The role of cellular prion protein in immune system
BMB Rep. 2023 Oct 11:6029. Online ahead of print.ABSTRACTNumerous studies have investigated the cellular prion protein (PrPC) since its discovery. These investigations have explained that its structure is predominantly composed of alpha helices and short beta sheet segments, and when its abnormal scrapie isoform (PrPSc) is infected, PrPSc transforms the PrPC, leading to prion diseases, including Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Given its ubiquitous distribution across a variety of cellular types, the PrPC manifests a diverse range of biological functions, including cell-ce...
Source: BMB Reports - October 11, 2023 Category: Biochemistry Authors: Seunghwa Cha Mi-Yeon Kim Source Type: research
The role of cellular prion protein in immune system
BMB Rep. 2023 Oct 11:6029. Online ahead of print.ABSTRACTNumerous studies have investigated the cellular prion protein (PrPC) since its discovery. These investigations have explained that its structure is predominantly composed of alpha helices and short beta sheet segments, and when its abnormal scrapie isoform (PrPSc) is infected, PrPSc transforms the PrPC, leading to prion diseases, including Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Given its ubiquitous distribution across a variety of cellular types, the PrPC manifests a diverse range of biological functions, including cell-ce...
Source: BMB Reports - October 11, 2023 Category: Biochemistry Authors: Seunghwa Cha Mi-Yeon Kim Source Type: research
The role of cellular prion protein in immune system
BMB Rep. 2023 Oct 11:6029. Online ahead of print.ABSTRACTNumerous studies have investigated the cellular prion protein (PrPC) since its discovery. These investigations have explained that its structure is predominantly composed of alpha helices and short beta sheet segments, and when its abnormal scrapie isoform (PrPSc) is infected, PrPSc transforms the PrPC, leading to prion diseases, including Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Given its ubiquitous distribution across a variety of cellular types, the PrPC manifests a diverse range of biological functions, including cell-ce...
Source: BMB Reports - October 11, 2023 Category: Biochemistry Authors: Seunghwa Cha Mi-Yeon Kim Source Type: research
The role of cellular prion protein in immune system
BMB Rep. 2023 Oct 11:6029. Online ahead of print.ABSTRACTNumerous studies have investigated the cellular prion protein (PrPC) since its discovery. These investigations have explained that its structure is predominantly composed of alpha helices and short beta sheet segments, and when its abnormal scrapie isoform (PrPSc) is infected, PrPSc transforms the PrPC, leading to prion diseases, including Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Given its ubiquitous distribution across a variety of cellular types, the PrPC manifests a diverse range of biological functions, including cell-ce...
Source: BMB Reports - October 11, 2023 Category: Biochemistry Authors: Seunghwa Cha Mi-Yeon Kim Source Type: research
The role of cellular prion protein in immune system
BMB Rep. 2023 Oct 11:6029. Online ahead of print.ABSTRACTNumerous studies have investigated the cellular prion protein (PrPC) since its discovery. These investigations have explained that its structure is predominantly composed of alpha helices and short beta sheet segments, and when its abnormal scrapie isoform (PrPSc) is infected, PrPSc transforms the PrPC, leading to prion diseases, including Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Given its ubiquitous distribution across a variety of cellular types, the PrPC manifests a diverse range of biological functions, including cell-ce...
Source: BMB Reports - October 11, 2023 Category: Biochemistry Authors: Seunghwa Cha Mi-Yeon Kim Source Type: research
The role of cellular prion protein in immune system
BMB Rep. 2023 Oct 11:6029. Online ahead of print.ABSTRACTNumerous studies have investigated the cellular prion protein (PrPC) since its discovery. These investigations have explained that its structure is predominantly composed of alpha helices and short beta sheet segments, and when its abnormal scrapie isoform (PrPSc) is infected, PrPSc transforms the PrPC, leading to prion diseases, including Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Given its ubiquitous distribution across a variety of cellular types, the PrPC manifests a diverse range of biological functions, including cell-ce...
Source: BMB Reports - October 11, 2023 Category: Biochemistry Authors: Seunghwa Cha Mi-Yeon Kim Source Type: research
The role of cellular prion protein in immune system
BMB Rep. 2023 Oct 11:6029. Online ahead of print.ABSTRACTNumerous studies have investigated the cellular prion protein (PrPC) since its discovery. These investigations have explained that its structure is predominantly composed of alpha helices and short beta sheet segments, and when its abnormal scrapie isoform (PrPSc) is infected, PrPSc transforms the PrPC, leading to prion diseases, including Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Given its ubiquitous distribution across a variety of cellular types, the PrPC manifests a diverse range of biological functions, including cell-ce...
Source: BMB Reports - October 11, 2023 Category: Biochemistry Authors: Seunghwa Cha Mi-Yeon Kim Source Type: research
The role of cellular prion protein in immune system
BMB Rep. 2023 Oct 11:6029. Online ahead of print.ABSTRACTNumerous studies have investigated the cellular prion protein (PrPC) since its discovery. These investigations have explained that its structure is predominantly composed of alpha helices and short beta sheet segments, and when its abnormal scrapie isoform (PrPSc) is infected, PrPSc transforms the PrPC, leading to prion diseases, including Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Given its ubiquitous distribution across a variety of cellular types, the PrPC manifests a diverse range of biological functions, including cell-ce...
Source: BMB Reports - October 11, 2023 Category: Biochemistry Authors: Seunghwa Cha Mi-Yeon Kim Source Type: research
The role of cellular prion protein in immune system
BMB Rep. 2023 Oct 11:6029. Online ahead of print.ABSTRACTNumerous studies have investigated the cellular prion protein (PrPC) since its discovery. These investigations have explained that its structure is predominantly composed of alpha helices and short beta sheet segments, and when its abnormal scrapie isoform (PrPSc) is infected, PrPSc transforms the PrPC, leading to prion diseases, including Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Given its ubiquitous distribution across a variety of cellular types, the PrPC manifests a diverse range of biological functions, including cell-ce...
Source: BMB Reports - October 11, 2023 Category: Biochemistry Authors: Seunghwa Cha Mi-Yeon Kim Source Type: research
The role of cellular prion protein in immune system
BMB Rep. 2023 Oct 11:6029. Online ahead of print.ABSTRACTNumerous studies have investigated the cellular prion protein (PrPC) since its discovery. These investigations have explained that its structure is predominantly composed of alpha helices and short beta sheet segments, and when its abnormal scrapie isoform (PrPSc) is infected, PrPSc transforms the PrPC, leading to prion diseases, including Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Given its ubiquitous distribution across a variety of cellular types, the PrPC manifests a diverse range of biological functions, including cell-ce...
Source: BMB Reports - October 11, 2023 Category: Biochemistry Authors: Seunghwa Cha Mi-Yeon Kim Source Type: research
The role of cellular prion protein in immune system
BMB Rep. 2023 Oct 11:6029. Online ahead of print.ABSTRACTNumerous studies have investigated the cellular prion protein (PrPC) since its discovery. These investigations have explained that its structure is predominantly composed of alpha helices and short beta sheet segments, and when its abnormal scrapie isoform (PrPSc) is infected, PrPSc transforms the PrPC, leading to prion diseases, including Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Given its ubiquitous distribution across a variety of cellular types, the PrPC manifests a diverse range of biological functions, including cell-ce...
Source: BMB Reports - October 11, 2023 Category: Biochemistry Authors: Seunghwa Cha Mi-Yeon Kim Source Type: research
Magnetic resonance imaging arterial spin labeling hypoperfusion with diffusion-weighted image hyperintensity is useful for diagnostic imaging of Creutzfeldt –Jakob disease
DiscussionPatients with CJD showed ASL hypoperfusion in lesions with DWI hyperintensity, suggesting that ASL-CBF could be beneficial for the diagnostic aid of CJD. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - October 10, 2023 Category: Neurology Source Type: research
Diagnostic challenge of Creutzfeldt-Jakob disease in a patient with multimorbidity: a case-report
Creutzfeldt-Jakob disease (CJD) is a rapidly progressive and ultimately fatal neurodegenerative condition caused by prions. The clinical symptoms of CJD vary with its subtype, and may include dementia, visual ... (Source: BMC Neurology)
Source: BMC Neurology - October 2, 2023 Category: Neurology Authors: Amber Yaqub, Mohammad Kamran Ikram, Jeroen Blankevoort and Mohammad Arfan Ikram Tags: Case Report Source Type: research
Correction to: Anakinra in Creutzfeldt-Jakob disease
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - October 1, 2023 Category: Neurology Source Type: research
A first seizure episode
Clinical introduction A middle-aged man is brought to your ED following a self-limiting generalised tonic–clonic seizure. He is a smoker, with a history of chronic obstructive pulmonary disease (COPD) and peripheral vascular disease, but no previous seizures. He is on aspirin and clopidogrel. On assessment, you see no evidence of trauma. He is confused, with a Glasgow Coma Scale 14 (E4, V4, M6) and mild global limb weakness but no focal neurology. He is newly hypertensive (210/140 mm Hg). His laboratory investigations and CT-brain are normal. An urgent MRI-brain is performed (see figure 1). Question What is the most ...
Source: Emergency Medicine Journal - September 27, 2023 Category: Emergency Medicine Authors: MacMahon, T. Tags: EMJ Image Challenge Source Type: research
