and fireworks. Visual prognosis is dependent on the concentration, quantity, and pH of the chemical involved as well ... (Source: SafetyLit)
Source: SafetyLit - August 11, 2021 Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Magnesium deficiency symptoms - the major signs you could be running low on vital mineral
MAGNESIUM is a metallic element that is essential to our health and wellbeing. So what are the signs and symptoms of magnesium deficiency? (Source: Daily Express - Health)
Source: Daily Express - Health - August 3, 2021 Category: Consumer Health News Source Type: news
Company led medicines recall: Morphine Syringe 50mg/50ml (unlicensed medicine) and Magnesium Sulphate 8mmol/20ml infusion (unlicensed medicine)
Nova Laboratories Limited is recalling specific batches of the impacted products, Morphine Syringe 50mg/50ml and Magnesium Sulphate 8mmol/20ml infusion due to a potential risk of contamination.
Furth (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - July 1, 2021 Category: Drugs & Pharmacology Source Type: news
