Gut microbiota and metabolome in sporadic Creutzfeldt –Jakob disease
ConclusionOur findings provide new insights into the relationship between gut microbiota and metabolites and sCJD. Some compounds, especially those related to the biosynthesis of phenylpropanoids were significantly altered in patients with sCJD, and those related to linoleic acid metabolism and steroid hormone biosynthesis might be biomarkers of evaluating disease severity. (Source: Journal of Neurology)
Source: Journal of Neurology - November 9, 2023 Category: Neurology Source Type: research
Development of a sensitive real-time quaking-induced conversion (RT-QuIC) assay for application in prion-infected blood
by Charlotte M. Thomas, M. Khalid F. Salamat, Christopher de Wolf, Sandra McCutcheon, A. Richard Alejo Blanco, Jean C. Manson, Nora Hunter, E. Fiona Houston
Efforts to prevent human-to-human transmission of variant Creutzfeldt-Jakob disease (vCJD) by contaminated blood would be aided by the development of a sensitive diagnostic test that could be routinely used to screen blood donations. As blood samples from vCJD patients are extremely rare, here we describe the optimisation of real-time quaking-induced conversion (RT-QuIC) for detection of PrPSc (misfolded prion protein, a marker of prion infection) in blood samples fro...
Source: PLoS One - November 2, 2023 Category: Biomedical Science Authors: Charlotte M. Thomas Source Type: research
Levels of plasma brain-derived tau and p-tau181 in Alzheimer's disease and rapidly progressive dementias
DISCUSSION: Plasma BD-tau and p-tau181 mimic their corresponding cerebrospinal fluid (CSF) markers. P-tau significantly increased in AD but not in RPD. Plasma BD-tau, like CSF t-tau, increases according to neurodegeneration intensity.PMID:37858957 | DOI:10.1002/alz.13516 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - October 20, 2023 Category: Psychiatry Authors: Fernando Gonzalez-Ortiz Thomas K Karikari Giuseppe Mario Bentivenga Simone Baiardi Angela Mammana Michael Turton Przemys ław R Kac Andrea Mastrangelo Peter Harrison Sabina Capellari Henrik Zetterberg Kaj Blennow Piero Parchi Source Type: research
Non-convulsive status epilepticus versus periodic EEG pattern in sporadic Creutzfeldt-Jakob disease: two sides of the same coin?
. (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - October 19, 2023 Category: Neuroscience Authors: Martina FanellaGiada ValenteLaura BorrelloFabiana MarinelliMartina BracagliaOttavio Di MarcoFilippo CostanzoFabrizio ApponiRoberto De Simonea Neurology Unit, Hospital F. Spaziani, Frosinone, Italyb Radiology Unit, Hospital F. Spaziani, Frosinone, Italyc P Source Type: research
Resp & #305;ratuar Changes & #305;n Creutzfeldt-Jakob D & #305;sease: B & #305;ot L & #305;ke Resp & #305;ratuar Pattern
Ince Aysenur, Kozak H HuseyınNeurology India 2023 71(5):1068-1069 (Source: Neurology India)
Source: Neurology India - October 18, 2023 Category: Neurology Authors: Ince Aysenur Kozak H Husey & #305;n Source Type: research
Diagnostic accuracy of diffusion-weighted imaging in variant Creutzfeldt –Jakob disease
ConclusionDWI showed reduced sensitivity compared to FLAIR imaging in detecting the pulvinar sign in vCJD. Conversely, DWI can more distinctively identify basal ganglia and cortical hyperintensities, thus leading to imaging patterns more characteristic of sCJD. Therefore, DWI should be cautiously interpreted in vCJD diagnosis, with axial FLAIR potentially providing a more precise evaluation of the pulvinar sign. (Source: Neuroradiology)
Source: Neuroradiology - October 13, 2023 Category: Radiology Source Type: research
The role of cellular prion protein in immune system
BMB Rep. 2023 Oct 11:6029. Online ahead of print.ABSTRACTNumerous studies have investigated the cellular prion protein (PrPC) since its discovery. These investigations have explained that its structure is predominantly composed of alpha helices and short beta sheet segments, and when its abnormal scrapie isoform (PrPSc) is infected, PrPSc transforms the PrPC, leading to prion diseases, including Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Given its ubiquitous distribution across a variety of cellular types, the PrPC manifests a diverse range of biological functions, including cell-ce...
Source: BMB Reports - October 11, 2023 Category: Biochemistry Authors: Seunghwa Cha Mi-Yeon Kim Source Type: research
The role of cellular prion protein in immune system
BMB Rep. 2023 Oct 11:6029. Online ahead of print.ABSTRACTNumerous studies have investigated the cellular prion protein (PrPC) since its discovery. These investigations have explained that its structure is predominantly composed of alpha helices and short beta sheet segments, and when its abnormal scrapie isoform (PrPSc) is infected, PrPSc transforms the PrPC, leading to prion diseases, including Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Given its ubiquitous distribution across a variety of cellular types, the PrPC manifests a diverse range of biological functions, including cell-ce...
Source: BMB Reports - October 11, 2023 Category: Biochemistry Authors: Seunghwa Cha Mi-Yeon Kim Source Type: research
The role of cellular prion protein in immune system
BMB Rep. 2023 Oct 11:6029. Online ahead of print.ABSTRACTNumerous studies have investigated the cellular prion protein (PrPC) since its discovery. These investigations have explained that its structure is predominantly composed of alpha helices and short beta sheet segments, and when its abnormal scrapie isoform (PrPSc) is infected, PrPSc transforms the PrPC, leading to prion diseases, including Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Given its ubiquitous distribution across a variety of cellular types, the PrPC manifests a diverse range of biological functions, including cell-ce...
Source: BMB Reports - October 11, 2023 Category: Biochemistry Authors: Seunghwa Cha Mi-Yeon Kim Source Type: research
The role of cellular prion protein in immune system
BMB Rep. 2023 Oct 11:6029. Online ahead of print.ABSTRACTNumerous studies have investigated the cellular prion protein (PrPC) since its discovery. These investigations have explained that its structure is predominantly composed of alpha helices and short beta sheet segments, and when its abnormal scrapie isoform (PrPSc) is infected, PrPSc transforms the PrPC, leading to prion diseases, including Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Given its ubiquitous distribution across a variety of cellular types, the PrPC manifests a diverse range of biological functions, including cell-ce...
Source: BMB Reports - October 11, 2023 Category: Biochemistry Authors: Seunghwa Cha Mi-Yeon Kim Source Type: research
