MRI abnormalities in Creutzfeldt –Jakob disease and other rapidly progressive dementia
ConclusionsIn the diagnostic work-up of RPD, negative/doubtful DWI makes CJD diagnosis rather unlikely, while specific DWI patterns help differentiating CJD from alternative diagnoses. The pulvinar sign is not exclusive of the variant form. (Source: Journal of Neurology)
Source: Journal of Neurology - September 12, 2023 Category: Neurology Source Type: research
Spontaneous prion disease in homozygous and heterozygous transgenic mouse models of T188K genetic Creutzfeldt-Jakob disease
Neurobiol Aging. 2023 Jul 31;131:156-169. doi: 10.1016/j.neurobiolaging.2023.07.024. Online ahead of print.ABSTRACTGenetic Creutzfeldt-Jakob disease with T188K mutation (T188K gCJD) is the most frequent genetic prion disease in China. To explore the penetration of T188K mutation and the pathogenesis of T188K gCJD, we constructed 2 lines of transgenic mouse models: homozygous Tg188K+/+ mice containing T188K mutation in 2 alleles of human PRNP background and heterozygous Tg188K+/- mice containing 1 allele of T188K human PRNP and 1 allele of the wild-type mouse PRNP. Spontaneous neurological illnesses were identified in all T...
Source: Neurobiology of Aging - September 3, 2023 Category: Geriatrics Authors: Yue-Zhang Wu Li-Ping Gao Dong-Dong Chen Dong-Lin Liang Jia Chen Kang Xiao Chao Hu Cao Chen Qi Shi Xiao-Ping Dong Source Type: research
Spontaneous prion disease in homozygous and heterozygous transgenic mouse models of T188K genetic Creutzfeldt-Jakob disease
Neurobiol Aging. 2023 Jul 31;131:156-169. doi: 10.1016/j.neurobiolaging.2023.07.024. Online ahead of print.ABSTRACTGenetic Creutzfeldt-Jakob disease with T188K mutation (T188K gCJD) is the most frequent genetic prion disease in China. To explore the penetration of T188K mutation and the pathogenesis of T188K gCJD, we constructed 2 lines of transgenic mouse models: homozygous Tg188K+/+ mice containing T188K mutation in 2 alleles of human PRNP background and heterozygous Tg188K+/- mice containing 1 allele of T188K human PRNP and 1 allele of the wild-type mouse PRNP. Spontaneous neurological illnesses were identified in all T...
Source: Neurobiology of Aging - September 3, 2023 Category: Geriatrics Authors: Yue-Zhang Wu Li-Ping Gao Dong-Dong Chen Dong-Lin Liang Jia Chen Kang Xiao Chao Hu Cao Chen Qi Shi Xiao-Ping Dong Source Type: research
Spontaneous prion disease in homozygous and heterozygous transgenic mouse models of T188K genetic Creutzfeldt-Jakob disease
Neurobiol Aging. 2023 Jul 31;131:156-169. doi: 10.1016/j.neurobiolaging.2023.07.024. Online ahead of print.ABSTRACTGenetic Creutzfeldt-Jakob disease with T188K mutation (T188K gCJD) is the most frequent genetic prion disease in China. To explore the penetration of T188K mutation and the pathogenesis of T188K gCJD, we constructed 2 lines of transgenic mouse models: homozygous Tg188K+/+ mice containing T188K mutation in 2 alleles of human PRNP background and heterozygous Tg188K+/- mice containing 1 allele of T188K human PRNP and 1 allele of the wild-type mouse PRNP. Spontaneous neurological illnesses were identified in all T...
Source: Neurobiology of Aging - September 3, 2023 Category: Geriatrics Authors: Yue-Zhang Wu Li-Ping Gao Dong-Dong Chen Dong-Lin Liang Jia Chen Kang Xiao Chao Hu Cao Chen Qi Shi Xiao-Ping Dong Source Type: research
Familial Creutzfeldt-Jakob Disease with early onset myoclonus: A case for fulminant progression
Indian J Psychiatry. 2023 Jul;65(7):795-796. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_261_23. Epub 2023 Jul 12.NO ABSTRACTPMID:37645366 | PMC:PMC10461591 | DOI:10.4103/indianjpsychiatry.indianjpsychiatry_261_23 (Source: Indian Journal of Psychiatry)
Source: Indian Journal of Psychiatry - August 30, 2023 Category: Psychiatry Authors: Indira Naskar None Navya Pooja Sharma Nishant Goyal Source Type: research
