The advances in the early and accurate diagnosis of Creutzfeldt-Jakob disease and other prion diseases: where are we today?
Expert Rev Neurother. 2023 Jul-Dec;23(9):803-817. doi: 10.1080/14737175.2023.2246653. Epub 2023 Aug 15.ABSTRACTINTRODUCTION: Before the introduction of MRI diffusion-weighted images (DWI), the diagnosis of Creutzfeldt-Jakob disease (CJD) relied upon nonspecific findings including clinical symptoms, EEG abnormalities, and elevated levels of cerebrospinal fluid 14-3-3 protein. Subsequently, the use of DWI has improved diagnostic accuracy, but it sometimes remains difficult to differentiate CJD from encephalitis, epilepsy, and other dementing disorders. The revised diagnostic criteria include real-time quaking-induced convers...
Source: Expert Review of Neurotherapeutics - August 15, 2023 Category: Neurology Authors: Hitaru Kishida Naohisa Ueda Fumiaki Tanaka Source Type: research
