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Experiences of Caregivers of Persons Dying with Rapidly Progressive versus Slower-Duration Dementia Syndromes (GP122)
1. Understand the end-of-life experiences from the perspective of bereaved care partners with sporadic Creutzfeldt Jacob Disease.2. Evaluate end-of-life experiences from the perspective of bereaved care partners with Alzheimer's dementia or other slower-course dementia syndromes. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Krista L. Harrison, Madina Halim, Sarah B. Garrett, Christine S. Ritchie, Alexander Smith Source Type: research

Religion, Faith, and Spiritual Beliefs in Documented Goals of Care Conversations Following Acute Stroke (RP109)
1. Identify key themes about religion, faith, and spirituality documented during goals of care conversations with acute stroke patients.2. Apply new knowledge about gaps in documenting goals of care conversations about religion, faith, and spirituality. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Shelley E. Varner-Perez, Mckenzi Marchand, Stephanie Bartlett, Lynn E. DCruz, Linda S. Williams, Carly Waite, Areeba Jawed, Robert G. Holloway, Claire Creutzfeldt, James E. Slaven, Alexia Torke, Amber Comer Source Type: research

Palliating Undifferentiated Encephalopathy in Creutzfeldt-Jakob Disease vs. Autoimmune Encephalitis
1. Utilizing a case based approach, learners will be able to describe the pathophysiology of Creutzfeldt-Jakob Disease (CJD) and autoimmune encephalitis (AE) that predicts the challenges of managing delirium and agitation.2. Learners will be able to recognize the nuances of undifferentiated encephalopathy in order to mitigate potential harms of an indiscriminate approach to neurocognitive palliation with potent dopaminergic antagonists and consider a more sophisticated approach with second generation antipsychotics possessing less dopaminergic antagonism. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Christy Meyer, Cayman Martin, Natsu Fukui Source Type: research

Characterisation of RT-QuIC negative cases from the UK National CJD Research and Surveillance programme
ConclusionsIndividuals with sporadic CJD and a negative CSF RT-QuIC present with younger age of onset, different clinical features and are over-represented with the VV1 and MM2 subtypes of sporadic CJD. Further work is required to better understand the biochemical properties contributing to RT-QuIC negative results in these cases. (Source: Journal of Neurology)
Source: Journal of Neurology - April 10, 2024 Category: Neurology Source Type: research

Genetic and pathological features encipher the phenotypic heterogeneity of Gerstmann-Str äussler-Scheinker disease
CONCLUSION: This study reveals GSS's intricate nature, showing significant variations in clinical presentations, diagnostic findings, and pathological features. Mutation sites and pathological changes play crucial roles in determining the GSS clinical heterogeneity.PMID:38583641 | DOI:10.1016/j.nbd.2024.106497 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - April 7, 2024 Category: Neurology Authors: Zhongyun Chen Yu Kong Jing Zhang Wen-Quan Zou Liyong Wu Source Type: research

Creutzfeldt-Jakob disease in a man surviving COVID-19: disentangling a casual or causal association by neuropathology
DiscussionTo disentangle the link between COVID-19 infection and CJD, neuropathology is essential determining the extent of changes related to both conditions. In our patient, we did not find any specific abnormality related to COVID-19. Our conclusion is in line with the current worldwide epidemiological data that do not show an increase in CJD cases since the beginning of the COVID-19 pandemic. (Source: Neurological Sciences)
Source: Neurological Sciences - April 5, 2024 Category: Neurology Source Type: research

Can new drugs stop a deadly set of brain-eating diseases?
Related podcast Hope in the fight against deadly prion diseases, and side effects of organic agriculture BY Sarah Crespi , Katherine Irving , Meredith Wadman Podcast 21 Mar 2024 My friend Charlie Clark began complaining that his eyeglasses were faulty in September 2023. A trip to the optician didn’t fix them; they were still “out of alignment,” he said. The same month, his insomnia,...
Source: Science of Aging Knowledge Environment - March 21, 2024 Category: Geriatrics Source Type: research

Clinical characteristics and diagnostics of human spongiform encephalopathies: an update
Nervenarzt. 2024 Mar 19. doi: 10.1007/s00115-024-01644-2. Online ahead of print.ABSTRACTHuman spongiform encephalopathies are rare transmissible neurodegenerative diseases of the brain and the nervous system that are caused by misfolding of the physiological prion protein into a pathological form and its deposition in the central nervous system (CNS). Prion diseases include Creutzfeldt-Jakob disease (CJD, sporadic or familial), Gerstmann-Straussler-Scheinker syndrome (GSS) and fatal familial insomnia (FFI). Prion diseases can be differentiated into three etiological categories: spontaneous (sporadic CJD), inherited (famili...
Source: Der Nervenarzt - March 20, 2024 Category: Neurology Authors: Peter Hermann Stefan Goebel Inga Zerr Source Type: research