Magnesium and vitamin D in long COVID syndrome; do they help?
Magnes Res. 2024 Apr 23;0(0). doi: 10.1684/mrh.2024.0521. Online ahead of print.ABSTRACTSince the start of the COVID-19 pandemic, it has become increasingly clear that the disease can have relevant multisystemic and long-term effects, and several studies have attempted to identify key determinants of the disease course. Here we discuss recent evidence suggesting that, in long COVID patients, combined magnesium and vitamin D deficiencies associate with a higher number of clinical manifestations, as compared to patients with normal levels of both nutrients. We highlight the potential synergistic effects of these deficiencies...
Source: Magnesium Research - April 23, 2024 Category: Biochemistry Authors: Federica I Wolf Valentina Trapani Source Type: research
Heavy metals bioaccumulation in free-ranging South American rattlesnakes (Crotalus durissus) in Southeastern Brazil
Environ Sci Pollut Res Int. 2024 Apr 23. doi: 10.1007/s11356-024-33432-5. Online ahead of print.ABSTRACTAnthropogenic activities are the main sources of soil, air, and water pollution by metals, including cadmium (Cd), lead (Pb), chromium (Cr), the metalloid arsenic (As), magnesium (Mg), zinc (Zn), and copper (Cu). The goal of this study was to assess the presence and concentration of toxic (As, Cd, Pb, and Cr) and essential metals (Mg, Zn, and Cu) in the liver and kidneys from 96 free-ranging rattlesnakes (Crotalus durissus) from Minas Gerais (Brazil). Bioaccumulation of Cd and Pb were significantly higher in males and he...
Source: Environmental Science and Pollution Research International - April 23, 2024 Category: Environmental Health Authors: Frank August de Oliveira Toledo Daniel Oliveira Dos Santos Izabela Magalh ães Arthuso Vasconcelos Ayisa Rodrigues Oliveira Juliana Ara újo Gomes Cabral R ômulo Antônio Righi de Toledo Pedro Hugo Henriques Cunha Diego Felipe Alves Batista Fabiola de Ol Source Type: research
Neuronal Mitochondrial Calcium Uniporter (MCU) Deficiency Is Neuroprotective in Hyperexcitability by Modulation of Metabolic Pathways and ROS Balance
This study highlights the importance of MCU at the interface of Ca2+ handling and metabolism as a mediator of stress-related mitochondrial dysfunction, which indicates the modulation of MCU as a potential target for future antiepileptogenic therapy. (Source: Molecular Neurobiology)
Source: Molecular Neurobiology - April 23, 2024 Category: Neurology Source Type: research
Acutely shaky hand
Clinical introduction A 57-year-old man presented acutely with involuntary movements of his left hand. He had hypertension, chronic kidney disease and chronic obstructive pulmonary disease. These movements were best described as sudden, recurrent and arrhythmic loss of tone and power of the left wrist and fingers (video 1). They were most prominent when extending the left wrist, but were absent when the arms were at rest and were not elsewhere. There were no additional neurological deficits. Serum urea, ammonia, sodium, potassium, calcium, magnesium, phosphate and glucose levels were normal. His haematological profile, inf...
Source: Emergency Medicine Journal - April 22, 2024 Category: Emergency Medicine Authors: Tan, Y.-J., Teo, C. H., Chan, C. Tags: EMJ Image Challenge Source Type: research
HELLP Syndrome at 20 Gestational Weeks Managed Using the Mississippi Protocol: A Case Report
This report indicates that early and intensive treatment of patients with HELLP syndrome occurring before 22 GWs according to the Mississippi protocol may enable clinicians to complete pregnancy termination without maternal complications and provide useful information to clinical practitioners in perinatal medicine.PMID:38644297 | DOI:10.24546/0100488386 (Source: Kobe J Med Sci)
Source: Kobe J Med Sci - April 21, 2024 Category: General Medicine Authors: Naohisa Masuko Kenji Tanimura Masayuki Tanaka Akiko Uchida Ryosuke Takahashi Hitomi Imafuku Masashi Deguchi Yoshito Terai Source Type: research
Exploring Micronutrient Dynamics in COVID-19 Severity and Mortality: Unraveling the Roles of Vitamin D, Calcium, Phosphorus, Magnesium and ALP
This study explores the impact of Vitamin D, calcium, phosphorus, magnesium, and alkaline phosphatase (ALP) on COVID-19 severity and mortality. The study involves 200 participants (100 COVID-19 patients, 100 controls), we meticulously analyzed micronutrient dynamics. Calcium, phosphorus, magnesium and ALP was measured spectrophotometrically. Vitamin D was measured using Chemiluminescent method. The study reveals that diminished levels of calcium, phosphorus, magnesium, and with elevated ALP, are significantly associated with COVID-19 cases. Whereas the Vitamin D levels in severe group was increased when compared to mild ca...
Source: Indian Journal of Clinical Biochemistry - April 21, 2024 Category: Biochemistry Source Type: research
A Magnesium Binding Site And The Anomeric Effect Regulate The Abiotic Redox Chemistry Of Nicotinamide Nucleotides
Chemistry. 2024 Apr 19:e202400411. doi: 10.1002/chem.202400411. Online ahead of print.ABSTRACTNicotinamide adenine dinucleotide (NAD+) is a redox active molecule that is universally found in biology. Despite the importance and simplicity of this molecule, few reports exist that investigate which molecular features are important for the activity of this ribodinucleotide. By exploiting the nonenzymatic reduction and oxidation of NAD+ by pyruvate and methylene blue, respectively, we were able to identify key molecular features necessary for the intrinsic activity of NAD+ through kinetic analysis. Such features may explain how...
Source: Chemistry - April 19, 2024 Category: Chemistry Authors: Lorenzo Sebastianelli Harpreet Kaur Ziniu Chen Ramanarayanan Krishnamurthy Sheref S Mansy Source Type: research
Daring ‘James Bond’ mission to drill Antarctic ices cores could reveal future of sea level rise
The helicopter hovered overhead, whipping up snow. Shielding his face, Peter Neff grabbed the dangling cargo load and guided it to the Antarctic ice. The helicopter sped back to the South Korean icebreaker
RV Araon
, 20 kilometers away, to fetch more gear. One trip down, 17 more to go,
thought Neff, a polar glaciologist
at the University of Minnesota (UM) Twin Cities. Time was ticking away on this day in January. In the best-case scenario, Neff and his team would have just 10 days to drill ice cores on Canisteo, a peninsula on the west coast of Antarctica—and a blizzard was already looming.
Ever...
Source: Science of Aging Knowledge Environment - April 18, 2024 Category: Geriatrics Source Type: research
Integrating machine learning models with cross-validation and bootstrapping for evaluating groundwater quality in Kanchanaburi Province, Thailand
This study aimed to explore the applicability of random forest (RF) and artificial neural networks (ANN) models to predict groundwater quality. Particularly, these two models were integrated into cross-validation (CV) and bootstrapping (B) techniques to build predictive models, including RF-CV, RF-B, ANN-CV, and ANN-B. Entropy groundwater quality index (EWQI) was converted to normalized EWQI which was then classified into five levels from very poor to very good. A total of twelve physicochemical parameters from 180 groundwater wells, including potassium, sodium, calcium, magnesium, chloride, sulfate, bicarbonate, nitrate, ...
Source: Environmental Research - April 18, 2024 Category: Environmental Health Authors: Nguyen Ngoc Thanh Srilert Chotpantarat Nguyen Huu Ngu Pongsathron Thunyawatcharakul Narongsak Kaewdum Source Type: research
Comparison of trace elements in peripheral blood and bone marrow of newly diagnosed multiple myeloma patients
In this study, we aimed to evaluate alterations in trace elements in the blood and bone marrow serum of patients with newly diagnosed multiple myeloma (NMM). The levels of zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), magnesium (Mg), selenium (Se), arsenic (As), boron (B), nickel (Ni), silicon (Si) and chromium (Cr) were analyzed in the venous blood samples of the patient group comprising 70 patients with NMM (41 males and 29 females) and compared to those in the control group comprising 30 individuals (18 males and 12 females). In addition, trace element levels were analyzed in bone marrow samples from the patient gr...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Ayse Nilgun Kul Bahar Ozturk Kurt Source Type: research
Impacts of substituting magnesium by zinc on crystallization behaviors in an aluminosilicate glass
Phys. Chem. Chem. Phys., 2024, Accepted Manuscript DOI: 10.1039/D4CP00668B, PaperBiwei Huang, Qingshuang Zheng, Muzhi Cai, Ang Qiao, Haizheng Tao Series of zinc-magnesium mixed aluminosilicate glasses with the molar composition (1-r)MgO ·rZnO·Al2O3·2.5SiO2, where r = 0.00, 0.25, 0.50, 0.65, 0.75, 1.00, were fabricated to probe the effects of substitution of magnesium... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 17, 2024 Category: Chemistry Authors: Biwei Huang Source Type: research
Improved Structure Stability and Performance of LiFeSO4F Cathode Material for Lithium –Ion Batteries by Magnesium Substitution
Phys. Chem. Chem. Phys., 2024, Accepted Manuscript DOI: 10.1039/D4CP00344F, PaperZhendong Guo, Tieyan Wang, Mingchen Ni, Fenhong Song, Jing Fan, Xiaorui Dong, Dashuai Wang Tavorite LiFeSO4F with high Li-ion conductivity has been considered a promising alternative to LiFePO4. However, its poor cycle stability and low electronic conductivity limit the practical application of Tavorite LiFeSO4F.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 17, 2024 Category: Chemistry Authors: Zhendong Guo Source Type: research
Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
ConclusionWe found that ~ 50% of the pregnant women used medications before and during pregnancy and some took potential teratogenic medications during pregnancy. In birth genomic cohort study, it is expected that investigations into the safety and effectiveness of medications used during pregnancy will advance. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 17, 2024 Category: Drugs & Pharmacology Source Type: research
Comparison of trace elements in peripheral blood and bone marrow of newly diagnosed multiple myeloma patients
In this study, we aimed to evaluate alterations in trace elements in the blood and bone marrow serum of patients with newly diagnosed multiple myeloma (NMM). The levels of zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), magnesium (Mg), selenium (Se), arsenic (As), boron (B), nickel (Ni), silicon (Si) and chromium (Cr) were analyzed in the venous blood samples of the patient group comprising 70 patients with NMM (41 males and 29 females) and compared to those in the control group comprising 30 individuals (18 males and 12 females). In addition, trace element levels were analyzed in bone marrow samples from the patient gr...
Source: Clinical and Experimental Medicine - April 17, 2024 Category: Research Source Type: research
The Pharmacologic Management of Cardiac Arrest
This article covers the current state of evidence for the effectiveness of the vasopressor epinephrine and the combination of vasopressin-steroids-epinephrine and antiarrhythmic medications amiodarone and lidocaine and reviews the role of other med ications such as calcium, sodium bicarbonate, magnesium, and atropine in cardiac arrest care. We additionally review the role of β-blockers for refractory pulseless ventricular tachycardia/ventricular fibrillation and thrombolytics in undifferentiated cardiac arrest and suspected fatal pulmonary em bolism. (Source: Cardiology Clinics)
Source: Cardiology Clinics - April 16, 2024 Category: Cardiology Authors: Amandeep Singh, Megan Heeney, Martha E. Montgomery Source Type: research
