Accidental insertion of double-J in the inferior vena cava in a patient with retroperitoneal fibrosis: a case report
CONCLUSIONS: Situations such as this require caution during the implantation of the drainage device, with the occurrence of resistance indicating the need to discontinue the procedure and perform a new assessment with imaging exams. No intraoperative or postoperative complications occurred and the patient is currently in outpatient follow-up.PMID:37492792 | PMC:PMC10364004 | DOI:10.21037/acr-22-93 (Source: Cancer Control)
Source: Cancer Control - July 26, 2023 Category: Cancer & Oncology Authors: Jo ão Henrique Godoy Rodrigues Murillo de Souza Tuckumantel Lu ís Cesar Fava Spessoto Fernando Nestor Facio Source Type: research
A pathological complete response after immunotherapy with pembrolizumab for distal duodenal adenocarcinoma caused by Lynch syndrome: a case report
We present the case of a 55-year-old woman who was diagnosed with duodenal cancer. Biopsy findings revealed MSI-H, and pembrolizumab therapy was initiated because the tumor was in contact with the left renal vein and had metastasized to the mesenteric lymph nodes of the small intestine. Subsequently, after completing two courses of pembrolizumab therapy, the patient developed duodenal stenosis and underwent surgery. Pathological analysis of the resected specimen revealed no evidence of malignancy. Given the patient ’s previous cancer history and the occurrence of cancer in close relatives, genetic testing of peripheral b...
Source: International Cancer Conference Journal - July 26, 2023 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 15, Pages 3780: The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative Review
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Paolo Delrio
The history of Lynch syndrome changed definitively in 2000, when a study published in Gastroenterology demonstrated a significant reduction in mortality among individuals with Lynch syndrome who undergo regular endoscopic surveillance. As a consequence of this clinical evidence, all scientific societies developed guidelines, which highlighted the role of colonoscopy in the management of Lynch syndrome, especially for individuals at high risk of colorectal cancer. Over the years, these guidelines were modified and updated. Specialized networks were developed in order to standardize endoscopic surveill...
Source: Cancers - July 26, 2023 Category: Cancer & Oncology Authors: Valentina D ’Angelo Daniela Rega Pietro Marone Elena Di Girolamo Corrado Civiletti Fabiana Tatangelo Francesca Duraturo Marina De Rosa Mario de Bellis Paolo Delrio Tags: Review Source Type: research
Efficacy of PD-1 inhibitors for Colorectal Cancer and Polyps in Lynch Syndrome Patients
Programmed death-1 (PD-1) inhibitor is effective for colorectal cancer (CRC) with deficient mismatch repair (dMMR) or high microsatellite instability (MSI-H). We aimed to explore its effects on CRCs and colonic polyps in Lynch syndrome (LS) patients. (Source: European Journal of Cancer)
Source: European Journal of Cancer - July 25, 2023 Category: Cancer & Oncology Authors: Jie-Hai Yu, Bin-Yi Xiao, Jing-Hua Tang, Dan-Dan Li, Fang Wang, Ya Ding, Kai Han, Ling-Heng Kong, Yi-Hong Ling, Wei-Jian Mei, Zhi-Gang Hong, Le-En Liao, Wan-Jun Yang, Zhi-Zhong Pan, Xiao-Shi Zhang, Wu Jiang, Pei-Rong Ding Tags: Original Research Source Type: research
Precision Medicine in the Era of Genetic Testing: Microsatellite Instability Evolved
Clin Colon Rectal Surg DOI: 10.1055/s-0043-1770385The recognized importance of microsatellite instability (MSI) in cancer has evolved considerably in the past 30 years. From its beginnings as a molecular predictor for Lynch syndrome, MSI first transitioned to a universal screening test in all colorectal and endometrial cancers, substantially increasing the identification of patients with Lynch syndrome among cancer patients. More recently, MSI has been shown to be a powerful biomarker of response to immune checkpoint blockade therapy across a diversity of tumor types, and in 2017 was granted Food and Drug Administration ap...
Source: Clinics in Colon and Rectal Surgery - July 25, 2023 Category: Surgery Authors: Ioffe, Dina McSweeny, Michelle Hall, Michael J. Tags: Review Article Source Type: research
Serum matrix metalloproteinase-7: a potential biomarker in patients with Lynch Syndrome
CONCLUSIONS: Age-adjusted serum MMP-7 levels in asymptomatic LS carriers are higher than its levels in healthy population. While in colon cancer, MMP-7 higher level probably reflects the tumor burden and may have a prognostic effect, its significance and clinical applicability as a biomarker for tumorigenesis in LS is less clear and should be elucidated.PMID:37480510 | DOI:10.1007/s11033-023-08614-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - July 22, 2023 Category: Molecular Biology Authors: Doron Yablecovitch Hussein Mahajna Nir Horesh Efraim Katz Orit Picard Miri Yavzori Ella Fudim Talia Saker Shomron Ben-Horin Ido Laish Source Type: research
Serum matrix metalloproteinase-7: a potential biomarker in patients with Lynch Syndrome
CONCLUSIONS: Age-adjusted serum MMP-7 levels in asymptomatic LS carriers are higher than its levels in healthy population. While in colon cancer, MMP-7 higher level probably reflects the tumor burden and may have a prognostic effect, its significance and clinical applicability as a biomarker for tumorigenesis in LS is less clear and should be elucidated.PMID:37480510 | DOI:10.1007/s11033-023-08614-y (Source: Cancer Control)
Source: Cancer Control - July 22, 2023 Category: Cancer & Oncology Authors: Doron Yablecovitch Hussein Mahajna Nir Horesh Efraim Katz Orit Picard Miri Yavzori Ella Fudim Talia Saker Shomron Ben-Horin Ido Laish Source Type: research
Serum matrix metalloproteinase-7: a potential biomarker in patients with Lynch Syndrome
CONCLUSIONS: Age-adjusted serum MMP-7 levels in asymptomatic LS carriers are higher than its levels in healthy population. While in colon cancer, MMP-7 higher level probably reflects the tumor burden and may have a prognostic effect, its significance and clinical applicability as a biomarker for tumorigenesis in LS is less clear and should be elucidated.PMID:37480510 | DOI:10.1007/s11033-023-08614-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - July 22, 2023 Category: Molecular Biology Authors: Doron Yablecovitch Hussein Mahajna Nir Horesh Efraim Katz Orit Picard Miri Yavzori Ella Fudim Talia Saker Shomron Ben-Horin Ido Laish Source Type: research
Retracted: Functional Characterization of a Missense Variant of < em > MLH1 < /em > Identified in Lynch Syndrome Pedigree
Dis Markers. 2023 Jul 12;2023:9784325. doi: 10.1155/2023/9784325. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2020/8360841.].PMID:37476627 | PMC:PMC10356467 | DOI:10.1155/2023/9784325 (Source: Disease Markers)
Source: Disease Markers - July 21, 2023 Category: Laboratory Medicine Authors: Disease Markers Source Type: research
Advances in vaccine development for cancer prevention and treatment in Lynch Syndrome
Mol Aspects Med. 2023 Jul 19;93:101204. doi: 10.1016/j.mam.2023.101204. Online ahead of print.ABSTRACTLynch Syndrome (LS) is one of the most common hereditary cancer syndromes, and is caused by mutations in one of the four DNA mismatch repair (MMR) genes, namely MLH1, MSH2, MSH6 and PMS2. Tumors developed by LS carriers display high levels of microsatellite instability, which leads to the accumulation of large numbers of mutations, among which frameshift insertion/deletions (indels) within microsatellite (MS) loci are the most common. As a result, MMR-deficient (MMRd) cells generate increased rates of tumor-specific neoant...
Source: Molecular Medicine - July 21, 2023 Category: Molecular Biology Authors: Ana M Bolivar Fahriye Duzagac Krishna M Sinha Eduardo Vilar Source Type: research
Retracted: Functional Characterization of a Missense Variant of < em > MLH1 < /em > Identified in Lynch Syndrome Pedigree
Dis Markers. 2023 Jul 12;2023:9784325. doi: 10.1155/2023/9784325. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2020/8360841.].PMID:37476627 | PMC:PMC10356467 | DOI:10.1155/2023/9784325 (Source: Disease Markers)
Source: Disease Markers - July 21, 2023 Category: Laboratory Medicine Authors: Disease Markers Source Type: research
